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2021 Journal Article Analogues of the herbicide, N-hydroxy-N-isopropyloxamate, inhibit Mycobacterium tuberculosis ketol-acid reductoisomerase and their prodrugs are promising anti-TB drug leadsKandale, Ajit, Patel, Khushboo, Hussein, Waleed M., Wun, Shun Jie, Zheng, Shan, Tan, Lendl, West, Nicholas P., Schenk, Gerhard, Guddat, Luke W. and McGeary, Ross P. (2021). Analogues of the herbicide, N-hydroxy-N-isopropyloxamate, inhibit Mycobacterium tuberculosis ketol-acid reductoisomerase and their prodrugs are promising anti-TB drug leads. Journal of Medicinal Chemistry, 64 (3) acs.jmedchem.0c01919, 1670-1684. doi: 10.1021/acs.jmedchem.0c01919 |
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2020 Journal Article A dual-adjuvanting strategy for peptide-based subunit vaccines against group A Streptococcus: lipidation and polyelectrolyte complexesZhao, Lili, Yang, Jieru, Nahar, Ummey Jannatun, Khalil, Zeinab G., Capon, Robert J., Hussein, Waleed M., Skwarczynski, Mariusz and Toth, Istvan (2020). A dual-adjuvanting strategy for peptide-based subunit vaccines against group A Streptococcus: lipidation and polyelectrolyte complexes. Bioorganic and Medicinal Chemistry, 28 (24) 115823, 115823. doi: 10.1016/j.bmc.2020.115823 |
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2020 Journal Article Design, synthesis, biological evaluation and in silico studies of certain aryl sulfonyl hydrazones conjugated with 1,3-diaryl pyrazoles as potent metallo-β-lactamase inhibitorsShaaban, Marwa M., Ragab, Hanan M., Akaji, Kenichi, McGeary, Ross P., Bekhit, Alaa-Eldin A., Hussein, Waleed M., Kurz, Julia L., Elwakil, Bassma H., Bekhit, Salma A., Ibrahim, Tamer M., Mahran, Mona A. and Bekhit, Adnan A. (2020). Design, synthesis, biological evaluation and in silico studies of certain aryl sulfonyl hydrazones conjugated with 1,3-diaryl pyrazoles as potent metallo-β-lactamase inhibitors. Bioorganic Chemistry, 105 104386, 104386. doi: 10.1016/j.bioorg.2020.104386 |
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2020 Journal Article Polyethylenimine: an intranasal adjuvant for liposomal peptide-based subunit vaccine against Group A StreptococcusDai, Charles C., Yang, Jieru, Hussein, Waleed M., Zhao, Lili, Wang, Xiumin, Khalil, Zeinab G., Capon, Robert J., Toth, Istvan and Stephenson, Rachel J. (2020). Polyethylenimine: an intranasal adjuvant for liposomal peptide-based subunit vaccine against Group A Streptococcus. ACS Infectious Diseases, 6 (9) acsinfecdis.0c00452, 2502-2512. doi: 10.1021/acsinfecdis.0c00452 |
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2020 Journal Article Progress in the development of subunit vaccines against malariaSkwarczynski, Mariusz, Chandrudu, Saranya, Rigau-Planella, Berta, Islam, Md. Tanjir, Cheong, Yee S., Liu, Genan, Wang, Xiumin, Toth, Istvan and Hussein, Waleed M. (2020). Progress in the development of subunit vaccines against malaria. Vaccines, 8 (3) 373, 1-19. doi: 10.3390/vaccines8030373 |
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2020 Journal Article Opsonic activity of conservative versus variable regions of the Group A Streptococcus M proteinDai, Chuankai, Khalil, Zeinab G., Hussein, Waleed M., Yang, Jieru, Wang, Xiumin, Zhao, Lili, Capon, Robert J., Toth, Istvan and Stephenson, Rachel J. (2020). Opsonic activity of conservative versus variable regions of the Group A Streptococcus M protein. Vaccines, 8 (2) 210, 210. doi: 10.3390/vaccines8020210 |
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2020 Journal Article Structure–activity analysis of cyclic multicomponent lipopeptide self-adjuvanting vaccine candidates presenting Group A Streptococcus antigensMadge, Harrison Y. R., Sharma, Hansa, Hussein, Waleed M., Khalil, Zeinab G., Capon, Robert John, Toth, Istvan and Stephenson, Rachel (2020). Structure–activity analysis of cyclic multicomponent lipopeptide self-adjuvanting vaccine candidates presenting Group A Streptococcus antigens. Journal of Medicinal Chemistry, 63 (10) acs.jmedchem.0c00203, 5387-5397. doi: 10.1021/acs.jmedchem.0c00203 |
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2020 Journal Article Development of polyelectrolyte complexes for the delivery of peptide-based subunit vaccines against group A streptococcusZhao, Lili, Jin, Wanli, Cruz, Jazmina Gonzalez, Marasini, Nirmal, Khalil, Zeinab G., Capon, Robert J., Hussein, Waleed M., Skwarczynski, Mariusz and Toth, Istvan (2020). Development of polyelectrolyte complexes for the delivery of peptide-based subunit vaccines against group A streptococcus. Nanomaterials, 10 (5) 823, 823. doi: 10.3390/nano10050823 |
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2020 Journal Article Discovery, synthesis and evaluation of a novel ketol-acid reductoisomerase inhibitorBayaraa, Tenuun, Kurz, Julia L., Patel, Khushboo M., Hussein, Waleed M., Bilyj, Jessica K., West, Nicholas P., Schenk, Gerhard, McGeary, Ross P. and Guddat, Luke William (2020). Discovery, synthesis and evaluation of a novel ketol-acid reductoisomerase inhibitor. Chemistry - A European Journal, 26 (41), 8958-8968. doi: 10.1002/chem.202000899 |
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2020 Journal Article Poly(amino acids) as a potent self-adjuvanting delivery system for peptide-based nanovaccinesSkwarczynski, Mariusz, Zhao, Guangzu, Boer, Jennifer C., Ozberk, Victoria, Azuar, Armira, Gonzalez Cruz, Jazmina, Kumar Giddam, Ashwini, Khalil, Zeinab G., Pandey, Manisha, Shibu, Mohini A., Hussein, Waleed M., Nevagi, Reshma J., Batzloff, Michael R., Wells, James W., Capon, Robert J., Plebanski, Magdalena, Good, Michael F. and Toth, Istvan (2020). Poly(amino acids) as a potent self-adjuvanting delivery system for peptide-based nanovaccines. Science Advances, 6 (5) eaax2285, eaax2285. doi: 10.1126/sciadv.aax2285 |
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2020 Journal Article Polyacrylate–peptide antigen conjugate as a single-dose oral vaccine against Group A StreptococcusFaruck, Mohammad Omer, Zhao, Lili, Hussein, Waleed M., Khalil, Zeinab G., Capon, Robert J., Skwarczynski, Mariusz and Toth, Istvan (2020). Polyacrylate–peptide antigen conjugate as a single-dose oral vaccine against Group A Streptococcus. Vaccines, 8 (1) 23, 1-10. doi: 10.3390/vaccines8010023 |
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2020 Journal Article Hydroxyl substituted benzoic acid/cinnamic acid derivatives: tyrosinase inhibitory kinetics, anti-melanogenic activity and molecular docking studiesNazir, Yasir, Saeed, Aamer, Rafiq, Muhammad, Afzal, Samina, Ali, Anser, Latif, Muhammad, Zuegg, Johannes, Hussein, Waleed M., Fercher, Christian, Barnard, Ross T., Cooper, Matthew A., Blaskovich, Mark A.T., Ashraf, Zaman and Ziora, Zyta M. (2020). Hydroxyl substituted benzoic acid/cinnamic acid derivatives: tyrosinase inhibitory kinetics, anti-melanogenic activity and molecular docking studies. Bioorganic and Medicinal Chemistry Letters, 30 (1) 126722, 1-5. doi: 10.1016/j.bmcl.2019.126722 |
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2019 Journal Article Mannosylated liposomes formulated with whole parasite P. falciparum blood-stage antigens are highly immunogenic in miceSsemaganda, Aloysious, Giddam, Ashwini Kumar, Low, Leanne M., Liu, Xue Q., Ho, Mei-Fong, Zaman, Mehfuz, Hussein, Waleed M., Skwarczynski, Mariusz, Toth, Istvan, Stanisic, Danielle I. and Good, Michael F. (2019). Mannosylated liposomes formulated with whole parasite P. falciparum blood-stage antigens are highly immunogenic in mice. Vaccine, 38 (6), 1494-1504. doi: 10.1016/j.vaccine.2019.11.063 |
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2019 Journal Article Synthesis, evaluation and structural investigations of potent purple acid phosphatase inhibitors as drug leads for osteoporosisFeder, Daniel, Kan, Meng-Wei, Hussein, Waleed M., Guddat, Luke W., Schenk, Gerhard and McGeary, Ross P. (2019). Synthesis, evaluation and structural investigations of potent purple acid phosphatase inhibitors as drug leads for osteoporosis. European Journal of Medicinal Chemistry, 182 111611, 111611. doi: 10.1016/j.ejmech.2019.111611 |
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2019 Journal Article Cholic acid-based delivery system for vaccine candidates against Group A StreptococcusAzuar, Armira, Zhao, Lili, Hei, Tsui Ting, Nevagi, Reshma J., Bartlett, Stacey, Hussein, Waleed M., Khalil, Zeinab G., Capon, Robert J., Toth, Istvan and Skwarczynski, Mariusz (2019). Cholic acid-based delivery system for vaccine candidates against Group A Streptococcus. ACS Medicinal Chemistry Letters, 10 (9) acsmedchemlett.9b00239, 1253-1259. doi: 10.1021/acsmedchemlett.9b00239 |
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2019 Journal Article Peptide-based targeted polymeric nanoparticles for siRNA deliveryHussein, Waleed M., Cheong, Yee S., Liu, Chang, Liu, Genan, Begum, Anjuman Ara, Attallah, Maria Adly, Moyle, Peter Michael, Torchilin, Vladimir, Smith, Roger and Toth, Istvan (2019). Peptide-based targeted polymeric nanoparticles for siRNA delivery. Nanotechnology, 30 (41) 415604, 415604. doi: 10.1088/1361-6528/ab313d |
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2019 Journal Article Recent advances in the development of peptide vaccines and their delivery systems against Group A StreptococcusAzuar, Armira, Jin, Wanli , Mukaida, Saori, Hussein, Waleed , Toth, Istvan and Skwarczynski, Mariusz (2019). Recent advances in the development of peptide vaccines and their delivery systems against Group A Streptococcus. Vaccines, 7 (3) 58, 58. doi: 10.3390/vaccines7030058 |
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2019 Journal Article Self-assembly of trimethyl chitosan and poly(anionic amino acid)-peptide antigen conjugate to produce a potent self-adjuvanting nanovaccine delivery systemNevagi, Reshma J., Dai, Wei, Khalil, Zeinab G., Hussein, Waleed M., Capon, Robert J., Skwarczynski, Mariusz and Toth, Istvan (2019). Self-assembly of trimethyl chitosan and poly(anionic amino acid)-peptide antigen conjugate to produce a potent self-adjuvanting nanovaccine delivery system. Bioorganic and Medicinal Chemistry, 27 (14), 3082-3088. doi: 10.1016/j.bmc.2019.05.033 |
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2019 Journal Article Structure-activity relationship of group A streptococcus lipopeptide vaccine candidates in trimethyl chitosan-based self-adjuvanting delivery systemNevagi, Reshma J., Dai, Wei, Khalil, Zeinab G., Hussein, Waleed M., Capon, Robert J., Skwarczynski, Mariusz and Toth, Istvan (2019). Structure-activity relationship of group A streptococcus lipopeptide vaccine candidates in trimethyl chitosan-based self-adjuvanting delivery system. European Journal of Medicinal Chemistry, 179, 100-108. doi: 10.1016/j.ejmech.2019.06.047 |
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2019 Journal Article Advances in targeted gene deliveryBegum, Anjuman A., Toth, Istvan, Hussein, Waleed M. and Moyle, Peter Michael (2019). Advances in targeted gene delivery. Current Drug Delivery, 16 (7), 588-608. doi: 10.2174/1567201816666190529072914 |
