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2025 Journal Article Unlocking Disease‐Modifying Treatments for TDP‐43‐Mediated NeurodegenerationSan Gil, Rebecca and Walker, Adam K. (2025). Unlocking Disease‐Modifying Treatments for TDP‐43‐Mediated Neurodegeneration. BioEssays, 47 (4) e202400257. doi: 10.1002/bies.202400257 |
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2024 Journal Article A transient protein folding response targets aggregation in the early phase of TDP-43-mediated neurodegenerationSan Gil, Rebecca, Pascovici, Dana, Venturato, Juliana, Brown-Wright, Heledd, Mehta, Prachi, Madrid San Martin, Lidia, Wu, Jemma, Luan, Wei, Chui, Yi Kit, Bademosi, Adekunle T., Swaminathan, Shilpa, Naidoo, Serey, Berning, Britt A., Wright, Amanda L., Keating, Sean S., Curtis, Maurice A., Faull, Richard L. M., Lee, John D., Ngo, Shyuan T., Lee, Albert, Morsch, Marco, Chung, Roger S., Scotter, Emma, Lisowski, Leszek, Mirzaei, Mehdi and Walker, Adam K. (2024). A transient protein folding response targets aggregation in the early phase of TDP-43-mediated neurodegeneration. Nature Communications, 15 (1) 1508, 1508. doi: 10.1038/s41467-024-45646-9 |
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2023 Journal Article UndERACting ion channels in neurodegenerationJacobs, Matisse T., San Gil, Rebecca and Walker, Adam K. (2023). UndERACting ion channels in neurodegeneration. Trends in Neurosciences, 47 (2), 87-89. doi: 10.1016/j.tins.2023.11.002 |
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2023 Journal Article Early activation of cellular stress and death pathways caused by cytoplasmic TDP-43 in the rNLS8 mouse model of ALS and FTDLuan, Wei, Wright, Amanda L., Brown-Wright, Heledd, Le, Sheng, San Gil, Rebecca, Madrid San Martin, Lidia, Ling, Karen, Jafar-Nejad, Paymaan, Rigo, Frank and Walker, Adam K. (2023). Early activation of cellular stress and death pathways caused by cytoplasmic TDP-43 in the rNLS8 mouse model of ALS and FTD. Molecular Psychiatry, 28 (6), 2445-2461. doi: 10.1038/s41380-023-02036-9 |
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2023 Journal Article Aggregation-prone TDP-43 sequesters and drives pathological transitions of free nuclear TDP-43Keating, Sean S., Bademosi, Adekunle T., San Gil, Rebecca and Walker, Adam K. (2023). Aggregation-prone TDP-43 sequesters and drives pathological transitions of free nuclear TDP-43. Cellular and Molecular Life Sciences, 80 (4) 95, 1-23. doi: 10.1007/s00018-023-04739-2 |
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2022 Journal Article TDP-43 pathology: from noxious assembly to therapeutic removalKeating, Sean S., San Gil, Rebecca, Swanson, Molly E.V., Scotter, Emma L. and Walker, Adam K. (2022). TDP-43 pathology: from noxious assembly to therapeutic removal. Progress in Neurobiology, 211 102229, 102229. doi: 10.1016/j.pneurobio.2022.102229 |
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2021 Journal Article Riluzole does not ameliorate disease caused by cytoplasmic TDP‐43 in a mouse model of amyotrophic lateral sclerosisWright, Amanda L., Della Gatta, Paul A., Le, Sheng, Berning, Britt A., Mehta, Prachi, Jacobs, Kelly R., Gul, Hossai, San Gil, Rebecca, Hedl, Thomas J., Riddell, Winonah R., Watson, Owen, Keating, Sean S., Venturato, Juliana, Chung, Roger S., Atkin, Julie D., Lee, Albert, Shi, Bingyang, Blizzard, Catherine A., Morsch, Marco and Walker, Adam K. (2021). Riluzole does not ameliorate disease caused by cytoplasmic TDP‐43 in a mouse model of amyotrophic lateral sclerosis. European Journal of Neuroscience, 54 (6) ejn.15422, 6237-6255. doi: 10.1111/ejn.15422 |
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2021 Journal Article Regional differences in heat shock protein 25 expression in brain and spinal cord astrocytes of wild-type and SOD1 G93A miceSan Gil, Rebecca, Clarke, Benjamin E., Ecroyd, Heath, Kalmar, Bernadett and Greensmith, Linda (2021). Regional differences in heat shock protein 25 expression in brain and spinal cord astrocytes of wild-type and SOD1 G93A mice. Cells, 10 (5) 1257, 1-18. doi: 10.3390/cells10051257 |
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2020 Journal Article First person - Rebecca San GilSan Gil, Rebecca (2020). First person - Rebecca San Gil. Journal of Cell Science, 133 (15) jcs251918, 1-2. doi: 10.1242/jcs.251918 |
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2020 Journal Article Neurodegenerative disease-associated protein aggregates are poor inducers of the heat shock response in neuronal cellsGil, R. San, Cox, D., McAlary, L., Berg, T., Walker, A. K., Yerbury, J. J., Ooi, L. and Ecroyd, H. (2020). Neurodegenerative disease-associated protein aggregates are poor inducers of the heat shock response in neuronal cells. Journal of Cell Science, 133 (15), 1-15. doi: 10.1242/jcs.243709 |
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2019 Journal Article Proteomics approaches for biomarker and drug target discovery in ALS and FTDHedl, Thomas J., San Gil, Rebecca, Cheng, Flora, Rayner, Stephanie L., Davidson, Jennilee M., De Luca, Alana, Villalva, Maria D., Ecroyd, Heath, Walker, Adam K. and Lee, Albert (2019). Proteomics approaches for biomarker and drug target discovery in ALS and FTD. Frontiers in Neuroscience, 13 (JUN) 548, 548. doi: 10.3389/fnins.2019.00548 |
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2019 Journal Article Regional differences in the inflammatory and heat shock response in glia: implications for ALSClarke, Benjamin E., Gil, Rebecca San, Yip, Jing, Kalmar, Bernadett and Greensmith, Linda (2019). Regional differences in the inflammatory and heat shock response in glia: implications for ALS. Cell Stress and Chaperones, 24 (5), 857-870. doi: 10.1007/s12192-019-01005-y |
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2018 Journal Article The small heat shock protein Hsp27 binds α-synuclein fibrils, preventing elongation and cytotoxicityCox, Dezerae, Whiten, Daniel R., Brown, James W. P., Horrocks, Mathew H., San Gil, Rebecca, Dobson, Christopher M., Klenerman, David, van Oijen, Antoine M. and Ecroyd, Heath (2018). The small heat shock protein Hsp27 binds α-synuclein fibrils, preventing elongation and cytotoxicity. Journal of Biological Chemistry, 293 (12), 4486-4497. doi: 10.1074/jbc.m117.813865 |
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2017 Journal Article The heat shock response in neurons and astroglia and its role in neurodegenerative diseasesSan Gil, Rebecca, Ooi, Lezanne, Yerbury, Justin J. and Ecroyd, Heath (2017). The heat shock response in neurons and astroglia and its role in neurodegenerative diseases. Molecular Neurodegeneration, 12 (1) 65. doi: 10.1186/s13024-017-0208-6 |
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2017 Journal Article Using bicistronic constructs to evaluate the chaperone activities of heat shock proteins in cellsSan Gil, Rebecca, Berg, Tracey and Ecroyd, Heath (2017). Using bicistronic constructs to evaluate the chaperone activities of heat shock proteins in cells. Scientific Reports, 7 (1) 2387. doi: 10.1038/s41598-017-02459-9 |
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2016 Journal Article Rapid flow cytometric measurement of protein inclusions and nuclear traffickingWhiten, D. R., San Gil, R., McAlary, L., Yerbury, J. J., Ecroyd, H. and Wilson, M. R. (2016). Rapid flow cytometric measurement of protein inclusions and nuclear trafficking. Scientific Reports, 6 (1) 31138. doi: 10.1038/srep31138 |
