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2024 Journal Article Valproic acid-induced teratogenicity is driven by senescence and prevented by Rapamycin in human spinal cord and animal modelsPietrogrande, Giovanni, Shaker, Mohammed R., Stednitz, Sarah J., Soheilmoghaddam, Farhad, Aguado, Julio, Morrison, Sean D., Zambrano, Samuel, Tabassum, Tahmina, Javed, Ibrahim, Cooper-White, Justin, Davis, Thomas P., O’Brien, Terence J., Scott, Ethan K. and Wolvetang, Ernst J. (2024). Valproic acid-induced teratogenicity is driven by senescence and prevented by Rapamycin in human spinal cord and animal models. Molecular Psychiatry, 1-13. doi: 10.1038/s41380-024-02732-0 |
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2023 Journal Article Senolytic therapy alleviates physiological human brain aging and COVID-19 neuropathologyAguado, Julio, Amarilla, Alberto A., Taherian Fard, Atefeh, Albornoz, Eduardo A., Tyshkovskiy, Alexander, Schwabenland, Marius, Chaggar, Harman K., Modhiran, Naphak, Gómez-Inclán, Cecilia, Javed, Ibrahim, Baradar, Alireza A., Liang, Benjamin, Peng, Lianli, Dharmaratne, Malindrie, Pietrogrande, Giovanni, Padmanabhan, Pranesh, Freney, Morgan E., Parry, Rhys, Sng, Julian D. J., Isaacs, Ariel, Khromykh, Alexander A., Valenzuela Nieto, Guillermo, Rojas-Fernandez, Alejandro, Davis, Thomas P., Prinz, Marco, Bengsch, Bertram, Gladyshev, Vadim N., Woodruff, Trent M., Mar, Jessica C. ... Wolvetang, Ernst J. (2023). Senolytic therapy alleviates physiological human brain aging and COVID-19 neuropathology. Nature Aging, 3 (12), 1561-1575. doi: 10.1038/s43587-023-00519-6 |
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2023 Journal Article CRISPR-Cas9 direct fusions for improved genome editing via enhanced homologous recombinationTabassum, Tahmina, Pietrogrande, Giovanni, Healy, Michael and Wolvetang, Ernst J. (2023). CRISPR-Cas9 direct fusions for improved genome editing via enhanced homologous recombination. International Journal of Molecular Sciences, 24 (19) 14701, 1-17. doi: 10.3390/ijms241914701 |
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2023 Journal Article Deconstructing heterogeneity of replicative senescence in human mesenchymal stem cells at single cell resolutionTaherian Fard, Atefeh, Leeson, Hannah C., Aguado, Julio, Pietrogrande, Giovanni, Power, Dominique, Gómez-Inclán, Cecilia, Zheng, Huiwen, Nelson, Christopher B., Soheilmoghaddam, Farhad, Glass, Nick, Dharmaratne, Malindrie, Watson, Ebony R., Lu, Jennifer, Martin, Sally, Pickett, Hilda A., Cooper-White, Justin, Wolvetang, Ernst J. and Mar, Jessica C. (2023). Deconstructing heterogeneity of replicative senescence in human mesenchymal stem cells at single cell resolution. GeroScience, 46 (1), 1-17. doi: 10.1007/s11357-023-00829-y |
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2022 Journal Article Neural epidermal growth factor-like like protein 2 is expressed in human oligodendroglial cell typesShaker, Mohammed R., Kahtan, Amna, Prasad, Renuka, Lee, Ju-Hyun, Pietrogrande, Giovanni, Leeson, Hannah C., Sun, Woong, Wolvetang, Ernst J. and Slonchak, Andrii (2022). Neural epidermal growth factor-like like protein 2 is expressed in human oligodendroglial cell types. Frontiers in Cell and Developmental Biology, 10 803061, 803061. doi: 10.3389/fcell.2022.803061 |
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2021 Journal Article Corticosterone administration alters white matter tract structure and reduces gliosis in the sub-acute phase of experimental strokeZalewska, Katarzyna, Hood, Rebecca J., Pietrogrande, Giovanni, Sanchez-Bezanilla, Sonia, Ong, Lin Kooi, Johnson, Sarah J., Young, Kaylene M., Nilsson, Michael and Walker, Frederick R. (2021). Corticosterone administration alters white matter tract structure and reduces gliosis in the sub-acute phase of experimental stroke. International Journal of Molecular Sciences, 22 (13) 6693, 6693. doi: 10.3390/ijms22136693 |
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2021 Journal Article Exploring how low oxygen post conditioning improves stroke-induced cognitive impairment: a consideration of amyloid-beta loading and other mechanismsZhao, Zidan, Hood, Rebecca J., Ong, Lin Kooi, Pietrogrande, Giovanni, Sanchez Bezanilla, Sonia, Warren, Kirby E., Ilicic, Marina, Kluge, Murielle G., TeBay, Clifford, Ottersen, Ole P., Johnson, Sarah J., Nilsson, Michael and Walker, Frederick R. (2021). Exploring how low oxygen post conditioning improves stroke-induced cognitive impairment: a consideration of amyloid-beta loading and other mechanisms. Frontiers in Neurology, 12 585189, 1-14. doi: 10.3389/fneur.2021.585189 |
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2021 Journal Article Rapid and efficient generation of myelinating human oligodendrocytes in organoidsShaker, Mohammed R., Pietrogrande, Giovanni, Martin, Sally, Lee, Ju-Hyun, Woong, Sun and Wolvetang, Ernst J. (2021). Rapid and efficient generation of myelinating human oligodendrocytes in organoids. Frontiers in Cellular Neuroscience, 15 631548, 1-11. doi: 10.3389/fncel.2021.631548 |
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2018 Journal Article Low oxygen post conditioning as an efficient non-pharmacological strategy to promote motor function after strokePietrogrande, Giovanni, Zalewska, Katarzyna, Zhao, Zidan, Johnson, Sarah J., Nilsson, Michael and Walker, Frederick R. (2018). Low oxygen post conditioning as an efficient non-pharmacological strategy to promote motor function after stroke. Translational Stroke Research, 10 (4), 402-412. doi: 10.1007/s12975-018-0656-5 |
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2015 Journal Article Urokinase receptor promotes skin tumor formation by preventing epithelial cell activation of Notch1Mazzieri, Roberta, Pietrogrande, Giovanni, Gerasi, Laura, Gandelli, Alessandro, Colombo, Piergiuseppe, Moi, Davide, Brombin, Chiara, Ambrosi, Alessandro, Danese, Silvio, Mignatti, Paolo, Blasi, Francesco and D'Alessio, Silvia (2015). Urokinase receptor promotes skin tumor formation by preventing epithelial cell activation of Notch1. Cancer Research, 75 (22), 4895-4909. doi: 10.1158/0008-5472.CAN-15-0378 |
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2014 Journal Article VEGF-C-dependent stimulation of lymphatic function ameliorates experimental inflammatory bowel diseaseD'Alessio, Silvia, Correale, Carmen, Tacconi, Carlotta, Gandelli, Alessandro, Pietrogrande, Giovanni, Vetrano, Stefania, Genua, Marco, Arena, Vincenzo, Spinelli, Antonino, Peyrin-Biroulet, Laurent, Fiocchi, Claudio and Danese, Silvio (2014). VEGF-C-dependent stimulation of lymphatic function ameliorates experimental inflammatory bowel disease. Journal of Clinical Investigation, 124 (9), 3863-3878. doi: 10.1172/JCI72189 |
