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2025 Journal Article Mixed-chirality prohibitin peptide: D-(RLARLAR)2 enhances stability and in vivo effects on obesityChan, Lai Yue, Weger, Benjamin D., Weger, Meltem, Du, Junqiao, Lawrence, Nicole, Cardoso, Marlon H., de Rezende, Samilla B., Muller, Jéssica A.I., Yap, Kuok, Tse, Brian W−C, Sokolowski, Kamil A., Sullivan, Robert K.P., Gunter, Jennifer, Franco, Octávio L., Gachon, Frédéric and Craik, David J. (2025). Mixed-chirality prohibitin peptide: D-(RLARLAR)2 enhances stability and in vivo effects on obesity. Journal of the American Chemical Society. doi: 10.1021/jacs.5c05536 |
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2025 Journal Article Avian circadian clock genes: ontogeny and role for adaptive programming in avian embryosWellard, Caleb J., Weger, Meltem, Gachon, Frédéric and Buchanan, Katherine L. (2025). Avian circadian clock genes: ontogeny and role for adaptive programming in avian embryos. Frontiers in Physiology, 16 1586580, 16. doi: 10.3389/fphys.2025.1586580 |
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2025 Journal Article Potential bidirectional communication between the liver and the central circadian clock in MASLDGachon, Frédéric, Bugianesi, Elisabetta, Castelnuovo, Gabriele, Oster, Henrik, Pendergast, Julie S. and Montagnese, Sara (2025). Potential bidirectional communication between the liver and the central circadian clock in MASLD. npj Metabolic Health and Disease, 3 (1) 15. doi: 10.1038/s44324-025-00058-1 |
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2025 Journal Article The time is now: accounting for time-of-day effects to improve reproducibility and translation of metabolism researchDeota, Shaunak, Pendergast, Julie S., Kolthur-Seetharam, Ullas, Esser, Karyn A., Gachon, Frédéric, Asher, Gad, Dibner, Charna, Benitah, Salvador Aznar, Escobar, Carolina, Muoio, Deborah M., Zhang, Eric Erquan, Hotamışlıgil, Gökhan S., Bass, Joseph, Takahashi, Joseph S., Rabinowitz, Joshua D., Lamia, Katja A., de Cabo, Rafael, Kajimura, Shingo, Longo, Valter D., Xu, Ying, Lazar, Mitchell A., Verdin, Eric, Zierath, Juleen R., Auwerx, Johan, Drucker, Daniel J. and Panda, Satchidananda (2025). The time is now: accounting for time-of-day effects to improve reproducibility and translation of metabolism research. Nature Metabolism, 7 (3) 142, 454-468. doi: 10.1038/s42255-025-01237-6 |
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2024 Journal Article The effect of an improved ICU physical environment on outcomes and post-ICU recovery—a protocolTronstad, Oystein, Zangerl, Barbara, Patterson, Sue, Flaws, Dylan, Yerkovich, Stephanie, Szollosi, Irene, White, Nicole, Garcia-Hansen, Veronica, Leonard, Francisca Rodriguez, Weger, Benjamin D., Gachon, Frédéric, Brain, David, Lavana, Jayshree, Hodgson, Carol and Fraser, John F. (2024). The effect of an improved ICU physical environment on outcomes and post-ICU recovery—a protocol. Trials, 25 (1) 376. doi: 10.1186/s13063-024-08222-6 |
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2024 Journal Article Maternal high fat diet induces circadian clock-independent endocrine alterations impacting the metabolism of the offspringDing, Lu, Weger, Benjamin D., Liu, Jieying, Zhou, Liyuan, Lim, Yenkai, Wang, Dongmei, Xie, Ziyan, Liu, Jing, Ren, Jing, Zheng, Jia, Zhang, Qian, Yu, Miao, Weger, Meltem, Morrison, Mark, Xiao, Xinhua and Gachon, Frédéric (2024). Maternal high fat diet induces circadian clock-independent endocrine alterations impacting the metabolism of the offspring. iScience, 27 (7) 110343, 110343. doi: 10.1016/j.isci.2024.110343 |
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2024 Journal Article Steve Brown's legacy: tools to study the individual human molecular circadian clock and its regulationGachon, Frédéric (2024). Steve Brown's legacy: tools to study the individual human molecular circadian clock and its regulation. European Journal of Neuroscience, 60 (2), 3823-3827. doi: 10.1111/ejn.16335 |
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2023 Journal Article A gene-by-sex interaction contributes to liver disease susceptibility in womenGachon, Fred (2023). A gene-by-sex interaction contributes to liver disease susceptibility in women. Nature Medicine, 29 (10), 2422-2423. |
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2023 Journal Article Understanding circadian dynamics: current progress and future directions for chronobiology in drug discoveryWeger, Meltem, Weger, Benjamin D. and Gachon, Frédéric (2023). Understanding circadian dynamics: current progress and future directions for chronobiology in drug discovery. Expert Opinion on Drug Discovery, 18 (8), 893-901. doi: 10.1080/17460441.2023.2224554 |
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2023 Journal Article Mice with humanized livers reveal the role of hepatocyte clocks in rhythmic behaviorDelbès, Anne-Sophie, Quiñones, Mar, Gobet, Cédric, Castel, Julien, Denis, Raphaël G. P., Berthelet, Jérémy, Weger, Benjamin D., Challet, Etienne, Charpagne, Aline, Metairon, Sylviane, Piccand, Julie, Kraus, Marine, Rohde, Bettina H., Bial, John, Wilson, Elizabeth M., Vedin, Lise-Lotte, Minniti, Mirko E., Pedrelli, Matteo, Parini, Paolo, Gachon, Frédéric and Luquet, Serge (2023). Mice with humanized livers reveal the role of hepatocyte clocks in rhythmic behavior. Science Advances, 9 (20) eadf2982, 1-14. doi: 10.1126/sciadv.adf2982 |
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2023 Journal Article Multiomics reveals multilevel control of renal and systemic metabolism by the renal tubular circadian clockBignon, Yohan, Wigger, Leonore, Ansermet, Camille, Weger, Benjamin D., Lagarrigue, Sylviane, Centeno, Gabriel, Durussel, Fanny, Götz, Lou, Ibberson, Mark, Pradervand, Sylvain, Quadroni, Manfredo, Weger, Meltem, Amati, Francesca, Gachon, Frédéric and Firsov, Dmitri (2023). Multiomics reveals multilevel control of renal and systemic metabolism by the renal tubular circadian clock. Journal of Clinical Investigation, 133 (8) e167133, 1-17. doi: 10.1172/JCI167133 |
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2022 Journal Article Voicing the need to consider sex-specific differences in researchMiguel-Aliaga, Irene, Vunjak-Novakovic, Gordana, Stephenson, Erin J., Gachon, Frederic, Milagre, Inês, Mills, Evanna, Rubin, Joshua B. and Kelava, Iva (2022). Voicing the need to consider sex-specific differences in research. Developmental Cell, 57 (24), 2675-2678. doi: 10.1016/j.devcel.2022.11.018 |
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2022 Journal Article Timing is everything: impact of development, ageing and circadian rhythm on macrophage functions in urinary tract infectionsWang, Alison S., Steers, Nicholas J., Parab, Adwaita R., Gachon, Frédéric, Sweet, Matthew J. and Mysorekar, Indira U. (2022). Timing is everything: impact of development, ageing and circadian rhythm on macrophage functions in urinary tract infections. Mucosal Immunology, 15 (6), 1-13. doi: 10.1038/s41385-022-00558-z |
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2022 Journal Article Disruption of the circadian clock component BMAL1 elicits an endocrine adaption impacting on insulin sensitivity and liver diseaseJouffe, Céline, Weger, Benjamin D., Martin, Eva, Atger, Florian, Weger, Meltem, Gobet, Cédric, Ramnath, Divya, Charpagne, Aline, Morin-Rivron, Delphine, Powell, Elizabeth E., Sweet, Matthew J., Masoodi, Mojgan, Uhlenhaut, N. Henriette and Gachon, Frédéric (2022). Disruption of the circadian clock component BMAL1 elicits an endocrine adaption impacting on insulin sensitivity and liver disease. Proceedings of the National Academy of Sciences, 119 (10) e2200083119, e2200083119. doi: 10.1073/pnas.2200083119 |
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2022 Journal Article The mechanisms and physiological consequences of diurnal hepatic cell size fluctuations: a brief reviewWeger, Meltem, Weger, Benjamin D. and Gachon, Frédéric (2022). The mechanisms and physiological consequences of diurnal hepatic cell size fluctuations: a brief review. Cellular Physiology and Biochemistry, 56 (S2), 1-11. doi: 10.33594/000000489 |
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2021 Journal Article Dysfunction of the circadian clock in the kidney tubule leads to enhanced kidney gluconeogenesis and exacerbated hyperglycemia in diabetesAnsermet, Camille, Centeno, Gabriel, Bignon, Yohan, Ortiz, Daniel, Pradervand, Sylvain, Garcia, Andy, Menin, Laure, Gachon, Frédéric, Yoshihara, Hikari AI. and Firsov, Dmitri (2021). Dysfunction of the circadian clock in the kidney tubule leads to enhanced kidney gluconeogenesis and exacerbated hyperglycemia in diabetes. Kidney International, 101 (3), 563-573. doi: 10.1016/j.kint.2021.11.016 |
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2021 Journal Article The Insulin/Insulin‐like Growth Factor signaling connects metabolism with sexual differentiationWeger, Benjamin D. and Gachon, Frédéric (2021). The Insulin/Insulin‐like Growth Factor signaling connects metabolism with sexual differentiation. Acta Physiologica, 231 (3) e13576, e13576. doi: 10.1111/apha.13576 |
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2021 Journal Article Systematic analysis of differential rhythmic liver gene expression mediated by the circadian clock and feeding rhythmsWeger, Benjamin D., Gobet, Cédric, David, Fabrice P. A., Atger, Florian, Martin, Eva, Phillips, Nicholas E., Charpagne, Aline, Weger, Meltem, Naef, Felix and Gachon, Frédéric (2021). Systematic analysis of differential rhythmic liver gene expression mediated by the circadian clock and feeding rhythms. Proceedings of the National Academy of Sciences, 118 (3) e2015803118, 1-12. doi: 10.1073/pnas.2015803118 |
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2020 Journal Article Neuronal activity regulates blood-brain barrier efflux transport through endothelial circadian genesPulido, Robert S., Munji, Roeben N., Chan, Tamara C., Quirk, Clare R., Weiner, Geoffrey A., Weger, Benjamin D., Rossi, Meghan J., Elmsaouri, Sara, Malfavon, Mario, Deng, Aaron, Profaci, Caterina P., Blanchette, Marie, Qian, Tongcheng, Foreman, Koji L., Shusta, Eric V., Gorman, Michael R., Gachon, Frédéric, Leutgeb, Stefan and Daneman, Richard (2020). Neuronal activity regulates blood-brain barrier efflux transport through endothelial circadian genes. Neuron, 108 (5), 937-952.e7. doi: 10.1016/j.neuron.2020.09.002 |
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2020 Journal Article Time to listen: circadian impact on auditory researchCederroth, Christopher, Gachon, Frédéric and Canlon, Barbara (2020). Time to listen: circadian impact on auditory research. Current Opinion in Physiology, 18, 95-99. doi: 10.1016/j.cophys.2020.09.005 |
