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2025 Journal Article GWAS meta-analysis identifies five susceptibility loci for endometrial cancerRamachandran, Dhanya, Wang, Xuemin, Laisk, Triin, Zheng, Ying, Ingold, Nathan, Canson, Daffodil M., Kho, Pik Fang, Naumann, Bianca J., Chapman, Carly J., Bousset, Kristine, Krause, Anna V., Schürmann, Peter, Wieland, Britta, Hanel, Patricia, Hülse, Fabienne, Häfner, Norman, Runnebaum, Ingo, Dubrowinskaja, Natalia, Turmanov, Nurzhan, Yugay, Tatyana, Yessimsiitova, Zura Berkutovna, Amant, Frédéric, Annibali, Daniela, Beckmann, Matthias W., Bodelon, Clara, Buchanan, Daniel D., Chen, Chu, Clarke, Megan A., Cook, Linda S. ... O'Mara, Tracy A. (2025). GWAS meta-analysis identifies five susceptibility loci for endometrial cancer. eBioMedicine, 118 105830. doi: 10.1016/j.ebiom.2025.105830 |
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2025 Journal Article Multi-tissue expression and splicing data prioritise anatomical subsite- and sex-specific colorectal cancer susceptibility genesHazelwood, Emma, Canson, Daffodil M., Deslandes, Benedita, Wang, Xuemin, Kho, Pik Fang, Legge, Danny, Constantinescu, Andrei-Emil, Lee, Matthew A., Bishop, D. Timothy, Chan, Andrew T., Gruber, Stephen B., Hampe, Jochen, Le Marchand, Loic, Woods, Michael O., Pai, Rish K., Schmit, Stephanie L., Figueiredo, Jane C., Zheng, Wei, Huyghe, Jeroen R., Murphy, Neil, Gunter, Marc J., Richardson, Tom G., Whitehall, Vicki L. J., Vincent, Emma E., Glubb, Dylan M. and O’Mara, Tracy A. (2025). Multi-tissue expression and splicing data prioritise anatomical subsite- and sex-specific colorectal cancer susceptibility genes. Nature Communications, 16 (1) 5043, 5043. doi: 10.1038/s41467-025-60275-6 |
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2025 Journal Article Endometrial tumorigenesis involves epigenetic plasticity demarcating non-coding somatic mutations and 3D-genome alterationsGregoricchio, Sebastian, Kojic, Aleksandar, Hoogstraat, Marlous, Schuurman, Karianne, Stelloo, Suzan, Severson, Tesa M., O’Mara, Tracy A., Droog, Marjolein, Singh, Abhishek A., Glubb, Dylan M., Wessels, Lodewyk F. A., Vermeulen, Michiel, van Leeuwen, Flora E. and Zwart, Wilbert (2025). Endometrial tumorigenesis involves epigenetic plasticity demarcating non-coding somatic mutations and 3D-genome alterations. Genome Biology, 26 (1) 124, 1. doi: 10.1186/s13059-025-03596-5 |
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2025 Journal Article The Multi-Kinase Inhibitor GZD824 (Olverembatinib) Shows Pre-Clinical Efficacy in Endometrial CancerLiu, Dongli, Glubb, Dylan, O'Mara, Tracy and Ford, Caroline E. (2025). The Multi-Kinase Inhibitor GZD824 (Olverembatinib) Shows Pre-Clinical Efficacy in Endometrial Cancer. Cancer Medicine, 14 (1) e70531, 1. doi: 10.1002/cam4.70531 |
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2024 Journal Article Correction to: AI is a viable alternative to high throughput screening: a 318-target study (Scientific Reports, (2024), 14, 1, (7526), 10.1038/s41598-024-54655-z)Giles, Ellie, Heifets, Abraham, Artía, Zoraima, Inde, Zintis, Liu, Zhongle, Zhang, Zhiguo, Wang, Zhenghe, Su, Zhengchen, Chung, Zara, Frangos, Zachary J., Li, Yunlong, Yen, Yun, Sidorova, Yulia A., Tse-Dinh, Yuk-Ching, He, Yuan, Tang, Young, Li, Yong, Pérez-Pertejo, Yolanda, Gupta, Yogesh K., Zhu, Yini, Sun, Ying, Li, Yihe, Chen, Yicheng, Aldhamen, Yasser Ali, Hu, Yanmei, Zhang, Yan Jessie, Zhang, Xu, Yuan, Xinrui, Wang, Xingyou ... Wallach, Izhar (2024). Correction to: AI is a viable alternative to high throughput screening: a 318-target study (Scientific Reports, (2024), 14, 1, (7526), 10.1038/s41598-024-54655-z). Scientific Reports, 14 (1) 21579. doi: 10.1038/s41598-024-70321-w |
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2024 Journal Article AI is a viable alternative to high throughput screening: a 318-target studyWallach, Izhar, Bernard, Denzil, Nguyen, Kong, Ho, Gregory, Morrison, Adrian, Stecula, Adrian, Rosnik, Andreana, O’Sullivan, Ann Marie, Davtyan, Aram, Samudio, Ben, Thomas, Bill, Worley, Brad, Butler, Brittany, Laggner, Christian, Thayer, Desiree, Moharreri, Ehsan, Friedland, Greg, Truong, Ha, van den Bedem, Henry, Ng, Ho Leung, Stafford, Kate, Sarangapani, Krishna, Giesler, Kyle, Ngo, Lien, Mysinger, Michael, Ahmed, Mostafa, Anthis, Nicholas J., Henriksen, Niel, Gniewek, Pawel ... The Atomwise AIMS Program (2024). AI is a viable alternative to high throughput screening: a 318-target study. Scientific Reports, 14 (1) 7526, 1-16. doi: 10.1038/s41598-024-54655-z |
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2023 Journal Article The clinical utility and costs of whole-genome sequencing to detect cancer susceptibility variants—a multi-site prospective cohort studyDavidson, Aimee L., Dressel, Uwe, Norris, Sarah, Canson, Daffodil M., Glubb, Dylan M., Fortuno, Cristina, Hollway, Georgina E., Parsons, Michael T., Vidgen, Miranda E., Holmes, Oliver, Koufariotis, Lambros T., Lakis, Vanessa, Leonard, Conrad, Wood, Scott, Xu, Qinying, McCart Reed, Amy E., Pickett, Hilda A., Al-Shinnag, Mohammad K., Austin, Rachel L., Burke, Jo, Cops, Elisa J., Nichols, Cassandra B., Goodwin, Annabel, Harris, Marion T., Higgins, Megan J., Ip, Emilia L., Kiraly-Borri, Catherine, Lau, Chiyan, Mansour, Julia L. ... Ward, Robyn L. (2023). The clinical utility and costs of whole-genome sequencing to detect cancer susceptibility variants—a multi-site prospective cohort study. Genome Medicine, 15 (1) 74, 1-16. doi: 10.1186/s13073-023-01223-1 |
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2023 Journal Article Multi-trait GWAS identifies a novel endometrial cancer risk locus that associates with testosterone levelsWang, Xuemin, Kho, Pik Fang, Ramachandran, Dhanya, Bafligil, Cemsel, Amant, Frederic, Goode, Ellen L., Scott, Rodney J., Tomlinson, Ian, Evans, D. Gareth, Crosbie, Emma J., Dörk, Thilo, Spurdle, Amanda B., Glubb, Dylan M. and O'Mara, Tracy A. (2023). Multi-trait GWAS identifies a novel endometrial cancer risk locus that associates with testosterone levels. iScience, 26 (5) 106590, 1-19. doi: 10.1016/j.isci.2023.106590 |
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2023 Journal Article Splicing annotation of endometrial cancer GWAS risk loci reveals potentially causal variants and supports a role for NF1 and SKAP1 as susceptibility genesCanson, Daffodil M., O’Mara, Tracy A., Spurdle, Amanda B. and Glubb, Dylan M. (2023). Splicing annotation of endometrial cancer GWAS risk loci reveals potentially causal variants and supports a role for NF1 and SKAP1 as susceptibility genes. Human Genetics and Genomics Advances, 4 (2) 100185, 1-7. doi: 10.1016/j.xhgg.2023.100185 |
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2023 Journal Article SpliceAI-10k calculator for the prediction of pseudoexonization, intron retention, and exon deletionCanson, Daffodil M., Davidson, Aimee L., de la Hoya, Miguel, Parsons, Michael T., Glubb, Dylan M., Kondrashova, Olga and Spurdle, Amanda B. (2023). SpliceAI-10k calculator for the prediction of pseudoexonization, intron retention, and exon deletion. Bioinformatics, 39 (4) btad179, 1-3. doi: 10.1093/bioinformatics/btad179 |
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2023 Journal Article Dietary factors and endometrial cancer risk: A Mendelian randomization studyWang, Xuemin, Glubb, Dylan M. and O’Mara, Tracy A. (2023). Dietary factors and endometrial cancer risk: A Mendelian randomization study. Nutrients, 15 (3) 603, 1-11. doi: 10.3390/nu15030603 |
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2023 Journal Article Erratum: The splicing effect of variants at branchpoint elements in cancer genes (Genetics in Medicine (2022) 24(2) (398–409), (S109836002105348X), (10.1016/j.gim.2021.09.020))Canson, Daffodil M., Dumenil, Troy, Parsons, Michael T., O'Mara, Tracy A., Davidson, Aimee L., Okano, Satomi, Signal, Bethany, Mercer, Tim R., Glubb, Dylan M. and Spurdle, Amanda B. (2023). Erratum: The splicing effect of variants at branchpoint elements in cancer genes (Genetics in Medicine (2022) 24(2) (398–409), (S109836002105348X), (10.1016/j.gim.2021.09.020)). Genetics in Medicine, 25 (1), 166-166. doi: 10.1016/j.gim.2022.11.015 |
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2022 Journal Article Variant effect on splicing regulatory elements, branchpoint usage, and pseudoexonization: strategies to enhance bioinformatic prediction using hereditary cancer genes as exemplarsCanson, Daffodil, Glubb, Dylan and Spurdle, Amanda B. (2022). Variant effect on splicing regulatory elements, branchpoint usage, and pseudoexonization: strategies to enhance bioinformatic prediction using hereditary cancer genes as exemplars. Human Mutation, 43 (12), 2328-2328. doi: 10.1002/humu.24500 |
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2022 Journal Article 10 Years of GWAS discovery in endometrial cancer: aetiology, function and translationWang, Xuemin, Glubb, Dylan M. and O'Mara, Tracy A. (2022). 10 Years of GWAS discovery in endometrial cancer: aetiology, function and translation. eBioMedicine, 77 103895, 1-13. doi: 10.1016/j.ebiom.2022.103895 |
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2022 Journal Article The splicing effect of variants at branchpoint elements in cancer genesCanson, Daffodil M., Dumenil, Troy, Parsons, Michael T., O'Mara, Tracy A., Davidson, Aimee L., Okano, Satomi, Signal, Bethany, Mercer, Tim R., Glubb, Dylan M. and Spurdle, Amanda B. (2022). The splicing effect of variants at branchpoint elements in cancer genes. Genetics in Medicine, 24 (2), 398-409. doi: 10.1016/j.gim.2021.09.020 |
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2021 Journal Article Multi-tissue transcriptome-wide association study identifies eight candidate genes and tissue-specific gene expression underlying endometrial cancer susceptibilityKho, Pik Fang, Wang, Xuemin, Cuéllar-Partida, Gabriel, Dörk, Thilo, Goode, Ellen L., Lambrechts, Diether, Scott, Rodney J., Spurdle, Amanda B., O’Mara, Tracy A. and Glubb, Dylan M. (2021). Multi-tissue transcriptome-wide association study identifies eight candidate genes and tissue-specific gene expression underlying endometrial cancer susceptibility. Communications Biology, 4 (1) 1211, 1211. doi: 10.1038/s42003-021-02745-3 |
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2021 Journal Article Genetic analyses of gynecological disease identify genetic relationships between uterine fibroids and endometrial cancer, and a novel endometrial cancer genetic risk region at the WNT4 1p36.12 locusKho, Pik Fang, Mortlock, Sally, Endometrial Cancer Association Consortium , International Endometriosis Genetics Consortium, Rogers, Peter A. W., Nyholt, Dale R., Montgomery, Grant W., Spurdle, Amanda B., Glubb, Dylan M. and O'Mara, Tracy A. (2021). Genetic analyses of gynecological disease identify genetic relationships between uterine fibroids and endometrial cancer, and a novel endometrial cancer genetic risk region at the WNT4 1p36.12 locus. Human Genetics, 140 (9), 1353-1365. doi: 10.1007/s00439-021-02312-0 |
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2021 Journal Article Identification of a locus near ULK1 associated with progression-free survival in ovarian cancerQuinn, Michael CJ, McCue, Karen, Shi, Wei, Johnatty, Sharon E., Beesley, Jonathan, Civitarese, Andrew, O'Mara, Tracy A, Glubb, Dylan M, Tyrer, Jonathan P, Armasu, Sebastian M., Ong, Jue-Sheng, Gharahkhani, Puya, Lu, Yi, Gao, Bo, Patch, Ann-Marie, Fasching, Peter A., Beckmann, Matthias W., Lambrechts, Diether, Vergote, Ignace, Velez Edwards, Digna, Beeghly-Fadiel, Alicia, Benitez, Javier, Garcia, Maria J, Goodman, Marc T., Dork, Thilo, Durst, Matthias, Modugno, Francesmary, Moysich, Kirsten, du Bois, Andreas ... Chenevix-Trench, Georgia (2021). Identification of a locus near ULK1 associated with progression-free survival in ovarian cancer. Cancer Epidemiology Biomarkers and Prevention, 30 (9), 1669-1680. doi: 10.1158/1055-9965.epi-20-1817 |
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2021 Journal Article Associations between genetically predicted circulating protein concentrations and endometrial cancer riskZhu, Jingjing, O’mara, Tracy A., Liu, Duo, Setiawan, Veronica Wendy, Glubb, Dylan, Spurdle, Amanda B., Fasching, Peter A., Lambrechts, Diether, Buchanan, Daniel, Kho, Pik Fang, Cook, Linda S., Friedenreich, Christine, Lacey, James V., Chen, Chu, Wentzensen, Nicolas, De Vivo, Immaculata, Sun, Yan, Long, Jirong, Du, Mengmeng, Shu, Xiao-Ou, Zheng, Wei, Wu, Lang and Yu, Herbert (2021). Associations between genetically predicted circulating protein concentrations and endometrial cancer risk. Cancers, 13 (9) 2088, 2088. doi: 10.3390/cancers13092088 |
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2021 Journal Article Mendelian randomization analyses suggest a role for cholesterol in the development of endometrial cancerKho, Pik-Fang, Amant, Frederic, Annibali, Daniela, Ashton, Katie, Attia, John, Auer, Paul L., Beckmann, Matthias W., Black, Amanda, Brinton, Louise, Buchanan, Daniel D., Chanock, Stephen J., Chen, Chu, Chen, Maxine M., Cheng, Timothy H. T., Cook, Linda S., Crous-Bous, Marta, Czene, Kamila, De Vivo, Immaculata, Dennis, Joe, Dörk, Thilo, Dowdy, Sean C., Dunning, Alison M., Dürst, Matthias, Easton, Douglas F., Ekici, Arif B., Fasching, Peter A., Fridley, Brooke L., Friedenreich, Christine M., García-Closas, Montserrat ... O'Mara, Tracy A. (2021). Mendelian randomization analyses suggest a role for cholesterol in the development of endometrial cancer. International Journal of Cancer, 148 (2), 307-319. doi: 10.1002/ijc.33206 |
