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2021 Journal Article Chemical modulators of mucosal associated Invariant T cellsMak, Jeffrey Y.W., Liu, Ligong and Fairlie, David P. (2021). Chemical modulators of mucosal associated Invariant T cells. Accounts of Chemical Research, 54 (17) acs.accounts.1c00359, 3462-3475. doi: 10.1021/acs.accounts.1c00359 |
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2021 Journal Article MAIT cells regulate NK cell-mediated tumor immunityPetley, Emma V., Koay, Hui-Fern, Henderson, Melissa A., Sek, Kevin, Todd, Kirsten L., Keam, Simon P., Lai, Junyun, House, Imran G., Li, Jasmine, Zethoven, Magnus, Chen, Amanda X. Y., Oliver, Amanda J., Michie, Jessica, Freeman, Andrew J., Giuffrida, Lauren, Chan, Jack D., Pizzolla, Angela, Mak, Jeffrey Y. W., McCulloch, Timothy R., Souza-Fonseca-Guimaraes, Fernando, Kearney, Conor J., Millen, Rosemary, Ramsay, Robert G., Huntington, Nicholas D., McCluskey, James, Oliaro, Jane, Fairlie, David P., Neeson, Paul J., Godfrey, Dale I. ... Darcy, Phillip K. (2021). MAIT cells regulate NK cell-mediated tumor immunity. Nature Communications, 12 (1) 4746, 1-15. doi: 10.1038/s41467-021-25009-4 |
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2021 Journal Article Histone deacetylase inhibitor AR-42 and achiral analogues kill malaria parasites in vitro and in miceChua, Ming Jang, Tng, Jiahui, Hesping, Eva, Fisher, Gillian M., Goodman, Christopher D., Skinner-Adams, Tina, Do, Darren, Lucke, Andrew J., Reid, Robert C., Fairlie, David P. and Andrews, Katherine T. (2021). Histone deacetylase inhibitor AR-42 and achiral analogues kill malaria parasites in vitro and in mice. International Journal for Parasitology: Drugs and Drug Resistance, 17, 118-127. doi: 10.1016/j.ijpddr.2021.08.006 |
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2021 Journal Article Francisella tularensis induces Th1 like MAIT cells conferring protection against systemic and local infectionZhao, Zhe, Wang, Huimeng, Shi, Mai, Zhu, Tianyuan, Pediongco, Troi, Lim, Xin Yi, Meehan, Bronwyn S., Nelson, Adam G., Fairlie, David P., Mak, Jeffrey Y. W., Eckle, Sidonia B. G., de Lima Moreira, Marcela, Tumpach, Carolin, Bramhall, Michael, Williams, Cameron G., Lee, Hyun Jae, Haque, Ashraful, Evrard, Maximilien, Rossjohn, Jamie, McCluskey, James, Corbett, Alexandra J. and Chen, Zhenjun (2021). Francisella tularensis induces Th1 like MAIT cells conferring protection against systemic and local infection. Nature Communications, 12 (1) 4355, 1-15. doi: 10.1038/s41467-021-24570-2 |
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2021 Journal Article PAR2-induced tissue factor synthesis by primary cultures of human kidney tubular epithelial cells is modified by glucose availabilityHumphries, Tyrone L. R., Shen, Kunyu, Iyer, Abishek, Johnson, David W., Gobe, Glenda C., Nikolic-Paterson, David, Fairlie, David P. and Vesey, David A. (2021). PAR2-induced tissue factor synthesis by primary cultures of human kidney tubular epithelial cells is modified by glucose availability. International Journal of Molecular Sciences, 22 (14) 7532, 1-12. doi: 10.3390/ijms22147532 |
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2021 Journal Article Targeting Class IIa HDACs: insights from henotypes and inhibitorsLiu, Ligong, Dong, Lilong, Bourguet, Erika and Fairlie, David P. (2021). Targeting Class IIa HDACs: insights from henotypes and inhibitors. Current Medicinal Chemistry, 28 (42), 8628-8672. doi: 10.2174/0929867328666210629160647 |
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2021 Journal Article Late‐stage hydrocarbon conjugation and cyclisation in synthetic peptides and proteinsAraujo, Aline D., Nguyen, Huy T. and Fairlie, David P. (2021). Late‐stage hydrocarbon conjugation and cyclisation in synthetic peptides and proteins. ChemBioChem, 22 (10), 1784-1789. doi: 10.1002/cbic.202000796 |
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2021 Journal Article Front Cover: Late‐Stage Hydrocarbon Conjugation and Cyclisation in Synthetic Peptides and Proteins (ChemBioChem 10/2021)Araujo, Aline D., Nguyen, Huy T. and Fairlie, David P. (2021). Front Cover: Late‐Stage Hydrocarbon Conjugation and Cyclisation in Synthetic Peptides and Proteins (ChemBioChem 10/2021). ChemBioChem, 22 (10), 1686-1686. doi: 10.1002/cbic.202100189 |
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2021 Journal Article Expression of protease activated receptor-2 is reduced in renal cell carcinoma biopsies and cell linesMorais, Christudas, Rajandram, Retnagowri, Blakeney, Jade S., Iyer, Abishek, Suen, Jacky Y., Johnson, David W., Gobe, Glenda C., Fairlie, David P. and Vesey, David A. (2021). Expression of protease activated receptor-2 is reduced in renal cell carcinoma biopsies and cell lines. PLoS One, 16 (3) e0248983, e0248983. doi: 10.1371/journal.pone.0248983 |
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2021 Journal Article Identification and phenotype of MAIT cells in cattle and their response to bacterial infectionsEdmans, Matthew D., Connelley, Timothy K., Jayaraman, Siddharth, Vrettou, Christina, Vordermeier, Martin, Mak, Jeffrey Y. W., Liu, Ligong, Fairlie, David P., Maze, Emmanuel Atangana, Chrun, Tiphany, Klenerman, Paul, Eckle, Sidonia B. G., Tchilian, Elma and Benedictus, Lindert (2021). Identification and phenotype of MAIT cells in cattle and their response to bacterial infections. Frontiers in Immunology, 12 627173, 627173. doi: 10.3389/fimmu.2021.627173 |
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2021 Journal Article PAR2 activation on human kidney tubular epithelial cells induces tissue factor synthesis, that enhances blood clottingIyer, Abishek, Humphries, Tyrone L. R., Owens, Evan P., Zhao, Kong-Nan, Masci, Paul P., Johnson, David W., Nikolic-Paterson, David, Gobe, Glenda C., Fairlie, David P. and Vesey, David A. (2021). PAR2 activation on human kidney tubular epithelial cells induces tissue factor synthesis, that enhances blood clotting. Frontiers in Physiology, 12 615428, 615428. doi: 10.3389/fphys.2021.615428 |
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2021 Journal Article Connecting hydrophobic surfaces in cyclic peptides increases membrane permeabilityHoang, Huy N., Hill, Timothy A. and Fairlie, David P. (2021). Connecting hydrophobic surfaces in cyclic peptides increases membrane permeability. Angewandte Chemie International Edition, 60 (15), 8385-8390. doi: 10.1002/anie.202012643 |
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2021 Journal Article Mucosal-associated invariant t cell effector function is an intrinsic cell property that can be augmented by the metabolic cofactor α-ketoglutarateHowson, Lauren J., Li, Jasmine, von Borstel, Anouk, Barugahare, Adele, Mak, Jeffrey Y. W., Fairlie, David P., McCluskey, James, Turner, Stephen J., Davey, Martin S. and Rossjohn, Jamie (2021). Mucosal-associated invariant t cell effector function is an intrinsic cell property that can be augmented by the metabolic cofactor α-ketoglutarate. The Journal of Immunology, 206 (7) ji2001048, 1425-1435. doi: 10.4049/jimmunol.2001048 |
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2021 Journal Article HDAC7 inhibition by phenacetyl and phenylbenzoyl hydroxamatesMak, Jeffrey Y. W., Wu, Kai-Chen, Gupta, Praveer K., Barbero, Sheila, McLaughlin, Maddison G., Lucke, Andrew J., Tng, Jiahui, Lim, Junxian, Loh, Zhixuan, Sweet, Matthew J, Reid, Robert C., Liu, Ligong and Fairlie, David P. (2021). HDAC7 inhibition by phenacetyl and phenylbenzoyl hydroxamates. Journal of Medicinal Chemistry, 64 (4), 2186-2204. doi: 10.1021/acs.jmedchem.0c01967 |
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2021 Journal Article Activation of protease-activated receptor 2 is associated with blood pressure regulation and proteinuria reduction in metabolic syndromeMaruyama-Fumoto, Kana, McGuire, John J., Fairlie, David P., Shinozuka, Kazumasa and Kagota, Satomi (2021). Activation of protease-activated receptor 2 is associated with blood pressure regulation and proteinuria reduction in metabolic syndrome. Clinical and Experimental Pharmacology and Physiology, 48 (2), 211-220. doi: 10.1111/1440-1681.13431 |
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2021 Journal Article PAR2 induces ovarian cancer cell motility by merging three signalling pathways to transactivate EGFRJiang, Yuhong, Lim, Junxian, Wu, Kai‐Chen, Xu, Weijun, Suen, Jacky Y. and Fairlie, David P. (2021). PAR2 induces ovarian cancer cell motility by merging three signalling pathways to transactivate EGFR. British Journal of Pharmacology, 178 (4) bph.15332, 913-932. doi: 10.1111/bph.15332 |
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2021 Journal Article Mechanotransduction activates RhoA in the neighbors of apoptotic epithelial cells to engage apical extrusionDuszyc, Kinga, Gomez, Guillermo A., Lagendijk, Anne K., Yau, Mei-Kwan, Nanavati, Bageshri Naimish, Gliddon, Briony L., Hall, Thomas E., Verma, Suzie, Hogan, Benjamin M., Pitson, Stuart M., Fairlie, David P., Parton, Robert G. and Yap, Alpha S. (2021). Mechanotransduction activates RhoA in the neighbors of apoptotic epithelial cells to engage apical extrusion. Current Biology, 31 (6), 1326-1336.e5. doi: 10.1016/j.cub.2021.01.003 |
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2021 Journal Article Taking the Myc out of cancer: toward therapeutic strategies to directly inhibit c-MycMadden, Sarah K., de Araujo, Aline Dantas, Gerhardt, Mara, Fairlie, David P. and Mason, Jody M. (2021). Taking the Myc out of cancer: toward therapeutic strategies to directly inhibit c-Myc. Molecular Cancer, 20 (1) 3, 3. doi: 10.1186/s12943-020-01291-6 |
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2021 Journal Article A nucleotide analog prevents colitis associated cancer via Β-catenin independently of inflammation and autophagySheng, Yong Hua, Giri, Rabina, Davies, Julie, Schreiber, Veronika, Alabbas, Saleh, Movva, Ramya, He, Yaowu, Wu, Andy, Hooper, John, McWhinney, Brett, Oancea, Iulia, Kijanka, Gregor, Hasnain, Sumaira, Lucke, Andrew J., Fairlie, David P., McGuckin, Michael A., Florin, Timothy H. and Begun, Jakob (2021). A nucleotide analog prevents colitis associated cancer via Β-catenin independently of inflammation and autophagy. Cellular and Molecular Gastroenterology and Hepatology, 11 (1), 33-53. doi: 10.1016/j.jcmgh.2020.05.012 |
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2021 Journal Article Fortified coiled coils: enhancing eechanical stability with lactam or metal staplesLópez-García, Patricia, de Araujo, Aline D., Bergues-Pupo, Ana E., Tunn, Isabell, Fairlie, David P. and Blank, Kerstin G. (2021). Fortified coiled coils: enhancing eechanical stability with lactam or metal staples. Angewandte Chemie - International Edition, 60 (1) anie.202006971, 232-236. doi: 10.1002/anie.202006971 |
