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2015 Journal Article The Integrator complex controls the termination of transcription at diverse classes of gene targetsSkaar, Jeffrey R., Ferris, Andrea L., Wu, Xiaolin, Saraf, Anita, Khanna, Kum Kum, Florens, Laurence, Washburn, Michael P., Hughes, Stephen H. and Pagano, Michele (2015). The Integrator complex controls the termination of transcription at diverse classes of gene targets. Cell Research, 25 (3), 288-305. doi: 10.1038/cr.2015.19 |
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2015 Journal Article Single-strand DNA-binding protein SSB1 facilitates TERT recruitment to telomeres and maintains telomere G-overhangsPandita, Raj K., Chow, Tracy T., Udayakumar, Durga, Bain, Amanda L., Cubeddu, Liza, Hunt, Clayton R., Shi, Wei, Horikoshi, Nobuo, Zhao, Yong, Wright, Woodring E., Khanna, Kum Kum, Shay, Jerry W. and Pandita, Tej K. (2015). Single-strand DNA-binding protein SSB1 facilitates TERT recruitment to telomeres and maintains telomere G-overhangs. Cancer Research, 75 (5), 858-869. doi: 10.1158/0008-5472.CAN-14-2289 |
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2015 Journal Article Heregulin-HER3-HER2 signaling promotes matrix metalloproteinase-dependent blood-brain-barrier transendothelial migration of human breast cancer cell linesMomeny, Majid, Saunus, Jodi M., Marturana, Flavia, McCart Reed, Amy E., Black, Debra, Sala, Gianluca, Iacobelli, Stefano, Holland, Jane D., Yu, Dihua, Da Silva, Leonard, Simpson, Peter T., Khanna, Kum Kum, Chenevix-Trench, Georgia and Lakhani, Sunil R. (2015). Heregulin-HER3-HER2 signaling promotes matrix metalloproteinase-dependent blood-brain-barrier transendothelial migration of human breast cancer cell lines. Oncotarget, 6 (6), 3932-3946. doi: 10.18632/oncotarget.2846 |
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2015 Journal Article ATM-dependent phosphorylation of MRE11 controls extent of resection during homology directed repair by signalling through Exonuclease 1Kijas, Amanda W., Lim, Yi Chieh, Bolderson, Emma, Cerosaletti, Karen, Gatei, Magtouf, Jakob, Burkhard, Tobias, Frank, Taucher-Scholz, Gisela, Gueven, Nuri, Oakley, Greg, Concannon, Patrick, Wolvetang, Ernst, Khanna, Kum Kum, Wiesmuller, Lisa and Lavin, Martin F. (2015). ATM-dependent phosphorylation of MRE11 controls extent of resection during homology directed repair by signalling through Exonuclease 1. Nucleic Acids Research, 43 (17), 8352-8367. doi: 10.1093/nar/gkv754 |
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2014 Journal Article Natural killer cells are essential for the ability of BRAF inhibitors to control BRAFV600E-mutant metastatic melanomade Andrade, Lucas Ferrari, Ngiow, Shin F., Stannard, Kimberly, Rusakiewicz, Sylvie, Kalimutho, Murugan, Khanna, Kum Kum, Tey, Siok-Keen, Takeda, Kazyuoshi, Zitvogel, Laurence, Martinet, Ludovic and Smyth, Mark J. (2014). Natural killer cells are essential for the ability of BRAF inhibitors to control BRAFV600E-mutant metastatic melanoma. Cancer Research, 74 (24), 7298-7308. doi: 10.1158/0008-5472.CAN-14-1339 |
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2014 Journal Article Complex-based analysis of dysregulated cellular processes in cancerSrihari, Sriganesh, Madhamshettiwar, Piyush B., Song, Sarah, Liu, Chao, Simpson, Peter T., Khanna, Kumkum and Ragan, Mark A. (2014). Complex-based analysis of dysregulated cellular processes in cancer. BMC Systems Biology, 8 (Supplement 4) S1. doi: 10.1186/1752-0509-8-S4-S1 |
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2014 Journal Article SCF-FBXO31 E3 ligase targets DNA replication factor Cdt1 for proteolysis in the G 2 phase of cell cycle to prevent Re-replicationJohansson, Pegah, Jeffery, Jessie, Al-Ejeh, Fares, Schulz, Renèe B., Callen, David F., Kumar, Raman and Khanna, Kum Kum (2014). SCF-FBXO31 E3 ligase targets DNA replication factor Cdt1 for proteolysis in the G 2 phase of cell cycle to prevent Re-replication. Journal of Biological Chemistry, 289 (26), 18514-18525. doi: 10.1074/jbc.M114.559930 |
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2014 Journal Article Gemcitabine and CHK1 inhibition potentiate EGFR-directed radioimmunotherapy against pancreatic ductal adenocarcinomaAl-Ejeh, Fares, Pajic, Marina, Shi, Wei, Kalimutho, Murugan, Miranda, Mariska, Nagrial, Adnan M., Chou, Angela, Biankin, Andrew V., Grimmond, Sean M., Brown, Michael P. and Khanna, Kum Kum (2014). Gemcitabine and CHK1 inhibition potentiate EGFR-directed radioimmunotherapy against pancreatic ductal adenocarcinoma. Clinical Cancer Research, 20 (12), 3187-3197. doi: 10.1158/1078-0432.CCR-14-0048 |
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2014 Journal Article Human single-stranded DNA binding protein 1 (hSSB1/NABP2) is required for the stability and repair of stalled replication forksBolderson, Emma, Petermann, Eva, Croft, Laura, Suraweera, Amila, Pandita, Raj K., Pandita, Tej K., Helleday, Thomas, Khanna, Kum Kum and Richard, Derek J. (2014). Human single-stranded DNA binding protein 1 (hSSB1/NABP2) is required for the stability and repair of stalled replication forks. Nucleic Acids Research, 42 (10), 6326-6336. doi: 10.1093/nar/gku276 |
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2014 Journal Article A fine-scale dissection of the DNA double-strand break repair machinery and its implications for breast cancer therapyLiu, Chao, Srihari, Sriganesh, Le Cao, Kim-Anh, Chenevix-Trench, Georgia, Simpson, Peter T., Ragan, Mark A. and Khanna, Kum Kum (2014). A fine-scale dissection of the DNA double-strand break repair machinery and its implications for breast cancer therapy. Nucleic Acids Research, 42 (10), 6106-6127. doi: 10.1093/nar/gku284 |
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2014 Journal Article Meta-analysis of the global gene expression profile of triple-negative breast cancer identifies genes for the prognostication and treatment of aggressive breast cancerAl-Ejeh, F., Simpson, P. T., Sanus, J. M., Klein, K., Kalimutho, M., Shi, W., Miranda, M., Kutasovic, J., Raghavendra, A., Madore, J., Reid, L., Krause, L., Chenevix-Trench, G., Lakhani, S. R. and Khanna, K. K. (2014). Meta-analysis of the global gene expression profile of triple-negative breast cancer identifies genes for the prognostication and treatment of aggressive breast cancer. Oncogenesis, 3 (4) e100, 1-12. doi: 10.1038/oncsis.2014.14 |
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2014 Journal Article Kinome profiling reveals breast cancer heterogeneity and identifies targeted therapeutic opportunities for triple negative breast cancerAl-Ejeh, Fares, Miranda, Mariska, Shi,Wei, Simpson, Peter T., Song, Sarah, Vargas, Ana Cristina, Saunus, Jodi M., Smart, Chanel E., Mariasegaram, Mythily, Wiegmans, Adrian P., Chenevix-Trench, Georgia, Lakhani, Sunil R. and Khanna, Kum Kum (2014). Kinome profiling reveals breast cancer heterogeneity and identifies targeted therapeutic opportunities for triple negative breast cancer. Oncotarget, 5 (10), 3145-3158. doi: 10.18632/oncotarget.1865 |
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2014 Journal Article Rad51 supports triple negative breast cancer metastasisWiegmans, Adrian P., Al-Ejeh, Fares, Chee, Nicole, Yap, Pei-Yi, Gorski, Julia J., Da Silva, Leonard, Bolderson, Emma, Chenevix-Trench, Georgia, Anderson, Robin, Simpson, Peter T., Lakhani, Sunil R. and Khanna, Kum Kum (2014). Rad51 supports triple negative breast cancer metastasis. Oncotarget, 5 (10), 3261-3272. doi: 10.18632/oncotarget.1923 |
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2014 Journal Article Phosphorylation of EXO1 by CDKs 1 and 2 regulates DNA end resection and repair pathway choiceTomimatsu, Nozomi, Mukherjee, Bipasha, Catherine Hardebeck, Molly, Ilcheva, Mariya, Vanessa Camacho, Cristel, Louise Harris, Janelle, Porteus, Matthew, Llorente, Bertrand, Khanna, Kum K.um and Burma, Sandeep (2014). Phosphorylation of EXO1 by CDKs 1 and 2 regulates DNA end resection and repair pathway choice. Nature communications, 5 3561. doi: 10.1038/ncomms4561 |
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2014 Journal Article Selenoprotein S is a marker but not a regulator of endoplasmic reticulum stress in intestinal epithelial cellsSpeckmann, Bodo, Gerloff, Kirsten, Simms, Lisa, Oancea, Iulia, Shi, Wei, McGuckin, Michael A., Radford-Smith, Graham and Khanna, Kum Kum (2014). Selenoprotein S is a marker but not a regulator of endoplasmic reticulum stress in intestinal epithelial cells. Free Radical Biology and Medicine, 67, 265-277. doi: 10.1016/j.freeradbiomed.2013.11.001 |
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2013 Journal Article Tumor protein D52 represents a negative regulator of ATM protein levelsChen, Yuyan, Kamili, Alvin, Hardy, Jayne R., Groblewski, Guy E., Khanna, Kum Kum and Byrne, Jennifer A. (2013). Tumor protein D52 represents a negative regulator of ATM protein levels. Cell Cycle, 12 (18), 3083-3097. doi: 10.4161/cc.26146 |
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2013 Journal Article Mouse models uncap novel roles of SSBsBain, Amanda L., Shi, Wei and Khanna, Kum Kum (2013). Mouse models uncap novel roles of SSBs. Cell Research, 23 (6), 744-745. doi: 10.1038/cr.2013.63 |
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2013 Journal Article Treatment of triple-negative breast cancer using anti-EGFR-directed radioimmunotherapy combined with radiosensitizing chemotherapy and PARP inhibitorAl-Ejeh, Fares, Shi, Wei, Miranda, Mariska, Simpson, Peter T., Vargas, Ana Cristina, Song, Sarah, Wiegmans, Adrian P., Swarbrick, Alex, Welm, Alana L., Brown, Michael P., Chenevix-Trench, Georgia, Lakhani, Sunil R. and Khanna, Kum Kum (2013). Treatment of triple-negative breast cancer using anti-EGFR-directed radioimmunotherapy combined with radiosensitizing chemotherapy and PARP inhibitor. Journal of Nuclear Medicine, 54 (6), 913-921. doi: 10.2967/jnumed.112.111534 |
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2013 Journal Article Centrobin regulates centrosome function in interphase cells by limiting pericentriolar matrix recruitmentJeffery, Jessie M., Grigoriev, Ilya, Poser, Ina, van der Horst, Armando, Hamilton, Nicholas, Waterhouse, Nigel, Bleier, Jonathan, Subramaniam, V. Nathan, Maly, Ivan V., Akhmanova, Anna and Khanna, Kum Kum (2013). Centrobin regulates centrosome function in interphase cells by limiting pericentriolar matrix recruitment. Cell Cycle, 12 (6), 899-906. doi: 10.4161/cc.23879 |
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2013 Journal Article Lamin A/C depletion enhances DNA damage-induced stalled replication fork arrestSingh, Mayank, Hunt, Clayton, Pandita, Raj K., Kumar, Rakesh, Yang, Chin-Rang, Horikoshi, Nobuo, Bachoo, Robert, Serag, Sara, Story, Michael D., Shay, Jerry W., Powell, Simon N., Gupta, Arun, Jeffery, Jessie, Pandita, Shruti, Chen, Benjamin P.C., Deckbar, Dorothee, Löbrich, Markus, Yang, Qin, Khanna, Kum Kum, Worman, Howard J. and Panditaa, Tej K. (2013). Lamin A/C depletion enhances DNA damage-induced stalled replication fork arrest. Molecular and Cellular Biology, 33 (6), 1210-1222. doi: 10.1128/MCB.01676-12 |
