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2025 Journal Article Gene therapy with feline anti-Müllerian hormone analogs disrupts folliculogenesis and induces pregnancy loss in female domestic catsStocker, William A., Olenick, Lauren, Maskey, Shreya, Skrombolas, Denise, Luan, Haitong, Harrison, Sophie G., Wilson, Matt, Traas, Anne, Heffernan, Mark, Busfield, Samantha, Walton, Kelly L. and Harrison, Craig A. (2025). Gene therapy with feline anti-Müllerian hormone analogs disrupts folliculogenesis and induces pregnancy loss in female domestic cats. Nature Communications, 16 (1) 1668. doi: 10.1038/s41467-025-56924-5 |
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2025 Journal Article Muscle-derived myostatin is a major endocrine driver of follicle-stimulating hormone synthesisOngaro, Luisina, Zhou, Xiang, Wang, Ying, Schultz, Hailey, Zhou, Ziyue, Buddle, Evan R. S., Brûlé, Emilie, Lin, Yeu-Farn, Schang, Gauthier, Hagg, Adam, Castonguay, Roselyne, Liu, Yewei, Su, Gloria H., Seidah, Nabil G., Ray, Kevin C., Karp, Seth J., Boehm, Ulrich, Ruf-Zamojski, Frederique, Sealfon, Stuart C., Walton, Kelly L., Lee, Se-Jin and Bernard, Daniel J. (2025). Muscle-derived myostatin is a major endocrine driver of follicle-stimulating hormone synthesis. Science, 387 (6731), 329-336. doi: 10.1126/science.adi4736 |
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2024 Journal Article Characterization of the molecular mechanisms that govern anti‐Müllerian hormone synthesis and activityStocker, William A., Howard, James A., Maskey, Shreya, Luan, Haitong, Harrison, Sophie G., Hart, Kaitlin N., Hok, Lucija, Thompson, Thomas B., Walton, Kelly L. and Harrison, Craig A. (2024). Characterization of the molecular mechanisms that govern anti‐Müllerian hormone synthesis and activity. The FASEB Journal, 38 (1) e23377, 1-18. doi: 10.1096/fj.202301335rr |
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2023 Journal Article Activin A level is associated with physical function in critically ill patientsWang, Yi Tian, Harrison, Craig A., Skinner, Elizabeth H., Haines, Kimberley J., Holdsworth, Clare, Lang, Jenna K., Hibbert, Elizabeth, Scott, David, Eynon, Nir, Tiruvoipati, Ravindranath, French, Craig J., Stepto, Nigel K., Bates, Samantha, Walton, Kelly L., Crozier, Tim M. and Haines, Terry P. (2023). Activin A level is associated with physical function in critically ill patients. Australian Critical Care, 36 (5), 702-707. doi: 10.1016/j.aucc.2022.10.019 |
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2023 Journal Article Targeting activins and inhibins to treat reproductive disorders and cancer cachexiaHagg, Adam, O'Shea, Eliza, Harrison, Craig A. and Walton, Kelly Louise (2023). Targeting activins and inhibins to treat reproductive disorders and cancer cachexia. Journal of Endocrinology, 258 (1) e220290, 1-15. doi: 10.1530/joe-22-0290 |
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2023 Journal Article Follistatin forms a stable complex with Inhibin A that does not interfere with Activin A antagonismKappes, Emily C, Kattamuri, Chandramohan, Czepnik, Magdalena, Yarawsky, Alexander E, Brûlé, Emilie, Wang, Ying, Ongaro, Luisina, Herr, Andrew B, Walton, Kelly L, Bernard, Daniel J and Thompson, Thomas B (2023). Follistatin forms a stable complex with Inhibin A that does not interfere with Activin A antagonism. Endocrinology, 164 (3) bqad017. doi: 10.1210/endocr/bqad017 |
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2022 Journal Article Inhibin inactivation in female mice leads to elevated FSH levels, ovarian over-stimulation, and pregnancy lossWalton, Kelly L., Goney, Monica P., Peppas, Zoe, Stringer, Jessica M., Winship, Amy, Hutt, Karla, Goodchild, Georgia, Maskey, Shreya, Chan, Karen L., Brûlé, Emilie, Bernard, Daniel J., Stocker, William A. and Harrison, Craig A. (2022). Inhibin inactivation in female mice leads to elevated FSH levels, ovarian over-stimulation, and pregnancy loss. Endocrinology, 163 (4) bqac025. doi: 10.1210/endocr/bqac025 |
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2022 Journal Article Human INHBB gene variant (c.1079T>C:p.Met360Thr) alters testisgerm cell content, but does not impact fertility in miceHouston, Brendan J, O’Connor, Anne E, Wang, Degang, Goodchild, Georgia, Merriner, D Jo, Luan, Haitong, Conrad, Don F, Nagirnaja, Liina, Aston, Kenneth I, Kliesch, Sabine, Wyrwoll, Margot J, Friedrich, Corinna, Tüttelmann, Frank, Harrison, Craig, O’Bryan, Moira K and Walton, Kelly (2022). Human INHBB gene variant (c.1079T>C:p.Met360Thr) alters testisgerm cell content, but does not impact fertility in mice. Endocrinology, 163 (3) bqab269. doi: 10.1210/endocr/bqab269 |
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2021 Journal Article TGFBR3L is an inhibin B co-receptor that regulates female fertilityBrûlé, Emilie, Wang, Ying, Li, Yining, Lin, Yeu-Farn, Zhou, Xiang, Ongaro, Luisina, Alonso, Carlos A. I., Buddle, Evan R. S., Schneyer, Alan L., Byeon, Chang-Hyeock, Hinck, Cynthia S., Mendelev, Natalia, Russell, John P., Cowan, Mitra, Boehm, Ulrich, Ruf-Zamojski, Frederique, Zamojski, Michel, Andoniadou, Cynthia L., Sealfon, Stuart C., Harrison, Craig A., Walton, Kelly L., Hinck, Andrew P. and Bernard, Daniel J. (2021). TGFBR3L is an inhibin B co-receptor that regulates female fertility. Science Advances, 7 (51) eabl4391, eabl4391. doi: 10.1126/sciadv.abl4391 |
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2021 Journal Article Structure of AMH bound to AMHR2 provides insight into a unique signaling pair in the TGF-β familyHart, Kaitlin N., Stocker, William A., Nagykery, Nicholas G., Walton, Kelly L., Harrison, Craig A., Donahoe, Patricia K., Pépin, David and Thompson, Thomas B. (2021). Structure of AMH bound to AMHR2 provides insight into a unique signaling pair in the TGF-β family. Proceedings of the National Academy of Sciences of the United States of America, 118 (26) e2104809118. doi: 10.1073/pnas.2104809118 |
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2020 Journal Article TMEPAI/PMEPA1 is a positive regulator of skeletal muscle massHagg, Adam, Kharoud, Swati, Goodchild, Georgia, Goodman, Craig A., Chen, Justin L., Thomson, Rachel E., Qian, Hongwei, Gregorevic, Paul, Harrison, Craig A. and Walton, Kelly L. (2020). TMEPAI/PMEPA1 is a positive regulator of skeletal muscle mass. Frontiers in Physiology, 11 560225, 560225. doi: 10.3389/fphys.2020.560225 |
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2020 Journal Article New insights into the genetic basis of premature ovarian insufficiency: novel causative variants and candidate genes revealed by genomic sequencingJaillard, Sylvie, Bell, Katrina, Akloul, Linda, Walton, Kelly, McElreavy, Kenneth, Stocker, William A., Beaumont, Marion, Harrisson, Craig, Jääskeläinen, Tiina, Palvimo, Jorma J., Robevska, Gorjana, Launay, Erika, Satié, Anne-Pascale, Listyasari, Nurin, Bendavid, Claude, Sreenivasan, Rajini, Duros, Solène, van den Bergen, Jocelyn, Henry, Catherine, Domin-Bernhard, Mathilde, Cornevin, Laurence, Dejucq-Rainsford, Nathalie, Belaud-Rotureau, Marc-Antoine, Odent, Sylvie, Ayers, Katie L., Ravel, Célia, Tucker, Elena J. and Sinclair, Andrew H. (2020). New insights into the genetic basis of premature ovarian insufficiency: novel causative variants and candidate genes revealed by genomic sequencing. Maturitas, 141, 9-19. doi: 10.1016/j.maturitas.2020.06.004 |
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2020 Journal Article Engineering the ovarian hormones inhibin A and inhibin B to enhance synthesis and activityGoney, Monica P., Wilce, Matthew C. J., Wilce, Jacqueline A., Stocker, William A., Goodchild, Georgia M., Chan, Karen L., Harrison, Craig A. and Walton, Kelly L. (2020). Engineering the ovarian hormones inhibin A and inhibin B to enhance synthesis and activity. Endocrinology, 161 (8) bqaa099, 1-12. doi: 10.1210/endocr/bqaa099 |
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2020 Journal Article A variant of human growth differentiation factor-9 that improves oocyte developmental competenceStocker, William A., Walton, Kelly L., Richani, Dulama, Chan, Karen L., Beilby, Kiri H., Finger, Bethany J., Green, Mark P., Gilchrist, Robert B. and Harrison, Craig A. (2020). A variant of human growth differentiation factor-9 that improves oocyte developmental competence. Journal of Biological Chemistry, 295 (23), 7981-7991. doi: 10.1074/jbc.ra120.013050 |
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2019 Journal Article Activin A–induced cachectic wasting is attenuated by systemic delivery of its cognate propeptide in male miceWalton, Kelly L., Chen, Justin L., Arnold, Quinn, Kelly, Emily, La, Mylinh, Lu, Louis, Lovrecz, George, Hagg, Adam, Colgan, Timothy D., Qian, Hongwei, Gregorevic, Paul and Harrison, Craig A. (2019). Activin A–induced cachectic wasting is attenuated by systemic delivery of its cognate propeptide in male mice. Endocrinology, 160 (10), 2417-2426. doi: 10.1210/en.2019-00257 |
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2019 Journal Article Serum concentrations of oocyte-secreted factors BMP15 and GDF9 during IVF and in women with reproductive pathologiesRiepsamen, Angelique H., Chan, Karen, Lien, Shelly, Sweeten, Prudence, Donoghoe, Mark W., Walker, Glenda, Fraison, Eloïse H. J., Stocker, William A., Walton, Kelly L., Harrison, Craig A., Ledger, William L., Robertson, David M. and Gilchrist, Robert B. (2019). Serum concentrations of oocyte-secreted factors BMP15 and GDF9 during IVF and in women with reproductive pathologies. Endocrinology, 160 (10), 2298-2313. doi: 10.1210/en.2019-00264 |
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2019 Journal Article Functional characterization of two new variants in the bone morphogenetic protein 7 prodomain in two pairs of monozygotic twins with hypospadiasBouty, Aurore, Walton, Kelly, Listyasari, Nurin Aisyiyah, Robevska, Gorjana, Van den Bergen, Jocelyn, Santosa, Ardy, Faradz, Sultana M H, Harrison, Craig, Ayers, Katie L and Sinclair, Andrew H (2019). Functional characterization of two new variants in the bone morphogenetic protein 7 prodomain in two pairs of monozygotic twins with hypospadias. Journal of the Endocrine Society, 3 (4), 814-824. doi: 10.1210/js.2018-00333 |
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2019 Journal Article Cumulin and FSH Cooperate to Regulate Inhibin B and Activin B Production by Human Granulosa-Lutein Cells In VitroRichani, Dulama, Constance, Katherine, Lien, Shelly, Agapiou, David, Stocker, William A., Hedger, Mark P., Ledger, William L., Thompson, Jeremy G., Robertson, David M., Mottershead, David G., Walton, Kelly L., Harrison, Craig A. and Gilchrist, Robert B. (2019). Cumulin and FSH Cooperate to Regulate Inhibin B and Activin B Production by Human Granulosa-Lutein Cells In Vitro. Endocrinology, 160 (4), 853-862. doi: 10.1210/en.2018-01026 |
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2018 Journal Article Inhibin: To Betaglycan, or Not to BetaglycanWalton, Kelly L. and Harrison, Craig A. (2018). Inhibin: To Betaglycan, or Not to Betaglycan. Endocrinology, 160 (2), 341-342. doi: 10.1210/en.2018-01049 |
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2018 Journal Article Molecular characterization of latent GDF8 reveals mechanisms of activationWalker, Ryan G., McCoy, Jason C., Czepnik, Magdalena, Mills, Melanie J., Hagg, Adam, Walton, Kelly L., Cotton, Thomas R., Hyvönen, Marko, Lee, Richard T., Gregorevic, Paul, Harrison, Craig A. and Thompson, Thomas B. (2018). Molecular characterization of latent GDF8 reveals mechanisms of activation. Proceedings of the National Academy of Sciences of the United States of America, 115 (5), E866-E875. doi: 10.1073/pnas.1714622115 |
