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2017 Journal Article Targeting TGF-β mediated SMAD signaling for the prevention of fibrosisWalton, Kelly L., Johnson, Katharine E. and Harrison, Craig A. (2017). Targeting TGF-β mediated SMAD signaling for the prevention of fibrosis. Frontiers in Pharmacology, 8 (JUL) 461. doi: 10.3389/fphar.2017.00461 |
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2017 Journal Article Specific targeting of TGF-β family ligands demonstrates distinct roles in the regulation of muscle mass in health and diseaseChen, Justin L., Walton, Kelly L., Hagg, Adam, Colgan, Timothy D., Johnson, Katharine, Qian, Hongwei, Gregorevic, Paul and Harrison, Craig A. (2017). Specific targeting of TGF-β family ligands demonstrates distinct roles in the regulation of muscle mass in health and disease. Proceedings of the National Academy of Sciences of the United States of America, 114 (26), E5266-E5275. doi: 10.1073/pnas.1620013114 |
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2017 Journal Article Multiple Soluble TGF-β Receptors in Addition to Soluble Endoglin Are Elevated in Preeclamptic Serum and They Synergistically Inhibit TGF-β SignalingWang, Yao, Chen, Qi, Zhao, Min, Walton, Kelly, Harrison, Craig and Nie, Guiying (2017). Multiple Soluble TGF-β Receptors in Addition to Soluble Endoglin Are Elevated in Preeclamptic Serum and They Synergistically Inhibit TGF-β Signaling. The Journal of Clinical Endocrinology & Metabolism, 102 (8), 3065-3074. doi: 10.1210/jc.2017-01150 |
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2017 Journal Article Structural basis for potency differences between GDF8 and GDF11Walker, Ryan G., Czepnik, Magdalena, Goebel, Erich J., McCoy, Jason C., Vujic, Ana, Cho, Miook, Oh, Juhyun, Aykul, Senem, Walton, Kelly L., Schang, Gauthier, Bernard, Daniel J., Hinck, Andrew P., Harrison, Craig A., Martinez-Hackert, Erik, Wagers, Amy J., Lee, Richard T. and Thompson, Thomas B. (2017). Structural basis for potency differences between GDF8 and GDF11. BMC Biology, 15 (1) 19. doi: 10.1186/s12915-017-0350-1 |
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2017 Journal Article BMP15 mutations associated with primary ovarian insufficiency reduce expression, activity, or synergy with GDF9Patino, Liliana C., Walton, Kelly L., Mueller, Thomas D., Johnson, Katharine E., Stocker, William, Richani, Dulama, Agapiou, David, Gilchrist, Robert B., Laissue, Paul and Harrison, Craig A. (2017). BMP15 mutations associated with primary ovarian insufficiency reduce expression, activity, or synergy with GDF9. Journal of Clinical Endocrinology and Metabolism, 102 (3), 1009-1019. doi: 10.1210/jc.2016-3503 |
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2017 Journal Article The angiotensin receptor blocker, Losartan, inhibits mammary tumor development and progression to invasive carcinomaCoulson, Rhiannon, Liew, Seng H., Connelly, Angela A., Yee, Nicholas S., Deb, Siddhartha, Kumar, Beena, Vargas, Ana C., O'Toole, Sandra A., Parslow, Adam C., Poh, Ashleigh, Putoczki, Tracy, Morrow, Riley J., Alorro, Mariah, Lazarus, Kyren A., Yeap, Evie F.W., Walton, Kelly L., Harrison, Craig A., Hannan, Natalie J., George, Amee J., Clyne, Colin D., Ernst, Matthias, Allen, Andrew M. and Chand, Ashwini L. (2017). The angiotensin receptor blocker, Losartan, inhibits mammary tumor development and progression to invasive carcinoma. Oncotarget, 8 (12), 18640-18656. doi: 10.18632/oncotarget.15553 |
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2016 Journal Article Differential effects of IL6 and activin A in the development of cancer-associated cachexiaChen, Justin L., Walton, Kelly L., Qian, Hongwei, Colgan, Timothy D., Hagg, Adam, Watt, Matthew J., Harrison, Craig A. and Gregorevic, Paul (2016). Differential effects of IL6 and activin A in the development of cancer-associated cachexia. Cancer Research, 76 (18), 5372-5382. doi: 10.1158/0008-5472.CAN-15-3152 |
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2016 Journal Article Smad7 gene delivery prevents muscle wasting associated with cancer cachexia in miceWinbanks, Catherine E., Murphy, Kate T., Bernardo, Bianca C., Qian, Hongwei, Liu, Yingying, Sepulveda, Patricio V., Beyer, Claudia, Hagg, Adam, Thomson, Rachel E., Chen, Justin L., Walton, Kelly L., Loveland, Kate L., McMullen, Julie R., Rodgers, Buel D., Harrison, Craig A., Lynch, Gordon S. and Gregorevic, Paul (2016). Smad7 gene delivery prevents muscle wasting associated with cancer cachexia in mice. Science Translational Medicine, 8 (348) 348ra98. doi: 10.1126/scitranslmed.aac4976 |
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2016 Journal Article A novel, more efficient approach to generate bioactive inhibinsWalton, Kelly L., Kelly, Emily K., Johnson, Katharine E., Robertson, David M., Stanton, Peter G. and Harrison, Craig A. (2016). A novel, more efficient approach to generate bioactive inhibins. Endocrinology, 157 (7), 2799-2809. doi: 10.1210/en.2015-1963 |
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2016 Journal Article Biological activity and <i>in vivo</i> half-life of pro-activin A in male ratsJohnson, Katharine E., Makanji, Yogeshwar, Temple-Smith, Peter, Kelly, Emily K., Barton, Peter A., Al-Musawi, Sara L., Mueller, Thomas D., Walton, Kelly L. and Harrison, Craig A. (2016). Biological activity and in vivo half-life of pro-activin A in male rats. Molecular and Cellular Endocrinology, 422 (C), 84-92. doi: 10.1016/j.mce.2015.12.007 |
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2015 Journal Article Inhibin Biosynthesis and Activity Are Limited by a Prodomain-Derived PeptideWalton, Kelly L., Kelly, Emily K., Chan, Karen L., Harrison, Craig A. and Robertson, David M. (2015). Inhibin Biosynthesis and Activity Are Limited by a Prodomain-Derived Peptide. Endocrinology, 156 (8), 3047-3057. doi: 10.1210/en.2014-2005 |
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2015 Journal Article Development of a high-throughput assay for human proprotein convertase 5/6 for detecting uterine receptivityHeng, Sophea, Dynon, Kemperly, Li, Ying, Edgell, Tracey, Walton, Kelly, Rombauts, Luk J., Vollenhoven, Beverley and Nie, Guiying (2015). Development of a high-throughput assay for human proprotein convertase 5/6 for detecting uterine receptivity. Analytical Biochemistry, 475, 14-21. doi: 10.1016/j.ab.2014.12.012 |
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2015 Journal Article Development of novel activin-targeted therapeuticsChen, Justin L., Walton, Kelly L., Al-Musawi, Sara L., Kelly, Emily K., Qian, Hongwei, La, Mylinh, Lu, Louis, Lovrecz, George, Ziemann, Mark, Lazarus, Ross, El-Osta, Assam, Gregorevic, Paul and Harrison, Craig A. (2015). Development of novel activin-targeted therapeutics. Molecular Therapy, 23 (3), 434-444. doi: 10.1038/mt.2014.221 |
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2014 Journal Article Elevated expression of activins promotes muscle wasting and cachexiaChen, Justin L., Walton, Kelly L., Winbanks, Catherine E., Murphy, Kate T., Thomson, Rachel E., Makanji, Yogeshwar, Qian, Hongwei, Lynch, Gordon S., Harrison, Craig A. and Gregorevic, Paul (2014). Elevated expression of activins promotes muscle wasting and cachexia. Faseb Journal, 28 (4), 1711-1723. doi: 10.1096/fj.13-245894 |
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2014 Journal Article Germline mutations of inhibins in early-onset ovarian epithelial tumorsTournier, Isabelle, Marlin, Régine, Walton, Kelly, Charbonnier, Françoise, Coutant, Sophie, Théry, Jean-Christophe, Charbonnier, Camille, Spurrell, Cailyn, Vezain, Myriam, Ippolito, Lorena, Bougeard, Gaëlle, Roman, Horace, Tinat, Julie, Sabourin, Jean-Christophe, Stoppa-Lyonnet, Dominique, Caron, Olivier, Bressac-de Paillerets, Brigitte, Vaur, Dominique, King, Mary-Claire, Harrison, Craig and Frebourg, Thierry (2014). Germline mutations of inhibins in early-onset ovarian epithelial tumors. Human Mutation, 35 (3), 294-297. doi: 10.1002/humu.22489 |
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2013 Journal Article Identification of protein binding partners of ALK-5 kinase inhibitorsCiayadi, Rudy, Kelso, Geoffrey F., Potdar, Mahesh K., Harris, Simon J., Walton, Kelly L., Harrison, Craig A. and Hearn, Milton T. W. (2013). Identification of protein binding partners of ALK-5 kinase inhibitors. Bioorganic & Medicinal Chemistry, 21 (21), 6496-6500. doi: 10.1016/j.bmc.2013.08.038 |
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2013 Journal Article Species Differences in the Expression and Activity of Bone Morphogenetic Protein 15Al-Musawi, Sara L., Walton, Kelly L., Heath, Derek, Simpson, Courtney M. and Harrison, Craig A. (2013). Species Differences in the Expression and Activity of Bone Morphogenetic Protein 15. Endocrinology, 154 (2), 888-899. doi: 10.1210/en.2012-2015 |
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2012 Journal Article Activin signaling regulates sertoli cell differentiation and functionNicholls, Peter K., Stanton, Peter G., Chen, Justin L., Olcorn, Justine S., Haverfield, Jenna T., Qian, Hongwei, Walton, Kelly L., Gregorevic, Paul and Harrison, Craig A. (2012). Activin signaling regulates sertoli cell differentiation and function. Endocrinology, 153 (12), 6065-6077. doi: 10.1210/en.2012-1821 |
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2012 Journal Article HtrA3 as an Early Marker for Preeclampsia: Specific Monoclonal Antibodies and Sensitive High-Throughput Assays for Serum ScreeningDynon, Kemperly, Heng, Sophea, Puryer, Michelle, Li, Ying, Walton, Kelly, Endo, Yaeta and Nie, Guiying (2012). HtrA3 as an Early Marker for Preeclampsia: Specific Monoclonal Antibodies and Sensitive High-Throughput Assays for Serum Screening. Plos One, 7 (9) e45956. doi: 10.1371/journal.pone.0045956 |
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2012 Journal Article Activation of latent human GDF9 by a single residue change (Gly391Arg) in the mature domainSimpson, Courtney M., Stanton, Peter G., Walton, Kelly L., Chan, Karen L., Ritter, Lesley J., Gilchrist, Robert B. and Harrison, Craig A. (2012). Activation of latent human GDF9 by a single residue change (Gly391Arg) in the mature domain. Endocrinology, 153 (3), 1301-1310. doi: 10.1210/en.2011-1632 |
