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2024 Journal Article Chromatin-based memory as a self-stabilizing influence on cell identityBell, Charles C., Faulkner, Geoffrey J. and Gilan, Omer (2024). Chromatin-based memory as a self-stabilizing influence on cell identity. Genome Biology, 25 (1) 320. doi: 10.1186/s13059-024-03461-x |
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2024 Journal Article Heterochromatin protein 1 alpha (HP1α) undergoes a monomer to dimer transition that opens and compacts live cell genome architectureLou, Jieqiong, Deng, Qiji, Zhang, Xiaomeng, Bell, Charles C, Das, Andrew B, Bediaga, Naiara G, Zlatic, Courtney O, Johanson, Timothy M, Allan, Rhys S, Griffin, Michael D W, Paradkar, PrasadN, Harvey, Kieran F, Dawson, Mark A and Hinde, Elizabeth (2024). Heterochromatin protein 1 alpha (HP1α) undergoes a monomer to dimer transition that opens and compacts live cell genome architecture. Nucleic Acids Research, 52 (18), 10918-10933. doi: 10.1093/nar/gkae720 |
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2024 Journal Article LINE-1 retrotransposons contribute to mouse PV interneuron developmentBodea, Gabriela O., Botto, Juan M., Ferreiro, Maria E., Sanchez-Luque, Francisco J., de los Rios Barreda, Jose, Rasmussen, Jay, Rahman, Muhammed A., Fenlon, Laura R., Jansz, Natasha, Gubert, Carolina, Gerdes, Patricia, Bodea, Liviu-Gabriel, Ajjikuttira, Prabha, Da Costa Guevara, Darwin J., Cumner, Linda, Bell, Charles C., Kozulin, Peter, Billon, Victor, Morell, Santiago, Kempen, Marie-Jeanne H. C., Love, Chloe J., Saha, Karabi, Palmer, Lucy M., Ewing, Adam D., Jhaveri, Dhanisha J., Richardson, Sandra R., Hannan, Anthony J. and Faulkner, Geoffrey J. (2024). LINE-1 retrotransposons contribute to mouse PV interneuron development. Nature Neuroscience, 27 (7), 1-34. doi: 10.1038/s41593-024-01650-2 |
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2024 Journal Article Comparative cofactor screens show the influence of transactivation domains and core promoters on the mechanisms of transcriptionBell, Charles C., Balic, Jesse J., Talarmain, Laure, Gillespie, Andrea, Scolamiero, Laura, Lam, Enid Y. N., Ang, Ching-Seng, Faulkner, Geoffrey J., Gilan, Omer and Dawson, Mark A. (2024). Comparative cofactor screens show the influence of transactivation domains and core promoters on the mechanisms of transcription. Nature Genetics, 56 (6), 1181-1192. doi: 10.1038/s41588-024-01749-z |
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2023 Journal Article CRISPR–ChIP reveals selective regulation of H3K79me2 by Menin in MLL leukemiaGilan, Omer, Talarmain, Laure, Bell, Charles C., Neville, Daniel, Knezevic, Kathy, Ferguson, Daniel T., Boudes, Marion, Chan, Yih-Chih, Davidovich, Chen, Lam, Enid Y. N. and Dawson, Mark A. (2023). CRISPR–ChIP reveals selective regulation of H3K79me2 by Menin in MLL leukemia. Nature Structural and Molecular Biology, 30 (10), 1592-1606. doi: 10.1038/s41594-023-01087-4 |
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2023 Journal Article Targeting Menin disrupts the KMT2A/B and polycomb balance to paradoxically activate bivalent genesSparbier, Christina E., Gillespie, Andrea, Gomez, Juliana, Kumari, Nishi, Motazedian, Ali, Chan, Kah Lok, Bell, Charles C., Gilan, Omer, Chan, Yih-Chih, Popp, Sarah, Gough, Daniel J., Eckersley-Maslin, Melanie A., Dawson, Sarah-Jane, Lehner, Paul J., Sutherland, Kate D., Ernst, Patricia, McGeehan, Gerard M., Lam, Enid Y. N., Burr, Marian L. and Dawson, Mark A. (2023). Targeting Menin disrupts the KMT2A/B and polycomb balance to paradoxically activate bivalent genes. Nature Cell Biology, 25 (2), 258-272. doi: 10.1038/s41556-022-01056-x |
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2021 Journal Article CDK4/6 inhibition reprograms the breast cancer enhancer landscape by stimulating AP-1 transcriptional activityWatt, April C., Cejas, Paloma, DeCristo, Molly J., Metzger-Filho, Otto, Lam, Enid Y. N., Qiu, Xintao, BrinJones, Haley, Kesten, Nikolas, Coulson, Rhiannon, Font-Tello, Alba, Lim, Klothilda, Vadhi, Raga, Daniels, Veerle W., Montero, Joan, Taing, Len, Meyer, Clifford A., Gilan, Omer, Bell, Charles C., Korthauer, Keegan D., Giambartolomei, Claudia, Pasaniuc, Bogdan, Seo, Ji-Heui, Freedman, Matthew L., Ma, Cynthia, Ellis, Matthew J., Krop, Ian, Winer, Eric, Letai, Anthony, Brown, Myles ... Goel, Shom (2021). CDK4/6 inhibition reprograms the breast cancer enhancer landscape by stimulating AP-1 transcriptional activity. Nature Cancer, 2 (1), 34-48. doi: 10.1038/s43018-020-00135-y |
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2020 Journal Article An Erg-driven transcriptional program controls B cell lymphopoiesisNg, Ashley P., Coughlan, Hannah D., Hediyeh-zadeh, Soroor, Behrens, Kira, Johanson, Timothy M., Low, Michael Sze Yuan, Bell, Charles C., Gilan, Omer, Chan, Yih-Chih, Kueh, Andrew J., Boudier, Thomas, Feltham, Rebecca, Gabrielyan, Anna, DiRago, Ladina, Hyland, Craig D., Ierino, Helen, Mifsud, Sandra, Viney, Elizabeth, Willson, Tracy, Dawson, Mark A., Allan, Rhys S., Herold, Marco J., Rogers, Kelly, Tarlinton, David M., Smyth, Gordon K., Davis, Melissa J., Nutt, Stephen L. and Alexander, Warren S. (2020). An Erg-driven transcriptional program controls B cell lymphopoiesis. Nature Communications, 11 (1) 3013, 1-14. doi: 10.1038/s41467-020-16828-y |
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2020 Journal Article Principles and mechanisms of non-genetic resistance in cancerBell, Charles C. and Gilan, Omer (2020). Principles and mechanisms of non-genetic resistance in cancer. British Journal of Cancer, 122 (4), 465-472. doi: 10.1038/s41416-019-0648-6 |
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2019 Journal Article Targeting enhancer switching overcomes non-genetic drug resistance in acute myeloid leukaemiaBell, Charles C., Fennell, Katie A., Chan, Yih-Chih, Rambow, Florian, Yeung, Miriam M., Vassiliadis, Dane, Lara, Luis, Yeh, Paul, Martelotto, Luciano G., Rogiers, Aljosja, Kremer, Brandon E., Barbash, Olena, Mohammad, Helai P., Johanson, Timothy M., Burr, Marian L., Dhar, Arindam, Karpinich, Natalie, Tian, Luyi, Tyler, Dean S., MacPherson, Laura, Shi, Junwei, Pinnawala, Nathan, Yew Fong, Chun, Papenfuss, Anthony T., Grimmond, Sean M., Dawson, Sarah-Jane, Allan, Rhys S., Kruger, Ryan G., Vakoc, Christopher R. ... Dawson, Mark A. (2019). Targeting enhancer switching overcomes non-genetic drug resistance in acute myeloid leukaemia. Nature Communications, 10 (1) 2723, 2723-10. doi: 10.1038/s41467-019-10652-9 |
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2019 Journal Article An evolutionarily conserved function of polycomb silences the MHC Class I antigen presentation pathway and enables immune evasion in cancerBurr, Marian L., Sparbier, Christina E., Chan, Kah Lok, Chan, Yih-Chih, Kersbergen, Ariena, Lam, Enid Y.N., Azidis-Yates, Elizabeth, Vassiliadis, Dane, Bell, Charles C., Gilan, Omer, Jackson, Susan, Tan, Lavinia, Wong, Stephen Q., Hollizeck, Sebastian, Michalak, Ewa M., Siddle, Hannah V., McCabe, Michael T., Prinjha, Rab K., Guerra, Glen R., Solomon, Benjamin J., Sandhu, Shahneen, Dawson, Sarah-Jane, Beavis, Paul A., Tothill, Richard W., Cullinane, Carleen, Lehner, Paul J., Sutherland, Kate D. and Dawson, Mark A. (2019). An evolutionarily conserved function of polycomb silences the MHC Class I antigen presentation pathway and enables immune evasion in cancer. Cancer Cell, 36 (4), 385-401.e8. doi: 10.1016/j.ccell.2019.08.008 |
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2019 Journal Article Interconversion between Tumorigenic and Differentiated States in Acute Myeloid LeukemiaMcKenzie, Mark D., Ghisi, Margherita, Oxley, Ethan P., Ngo, Steven, Cimmino, L., Esnault, Cécile, Liu, Ruijie, Salmon, Jessica M., Bell, Charles C., Ahmed, Nouraiz, Erlichster, Michael, Witkowski, Matthew T., Liu, Grace J., Chopin, Michael, Dakic, Aleksandar, Simankowicz, Emilia, Pomilio, Giovanna, Vu, Tina, Krsmanovic, P., Su, S., Tian, Luyi, Baldwin, Tracey M., Zalcenstein, Daniela A., DiRago, Ladina, Wang, Shu, Metcalf, Donald, Johnstone, Ricky W., Croker, B. A., Lancaster, Graeme I. ... Dickins, Ross A. (2019). Interconversion between Tumorigenic and Differentiated States in Acute Myeloid Leukemia. Cell Stem Cell, 25 (2), 258-272.e9. doi: 10.1016/j.stem.2019.07.001 |
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2019 Journal Article Dynamic molecular monitoring reveals that SWI–SNF mutations mediate resistance to ibrutinib plus venetoclax in mantle cell lymphomaAgarwal, Rishu, Chan, Yih-Chih, Tam, Constantine S., Hunter, Tane, Vassiliadis, Dane, Teh, Charis E., Thijssen, Rachel, Yeh, Paul, Wong, Stephen Q., Ftouni, Sarah, Lam, Enid Y. N., Anderson, Mary Ann, Pott, Christiane, Gilan, Omer, Bell, Charles C., Knezevic, Kathy, Blombery, Piers, Rayeroux, Kathleen, Zordan, Adrian, Li, Jason, Huang, David C. S., Wall, Meaghan, Seymour, John F., Gray, Daniel H. D., Roberts, Andrew W., Dawson, Mark A. and Dawson, Sarah-Jane (2019). Dynamic molecular monitoring reveals that SWI–SNF mutations mediate resistance to ibrutinib plus venetoclax in mantle cell lymphoma. Nature Medicine, 25 (1), 119-129. doi: 10.1038/s41591-018-0243-z |
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2019 Journal Article Epigenetic therapies in acute myeloid leukemia: Where to from here?Fennell, Katie A., Bell, Charles C. and Dawson, Mark A. (2019). Epigenetic therapies in acute myeloid leukemia: Where to from here?. Blood, 134 (22), 1891-1901. doi: 10.1182/blood.2019003262 |
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2018 Journal Article TFIID and MYB Share a Therapeutic Handshake in AMLBell, Charles C. and Dawson, Mark A. (2018). TFIID and MYB Share a Therapeutic Handshake in AML. Cancer Cell, 33 (1), 1-3. doi: 10.1016/j.ccell.2017.12.008 |
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2017 Journal Article CMTM6 maintains the expression of PD-L1 and regulates anti-Tumour immunityBurr, Marian L., Sparbier, Christina E., Chan, Yih-Chih, Williamson, James C., Woods, Katherine, Beavis, Paul A., Lam, Enid Y. N., Henderson, Melissa A., Bell, Charles C., Stolzenburg, Sabine, Gilan, Omer, Bloor, Stuart, Noori, Tahereh, Morgens, David W., Bassik, Michael C., Neeson, Paul J., Behren, Andreas, Darcy, Phillip K., Dawson, Sarah-Jane, Voskoboinik, Ilia, Trapani, Joseph A., Cebon, Jonathan, Lehner, Paul J. and Dawson, Mark A. (2017). CMTM6 maintains the expression of PD-L1 and regulates anti-Tumour immunity. Nature, 549 (7670), 101-105. doi: 10.1038/nature23643 |
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2017 Journal Article Direct targets of pStat5 signalling in erythropoiesisGillinder, Kevin R., Tuckey, Hugh, Bell, Charles C., Magor, Graham W., Huang, Stephen, Ilsley, Melissa D. and Perkins, Andrew C. (2017). Direct targets of pStat5 signalling in erythropoiesis. PLoS One, 12 (7) e0180922, e0180922. doi: 10.1371/journal.pone.0180922 |
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2017 Journal Article Click chemistry enables preclinical evaluation of targeted epigenetic therapiesTyler, Dean S., Vappiani, Johanna, Cañeque, Tatiana, Lam, Enid Y. N., Ward, Aoife, Gilan, Omer, Chan, Yih-Chih, Hienzsch, Antje, Rutkowska, Anna, Werner, Thilo, Wagner, Anne J., Lugo, Dave, Gregory, Richard, Molina, Cesar Ramirez, Garton, Neil, Wellaway, Christopher R., Jackson, Susan, Macpherson, Laura, Figueiredo, Margarida, Stolzenburg, Sabine, Bell, Charles C., House, Colin, Dawson, Sarah-Jane, Hawkins, Edwin D., Drewes, Gerard, Prinjha, Rab K., Rodriguez, Raphaël, Grandi, Paola and Dawson, Mark A. (2017). Click chemistry enables preclinical evaluation of targeted epigenetic therapies. Science, 356 (6345), 1397-1401. doi: 10.1126/science.aal2066 |
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2016 Journal Article The Evx1/Evx1as gene locus regulates anterior-posterior patterning during gastrulationBell, Charles C., Amaral, Paulo P., Kalsbeek, Anton, Magor, Graham W., Gillinder, Kevin R., Tangermann, Pierre, di Lisio, Lorena, Cheetham, Seth W., Gruhl, Franziska, Frith, Jessica, Tallack, Michael R., Ru, Ke-Lin, Crawford, Joanna, Mattick, John S., Dinger, Marcel E. and Perkins, Andrew C. (2016). The Evx1/Evx1as gene locus regulates anterior-posterior patterning during gastrulation. Scientific Reports, 6 (1) 26657, 26657. doi: 10.1038/srep26657 |
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2015 Journal Article KLF1-null neonates display hydrops fetalis and a deranged erythroid transcriptomeMagor, Graham W., Tallack, Michael R., Gillinder, Kevin R., Bell, Charles C., McCallum, Naomi, Williams, Bronwyn and Perkins, Andrew C. (2015). KLF1-null neonates display hydrops fetalis and a deranged erythroid transcriptome. Blood, 125 (15), 2405-2417. doi: 10.1182/blood-2014-08-590968 |
