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2024 Journal Article Computational design of α‐conotoxins to target specific nicotinic acetylcholine receptor subtypesWu, Xiaosa, Hone, Arik J., Huang, Yen-Hua, Clark, Richard J., McIntosh, J. Michael, Kaas, Quentin and Craik, David J. (2024). Computational design of α‐conotoxins to target specific nicotinic acetylcholine receptor subtypes. Chemistry – A European Journal, 30 (7) e202302909, 1-5. doi: 10.1002/chem.202302909 |
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2022 Journal Article Mutations within the selectivity filter reveal that Kv1 channels have distinct propensities to slow inactivateWu, Xiaosa, Gupta, Kanchan and Swartz, Kenton J. (2022). Mutations within the selectivity filter reveal that Kv1 channels have distinct propensities to slow inactivate. Journal of General Physiology, 154 (11) e202213222. doi: 10.1085/jgp.202213222 |
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2022 Journal Article ɑO-Conotoxin GeXIVA isomers modulate N-type calcium (CaV2.2) channels and inwardly-rectifying potassium (GIRK) channels via GABAB receptor activationYousuf, Arsalan, Wu, Xiaosa, Bony, Anuja R., Sadeghi, Mahsa, Huang, Yen-Hua, Craik, David J. and Adams, David J. (2022). ɑO-Conotoxin GeXIVA isomers modulate N-type calcium (CaV2.2) channels and inwardly-rectifying potassium (GIRK) channels via GABAB receptor activation. Journal of Neurochemistry, 160 (2), 154-171. doi: 10.1111/jnc.15535 |
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2021 Journal Article Interactions of globular and ribbon [γ4E]GID with α4β2 neuronal nicotinic acetylcholine receptorWu, Xiaosa, Craik, David J. and Kaas, Quentin (2021). Interactions of globular and ribbon [γ4E]GID with α4β2 neuronal nicotinic acetylcholine receptor. Marine Drugs, 19 (9) 482, 482. doi: 10.3390/md19090482 |
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2019 Journal Article Periplasmic expression of 4/7 alpha-conotoxin TxIA analogs in E. coli favors ribbon isomer formation suggestion of a binding mode at the α7 nAChREl Hamdaoui, Yamina, Wu, Xiaosa, Clark, Richard J., Giribaldi, Julien, Anangi, Raveendra, Craik, David J., King, Glenn F., Dutertre, Sebastien, Kaas, Quentin, Herzig, Volker and Nicke, Annette (2019). Periplasmic expression of 4/7 alpha-conotoxin TxIA analogs in E. coli favors ribbon isomer formation suggestion of a binding mode at the α7 nAChR. Frontiers in Pharmacology, 10 (MAY) 577, 577. doi: 10.3389/fphar.2019.00577 |
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2018 Journal Article Stoichiometry dependent inhibition of rat α3β4 nicotinic acetylcholine receptor by the ribbon isomer of α-conotoxin AuIBWu, Xiaosa, Tae, Han-Shen, Huang, Yen-Hua, Adams, David J., Craik, David J. and Kaas, Quentin (2018). Stoichiometry dependent inhibition of rat α3β4 nicotinic acetylcholine receptor by the ribbon isomer of α-conotoxin AuIB. Biochemical Pharmacology, 155, 288-297. doi: 10.1016/j.bcp.2018.07.007 |
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2017 Journal Article Backbone cyclization of analgesic conotoxin GeXIVA facilitates direct folding of the ribbon isomerWu, Xiaosa, Huang, Yen-Hua, Kaas, Quentin, Harvey, Peta J., Wang, Conan K., Tae, Han-Shen, Adams, David J. and Craik, David J. (2017). Backbone cyclization of analgesic conotoxin GeXIVA facilitates direct folding of the ribbon isomer. Journal of Biological Chemistry, 292 (41), 17101-17112. doi: 10.1074/jbc.M117.808386 |
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2016 Journal Article Cyclisation of disulfide-rich conotoxins in drug design applicationsWu, Xiaosa, Huang, Yen-Hua, Kaas, Quentin and Craik, David J. (2016). Cyclisation of disulfide-rich conotoxins in drug design applications. European Journal of Organic Chemistry, 2016 (21), 3462-3472. doi: 10.1002/ejoc.201600402 |
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2016 Journal Article Front Cover: Cyclisation of Disulfide-Rich Conotoxins in Drug Design Applications (Eur. J. Org. Chem. 21/2016)Wu, Xiaosa, Huang, Yen-Hua, Kaas, Quentin and Craik, David J. (2016). Front Cover: Cyclisation of Disulfide-Rich Conotoxins in Drug Design Applications (Eur. J. Org. Chem. 21/2016). European Journal of Organic Chemistry, 2016 (21), 3457-3457. doi: 10.1002/ejoc.201670211 |
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2014 Journal Article Influence of disulfide connectivity on structure and bioactivity of alpha-conotoxin TxIAWu, Yong, Wu, Xiaosa, Yu, Jinpeng, Zhu, Xiaopeng, Zhangsun, Dongting and Luo, Sulan (2014). Influence of disulfide connectivity on structure and bioactivity of alpha-conotoxin TxIA. Molecules, 19 (1), 966-979. doi: 10.3390/molecules19010966 |
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2013 Journal Article Optimal cleavage and oxidative folding of alpha-conotoxin TxIB as a therapeutic candidate pPeptideWu, Xiaosa, Wu, Yong, Zhu, Furong, Yang, Qiuyuan, Wu, Qianqian, Zhangsun, Dongting and Luo, Sulan (2013). Optimal cleavage and oxidative folding of alpha-conotoxin TxIB as a therapeutic candidate pPeptide. Marine Drugs, 11 (9), 3537-3553. doi: 10.3390/md11093537 |
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2013 Journal Article Expression and secretion of functional recombinant mu O-conotoxin MrVIB-His-tag in Escherichia coliGao, Bingmiao, Zhangsun, Dongting, Hu, Yuanyan, Wu, Yong, Sheng, Lizi, Fang, Licong, Wu, Xiaosa, Yu, Jinpeng and Luo, Sulan (2013). Expression and secretion of functional recombinant mu O-conotoxin MrVIB-His-tag in Escherichia coli. Toxicon, 72, 81-89. doi: 10.1016/j.toxicon.2013.06.012 |
