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2021

Journal Article

Production, composition, and mode of action of the painful defensive venom produced by a limacodid caterpillar, Doratifera vulnerans

Walker, Andrew A., Robinson, Samuel D., Paluzzi, Jean-Paul V., Merritt, David J., Nixon, Samantha A., Schroeder, Christina I., Jin, Jiayi, Goudarzi, Mohaddeseh Hedayati, Kotze, Andrew C., Dekan, Zoltan, Sombke, Andy, Alewood, Paul F., Fry, Bryan G., Epstein, Marc E., Vetter, Irina and King, Glenn F. (2021). Production, composition, and mode of action of the painful defensive venom produced by a limacodid caterpillar, Doratifera vulnerans. Proceedings of the National Academy of Sciences of the United States of America, 118 (18) 2023815118, e2023815118. doi: 10.1073/pnas.2023815118

Production, composition, and mode of action of the painful defensive venom produced by a limacodid caterpillar, Doratifera vulnerans

2021

Journal Article

Clinical implications of differential procoagulant toxicity of the palearctic viperid genus Macrovipera, and the relative neutralization efficacy of antivenoms and enzyme inhibitors

Chowdhury, Abhinandan, Zdenek, Christina N., Dobson, James S., Bourke, Lachlan A., Soria, Raul and Fry, Bryan G. (2021). Clinical implications of differential procoagulant toxicity of the palearctic viperid genus Macrovipera, and the relative neutralization efficacy of antivenoms and enzyme inhibitors. Toxicology Letters, 340, 77-88. doi: 10.1016/j.toxlet.2020.12.019

Clinical implications of differential procoagulant toxicity of the palearctic viperid genus Macrovipera, and the relative neutralization efficacy of antivenoms and enzyme inhibitors

2021

Journal Article

Getting stoned: Characterisation of the coagulotoxic and neurotoxic effects of reef stonefish (Synanceia verrucosa) venom

Harris, Richard J., Youngman, Nicholas J., Chan, Weili, Bosmans, Frank, Cheney, Karen L. and Fry, Bryan G. (2021). Getting stoned: Characterisation of the coagulotoxic and neurotoxic effects of reef stonefish (Synanceia verrucosa) venom. Toxicology Letters, 346, 16-22. doi: 10.1016/j.toxlet.2021.04.007

Getting stoned: Characterisation of the coagulotoxic and neurotoxic effects of reef stonefish (Synanceia verrucosa) venom

2021

Journal Article

Not Goanna Get Me: Mutations in the Savannah Monitor Lizard (Varanus exanthematicus) nicotinic acetylcholine receptor confer reduced susceptibility to sympatric cobra venoms

Jones, Lee, Harris, Richard J. and Fry, Bryan G. (2021). Not Goanna Get Me: Mutations in the Savannah Monitor Lizard (Varanus exanthematicus) nicotinic acetylcholine receptor confer reduced susceptibility to sympatric cobra venoms. Neurotoxicity Research, 39 (4), 1116-1122. doi: 10.1007/s12640-021-00351-z

Not Goanna Get Me: Mutations in the Savannah Monitor Lizard (Varanus exanthematicus) nicotinic acetylcholine receptor confer reduced susceptibility to sympatric cobra venoms

2021

Journal Article

A clot twist: extreme variation in coagulotoxicity mechanisms in Mexican neotropical rattlesnake venoms

Seneci, Lorenzo, Zdenek, Christina N., Chowdhury, Abhinandan, Rodrigues, Caroline F. B., Neri-Castro, Edgar, Benard-Valle, Melisa, Alagon, Alejandro and Fry, Bryan G. (2021). A clot twist: extreme variation in coagulotoxicity mechanisms in Mexican neotropical rattlesnake venoms. Frontiers in Immunology, 12 612846, 612846. doi: 10.3389/fimmu.2021.612846

A clot twist: extreme variation in coagulotoxicity mechanisms in Mexican neotropical rattlesnake venoms

2021

Journal Article

ERK and mTORC1 inhibitors enhance the anti-cancer capacity of the octpep-1 venom-derived peptide in melanoma BRAF(V600E) mutations

Moral-Sanz, Javier, Fernandez-Rojo, Manuel A., Potriquet, Jeremy, Mukhopadhyay, Pamela, Brust, Andreas, Wilhelm, Patrick, Smallwood, Taylor B., Clark, Richard J., Fry, Bryan G., Alewood, Paul F., Waddell, Nicola, Miles, John J., Mulvenna, Jason P. and Ikonomopoulou, Maria P. (2021). ERK and mTORC1 inhibitors enhance the anti-cancer capacity of the octpep-1 venom-derived peptide in melanoma BRAF(V600E) mutations. Toxins, 13 (2) 146, 1-19. doi: 10.3390/toxins13020146

ERK and mTORC1 inhibitors enhance the anti-cancer capacity of the octpep-1 venom-derived peptide in melanoma BRAF(V600E) mutations

2021

Journal Article

Electric blue: molecular evolution of three-finger toxins in the long-glanded coral snake species Calliophis bivirgatus

Dashevsky, Daniel, Rokyta, Darin, Frank, Nathaniel, Nouwens, Amanda and Fry, Bryan G. (2021). Electric blue: molecular evolution of three-finger toxins in the long-glanded coral snake species Calliophis bivirgatus. Toxins, 13 (2) 124, 1-16. doi: 10.3390/toxins13020124

Electric blue: molecular evolution of three-finger toxins in the long-glanded coral snake species Calliophis bivirgatus

2021

Journal Article

Extensive variation in the activities of Pseudocerastes and Eristicophis viper venoms suggests divergent envenoming strategies are used for prey capture

op den Brouw, Bianca, Coimbra, Francisco C. P., Bourke, Lachlan A., Huynh, Tam Minh, Vlecken, Danielle H. W., Ghezellou, Parviz, Visser, Jeroen C., Dobson, James S., Fernandez-Rojo, Manuel A., Ikonomopoulou, Maria P., Casewell, Nicholas R., Ali, Syed A., Fathinia, Behzad, Hodgson, Wayne C. and Fry, Bryan G. (2021). Extensive variation in the activities of Pseudocerastes and Eristicophis viper venoms suggests divergent envenoming strategies are used for prey capture. Toxins, 13 (2) 112, 1-21. doi: 10.3390/toxins13020112

Extensive variation in the activities of Pseudocerastes and Eristicophis viper venoms suggests divergent envenoming strategies are used for prey capture

2021

Journal Article

Anticoagulant Micrurus venoms: targets and neutralization

Dashevsky, Daniel, Benard-Valle, Melisa, Neri-Castro, Edgar, Youngman, Nicholas J., Zdenek, Christina N., Alagon, Alejandro, Portes-Junior, Jose A., Frank, Nathaniel and Fry, Bryan G. (2021). Anticoagulant Micrurus venoms: targets and neutralization. Toxicology Letters, 337, 91-97. doi: 10.1016/j.toxlet.2020.11.010

Anticoagulant Micrurus venoms: targets and neutralization

2021

Journal Article

Utilising venom activity to infer dietary composition of the Kenyan horned viper (Bitis worthingtoni)

Youngman, Nicholas J., Chowdhury, Abhinandan, Zdenek, Christina N., Coster, Kristian, Sundman, Eric, Braun, Ralph and Fry, Bryan G. (2021). Utilising venom activity to infer dietary composition of the Kenyan horned viper (Bitis worthingtoni). Comparative Biochemistry and Physiology Part C: Toxicology and Pharmacology, 240 108921, 108921. doi: 10.1016/j.cbpc.2020.108921

Utilising venom activity to infer dietary composition of the Kenyan horned viper (Bitis worthingtoni)

2021

Journal Article

Pan-American lancehead pit-vipers: coagulotoxic venom effects and antivenom neutralisation of Bothrops asper and B. atrox geographical variants

Bourke, Lachlan A., Zdenek, Christina N., Neri-Castro, Edgar, Bénard-Valle, Melisa, Alagón, Alejandro, Gutiérrez, José María, Sanchez, Eladio F., Aldridge, Matt and Fry, Bryan G. (2021). Pan-American lancehead pit-vipers: coagulotoxic venom effects and antivenom neutralisation of Bothrops asper and B. atrox geographical variants. Toxins, 13 (2) 78, 1-18. doi: 10.3390/toxins13020078

Pan-American lancehead pit-vipers: coagulotoxic venom effects and antivenom neutralisation of Bothrops asper and B. atrox geographical variants

2021

Journal Article

Electrostatic resistance to alpha-neurotoxins conferred by charge reversal mutations in nicotinic acetylcholine receptors

Harris, Richard J. and Fry, Bryan G. (2021). Electrostatic resistance to alpha-neurotoxins conferred by charge reversal mutations in nicotinic acetylcholine receptors. Proceedings of the Royal Society B: Biological Sciences, 288 (1942) 2703, 20202703. doi: 10.1098/rspb.2020.2703

Electrostatic resistance to alpha-neurotoxins conferred by charge reversal mutations in nicotinic acetylcholine receptors

2021

Journal Article

Widespread and differential neurotoxicity in venoms from the Bitis genus of viperid snakes

Youngman, Nicholas J., Harris, Richard J., Huynh, Tam M., Coster, Kristian, Sundman, Eric, Braun, Ralph, Naude, Arno, Hodgson, Wayne C. and Fry, Bryan G. (2021). Widespread and differential neurotoxicity in venoms from the Bitis genus of viperid snakes. Neurotoxicity Research, 39 (3), 697-704. doi: 10.1007/s12640-021-00330-4

Widespread and differential neurotoxicity in venoms from the Bitis genus of viperid snakes

2021

Journal Article

BoaγPLI from boa constrictor blood is a broad-spectrum inhibitor of venom PLA2 pathophysiological actions

Rodrigues, Caroline Fabri Bittencourt, Zdenek, Christina N., Serino-Silva, Caroline, de Morais-Zani, Karen, Grego, Kathleen Fernandes, Bénard-Valle, Melisa, Neri-Castro, Edgar, Alagón, Alejandro, Tanaka-Azevedo, Anita Mitico and Fry, Bryan Grieg (2021). BoaγPLI from boa constrictor blood is a broad-spectrum inhibitor of venom PLA2 pathophysiological actions. Journal of Chemical Ecology, 47 (10-11), 907-914. doi: 10.1007/s10886-021-01289-4

BoaγPLI from boa constrictor blood is a broad-spectrum inhibitor of venom PLA2 pathophysiological actions

2020

Journal Article

Slow lorises use venom as a weapon in intraspecific competition

Nekaris, K. A.I., Campera, Marco, Nijman, Vincent, Birot, Hélène, Rode-Margono, Eva Johanna, Fry, Bryan Grieg, Weldon, Ariana, Wirdateti, Wirdateti and Imron, Muhammad Ali (2020). Slow lorises use venom as a weapon in intraspecific competition. Current Biology, 30 (20), R1252-R1253. doi: 10.1016/j.cub.2020.08.084

Slow lorises use venom as a weapon in intraspecific competition

2020

Journal Article

Differential coagulotoxicity of metalloprotease isoforms from Bothrops neuwiedi snake venom and consequent variations in antivenom efficacy

Sousa, Leijiane F., Bernardoni, Juliana L., Zdenek, Christina N., Dobson, James, Coimbra, Francisco, Gillett, Amber, Lopes-Ferreira, Mônica, Moura-da-Silva, A.M. and Fry, Bryan G. (2020). Differential coagulotoxicity of metalloprotease isoforms from Bothrops neuwiedi snake venom and consequent variations in antivenom efficacy. Toxicology Letters, 333, 211-221. doi: 10.1016/j.toxlet.2020.08.009

Differential coagulotoxicity of metalloprotease isoforms from Bothrops neuwiedi snake venom and consequent variations in antivenom efficacy

2020

Journal Article

Assessing the binding of venoms from aquatic elapids to the nicotinic acetylcholine receptor orthosteric site of different prey models

Harris, Richard J., Youngman, Nicholas J., Zdenek, Christina N., Huynh, Tam M., Nouwens, Amanda, Hodgson, Wayne C., Harrich, David, Dunstan, Nathan, Portes-Junior, José A. and Fry, Bryan G. (2020). Assessing the binding of venoms from aquatic elapids to the nicotinic acetylcholine receptor orthosteric site of different prey models. International Journal of Molecular Sciences, 21 (19) 7377, 1-13. doi: 10.3390/ijms21197377

Assessing the binding of venoms from aquatic elapids to the nicotinic acetylcholine receptor orthosteric site of different prey models

2020

Journal Article

Widespread evolution of molecular resistance to snake venom α-neurotoxins in vertebrates

Khan, Muzaffar A., Dashevsky, Daniel, Kerkkamp, Harald, Kordiš, Dušan, de Bakker, Merijn A. G., Wouters, Roel, van Thiel, Jory, op den Brouw, Bianca, Vonk, Freek, Kini, R. Manjunatha, Nazir, Jawad, Fry, Bryan G. and Richardson, Michael K. (2020). Widespread evolution of molecular resistance to snake venom α-neurotoxins in vertebrates. Toxins, 12 (10) 638, 638. doi: 10.3390/toxins12100638

Widespread evolution of molecular resistance to snake venom α-neurotoxins in vertebrates

2020

Journal Article

Pets in peril: the relative susceptibility of cats and dogs to procoagulant snake venoms

Zdenek, Christina N., Llinas, Joshua, Dobson, James, Allen, Luke, Dunstan, Nathan, Sousa, Leijiane F., Moura da Silva, Ana M. and Fry, Bryan G. (2020). Pets in peril: the relative susceptibility of cats and dogs to procoagulant snake venoms. Comparative Biochemistry and Physiology. Part C: Toxicology and Pharmacology, 236 108769, 108769. doi: 10.1016/j.cbpc.2020.108769

Pets in peril: the relative susceptibility of cats and dogs to procoagulant snake venoms

2020

Journal Article

Varespladib (LY315920) neutralises phospholipase A2 mediated prothrombinase-inhibition induced by Bitis snake venoms

Youngman, Nicholas J., Walker, Andrew, Naude, Arno, Coster, Kristian, Sundman, Eric and Fry, Bryan G. (2020). Varespladib (LY315920) neutralises phospholipase A2 mediated prothrombinase-inhibition induced by Bitis snake venoms. Comparative Biochemistry and Physiology Part - C: Toxicology and Pharmacology, 236 108818, 108818. doi: 10.1016/j.cbpc.2020.108818

Varespladib (LY315920) neutralises phospholipase A2 mediated prothrombinase-inhibition induced by Bitis snake venoms