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2022 Journal Article Varespladib in the treatment of snakebite envenoming: development history and preclinical evidence supporting advancement to clinical trials in patients bitten by venomous snakesLewin, Matthew R., Carter, Rebecca W., Matteo, Isabel A., Samuel, Stephen P., Rao, Sunita, Fry, Bryan G. and Bickler, Philip E. (2022). Varespladib in the treatment of snakebite envenoming: development history and preclinical evidence supporting advancement to clinical trials in patients bitten by venomous snakes. Toxins, 14 (11) 783, 1-21. doi: 10.3390/toxins14110783 |
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2022 Journal Article Proteomic and toxicological characterization of the venoms of the most enigmatic group of rattlesnakes: the long-tailed rattlesnakesNeri-Castro, Edgar, Zarzosa, Vanessa, Colis-Torres, Andrea, Fry, Bryan G., Olvera-Rodríguez, Alejandro, Jones, Jason, Reyes-Velasco, Jacobo, Zamudio, Fernando, Borja, Miguel, Alagón, Alejandro and Lomonte, Bruno (2022). Proteomic and toxicological characterization of the venoms of the most enigmatic group of rattlesnakes: the long-tailed rattlesnakes. Biochimie, 202, 226-236. doi: 10.1016/j.biochi.2022.08.015 |
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2022 Journal Article Keel venom: Rhabdophis subminiatus (red-necked keelback) venom pathophysiologically affects diverse blood clotting pathwaysChowdhury, Abhinandan, Lewin, Matthew R., Carter, Rebecca W., Casewell, Nicholas R. and Fry, Bryan G. (2022). Keel venom: Rhabdophis subminiatus (red-necked keelback) venom pathophysiologically affects diverse blood clotting pathways. Toxicon, 218, 19-24. doi: 10.1016/j.toxicon.2022.08.017 |
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2022 Journal Article Diverse and dynamic alpha-neurotoxicity within venoms from the palearctic viperid snake clade of Daboia, Macrovipera, Montivipera, and ViperaChowdhury, Abhinandan, Zdenek, Christina N. and Fry, Bryan G. (2022). Diverse and dynamic alpha-neurotoxicity within venoms from the palearctic viperid snake clade of Daboia, Macrovipera, Montivipera, and Vipera. Neurotoxicity Research, 40 (6), 1-9. doi: 10.1007/s12640-022-00572-w |
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2022 Journal Article Convergent evolution of toxin resistance in animalsvan Thiel, Jory, Khan, Muzaffar A., Wouters, Roel M., Harris, Richard J., Casewell, Nicholas R., Fry, Bryan G., Kini, R. Manjunatha, Mackessy, Stephen P., Vonk, Freek J., Wüster, Wolfgang and Richardson, Michael K. (2022). Convergent evolution of toxin resistance in animals. Biological Reviews, 97 (5), 1823-1843. doi: 10.1111/brv.12865 |
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2022 Journal Article Untangling interactions between Bitis vipers and their prey using coagulotoxicity against diverse vertebrate plasmasYoungman, Nicholas J., Llinas, Joshua, Haworth, Mark, Gillett, Amber, Jones, Lee, Walker, Andrew A. and Fry, Bryan G. (2022). Untangling interactions between Bitis vipers and their prey using coagulotoxicity against diverse vertebrate plasmas. Toxicon, 216, 37-44. doi: 10.1016/j.toxicon.2022.06.012 |
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2022 Journal Article The relative efficacy of chemically diverse small-molecule enzyme-inhibitors against anticoagulant activities of Black Snake (Pseudechis spp.) venomsChowdhury, Abhinandan, Youngman, Nicholas J., Liu, Jiaojiao, Lewin, Matthew R., Carter, Rebecca W. and Fry, Bryan G. (2022). The relative efficacy of chemically diverse small-molecule enzyme-inhibitors against anticoagulant activities of Black Snake (Pseudechis spp.) venoms. Toxicology Letters, 366, 26-32. doi: 10.1016/j.toxlet.2022.06.009 |
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2022 Journal Article The target selects the toxin: specific amino acids in snake-prey nicotinic acetylcholine receptors that are selectively bound by king cobra venomsChandrasekara, Uthpala, Harris, Richard J. and Fry, Bryan G. (2022). The target selects the toxin: specific amino acids in snake-prey nicotinic acetylcholine receptors that are selectively bound by king cobra venoms. Toxins, 14 (8) 528, 1-12. doi: 10.3390/toxins14080528 |
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2022 Journal Article The structural conformation of the tachykinin domain drives the anti‐tumoral activity of an octopus peptide in melanoma BRAF <sup>V600E</sup>Moral‐Sanz, Javier, Fernandez‐Rojo, Manuel A., Colmenarejo, Gonzalo, Kurdyukov, Sergey, Brust, Andreas, Ragnarsson, Lotten, Andersson, Åsa, Vila, Sabela F., Cabezas‐Sainz, Pablo, Wilhelm, Patrick, Vela‐Sebastian, Ana, Fernández‐Carrasco, Isabel, Chin, Yanni K. Y., López‐ Mancheño, Yaiza, Smallwood, Taylor B., Clark, Richard J., Fry, Bryan G., King, Glenn F., Ramm, Grant A., Alewood, Paul F., Lewis, Richard J., Mulvenna, Jason P., Boyle, Glen M., Sanchez, Laura E., Neely, G. Gregory, Miles, John J. and Ikonomopoulou, Maria P. (2022). The structural conformation of the tachykinin domain drives the anti‐tumoral activity of an octopus peptide in melanoma BRAF V600E. British Journal of Pharmacology, 179 (20), 4878-4896. doi: 10.1111/bph.15923 |
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2022 Journal Article Differential antivenom and small-molecule inhibition of novel coagulotoxic variations in Atropoides, Cerrophidion, Metlapilcoatlus, and Porthidium American viperid snake venomsJones, Lee, Youngman, Nicholas J., Neri-Castro, Edgar, Guadarrama-Martínez, Alid, Lewin, Matthew R., Carter, Rebecca, Frank, Nathaniel and Fry, Bryan G. (2022). Differential antivenom and small-molecule inhibition of novel coagulotoxic variations in Atropoides, Cerrophidion, Metlapilcoatlus, and Porthidium American viperid snake venoms. Toxins, 14 (8) 511, 1-19. doi: 10.3390/toxins14080511 |
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2022 Journal Article Envenoming by a marine blood worm (Glycera)Durkin, Daniela M., Young, Alison N., Khtikian, Kent, Karjala, Zuzana, Isenstein, Arin L., Fry, Bryan G. and Lewin, Matthew R. (2022). Envenoming by a marine blood worm (Glycera). Toxins, 14 (7) 495, 1-5. doi: 10.3390/toxins14070495 |
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2022 Journal Article Differential coagulotoxic and neurotoxic venom activity from species of the arboreal viperid snake genus Bothriechis (palm-pitvipers)Youngman, Nicholas J., Peng, Yin-Hsuan, Harris, Richard J., Jones, Lee, Llinas, Joshua, Haworth, Mark, Gillett, Amber and Fry, Bryan G. (2022). Differential coagulotoxic and neurotoxic venom activity from species of the arboreal viperid snake genus Bothriechis (palm-pitvipers). Comparative Biochemistry and Physiology Part - C: Toxicology and Pharmacology, 256 109326, 109326. doi: 10.1016/j.cbpc.2022.109326 |
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2022 Journal Article Cloud serpent coagulotoxicity: the biochemical mechanisms underpinning the anticoagulant actions of Mixcoatlus and Ophryacus venomsYoungman, Nicholas J., Carlsson, Demi J., Jones, Lee, Neri-Castro, Edgar, Alagon, Alejandro and Fry, Bryan G. (2022). Cloud serpent coagulotoxicity: the biochemical mechanisms underpinning the anticoagulant actions of Mixcoatlus and Ophryacus venoms. Toxicon, 211, 44-49. doi: 10.1016/j.toxicon.2022.03.009 |
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2022 Journal Article Clinical and evolutionary implications of dynamic coagulotoxicity divergences in Bothrops (Lancehead Pit Viper) venomsBourke, Lachlan Allan, Zdenek, Christina N., Tanaka-Azevedo, Anita Mitico, Silveira, Giovanni Perez Machado, Sant’Anna, Sávio Stefanini, Grego, Kathleen Fernandes, Rodrigues, Caroline Fabri Bittencourt and Fry, Bryan Grieg (2022). Clinical and evolutionary implications of dynamic coagulotoxicity divergences in Bothrops (Lancehead Pit Viper) venoms. Toxins, 14 (5) 297, 297. doi: 10.3390/toxins14050297 |
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2022 Journal Article Cystine knot peptides with tuneable activity and mechanismLi, Choi Yi, Rehm, Fabian B. H., Yap, Kuok, Zdenek, Christina N., Harding, Maxim D., Fry, Bryan G., Durek, Thomas, Craik, David J. and Veer, Simon J. (2022). Cystine knot peptides with tuneable activity and mechanism. Angewandte Chemie, 61 (19) e202200951, e202200951. doi: 10.1002/ange.202200951 |
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2022 Journal Article Efficacy and limitations of chemically diverse small-molecule enzyme-inhibitors against the synergistic coagulotoxic activities of Bitis viper venomsYoungman, Nicholas J., Lewin, Matthew R., Carter, Rebecca, Naude, Arno and Fry, Bryan G. (2022). Efficacy and limitations of chemically diverse small-molecule enzyme-inhibitors against the synergistic coagulotoxic activities of Bitis viper venoms. Molecules, 27 (5) 1733, 1733. doi: 10.3390/molecules27051733 |
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2022 Journal Article Taxon-selective venom variation in adult and neonate Daboia russelii (Russell's Viper), and antivenom efficacyZdenek, Christina N., Chowdhury, Abhinandan, Haw, Grace Y.H., Violette, Aude, Fourmy, Rudy, Christ, Thomas, Vonk, Freek J. and Fry, Bryan G. (2022). Taxon-selective venom variation in adult and neonate Daboia russelii (Russell's Viper), and antivenom efficacy. Toxicon, 205, 11-19. doi: 10.1016/j.toxicon.2021.11.004 |
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2022 Journal Article Dynamic genetic differentiation drives the widespread structural and functional convergent evolution of snake venom proteinaceous toxinsXie, Bing, Dashevsky, Daniel, Rokyta, Darin, Ghezellou, Parviz, Fathinia, Behzad, Shi, Qiong, Richardson, Michael K. and Fry, Bryan G. (2022). Dynamic genetic differentiation drives the widespread structural and functional convergent evolution of snake venom proteinaceous toxins. BMC Biology, 20 (1) 4, 4. doi: 10.1186/s12915-021-01208-9 |
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2021 Journal Article A genus-wide bioactivity analysis of Daboia (Viperinae: Viperidae) viper venoms reveals widespread variation in haemotoxic propertiesop den Brouw, Bianca, Coimbra, Francisco C. P., Casewell, Nicholas R., Ali, Syed Abid, Vonk, Freek J. and Fry, Bryan G. (2021). A genus-wide bioactivity analysis of Daboia (Viperinae: Viperidae) viper venoms reveals widespread variation in haemotoxic properties. International Journal of Molecular Sciences, 22 (24) 13486, 13486. doi: 10.3390/ijms222413486 |
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2021 Journal Article A single-step, high throughput, and highly reproducible method for measuring IgM quantity and avidity directly from fish serum via biolayer interferometry (BLI)Li, Angus, Harris, Richard J., Fry, Bryan G. and Barnes, Andrew C. (2021). A single-step, high throughput, and highly reproducible method for measuring IgM quantity and avidity directly from fish serum via biolayer interferometry (BLI). Fish and Shellfish Immunology, 119, 231-237. doi: 10.1016/j.fsi.2021.10.003 |
