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2025 Journal Article Skin patch delivery of a SARS-CoV-2 Spike DNA vaccine produces broad neutralising antibody responsesMcMillan, Christopher L.D., Corner, Andrea V., Wijesundara, Danushka K., Choo, Jovin J.Y., Pittayakhajonwut, Daraporn, Poredi, Indrajeet, Parry, Rhys H., Bindra, Guneet K., Bruce, Kimberley, Khromykh, Alexander A., Fernando, Germain J.P., Dapremont, Laurent, Young, Paul R. and Muller, David A. (2025). Skin patch delivery of a SARS-CoV-2 Spike DNA vaccine produces broad neutralising antibody responses. Heliyon, 11 (4) e42533, e42533. doi: 10.1016/j.heliyon.2025.e42533 |
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2024 Journal Article Enhancement of cellular immunity following needle-free vaccination of mice with SARS-CoV-2 spike proteinMcMillan, Christopher L. D., Wijesundara, Danushka K., Choo, Jovin J. Y., Amarilla, Alberto A., Modhiran, Naphak, Fernando, Germain J. P., Khromykh, Alexander A., Watterson, Daniel, Young, Paul R. and Muller, David A. (2024). Enhancement of cellular immunity following needle-free vaccination of mice with SARS-CoV-2 spike protein. Journal of General Virology, 105 (1) 001947, 1-6. doi: 10.1099/jgv.0.001947 |
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2022 Journal Article An ultrahigh-density microneedle array for skin vaccination: inducing epidermal cell death by increasing microneedle density enhances total IgG and IgG1 immune responsesCoffey, Jacob W., van der Burg, Nicole M. D., Rananakomol, Thippayawan, Ng, Hwee-Ing, Fernando, Germain J. P. and Kendall, Mark A. F. (2022). An ultrahigh-density microneedle array for skin vaccination: inducing epidermal cell death by increasing microneedle density enhances total IgG and IgG1 immune responses. Advanced NanoBiomed Research, 2 (8) 2100151, 1-12. doi: 10.1002/anbr.202100151 |
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2022 Journal Article Dermal delivery of a SARS-CoV-2 subunit vaccine induces immunogenicity against variants of concernMcMillan, Christopher L. D., Azuar, Armira, Choo, Jovin J. Y., Modhiran, Naphak, Amarilla, Alberto A., Isaacs, Ariel, Honeyman, Kate E., Cheung, Stacey T. M., Liang, Benjamin, Wurm, Maria J., Pino, Paco, Kint, Joeri, Fernando, Germain J. P., Landsberg, Michael J., Khromykh, Alexander A., Hobson-Peters, Jody, Watterson, Daniel, Young, Paul R. and Muller, David A. (2022). Dermal delivery of a SARS-CoV-2 subunit vaccine induces immunogenicity against variants of concern. Vaccines, 10 (4) 578, 578. doi: 10.3390/vaccines10040578 |
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2021 Journal Article Developing a stabilizing formulation of a live chimeric dengue virus vaccine dry coated on a high-density microarray patchChoo, Jovin J. Y., McMillan, Christopher L. D., Fernando, Germain J. P., Hall, Roy A., Young, Paul R., Hobson-Peters, Jody and Muller, David A. (2021). Developing a stabilizing formulation of a live chimeric dengue virus vaccine dry coated on a high-density microarray patch. Vaccines, 9 (11) 1301, 1301. doi: 10.3390/vaccines9111301 |
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2021 Journal Article Complete protection by a single-dose skin patch–delivered SARS-CoV-2 spike vaccineMcMillan, Christopher L. D., Choo, Jovin J. Y., Idris, Adi, Supramaniam, Aroon, Modhiran, Naphak, Amarilla, Alberto A., Isaacs, Ariel, Cheung, Stacey T. M., Liang, Benjamin, Bielefeldt-Ohmann, Helle, Azuar, Armira, Acharya, Dhruba, Kelly, Gabrielle, Fernando, Germain J. P., Landsberg, Michael J., Khromykh, Alexander A., Watterson, Daniel, Young, Paul R., McMillan, Nigel A. J. and Muller, David A. (2021). Complete protection by a single-dose skin patch–delivered SARS-CoV-2 spike vaccine. Science Advances, 7 (44) eabj8065, eabj8065. doi: 10.1126/sciadv.abj8065 |
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2021 Journal Article Cellular responses at the application site of a high-density microarray patch delivering an influenza vaccine in a randomized, controlled phase I clinical trialDepelsenaire, Alexandra C. I., Witham, Katey, Veitch, Margaret, Wells, James W., Anderson, Christopher D., Lickliter, Jason D., Rockman, Steve, Bodle, Jesse, Treasure, Peter, Hickling, Julian, Fernando, Germain J. P. and Forster, Angus H. (2021). Cellular responses at the application site of a high-density microarray patch delivering an influenza vaccine in a randomized, controlled phase I clinical trial. PLoS One, 16 (7) e0255282, e0255282. doi: 10.1371/journal.pone.0255282 |
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2021 Journal Article A chimeric dengue virus vaccine candidate delivered by high density microarray patches protects against infection in miceChoo, Jovin J. Y., Vet, Laura J., McMillan, Christopher L. D., Harrison, Jessica J., Scott, Connor A. P., Depelsenaire, Alexandra C. I., Fernando, Germain J. P., Watterson, Daniel, Hall, Roy A., Young, Paul R., Hobson-Peters, Jody and Muller, David A. (2021). A chimeric dengue virus vaccine candidate delivered by high density microarray patches protects against infection in mice. npj Vaccines, 6 (1) 66, 66. doi: 10.1038/s41541-021-00328-1 |
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2020 Journal Article Safety, tolerability and immunogenicity of influenza vaccination with a high-density microarray patch: results from a randomized, controlled phase I clinical trialForster, Angus H, Witham, Katey, Depelsenaire, Alexandra C.I., Veitch, Margaret, Wells, James W., Wheatley, Adam, Pryor, Melinda, Lickliter, Jason, Francis, Barbara, Rockman, Steve, Bodle, Jesse, Treasure, Peter, Hickling, Julian and Fernando, Germain J.P. (2020). Safety, tolerability and immunogenicity of influenza vaccination with a high-density microarray patch: results from a randomized, controlled phase I clinical trial. PLoS Medicine, 17 (3) e1003024, e1003024. doi: 10.1371/journal.pmed.1003024 |
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2019 Journal Article Efficient delivery of dengue virus subunit vaccines to the skin by microprojection arraysMuller, David A., Depelsenaire, Alexandra C. I., Shannon, Ashleigh E., Watterson, Daniel, Corrie, Simon R., Owens, Nick S., Agyei-Yeboah, Christiana, Cheung, Stacey T. M., Zhang, Jin, Fernando, Germain J. P., Kendall, Mark A. F. and Young, Paul R. (2019). Efficient delivery of dengue virus subunit vaccines to the skin by microprojection arrays. Vaccines, 7 (4) 189, 189. doi: 10.3390/vaccines7040189 |
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2019 Journal Article Microprojection arrays applied to skin generate mechanical stress, induce an inflammatory transcriptome and cell death, and improve vaccine-induced immune responsesNg, Hwee-Ing, Tuong, Zewen K., Fernando, Germain J. P., Depelsenaire, Alexandra C. I., Meliga, Stefano C., Frazer, Ian H. and Kendall, Mark A. F. (2019). Microprojection arrays applied to skin generate mechanical stress, induce an inflammatory transcriptome and cell death, and improve vaccine-induced immune responses. npj Vaccines, 4 (1) 41, 41. doi: 10.1038/s41541-019-0134-4 |
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2018 Journal Article Safety, tolerability, acceptability and immunogenicity of an influenza vaccine delivered to human skin by a novel high-density microprojection array patch (Nanopatch™)Fernando, Germain J. P., Hickling, Julian, Jayashi Flores, Cesar M., Griffin, Paul, Anderson, Christopher D., Skinner, S. Rachel, Davies, Cristyn, Witham, Katey, Pryor, Melinda, Bodle, Jesse, Rockman, Steve, Frazer, Ian H. and Forster, Angus H. (2018). Safety, tolerability, acceptability and immunogenicity of an influenza vaccine delivered to human skin by a novel high-density microprojection array patch (Nanopatch™). Vaccine, 36 (26), 3779-3788. doi: 10.1016/j.vaccine.2018.05.053 |
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2017 Journal Article High-density microprojection array delivery to rat skin of low doses of trivalent inactivated poliovirus vaccine elicits potent neutralising antibody responsesMuller, David A., Fernando, Germain J. P., Owens, Nick S., Agyei-Yeboah, Christiana, Wei, Jonathan C. J., Depelsenaire, Alexandra C. I., Forster, Angus, Fahey, Paul, Weldon, William C., Oberste, M. Steven, Young, Paul R. and Kendall, Mark A. F. (2017). High-density microprojection array delivery to rat skin of low doses of trivalent inactivated poliovirus vaccine elicits potent neutralising antibody responses. Scientific Reports, 7 (1) 12644, 12644. doi: 10.1038/s41598-017-13011-0 |
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2016 Journal Article Influenza nucleoprotein DNA vaccination by a skin targeted, dry coated, densely packed microprojection array (Nanopatch) induces potent antibody and CD8+ T cell responsesFernando, Germain J. P., Zhang, Jin, Ng, Hwee-Ing, Haigh, Oscar L., Yukiko, Sally R. and Kendall, Mark A. F. (2016). Influenza nucleoprotein DNA vaccination by a skin targeted, dry coated, densely packed microprojection array (Nanopatch) induces potent antibody and CD8+ T cell responses. Journal of Controlled Release, 237, 35-41. doi: 10.1016/j.jconrel.2016.06.045 |
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2005 Journal Article Local inflammation is crucial for T cell mediated rejection of skin graft expressing foreign antigenZhong, J., De Kluyver, R., Leggatt, G. R., Fernando, G. J. and Frazer, I. H. (2005). Local inflammation is crucial for T cell mediated rejection of skin graft expressing foreign antigen. Tissue Antigens, 66 (5), 600-600. |
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2005 Journal Article A model of peripheral CD8(+) T cell tolerance against skin antigenNarayan, S., Fernando, G., Frazer, I. H. and Leggatt, G. (2005). A model of peripheral CD8(+) T cell tolerance against skin antigen. Tissue Antigens, 66 (5), 501-501. doi: 10.1111/j.1399-0039.2005.00523.x |
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2005 Journal Article The role of TH cells in memory CTL mediated tumor protectionGao, Feng-Guang, Fernando, Germain J. P. and Liu, Wen-Jun (2005). The role of TH cells in memory CTL mediated tumor protection. Chinese Journal of Microbiology and Immunology, 25 (4), 286-291. |
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2005 Journal Article Overcoming original antigenic sin to generate effective immune responses in antigen primed hostLiu, X., Leggatt, G., Fernando, G. J. and Frazer, I. H. (2005). Overcoming original antigenic sin to generate effective immune responses in antigen primed host. Tissue Antigens, 66 (5), 481-481. |
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2004 Journal Article Changes to peptide structure, not concentration, contribute to expansion of the lowest avidity cytotoxic T lymphocytesLeggatt, Graham R., Narayan, Sharmal, Fernando, Germain J. P. and Frazer, Ian H. (2004). Changes to peptide structure, not concentration, contribute to expansion of the lowest avidity cytotoxic T lymphocytes. Journal of Leukocyte Biology, 76 (4), 787-795. doi: 10.1189/jlb.0104026 |
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2000 Journal Article Immune responses induced by BCG recombinant for human papillomavirus L1 and E7 proteinsAbdul Jabbar, I., Fernando, G. J., Saunders, N. A., Aldovini, A., Young, R., Malcolm, K. M. and Frazer, I. H. (2000). Immune responses induced by BCG recombinant for human papillomavirus L1 and E7 proteins. Vaccine, 18 (22), 2444-2453. doi: 10.1016/S0264-410X(99)00550-2 |
