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2016 Journal Article Genetic coding variant in GPR65 alters lysosomal pH and links lysosomal dysfunction with colitis riskLassen, Kara G., McKenzie, Craig I., Mari, Muriel, Murano, Tatsuro, Begun, Jakob, Baxt, Leigh A., Goel, Gautam, Villablanca, Eduardo J., Kuo, Szu-Yu, Huang, Hailiang, Macia, Laurence, Bhan, Atul K., Batten, Marcel, Daly, Mark J., Reggiori, Fulvio, Mackay, Charles R. and Xavier, Ramnik J. (2016). Genetic coding variant in GPR65 alters lysosomal pH and links lysosomal dysfunction with colitis risk. Immunity, 44 (6), 1392-1405. doi: 10.1016/j.immuni.2016.05.007 |
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2016 Journal Article Towards an integrated understanding of the therapeutic utility of exclusive enteral nutrition in the treatment of Crohn's diseaseO Cuiv, Paraic, Begun, Jake, Keely, Simon, Lewindon, Peter and Morrison, Mark (2016). Towards an integrated understanding of the therapeutic utility of exclusive enteral nutrition in the treatment of Crohn's disease. Food and Function, 7 (4), 1741-1751. doi: 10.1039/C5FO01196E |
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2015 Journal Article Integrated genomics of crohn's disease risk variant identifies a role for CLEC12A in antibacterial autophagyBegun, Jakob, Lassen, Kara G., Jijon, Humberto B., Baxt, Leigh A., Goel, Gautam, Heath, Robert J., Ng, Aylwin, Tam, Jenny M., Kuo, Szu-Yu, Villablanca, Eduardo J., Fagbami, Lola, Oosting, Marije, Kumar, Vinod, Schenone, Monica, Carr, Steven A., Joosten, Leo A. B., Vyas, Jatin M., Daly, Mark J., Netea, Mihai G., Brown, Gordon D., Wijmenga, Cisca and Xavier, Ramnik J. (2015). Integrated genomics of crohn's disease risk variant identifies a role for CLEC12A in antibacterial autophagy. Cell Reports, 11 (12), 1905-1918. doi: 10.1016/j.celrep.2015.05.045 |
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2015 Journal Article Enteroliths in a Kock continent ileostomy: case report and review of the literatureMoattar, Hadi, Begun, Jakob and Florin, Timothy (2015). Enteroliths in a Kock continent ileostomy: case report and review of the literature. Endoscopy, 47 (S 01), E200-E201. doi: 10.1055/s-0034-1391302 |
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2014 Journal Article IL-1 receptor blockade restores autophagy and reduces inflammation in chronic granulomatous disease in mice and in humansde Luca, Antonella, Smeekens, Sanne P., Casagrande, Andrea, Iannitti, Rossana, Conway, Kara L., Gresnigt, Mark. S., Begun, Jakob, Plantinga, Theo S., Joosten, Leo A. B., van der Meer, Jos W. M., Chamilos, Georgios, Netea, Mihai G., Xavier, Ramnik J., Dinarello, Charles A., Romani, Luigina and van de Veerdonk, Frank L. (2014). IL-1 receptor blockade restores autophagy and reduces inflammation in chronic granulomatous disease in mice and in humans. Proceedings of the National Academy of Sciences of the United States of America, 111 (9), 3526-3531. doi: 10.1073/pnas.1322831111 |
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2013 Journal Article Autophagy at the crossroads of metabolism and cellular defenseBegun, Jakob and Xavier, Ramnik J. (2013). Autophagy at the crossroads of metabolism and cellular defense. Current Opinion in Gastroenterology, 29 (6), 588-596. doi: 10.1097/MOG.0b013e328365d34d |
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2013 Journal Article Deep resequencing of GWAS loci identifies rare variants in CARD9, IL23R and RNF186 that are associated with ulcerative colitisBeaudoin, Melissa, Goyette, Philippe, Boucher, Gabrielle, Lo, Ken Sin, Rivas, Manuel A., Stevens, Christine, Alikashani, Azadeh, Ladouceur, Martin, Ellinghaus, David, Torkvist, Leif, Goel, Gautam, Lagace, Caroline, Annese, Vito, Bitton, Alain, Begun, Jakob, Brant, Steve R., Bresso, Francesca, Cho, Judy H., Duerr, Richard H., Halfvarson, Jonas, McGovern, Dermot P. B., Radford-Smith, Graham, Schreiber, Stefan, Schumm, Philip L., Sharma, Yashoda, Silverberg, Mark S., Weersma, Rinse K., D'Amato, Mauro, Vermeire, Severine ... Rioux, John D. (2013). Deep resequencing of GWAS loci identifies rare variants in CARD9, IL23R and RNF186 that are associated with ulcerative colitis. PLoS Genetics, 9 (9) e1003723, e1003723.1-e1003723.11. doi: 10.1371/journal.pgen.1003723 |
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2012 Journal Article The LRR and RING domain protein LRSAM1 is an E3 ligase crucial for ubiquitin-dependent autophagy of intracellular salmonella typhimuriumHuett, Alan, Heath, Robert J., Begun, Jakob, Sassi, Slim O., Baxt, Leigh A., Vyas, Jatin M., Goldberg, Marcia B. and Xavier, Ramnik J. (2012). The LRR and RING domain protein LRSAM1 is an E3 ligase crucial for ubiquitin-dependent autophagy of intracellular salmonella typhimurium. Cell Host and Microbe, 12 (6), 778-790. doi: 10.1016/j.chom.2012.10.019 |
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2012 Journal Article ATG16L1 T300A dependent differential gene expression identifies genes required for anti-bacterial autophagy : P-227 YIBegun, Jakob, Ng, Aylwin and Xavier, Ramnik (2012). ATG16L1 T300A dependent differential gene expression identifies genes required for anti-bacterial autophagy : P-227 YI. Inflammatory Bowel Diseases, 18, S103. doi: 10.1097/00054725-201212001-00260 |
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2008 Journal Article DAF-16-dependent suppression of immunity during reproduction in Caenorhabditis elegansMiyata, Sachiko, Begun, Jakob, Troemel, Emily R. and Ausubel, Frederick M. (2008). DAF-16-dependent suppression of immunity during reproduction in Caenorhabditis elegans. Genetics, 178 (2), 903-918. doi: 10.1534/genetics.107.083923 |
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2007 Journal Article Staphylococcal biofilm exopolysaccharide protects against Caenorhabditis elegans immune defensesBegun, Jakob, Gaiani, Jessica M., Rohde, Holger, Mack, Dietrich, Calderwood, Stephen B., Ausubel, Frederick M. and Sifri, Costi D. (2007). Staphylococcal biofilm exopolysaccharide protects against Caenorhabditis elegans immune defenses. PLoS Pathogens, 3 (4), 526-540. doi: 10.1371/journal.ppat.0030057 |
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2005 Journal Article Staphylococcus aureus virulence factors identified by using a high-throughput Caenorhabditis elegans-killing modelBegun, Jakob, Sifri, Costi D., Goldman, Samuel, Calderwood, Stephen B. and Ausubel, Frederick M. (2005). Staphylococcus aureus virulence factors identified by using a high-throughput Caenorhabditis elegans-killing model. Infection and Immunity, 73 (2), 872-877. doi: 10.1128/IAI.73.2.872-877.2005 |
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2005 Journal Article The worm has turned - Microbial virulence modeled in Caenorhabditis elegansSifri, CD, Begun, J and Ausubel, FM (2005). The worm has turned - Microbial virulence modeled in Caenorhabditis elegans. Trends in Microbiology, 13 (3), 119-127. doi: 10.1016/j.tim.2005.01.003 |
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2004 Journal Article Bacterial Resistance of daf-2 Mutants [2] (multiple letters)Bolm, Maike, Chhatwal, Gursharan S., Jansen, Wouter T. M., Ausubel, Frederick M., Begun, Jakob, Kim, Dennis H., Moy, Terence, Ruvkun, Gary, Calderwood, Stephen B., Sifri, Costi D. and Garsin, Danielle A. (2004). Bacterial Resistance of daf-2 Mutants [2] (multiple letters). Science, 303 (5666) |
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2003 Journal Article Long-lived C. elegans daf-2 Mutants are resistant to bacterial pathogensGarsin, DA, Villanueva, JM, Begun, J, Kim, DH, Sifri, CD, Calderwood, SB, Ruvkun, G and Ausubel, FM (2003). Long-lived C. elegans daf-2 Mutants are resistant to bacterial pathogens. Science, 300 (5627), 1921-1921. doi: 10.1126/science.1080147 |
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2003 Journal Article Caenorhabditis elegans as a model host for Staphylococcus aureus pathogenesisSifri, Costi D., Begun, Jakob, Ausubel, Frederick M. and Calderwood, Stephen B. (2003). Caenorhabditis elegans as a model host for Staphylococcus aureus pathogenesis. Infection and Immunity, 71 (4), 2208-2217. doi: 10.1128/IAI.71.4.2208-2217.2003 |
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2001 Journal Article Crystal structure of an Xrcc4-DNA ligase IV complexSibanda, Bancinyane L., Critchlow, Susan E., Begun, Jake, Pei, Xue Y., Jackson, Stephen P., Blundell, Tom L. and Pellegrini, Luca (2001). Crystal structure of an Xrcc4-DNA ligase IV complex. Nature Structural Biology, 8 (12), 1015-1019. doi: 10.1038/nsb725 |
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2001 Journal Article Getting the adrenaline going: Crystal structure of the adrenaline-synthesizing enzyme PNMTMartin, J. L., Begun, J., McLeish, M. J., Caine, J. M. and Grunewald, G. L. (2001). Getting the adrenaline going: Crystal structure of the adrenaline-synthesizing enzyme PNMT. Structure, 9 (10), 977-985. doi: 10.1016/S0969-2126(01)00662-1 |
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1999 Journal Article Molecular recognition of macrocyclic peptidomimetic inhibitors by HIV-1 proteaseMartin, J. L., Begun, J., Schindeler, A., Wickramasinghe, W. A., Alewood, D., Alewood, P. F., Bergman, D. A., Brinkworth, R. I., Abbenante, G., March, D. R., Reid, R. C., Fairlie, D. P. and Armstrong, Richard A. (1999). Molecular recognition of macrocyclic peptidomimetic inhibitors by HIV-1 protease. Biochemistry, 38 (25), 7978-7988. doi: 10.1021/bi990174x |
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1996 Journal Article Substrate-based cyclic peptidomimetics of Phe-Ile-Val that inhibit HIV-1 protease using a novel enzyme-binding modeMarch, D. R., Abbenante, G., Bergman, D. A., Brinkworth, R. I., Wickramasinghe, W., Begun, J., Martin, J. L. and Fairlie, D. P. (1996). Substrate-based cyclic peptidomimetics of Phe-Ile-Val that inhibit HIV-1 protease using a novel enzyme-binding mode. Journal of The American Chemical Society, 118 (14), 3375-3379. doi: 10.1021/ja953790z |
