Dr Andrew Dalley
Dr

Andrew Dalley

Email: 
Phone: 
+61 7 334 66048

Background

Dr Andrew Dalley is a Postdoctoral Research Scientist within Dr Peter Simpson’s stream of the Molecular Pathology Research Programme at UQCCR. He is currently contributing to a clinician-lead research project that aims to validate diagnostic techniques for mediastinal lymph node dissemination of lung cancer.

Andrew is a practical molecular cell biologist with a strong focus towards clinically translatable research within the hospital setting. His academic experience spans adult and children’s burns research and adult cancer research. He has researched aberrant pharmacokinetics in burnt patients, post-burn hypertrophic scar development, cancer stem cell involvement in Head and Neck cancer development, and diagnostic techniques to define surgical borders for intra-oral cancer excision.

Andrew’s range of practical techniques includes: small molecule tissue sampling and analysis using microdialysis, HPLC and LC/MS; tissue imaging by fluorescence and confocal microscopy; cellular analysis by flow cytometry, live cell imaging, histology and real-time PCR; and patient sample molecular analysis by microarray and Next Generation Sequencing.

Andrew was recently Scientific Support Coordinator for the Cancer Programme at the Diamantina Institute, and prior to this he was Laboratory Studies Coordinator for Professor Camile Farah’s Oral Cancer Research Programme at UQCCR where he investigated the potential involvement of epithelial stem cells in pre-malignant oral dysplasia. Before this Andrew was part of the Burns Trauma & Critical Care Research Centre (BTCCRC) where he evaluated antibiotic distribution in extensively burned patients during surgery.

Formerly based in the UK, Andrew studied BSc Pharmacology and completed his PhD at The University of Sheffield under supervision from Professor Sheila MacNeil. Andrew’s PhD used 3-dimensional cultures to investigate regulation of normal and scar derived fibroblasts by dermal matrix and epithelial cells. Subsequently, he used in-vitro techniques to monitor the uptake of drugs across the gut mucosa and skin.

Andrew’s research interests include clinical diagnostic techniques, phenotypic and genotypic changes in pre-malignant dysplasia, extracellular matrix biology and its involvement in the pathophysiology of burn wound healing, epithelial / mesenchymal interaction across the basement membrane during the healing of cutaneous wounds, and drug distribution in critical patients.

Availability

Dr Andrew Dalley is:
Not available for supervision

Fields of research

Clinical sciences Pharmacology and pharmaceutical sciences

Qualifications

  • Bachelor of Science, University of Sheffield
  • Doctor of Philosophy, University of Sheffield

Research interests

  • Perioperative distribution of antibiotics in extensively burnt patients.

    We monitor the pharmacokinetic distribution of antibiotics in patients with extensive burns during debridement surgery and grafting. Subcutaneous microdialysis in burnt and non-burnt regions together with blood, urine and skin tissue sampling are the main methods used. Analysis is by HPLC and LCMS. Pharmacokinetic principles are applied to the data which is then interpreted with reference to the pharmacodynamics of the antimicrobial agents studied. The results have direct relevance to current clinical practice.

Search Professor Andrew Dalley’s works on UQ eSpace

53 works between 1996 and 2024
All (53) Journal Article (42) Book Chapter (1) Conference Publication (10)

1 - 20 of 53 works

2024

Journal Article

Performance of somatic structural variant calling in lung cancer using Oxford Nanopore sequencing technology

Liu, Lingchen, Zhang, Jia, Wood, Scott, Newell, Felicity, Leonard, Conrad, Koufariotis, Lambros T., Nones, Katia, Dalley, Andrew J., Chittoory, Haarika, Bashirzadeh, Farzad, Son, Jung Hwa, Steinfort, Daniel, Williamson, Jonathan P., Bint, Michael, Pahoff, Carl, Nguyen, Phan T., Twaddell, Scott, Arnold, David, Grainge, Christopher, Simpson, Peter T., Fielding, David, Waddell, Nicola and Pearson, John V. (2024). Performance of somatic structural variant calling in lung cancer using Oxford Nanopore sequencing technology. BMC genomics, 25 (1) 898. doi: 10.1186/s12864-024-10792-3

Performance of somatic structural variant calling in lung cancer using Oxford Nanopore sequencing technology

2024

Journal Article

Evaluation of Endobronchial Ultrasound-Guided Transbronchial Needle Aspiration (EBUS-TBNA) samples from advanced non-small cell lung cancer for whole genome, whole exome and comprehensive panel sequencing

Fielding, David, Lakis, Vanessa, Dalley, Andrew J., Chittoory, Haarika, Newell, Felicity, Koufariotis, Lambros T., Patch, Ann-Marie, Kazakoff, Stephen, Bashirzadeh, Farzad, Son, Jung Hwa, Ryan, Kimberley, Steinfort, Daniel, Williamson, Jonathan P., Bint, Michael, Pahoff, Carl, Nguyen, Phan Tien, Twaddell, Scott, Arnold, David, Grainge, Christopher, Pattison, Andrew, Fairbairn, David, Gune, Shailendra, Christie, Jemma, Holmes, Oliver, Leonard, Conrad, Wood, Scott, Pearson, John V., Lakhani, Sunil R., Waddell, Nicola ... Nones, Katia (2024). Evaluation of Endobronchial Ultrasound-Guided Transbronchial Needle Aspiration (EBUS-TBNA) samples from advanced non-small cell lung cancer for whole genome, whole exome and comprehensive panel sequencing. Cancers, 16 (4) 785. doi: 10.3390/cancers16040785

Evaluation of Endobronchial Ultrasound-Guided Transbronchial Needle Aspiration (EBUS-TBNA) samples from advanced non-small cell lung cancer for whole genome, whole exome and comprehensive panel sequencing

2023

Journal Article

Discrepancies in tumor mutation burden reporting from sequential endobronchial ultrasound transbronchial needle aspiration samples within single lymph node stations - brief report

Fielding, David, Dalley, Andrew J., Singh, Mahendra, Nandakumar, Lakshmy, Lakis, Vanessa, Chittoory, Haarika, Fairbairn, David, Patch, Ann-Marie, Kazakoff, Stephen H., Ferguson, Kaltin, Bashirzadeh, Farzad, Bint, Michael, Pahoff, Carl, Son, Jung Hwa, Ryan, Kimberley, Hodgson, Alan, Sharma, Sowmya, Pearson, John V., Waddell, Nicola, Lakhani, Sunil R., Hartel, Gunter, Simpson, Peter T. and Nones, Katia (2023). Discrepancies in tumor mutation burden reporting from sequential endobronchial ultrasound transbronchial needle aspiration samples within single lymph node stations - brief report. Frontiers in Oncology, 13 1259882, 1-10. doi: 10.3389/fonc.2023.1259882

Discrepancies in tumor mutation burden reporting from sequential endobronchial ultrasound transbronchial needle aspiration samples within single lymph node stations - brief report

2023

Journal Article

Whole genome sequencing in advanced lung cancer can be performed using diff-quik cytology smears derived from endobronchial ultrasound, transbronchial needle aspiration (EBUS TBNA)

Fielding, David, Dalley, Andrew J., Singh, Mahendra, Nandakumar, Lakshmy, Lakis, Vanessa, Chittoory, Haarika, Fairbairn, David, Ferguson, Kaltin, Bashirzadeh, Farzad, Bint, Michael, Pahoff, Carl, Son, Jung Hwa, Hodgson, Alan, Pearson, John V., Waddell, Nicola, Lakhani, Sunil R., Hartel, Gunter, Nones, Katia and Simpson, Peter T. (2023). Whole genome sequencing in advanced lung cancer can be performed using diff-quik cytology smears derived from endobronchial ultrasound, transbronchial needle aspiration (EBUS TBNA). Lung, 201 (4), 407-413. doi: 10.1007/s00408-023-00631-9

Whole genome sequencing in advanced lung cancer can be performed using diff-quik cytology smears derived from endobronchial ultrasound, transbronchial needle aspiration (EBUS TBNA)

2023

Journal Article

Evaluating Diff‐Quik cytology smears for large‐panel mutation testing in lung cancer—Predicting DNA content and success with low‐malignant‐cellularity samples

Fielding, David I., Dalley, Andrew J., Singh, Mahendra, Nandakumar, Lakshmy, Lakis, Vanessa, Chittoory, Haarika, Fairbairn, David, Patch, Ann‐Marie, Kazakoff, Stephen H., Ferguson, Kaltin, Bashirzadeh, Farzad, Bint, Michael, Pahoff, Carl, Son, Jung Hwa, Hodgson, Alan, Sharma, Sowmya, Waddell, Nicola, Lakhani, Sunil R., Hartel, Gunter, Nones, Katia and Simpson, Peter T. (2023). Evaluating Diff‐Quik cytology smears for large‐panel mutation testing in lung cancer—Predicting DNA content and success with low‐malignant‐cellularity samples. Cancer Cytopathology, 131 (6), 373-382. doi: 10.1002/cncy.22690

Evaluating Diff‐Quik cytology smears for large‐panel mutation testing in lung cancer—Predicting DNA content and success with low‐malignant‐cellularity samples

2023

Conference Publication

Diff-Quik smears from EBUS TBNA procedures: Evaluating measures of tumour cellularity and feasibility of whole genome sequencing (WGS)

Fielding, David, Dalley, Andrew, Singh, Mahendra, Nandakumar, Lakshmy, Lakis, Vanessa, Chittoory, Haarika, Bashirzadeh, Farzad, Bint, Michael, Pahoff, Carl, Son, Jung, Hodgson, Alan, Sharma, Sowmya, Godbolt, David, Coleman, Kylie, Whitfield, Lenore, Waddell, Nicola, Lakhani, Sunil, Nones, Katia, Hartel, Gunter and Simpson, Peter (2023). Diff-Quik smears from EBUS TBNA procedures: Evaluating measures of tumour cellularity and feasibility of whole genome sequencing (WGS). 26th Congress of the Asian Pacific Society of Respirology Above and Beyond, Seoul, Korea, 17-20 November 2022. Richmond, VIC, Australia: John Wiley & Sons. doi: 10.1111/resp.14433

Diff-Quik smears from EBUS TBNA procedures: Evaluating measures of tumour cellularity and feasibility of whole genome sequencing (WGS)

2022

Journal Article

Convergence of biofabrication technologies and cell therapies for wound healing

Hosseini, Motaharesadat, Dalley, Andrew J. and Shafiee, Abbas (2022). Convergence of biofabrication technologies and cell therapies for wound healing. Pharmaceutics, 14 (12) 2749, 2749. doi: 10.3390/pharmaceutics14122749

Convergence of biofabrication technologies and cell therapies for wound healing

2022

Journal Article

Prospective optimization of endobronchial ultrasound-guided transbronchial needle aspiration lymph node assessment for lung cancer: Three needle agitations are noninferior to 10 agitations for adequate tumor cell and DNA yield

Fielding, David, Dalley, Andrew J., Singh, Mahendra, Nandakumar, Lakshmy, Nones, Katia, Lakis, Vanessa, Chittoory, Haarika, Ferguson, Kaltin, Bashirzadeh, Farzad, Bint, Michael, Pahoff, Carl, Son, Jung Hwa, Hodgson, Alan, Sharma, Sowmya, Godbolt, David, Coleman, Kylie, Whitfield, Lenore, Waddell, Nicola, Lakhani, Sunil R., Hartel, Gunter and Simpson, Peter T. (2022). Prospective optimization of endobronchial ultrasound-guided transbronchial needle aspiration lymph node assessment for lung cancer: Three needle agitations are noninferior to 10 agitations for adequate tumor cell and DNA yield. JTO Clinical and Research Reports, 3 (10) 100403, 100403. doi: 10.1016/j.jtocrr.2022.100403

Prospective optimization of endobronchial ultrasound-guided transbronchial needle aspiration lymph node assessment for lung cancer: Three needle agitations are noninferior to 10 agitations for adequate tumor cell and DNA yield

2022

Journal Article

Comparison of actionable events detected in cancer genomes by whole-genome sequencing, in silico whole-exome and mutation panels

Ramarao-Milne, P, Kondrashova, O, Patch, A-M, Nones, K, Koufariotis, L T, Newell, F, Addala, V, Lakis, V, Holmes, O, Leonard, C, Wood, S, Xu, Q, Mukhopadhyay, P, Naeini, M M, Steinfort, D, Williamson, J P, Bint, M, Pahoff, C, Nguyen, P T, Twaddell, S, Arnold, D, Grainge, C, Basirzadeh, F, Fielding, D, Dalley, A J, Chittoory, H, Simpson, P T, Aoude, L G, Bonazzi, V F ... Waddell, N (2022). Comparison of actionable events detected in cancer genomes by whole-genome sequencing, in silico whole-exome and mutation panels. ESMO Open, 7 (4) 100540, 1-11. doi: 10.1016/j.esmoop.2022.100540

Comparison of actionable events detected in cancer genomes by whole-genome sequencing, in silico whole-exome and mutation panels

2022

Journal Article

Epigenome erosion and SOX10 drive neural crest phenotypic mimicry in triple-negative breast cancer

Saunus, Jodi M., De Luca, Xavier M., Northwood, Korinne, Raghavendra, Ashwini, Hasson, Alexander, McCart Reed, Amy E., Lim, Malcolm, Lal, Samir, Vargas, A. Cristina, Kutasovic, Jamie R., Dalley, Andrew J., Miranda, Mariska, Kalaw, Emarene, Kalita-de Croft, Priyakshi, Gresshoff, Irma, Al-Ejeh, Fares, Gee, Julia M. W., Ormandy, Chris, Khanna, Kum Kum, Beesley, Jonathan, Chenevix-Trench, Georgia, Green, Andrew R., Rakha, Emad A., Ellis, Ian O., Nicolau, Dan V., Simpson, Peter T. and Lakhani, Sunil R. (2022). Epigenome erosion and SOX10 drive neural crest phenotypic mimicry in triple-negative breast cancer. npj Breast Cancer, 8 (1) 57, 1-16. doi: 10.1038/s41523-022-00425-x

Epigenome erosion and SOX10 drive neural crest phenotypic mimicry in triple-negative breast cancer

2019

Journal Article

Exome sequencing of oral leukoplakia and oral squamous cell carcinoma implicates DNA damage repair gene defects in malignant transformation

Farah, Camile S., Jessri, Maryam, Bennett, Nigel C., Dalley, Andrew J., Shearston, Kate D. and Fox, Simon A. (2019). Exome sequencing of oral leukoplakia and oral squamous cell carcinoma implicates DNA damage repair gene defects in malignant transformation. Oral Oncology, 96, 42-50. doi: 10.1016/j.oraloncology.2019.07.005

Exome sequencing of oral leukoplakia and oral squamous cell carcinoma implicates DNA damage repair gene defects in malignant transformation

2019

Journal Article

LobSig is a multigene predictor of outcome in invasive lobular carcinoma

McCart Reed, Amy E., Lal, Samir, Kutasovic, Jamie R., Wockner, Leesa, Robertson, Alan, de Luca, Xavier M., Kalita-de Croft, Priyakshi, Dalley, Andrew J., Coorey, Craig P., Kuo, Luyu, Ferguson, Kaltin, Niland, Colleen, Miller, Gregory, Johnson, Julie, Reid, Lynne E., Males, Renique, Saunus, Jodi M., Chenevix-Trench, Georgia, Coin, Lachlan, Lakhani, Sunil R. and Simpson, Peter T. (2019). LobSig is a multigene predictor of outcome in invasive lobular carcinoma. npj Breast Cancer, 5 (1) 18, 18. doi: 10.1038/s41523-019-0113-y

LobSig is a multigene predictor of outcome in invasive lobular carcinoma

2019

Journal Article

Secreted cellular prion protein binds doxorubicin and correlates with anthracycline resistance in breast cancer

Wiegmans, Adrian P., Saunus, Jodi M., Ham, Sunyoung, Lobb, Richard J., Kutasovic, Jamie R., Dalley, Andrew J., Miranda, Mariska, Atkinson, Caroline, Foliaki, Simote T., Ferguson, Kaltin, Niland, Colleen, Johnstone, Cameron N., Lewis, Victoria, Collins, Steven, Lakhani, Sunil R., Al-Ejeh, Fares and Möller, Andreas (2019). Secreted cellular prion protein binds doxorubicin and correlates with anthracycline resistance in breast cancer. JCI Insight, 5 (6) e124092. doi: 10.1172/jci.insight.124092

Secreted cellular prion protein binds doxorubicin and correlates with anthracycline resistance in breast cancer

2019

Journal Article

Diff-Quik cytology smears from endobronchial ultrasound transbronchial needle aspiration lymph node specimens as a source of DNA for next-generation sequencing instead of cell blocks

Fielding, David, Dalley, Andrew J., Bashirzadeh, Farzad, Singh, Mahendra, Nandakumar, Lakshmy, McCart Reed, Amy E., Black, Debra, Kazakoff, Stephen, Pearson, John V., Nones, Katia, Waddell, Nicola, Lakhani, Sunil R. and Simpson, Peter T. (2019). Diff-Quik cytology smears from endobronchial ultrasound transbronchial needle aspiration lymph node specimens as a source of DNA for next-generation sequencing instead of cell blocks. Respiration, 97 (6), 1-14. doi: 10.1159/000495661

Diff-Quik cytology smears from endobronchial ultrasound transbronchial needle aspiration lymph node specimens as a source of DNA for next-generation sequencing instead of cell blocks

2019

Conference Publication

LobSig, a prognostic signature for Invasive Lobular Carcinoma

McCart Reed, Amy E., Lal, Samir, Kutasovic, Jamie R., Wockner, Leesa, Robertson, Alan, de Croft, Priyakshi Kalıta, Dalley, Andrew, Coorey, Craig P., Kuo, Luyu, Ferguson, Kaltin, Niland, Colleen, Miller, Gregory, Johnson, Julie, Reid, Lynne E., Males, Renique, Saunus, Jodi M., Chenevix-Trench, Georgia, Coin, Lachlan, Lakhani, Sunil R. and Simpson, Peter T. (2019). LobSig, a prognostic signature for Invasive Lobular Carcinoma. 7th International PacRim Breast and Prostate Cancer Meeting, Barossa Novotel, South Australia, Australia, 17-20 March 2019.

LobSig, a prognostic signature for Invasive Lobular Carcinoma

2019

Journal Article

Breast cancer metastasis to gynaecological organs: a clinico‐pathological and molecular profiling study

Kutasovic, Jamie R., McCart Reed, Amy E., Males, Renique, Sim, Sarah, Saunus, Jodi M., Dalley, Andrew, McEvoy, Christopher R., Dedina, Liana, Miller, Gregory, Peyton, Stephen, Reid, Lynne, Lal, Samir, Niland, Colleen, Ferguson, Kaltin, Fellowes, Andrew P., Al-Ejeh, Fares, Lakhani, Sunil R., Cummings, Margaret C. and Simpson, Peter T. (2019). Breast cancer metastasis to gynaecological organs: a clinico‐pathological and molecular profiling study. The Journal of Pathology: Clinical Research, 5 (1), 25-39. doi: 10.1002/cjp2.118

Breast cancer metastasis to gynaecological organs: a clinico‐pathological and molecular profiling study

2019

Conference Publication

Abstract P1-19-05: establishment of a human neural progenitor cell microenvironment model to investigate signalling events in triple negative breast cancer brain metastases in a high-throughput setting

Chalmers, S.B., Dalley, A.J., Kalita-de Croft, P., Saunus, J., Bassett, J.J., Sadras, F., Roberts-Thomson, S.J. and Monteith, G.R. (2019). Abstract P1-19-05: establishment of a human neural progenitor cell microenvironment model to investigate signalling events in triple negative breast cancer brain metastases in a high-throughput setting. 2018 San Antonio Breast Cancer Symposium, San Antonio, TX, United States, 4-8 December 2018. Philadelphia, PA, United States: American Association for Cancer Research (AACR). doi: 10.1158/1538-7445.sabcs18-p1-19-05

Abstract P1-19-05: establishment of a human neural progenitor cell microenvironment model to investigate signalling events in triple negative breast cancer brain metastases in a high-throughput setting

2018

Journal Article

Transcriptome changes induced in vitro by alcohol-containing mouthwashes in normal and dysplastic oral keratinocytes

Fox, Simon A., Currie, Sean S., Dalley, Andrew J. and Farah, Camile S. (2018). Transcriptome changes induced in vitro by alcohol-containing mouthwashes in normal and dysplastic oral keratinocytes. Journal of Oral Pathology and Medicine , 47 (5), 511-518. doi: 10.1111/jop.12704

Transcriptome changes induced in vitro by alcohol-containing mouthwashes in normal and dysplastic oral keratinocytes

2018

Journal Article

Integrated miRNA-mRNA spatial signature for oral squamous cell carcinoma: a prospective profiling study of Narrow Band Imaging guided resection

Farah, Camile S., Fox, Simon A. and Dalley, Andrew J. (2018). Integrated miRNA-mRNA spatial signature for oral squamous cell carcinoma: a prospective profiling study of Narrow Band Imaging guided resection. Scientific Reports, 8 (1) 823, 1-13. doi: 10.1038/s41598-018-19341-x

Integrated miRNA-mRNA spatial signature for oral squamous cell carcinoma: a prospective profiling study of Narrow Band Imaging guided resection

2017

Journal Article

Multidimensional phenotyping of breast cancer cell lines to guide preclinical research

Saunus, Jodi M., Smart, Chanel E., Kutasovic, Jamie R., Johnston, Rebecca L., Kalita-de Croft, Priyakshi, Miranda, Mariska, Rozali, Esdy N., Vargas, Ana Cristina, Reid, Lynne E., Lorsy, Eva, Cocciardi, Sibylle, Seidens, Tatjana, McCart Reed, Amy E., Dalley, Andrew J., Wockner, Leesa F., Johnson, Julie, Sarkar, Debina, Askarian-Amiri, Marjan E., Simpson, Peter T., Khanna, Kum Kum, Chenevix-Trench, Georgia, Al-Ejeh, Fares and Lakhani, Sunil R. (2017). Multidimensional phenotyping of breast cancer cell lines to guide preclinical research. Breast Cancer Research and Treatment, 167 (1), 1-13. doi: 10.1007/s10549-017-4496-x

Multidimensional phenotyping of breast cancer cell lines to guide preclinical research

Past funding

  • 2013
    DNA mismatch repair in oral carcinogenesis
    Australian Dental Research Fund Inc
    Open grant
  • 2012 - 2013
    Oral epithelial stem cell markers as a platform for better diagnosis of mouth cancer
    Cancer Council Queensland
    Open grant
  • 2012
    Tandem fluorescent and phase-contrast imaging of live cells in real time for application to cancer cell biology, developmental biology, respiratory biology, wound healing investigation and cellular to
    UQ Major Equipment and Infrastructure
    Open grant
  • 2011 - 2013
    In vitro analysis of cellular genotoxicity in human oral epithelial cells after treatment with alcoholic mouthwashes. Part 2
    Australian Dental Research Fund Inc
    Open grant
  • 2008
    Imaging of the microcirculation using the Microscan (orthogonal polarization spectral imaging) and providing improved quality of drug analysis for PK studies in critically ill patients
    NHMRC Equipment Grant
    Open grant
  • 2008
    Improved quantification of spatial and temporal changes in plasma and tissue drug levels and tissue pathology
    NHMRC Equipment Grant
    Open grant
  • 2006 - 2007
    Pharmacokinetic Modelling of Various B-lactam Antibiotics in Critically-ill Patients using Microdialysis
    Australian & New Zealand College of Anaesthetists
    Open grant
  • 2005
    NHMRC Equipment Grant : Estimation of drugs, peptides and metabolites using HPLC-Mass-spectrometry-microdialysis
    NHMRC Equipment Grant
    Open grant

Availability

Dr Andrew Dalley is:
Not available for supervision

Supervision history

Completed supervision

Enquiries

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