Overview
Background
I completed my MBBS and PhD at UQ in 2015. The topic of my PhD was "The Anaphylatoxin Receptors in Neural Progenitor Cell Physiology". In this thesis we examined the function of the anaphylatoxin receptors, C3aR and C5aR1, in a novel location - the neural progenitor cells of the developing brain.
I am currently working as a medical officer at the Royal Brisbane and Women's Hospital. I continue to have close links with my previous lab and would be happy to hear from potential students interested in projects in neuroinflammation or developmental neurobiology.
Availability
- Dr Liam Coulthard is:
- Available for supervision
- Media expert
Qualifications
- Bachelor (Honours) of Biochemistry and Molecular Biology, The University of Queensland
- Bachelor (Honours) of Biochemistry, The University of Queensland
- Bachelor of Medicine Surgery, The University of Queensland
- Doctor of Philosophy of Neurobiology, The University of Queensland
Works
Search Professor Liam Coulthard’s works on UQ eSpace
2019
Journal Article
Commentary: Beyond C4: analysis of the complement gene pathway shows enrichment for IQ in patients with psychotic disorders and healthy controls by Holland, J. F., Cosgrove, D., Whitton, L., Harold, D., Corvin, A., Gill, M., et al. (2019). Genes Brain Behav. 18:e12602
Coulthard, Liam G. and Woodruff, Trent M. (2019). Commentary: Beyond C4: analysis of the complement gene pathway shows enrichment for IQ in patients with psychotic disorders and healthy controls by Holland, J. F., Cosgrove, D., Whitton, L., Harold, D., Corvin, A., Gill, M., et al. (2019). Genes Brain Behav. 18:e12602. Frontiers in Immunology, 10 2853, 2853. doi: 10.3389/fimmu.2019.02853
2019
Journal Article
Complement dysregulation in the central nervous system during development and disease
Lee, John D., Coulthard, Liam G. and Woodruff, Trent M. (2019). Complement dysregulation in the central nervous system during development and disease. Seminars in Immunology, 45 101340, 101340. doi: 10.1016/j.smim.2019.101340
2019
Journal Article
Complement peptide receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database
Cianciulli, Antonia, Coulthard, Liam, Hawksworth, Owen, Lee, John D., Mitolo, Vincenzo, Monk, Peter, Panaro, Maria A. and Woodruff, Trent M. (2019). Complement peptide receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database. IUPHAR/BPS Guide to Pharmacology CITE, 2019 (4). doi: 10.2218/gtopdb/f5/2019.4
2018
Journal Article
Complement C3a receptor modulates embryonic neural progenitor cell proliferation and cognitive performance
Coulthard, Liam G., Hawksworth, Owen A., Conroy, Jacinta, Lee, John D. and Woodruff, Trent M. (2018). Complement C3a receptor modulates embryonic neural progenitor cell proliferation and cognitive performance. Molecular Immunology, 101, 176-181. doi: 10.1016/j.molimm.2018.06.271
2018
Journal Article
Complement: the emerging architect of the developing brain
Coulthard, Liam G., Hawksworth, Owen A. and Woodruff, Trent M. (2018). Complement: the emerging architect of the developing brain. Trends in Neurosciences, 41 (6), 373-384. doi: 10.1016/j.tins.2018.03.009
2018
Journal Article
Complement in stem cells and development
Hawksworth, Owen A., Coulthard, Liam G., Mantovani, Susanna and Woodruff, Trent M (2018). Complement in stem cells and development. Seminars in Immunology, 37 (C), 74-84. doi: 10.1016/j.smim.2018.02.009
2018
Book Chapter
C3aR1
Coulthard, Liam G., Hawksworth, Owen A. and Woodruff, Trent M. (2018). C3aR1. The complement FactsBook. (pp. 385-396) edited by Scott Barnum and Theresa Schein. London, United Kingdom: Elsevier. doi: 10.1016/B978-0-12-810420-0.00036-5
2018
Book Chapter
C5aR1
Coulthard, Liam G., Hawksworth, Owen A. and Woodruff, Trent M. (2018). C5aR1. The Complement FactsBook. (pp. 397-405) edited by Scott Barnum and Theresa Schein. London, United Kingdom: Academic Press. doi: 10.1016/B978-0-12-810420-0.00037-7
2018
Book Chapter
C5aR2
Coulthard, Liam G., Hawksworth, Owen A. and Woodruff, Trent M. (2018). C5aR2. The complement FactsBook. (pp. 407-414) edited by Scott Barnum and Theresa Schein. London, United Kingdom: Academic Press. doi: 10.1016/B978-0-12-810420-0.00038-9
2017
Journal Article
New concepts on the therapeutic control of complement anaphylatoxin receptors
Hawksworth, Owen A., Li, Xaria X., Coulthard, Liam G., Wolvetang, Ernst J. and Woodruff, Trent M. (2017). New concepts on the therapeutic control of complement anaphylatoxin receptors. Molecular Immunology, 89, 36-43. doi: 10.1016/j.molimm.2017.05.015
2017
Journal Article
Complement C5aR1 signaling promotes polarization and proliferation of embryonic neural progenitor cells through PKCζ
Coulthard, Liam G., Hawksworth, Owen A., Li, Rui, Balachandran, Anushree, Lee, John D., Sepehrband, Farshid, Kurniawan, Nyoman, Jeanes, Angela, Simmons, David G., Wolvetang, Ernst and Woodruff, Trent M. (2017). Complement C5aR1 signaling promotes polarization and proliferation of embryonic neural progenitor cells through PKCζ. Journal of Neuroscience, 37 (22), 5395-5407. doi: 10.1523/JNEUROSCI.0525-17.2017
2017
Conference Publication
Complement anaphylatoxin receptors have critical physiological functions in the developing mammalian brain
Woodruff, Trent M., Hawksworth, Owen A., Li, Rui, Balachandran, Anushree, Leel, John D., Sepehrband', Farshid, Kurniawan, Nyoman, Jeanes, Angela, Simmons, David G., Wolvetang, Ernst and Coulthard, Liam G. (2017). Complement anaphylatoxin receptors have critical physiological functions in the developing mammalian brain. 16th European Meeting on Complement in Human Disease (EMCHD), Copenhagen Denmark, 8-12 September 2017. Kidlington, Oxford United Kingdom: Pergamon Press. doi: 10.1016/j.molimm.2017.06.178
2016
Journal Article
Complement in the fundamental processes of the cell
Hawksworth, Owen A., Coulthard, Liam G. and Woodruff, Trent M. (2016). Complement in the fundamental processes of the cell. Molecular Immunology, 84, 17-25. doi: 10.1016/j.molimm.2016.11.010
2015
Journal Article
Co-ordinated expression of innate immune molecules during mouse neurulation
Jeanes, Angela, Coulthard, Liam G., Mantovani, Susanna, Markham, Kathryn and Woodruff, Trent M. (2015). Co-ordinated expression of innate immune molecules during mouse neurulation. Molecular Immunology, 68 (2), 253-260. doi: 10.1016/j.molimm.2015.09.004
2015
Journal Article
The role of C5a receptor signaling in endotoxin-induced miscarriage and preterm birth
Denny, Kerina J., Coulthard, Liam G., Mantovani, Susanna, Simmons, David, Taylor, Stephen M. and Woodruff, Trent M. (2015). The role of C5a receptor signaling in endotoxin-induced miscarriage and preterm birth. American Journal of Reproductive Immunology, 74 (2), 148-155. doi: 10.1111/aji.12386
2015
Journal Article
Is the complement activation product C3a a proinflammatory molecule? Re-evaluating the evidence and the myth
Coulthard, Liam G. and Woodruff, Trent M. (2015). Is the complement activation product C3a a proinflammatory molecule? Re-evaluating the evidence and the myth. Journal of Immunology, 194 (8), 3542-3548. doi: 10.4049/jimmunol.1403068
2014
Journal Article
Brief report: Complement C5a promotes human embryonic stem cell pluripotency in the absence of FGF2
Hawksworth, Owen A., Coulthard, Liam G., Taylor, Stephen M., Wolvetang, Ernst J. and Woodruff, Trent M. (2014). Brief report: Complement C5a promotes human embryonic stem cell pluripotency in the absence of FGF2. Stem Cells, 32 (12), 3278-3284. doi: 10.1002/stem.1801
2013
Journal Article
Elevated complement factor C5a in maternal and umbilical cord plasma in preeclampsia
Denny, Kerina J., Coulthard, Liam G., Finnell, Richard H., Callaway, Leonie K., Taylor, Stephen M. and Woodruff, Trent M. (2013). Elevated complement factor C5a in maternal and umbilical cord plasma in preeclampsia. Journal of Reproductive Immunology, 97 (2), 211-216. doi: 10.1016/j.jri.2012.11.006
2013
Journal Article
C5a receptor signaling prevents folate deficiency-induced neural tube defects in mice
Denny, Kerina J., Coulthard, Liam G., Jeanes, Angela, Lisgo, Steven, Simmons, David G., Callaway, Leonie K., Wlodarczyk, Bogdan, Finnell, Richard H., Woodruff, Trent M. and Taylor, Stephen M. (2013). C5a receptor signaling prevents folate deficiency-induced neural tube defects in mice. Journal of Immunology, 190 (7), 3493-3499. doi: 10.4049/jimmunol.1203072
2013
Journal Article
C5L2: a controversial receptor of complement anaphylatoxin, C5a
Li, Rui, Coulthard, Liam G., Wu, M. C. L., Taylor, Stephen M. and Woodruff, Trent M. (2013). C5L2: a controversial receptor of complement anaphylatoxin, C5a. FASEB Journal, 27 (3), 855-864. doi: 10.1096/fj.12-220509
Supervision
Availability
- Dr Liam Coulthard is:
- Available for supervision
Before you email them, read our advice on how to contact a supervisor.
Supervision history
Current supervision
-
Doctor Philosophy
Complement in subarachnoid haemorrhage
Principal Advisor
Other advisors: Professor Trent Woodruff, Dr John Lee
Media
Enquiries
Contact Dr Liam Coulthard directly for media enquiries about:
- Anaphylatoxin
- Complement
- Development
- Neural stem cell
- Neurogenesis
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