Overview
Background
- My academic qualifications include a PhD in Neurosciences, an MSc in Biochemistry and Molecular Biology, and a Bachelor of Medicine.
- I have initiated and managed multiple projects to develop novel therapeutics for neurological disorders, including: 1) Developing a nanoparticle-based siRNA delivery system for the treatment of Huntington’s disease (ARC project; as Postdoctoral Research Fellow). 2) Examining the treatment effects of intravenous immunoglobulin (IVIg) on epilepsy (Advance Queensland Women’s Academic Fund; as Sole Investigator). 2) Examining the effectiveness of three neuroinflammation modulatory agents on traumatic brain injury and epilepsy through randomised controlled preclinical trials (Seed projects sponsored by industry partners: VivaZome Therapeutics, Implicit Bioscience, and Innate Immunotherapeutics; as Co-investigator). 3) Developing treatment strategies to prevent the development of epilepsy after severe traumatic brain injury and identifying medical imaging biomarkers to evaluate the risk of epilepsy post-injury (two U.S. Department of Defense, Congressionally Directed Medical Research Programs; as Co-investigator). 4) Developing exosomal therapy for traumatic brain injury (Cooperative Research Centres Projects (CRC-P) Grant with two research groups from academic institutions and three pharmaceutical companies; as Principal Investigator).
Availability
- Dr Min Chen is:
- Available for supervision
Fields of research
Qualifications
- Postgraduate Diploma, University of the Chinese Academy of Science
- Doctor of Philosophy, University of the Chinese Academy of Science
Research interests
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Preventing the development of post-traumatic epilepsy
Developing treatment strategies to prevent the development of epilepsy after severe traumatic brain injury and identifying medical imaging biomarkers to evaluate the risk of epilepsy post-injury
Research impacts
My major achievements from my career in research include: • Securing over AUD 2.5 million in research grants from government and industry funding bodies as a Chief Investigator. • Publishing 26 high-impact papers (Citations: 1,479, H-index: 18, i10-index: 22). • Winning first prize in the International Seizure Prediction contest, sponsored by the National Institutes of Health (NIH) and the American Epilepsy Society.
Works
Search Professor Min Chen’s works on UQ eSpace
2023
Journal Article
Complement Component 5 (C5) Deficiency Improves Cognitive Outcome After Traumatic Brain Injury and Enhances Treatment Effects of Complement Inhibitors C1-Inh and CR2-Crry in a Mouse Model
Chen, Min, Edwards, Stephen R., Maskey, Dhiraj, Woodruff, Trent M., Tomlinson, Stephen and Reutens, David (2023). Complement Component 5 (C5) Deficiency Improves Cognitive Outcome After Traumatic Brain Injury and Enhances Treatment Effects of Complement Inhibitors C1-Inh and CR2-Crry in a Mouse Model. Neurotrauma Reports, 4 (1), 663-681. doi: 10.1089/neur.2023.0024
2023
Journal Article
Effects of C1-INH treatment on neurobehavioral sequelae and late seizures after traumatic brain injury in a mouse model of controlled cortical impact
Chen, Min, Tieng, Quang M., Du, Jiaxin, Edwards, Stephen R., Maskey, Dhiraj, Peshtenski, Emil and Reutens, David (2023). Effects of C1-INH treatment on neurobehavioral sequelae and late seizures after traumatic brain injury in a mouse model of controlled cortical impact. Neurotrauma Reports, 4 (1), 124-136. doi: 10.1089/neur.2022.0011
2020
Journal Article
Genome-wide microRNA profiling in brain and blood samples in a mouse model of epileptogenesis
Chen, Min, Zhao, Qiong-Yi, Edson, Janette, Zhang, Zong Hong, Li, Xiang, Wei, Wei, Bredy, Timothy and Reutens, David C. (2020). Genome-wide microRNA profiling in brain and blood samples in a mouse model of epileptogenesis. Epilepsy Research, 166 106400, 106400. doi: 10.1016/j.eplepsyres.2020.106400
2020
Journal Article
Complement in the Development of Post-Traumatic Epilepsy: Prospects for Drug Repurposing
Chen, Min, Edwards, Stephen R. and Reutens, David C. (2020). Complement in the Development of Post-Traumatic Epilepsy: Prospects for Drug Repurposing. Journal of Neurotrauma, 37 (5), 692-705. doi: 10.1089/neu.2019.6942
2018
Journal Article
Utility of gradient recalled echo magnetic resonance imaging for the study of myelination in cuprizone mice treated with fingolimod
Ziser, Laura, Meyer-Schell, Naja, Kurniawan, Nyoman D, Sullivan, Robert, Reutens, David, Chen, Min and Vegh, Viktor (2018). Utility of gradient recalled echo magnetic resonance imaging for the study of myelination in cuprizone mice treated with fingolimod. NMR in Biomedicine, 31 (3) e3877, e3877. doi: 10.1002/nbm.3877
2017
Journal Article
Mouse epileptic seizure detection with multiple EEG features and simple thresholding technique
Tieng, Quang M., Anbazhagan, Ashwin, Chen, Min and Reutens, David C. (2017). Mouse epileptic seizure detection with multiple EEG features and simple thresholding technique. Journal of Neural Engineering, 14 (6) 066006, 1-15. doi: 10.1088/1741-2552/aa8069
2017
Journal Article
Disease-modifying effect of intravenous immunoglobulin in an experimental model of epilepsy
Chen, Min, Arumugam, Thiruma V., Leanage, Gayeshika, Tieng, Quang M., Yadav, Ashwin, Ullmann, Jeremy F. P., She, David T., Truong, Vy, Ruitenberg, Marc J. and Reutens, David C. (2017). Disease-modifying effect of intravenous immunoglobulin in an experimental model of epilepsy. Scientific Reports, 7 (1) 40528, 40528. doi: 10.1038/srep40528
2016
Journal Article
Crowdsourcing reproducible seizure forecasting in human and canine epilepsy
Brinkmann, Benjamin H, Wagenaar, Joost, Abbot, Drew, Adkins, Phillip, Bosshard, Simone, Chen, Min, Tieng, Quang M., He, Jialune, Mun˜oz-Almaraz, F. J., Botella-Rocamora, Paloma, Pardo, Juan, Zamora-Martinez, Francisco, Hills, Michael, Wu, Wei, Korshunova, Iryna, Cukierski, Will, Vite, Charles, Patterson, Edward E., Litt, Brian and Worrell, Gregory A. (2016). Crowdsourcing reproducible seizure forecasting in human and canine epilepsy. Brain, 139 (Pt 6), 1713-22. doi: 10.1093/brain/aww045
2016
Journal Article
Mouse EEG spike detection based on the adapted continuous wavelet transform
Tieng, Quang M., Kharatishvili, Irina, Chen, Min and Reutens, David C. (2016). Mouse EEG spike detection based on the adapted continuous wavelet transform. Journal of Neural Engineering, 13 (2) 026018, 026018. doi: 10.1088/1741-2560/13/2/026018
2014
Journal Article
The Netrin/RGM receptor, neogenin, controls adult neurogenesis by promoting neuroblast migration and cell cycle exit
O'Leary, Conor J., Bradford, DanaKai, Chen, Min, White, Amanda, Blackmore, Daniel G. and Cooper, Helen M. (2014). The Netrin/RGM receptor, neogenin, controls adult neurogenesis by promoting neuroblast migration and cell cycle exit. Stem Cells, 33 (2), 503-514. doi: 10.1002/stem.1861
2014
Journal Article
Engineering small MgAl-layered double hydroxide nanoparticles for enhanced gene delivery
Dong, Haiyan, Chen, Min, Rahman, Shafiur, Parekh, Harendra S., Cooper, Helen M. and Xu, Zhi Ping (2014). Engineering small MgAl-layered double hydroxide nanoparticles for enhanced gene delivery. Applied Clay Science, 100 (C), 66-75. doi: 10.1016/j.clay.2014.04.028
2013
Journal Article
One-pot preparation of highly fluorescent cadmium telluride/cadmium sulfide quantum dots under neutral-pH condition for biological applications
Zhu, Yian, Li, Zhen, Chen, Min, Cooper, Helen, Lu, Gao Qing (Max) and Xu, Zhi Ping (2013). One-pot preparation of highly fluorescent cadmium telluride/cadmium sulfide quantum dots under neutral-pH condition for biological applications. Journal of Colloid and Interface Science, 390 (1), 3-10. doi: 10.1016/j.jcis.2012.08.003
2013
Journal Article
Reduction in the size of layered double hydroxide nanoparticles enhances the efficiency of siRNA delivery
Chen, Min, Helen Cooper, Zhou, Ji Zhi, Bartlett, Perry F. and Xu, Zhi Ping (2013). Reduction in the size of layered double hydroxide nanoparticles enhances the efficiency of siRNA delivery. Journal of Colloid and Interface Science, 390 (1), 275-281. doi: 10.1016/j.jcis.2012.09.033
2013
Journal Article
Tuning core-shell SiO2@CdTe@SiO2 fluorescent nanoparticles for cell labeling
Zhu, Yian, Li, Zhen, Chen, Min, Cooper, Helen M. and Xu, Zhi Ping (2013). Tuning core-shell SiO2@CdTe@SiO2 fluorescent nanoparticles for cell labeling. Journal of Materials Chemistry B, 1 (17), 2315-2323. doi: 10.1039/c3tb20202j
2012
Journal Article
Efficiency of layered double hydroxide nanoparticle-mediated delivery of siRNA is determined by nucleotide sequence
Wong, Yunyi, Cooper, Helen M., Zhang, Kai, Chen, Min, Bartlett, Perry and Xu, Zhi Ping (2012). Efficiency of layered double hydroxide nanoparticle-mediated delivery of siRNA is determined by nucleotide sequence. Journal of Colloid and Interface Science, 369 (1), 453-459. doi: 10.1016/j.jcis.2011.12.046
2012
Journal Article
Zinc neurotoxicity to hippocampal neurons in vitro induces ubiquitin conjugation that requires p38 activation
Zhu, Lin, Ji, Xiang-jun, Wang, Han-dong, Pan, Hao, Chen, Min and Lu, Ting-jia (2012). Zinc neurotoxicity to hippocampal neurons in vitro induces ubiquitin conjugation that requires p38 activation. Brain Research, 1438, 1-7. doi: 10.1016/j.brainres.2011.12.031
2012
Journal Article
Synthesis of robust sandwich-like SiO2@CdTe@SiO2 fluorescent nanoparticles for cellular imaging
Zhu, Yian, Li, Zhen, Chen, Min, Cooper, Helen M., Lu, Gao Qing (Max) and Xu, Zhi Ping (2012). Synthesis of robust sandwich-like SiO2@CdTe@SiO2 fluorescent nanoparticles for cellular imaging. Chemistry of Materials, 24 (3), 421-423. doi: 10.1021/cm2033417
2010
Journal Article
Efficient delivery of siRNA to cortical neurons using layered double hydroxide nanoparticles
Wong, Yunyi, Markham, Kathryn, Xu, Zhi Ping, Chen, Min, Liu, Gao Qing (Max), Bartlett, Perry F. and Cooper, Helen M. (2010). Efficient delivery of siRNA to cortical neurons using layered double hydroxide nanoparticles. Biomaterials, 31 (33), 8770-8779. doi: 10.1016/j.biomaterials.2010.07.077
2009
Journal Article
Zn2+ mediates ischemia-induced impairment of the ubiquitin-proteasome system in the rat hippocampus
Chen, Min, Cheng, Qian, Cheng, Xue-Wen, Lu Ting-Jia, Liu, Han-Xing, Jia, Jie-Min, Zhang, Chi, Xu, Li and Xiong, Zhi-Qui (2009). Zn2+ mediates ischemia-induced impairment of the ubiquitin-proteasome system in the rat hippocampus. Journal of Neurochemistry, 111 (5), 1094-1103. doi: 10.1111/j.1471-4159.2009.06401.x
2008
Journal Article
Differential roles of NMDA receptor subtypes in ischemic neuronal cell death and ischemic tolerance
Chen, Min, Lu, Ting-Jia, Chen, Xiao-Jing, Zhou, Yang, Chen, Qian, Feng, Xiao-Yan, Xu, Li, Duan, Wen-Hu and Xiong, Zhi-Qi (2008). Differential roles of NMDA receptor subtypes in ischemic neuronal cell death and ischemic tolerance. Stroke, 39 (11), 3042-3048. doi: 10.1161/STROKEAHA.108.521898
Funding
Past funding
Supervision
Availability
- Dr Min Chen is:
- Available for supervision
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Supervision history
Current supervision
-
Doctor Philosophy
Danger Signalling, Traumatic Brain Injury and Epileptogenesis
Associate Advisor
Media
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