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Dr Meltem Weger
Dr

Meltem Weger

Email: 
Phone: 
+61 7 334 62060

Overview

Background

I am a basic science researcher trained in molecular and cell biology, with expertise in transdisciplinary research. My primary focus is investigating the circadian aspects of (patho-) physiology, specifically in relation to the liver. I am particularly interested in understanding how circadian, endocrine, and metabolic pathways work together to maintain homeostasis, as well as how disruptions in these pathways can contribute to pathological conditions.

Following the completion of my PhD at Heidelberg University in Germany in 2013, I pursued post-doctoral studies as a Marie-Curie Fellow at Birmingham University (UK) and École Polytechnique Fédérale de Lausanne (Switzerland). During this time, I utilized omics-approaches to elucidate the metabolic changes caused by impaired mitochondrial glucocorticoid biosynthesis and adrenal insufficiency. Additionally, I investigated the relationship between mitochondrial function and stress-induced depression. In order to understand the molecular mechanisms underlying rhythmic expression of metabolic genes, I also developed tools that facilitate the study of how circadian clock components and glucocorticoids cooperatively drive these processes.

In 2019, I have joined the Physiology of Circadian Rhythms laboratory at the Institute of Molecular Bioscience, University of Queensland, to investigate the role of the circadian clock and chronodisruption in metabolism and liver disease.

Availability

Dr Meltem Weger is:
Available for supervision

Fields of research

Qualifications

  • Doctor of Philosophy, Ruprecht Karls Universität Heidelberg

Works

Search Professor Meltem Weger’s works on UQ eSpace

25 works between 2011 and 2024

1 - 20 of 25 works

2024

Journal Article

Maternal high fat diet induces circadian clock-independent endocrine alterations impacting the metabolism of the offspring

Ding, Lu, Weger, Benjamin D., Liu, Jieying, Zhou, Liyuan, Lim, Yenkai, Wang, Dongmei, Xie, Ziyan, Liu, Jing, Ren, Jing, Zheng, Jia, Zhang, Qian, Yu, Miao, Weger, Meltem, Morrison, Mark, Xiao, Xinhua and Gachon, Frédéric (2024). Maternal high fat diet induces circadian clock-independent endocrine alterations impacting the metabolism of the offspring. iScience, 27 (7) 110343, 110343. doi: 10.1016/j.isci.2024.110343

Maternal high fat diet induces circadian clock-independent endocrine alterations impacting the metabolism of the offspring

2023

Journal Article

Understanding circadian dynamics: current progress and future directions for chronobiology in drug discovery

Weger, Meltem, Weger, Benjamin D. and Gachon, Frédéric (2023). Understanding circadian dynamics: current progress and future directions for chronobiology in drug discovery. Expert Opinion on Drug Discovery, 18 (8), 893-901. doi: 10.1080/17460441.2023.2224554

Understanding circadian dynamics: current progress and future directions for chronobiology in drug discovery

2023

Journal Article

Multiomics reveals multilevel control of renal and systemic metabolism by the renal tubular circadian clock

Bignon, Yohan, Wigger, Leonore, Ansermet, Camille, Weger, Benjamin D., Lagarrigue, Sylviane, Centeno, Gabriel, Durussel, Fanny, Götz, Lou, Ibberson, Mark, Pradervand, Sylvain, Quadroni, Manfredo, Weger, Meltem, Amati, Francesca, Gachon, Frédéric and Firsov, Dmitri (2023). Multiomics reveals multilevel control of renal and systemic metabolism by the renal tubular circadian clock. Journal of Clinical Investigation, 133 (8) e167133, 1-17. doi: 10.1172/JCI167133

Multiomics reveals multilevel control of renal and systemic metabolism by the renal tubular circadian clock

2022

Other Outputs

A role for caveolar proteins in regulation of the circadian clock

Fonseka, Sachini, Weger, Benjamin D., Weger, Meltem, Martel, Nick, Hall, Thomas Edward, Varasteh Moradi, Shayli, Gabriel, Christian H., Kramer, Achim, Ferguson, Charles, Fernández-Rojo, Manuel A., Alexandrov, Kirill, Rawashdeh, Oliver, McMahon, Kerrie-Ann, Gachon, Frederic and Parton, Robert G. (2022). A role for caveolar proteins in regulation of the circadian clock.

A role for caveolar proteins in regulation of the circadian clock

2022

Journal Article

Disruption of the circadian clock component BMAL1 elicits an endocrine adaption impacting on insulin sensitivity and liver disease

Jouffe, Céline, Weger, Benjamin D., Martin, Eva, Atger, Florian, Weger, Meltem, Gobet, Cédric, Ramnath, Divya, Charpagne, Aline, Morin-Rivron, Delphine, Powell, Elizabeth E., Sweet, Matthew J., Masoodi, Mojgan, Uhlenhaut, N. Henriette and Gachon, Frédéric (2022). Disruption of the circadian clock component BMAL1 elicits an endocrine adaption impacting on insulin sensitivity and liver disease. Proceedings of the National Academy of Sciences, 119 (10) e2200083119, e2200083119. doi: 10.1073/pnas.2200083119

Disruption of the circadian clock component BMAL1 elicits an endocrine adaption impacting on insulin sensitivity and liver disease

2022

Journal Article

The mechanisms and physiological consequences of diurnal hepatic cell size fluctuations: a brief review

Weger, Meltem, Weger, Benjamin D. and Gachon, Frédéric (2022). The mechanisms and physiological consequences of diurnal hepatic cell size fluctuations: a brief review. Cellular Physiology and Biochemistry, 56 (S2), 1-11. doi: 10.33594/000000489

The mechanisms and physiological consequences of diurnal hepatic cell size fluctuations: a brief review

2021

Journal Article

Systematic analysis of differential rhythmic liver gene expression mediated by the circadian clock and feeding rhythms

Weger, Benjamin D., Gobet, Cédric, David, Fabrice P. A., Atger, Florian, Martin, Eva, Phillips, Nicholas E., Charpagne, Aline, Weger, Meltem, Naef, Felix and Gachon, Frédéric (2021). Systematic analysis of differential rhythmic liver gene expression mediated by the circadian clock and feeding rhythms. Proceedings of the National Academy of Sciences, 118 (3) e2015803118, 1-12. doi: 10.1073/pnas.2015803118

Systematic analysis of differential rhythmic liver gene expression mediated by the circadian clock and feeding rhythms

2020

Journal Article

Mitochondrial gene signature in the prefrontal cortex for differential susceptibility to chronic stress

Weger, Meltem, Alpern, Daniel, Cherix, Antoine, Ghosal, Sriparna, Grosse, Jocelyn, Russeil, Julie, Gruetter, Rolf, de Kloet, E Ronald, Deplancke, Bart and Sandi, Carmen (2020). Mitochondrial gene signature in the prefrontal cortex for differential susceptibility to chronic stress. Scientific Reports, 10 (1) 18308, 1-15. doi: 10.1038/s41598-020-75326-9

Mitochondrial gene signature in the prefrontal cortex for differential susceptibility to chronic stress

2020

Journal Article

MondoA regulates gene expression in cholesterol biosynthesis-associated pathways required for zebrafish epiboly

Weger, Meltem, Weger, Benjamin D, Schink, Andrea, Takamiya, Masanari, Stegmaier, Johannes, Gobet, Cédric, Parisi, Alice, Kobitski, Andrei Yu, Mertes, Jonas, Krone, Nils, Strähle, Uwe, Nienhaus, Gerd Ulrich, Mikut, Ralf, Gachon, Frédéric, Gut, Philipp and Dickmeis, Thomas (2020). MondoA regulates gene expression in cholesterol biosynthesis-associated pathways required for zebrafish epiboly. eLife, 9 e57068, 1-35. doi: 10.7554/elife.57068

MondoA regulates gene expression in cholesterol biosynthesis-associated pathways required for zebrafish epiboly

2020

Journal Article

The glucocorticoid receptor in the nucleus accumbens plays a crucial role in social rank attainment in rodents

Papilloud, Aurélie, Weger, Meltem, Bacq, Alexandre, Zalachoras, Ioannis, Hollis, Fiona, Larrieu, Thomas, Battivelli, Dorian, Grosse, Jocelyn, Zanoletti, Olivia, Parnaudeau, Sébastien, Tronche, François and Sandi, Carmen (2020). The glucocorticoid receptor in the nucleus accumbens plays a crucial role in social rank attainment in rodents. Psychoneuroendocrinology, 112 104538, 104538. doi: 10.1016/j.psyneuen.2019.104538

The glucocorticoid receptor in the nucleus accumbens plays a crucial role in social rank attainment in rodents

2018

Journal Article

Glucocorticoid deficiency causes transcriptional and post-transcriptional reprogramming of glutamine metabolism

Weger, Meltem, Weger, Benjamin D., Goerling, Benjamin, Poschet, Gernot, Yildiz, Melek, Hell, Ruediger, Luy, Burkhard, Akcay, Teoman, Guran, Tulay, Dickmeis, Thomas, Mueller, Ferenc and Krone, Nils (2018). Glucocorticoid deficiency causes transcriptional and post-transcriptional reprogramming of glutamine metabolism. EBioMedicine, 36, 376-389. doi: 10.1016/j.ebiom.2018.09.024

Glucocorticoid deficiency causes transcriptional and post-transcriptional reprogramming of glutamine metabolism

2018

Journal Article

High anxiety trait: a vulnerable phenotype for stress-induced depression

Weger, Meltem and Sandi, Carmen (2018). High anxiety trait: a vulnerable phenotype for stress-induced depression. Neuroscience and Biobehavioral Reviews, 87, 27-37. doi: 10.1016/j.neubiorev.2018.01.012

High anxiety trait: a vulnerable phenotype for stress-induced depression

2018

Journal Article

Expression and activity profiling of the steroidogenic enzymes of glucocorticoid biosynthesis and the fdx1 co-factors in zebrafish

Weger, M., Diotel, N., Weger, B. D., Beil, T., Zaucker, A., Eachus, H. L., Oakes, J. A., do Rego, J. L., Storbeck, K. -H., Gut, P., Straehle, U., Rastegar, S., Mueller, F. and Krone, N. (2018). Expression and activity profiling of the steroidogenic enzymes of glucocorticoid biosynthesis and the fdx1 co-factors in zebrafish. Journal of Neuroendocrinology, 30 (4) e12586, e12586. doi: 10.1111/jne.12586

Expression and activity profiling of the steroidogenic enzymes of glucocorticoid biosynthesis and the fdx1 co-factors in zebrafish

2018

Journal Article

Increased brain glucocorticoid actions following social defeat in rats facilitates the long-term establishment of social subordination

Weger, Meltem, Sevelinges, Yannick, Grosse, Jocelyn, de Suduiraut, Isabelle Guillot, Zanoletti, Olivia and Sandi, Carmen (2018). Increased brain glucocorticoid actions following social defeat in rats facilitates the long-term establishment of social subordination. Physiology and Behavior, 186, 31-36. doi: 10.1016/j.physbeh.2018.01.008

Increased brain glucocorticoid actions following social defeat in rats facilitates the long-term establishment of social subordination

2017

Journal Article

Genetic disruption of 21-hydroxylase in zebrafish causes interrenal hyperplasia

Eachus, Helen, Zaucker, Andreas, Oakes, James A., Griffin, Aliesha, Weger, Meltem, Guran, Tulay, Taylor, Angela, Harris, Abigail, Greenfield, Andy, Quanson, Jonathan L., Storbeck, Karl-Heinz, Cunliffe, Vincent T., Muller, Ferenc and Krone, Nils (2017). Genetic disruption of 21-hydroxylase in zebrafish causes interrenal hyperplasia. Endocrinology, 158 (12), 4165-4173. doi: 10.1210/en.2017-00549

Genetic disruption of 21-hydroxylase in zebrafish causes interrenal hyperplasia

2017

Journal Article

Stem cells and the circadian clock

Weger, Meltem, Diotel, Nicolas, Dorsemans, Anne-Claire, Dickmeis, Thomas and Weger, Benjamin D. (2017). Stem cells and the circadian clock. Developmental Biology, 431 (2), 111-123. doi: 10.1016/j.ydbio.2017.09.012

Stem cells and the circadian clock

2017

Journal Article

Impaired constitutive and regenerative neurogenesis in adult hyperglycemic zebrafish

Dorsemans, Anne-Claire, Soule, Stephanie, Weger, Meltem, Bourdon, Emmanuel, d'Hellencourt, Christian Lefebvre, Meilhac, Olivier and Diotel, Nicolas (2017). Impaired constitutive and regenerative neurogenesis in adult hyperglycemic zebrafish. Journal of Comparative Neurology, 525 (3), 442-458. doi: 10.1002/cne.24065

Impaired constitutive and regenerative neurogenesis in adult hyperglycemic zebrafish

2016

Journal Article

Extensive regulation of diurnal transcription and metabolism by glucocorticoids

Weger, Benjamin D., Weger, Meltem, Goerling, Benjamin, Schink, Andrea, Gobet, Cedric, Keime, Celine, Poschet, Gernot, Jost, Bernard, Krone, Nils, Hell, Ruediger, Gachon, Frederic, Luy, Burkhard and Dickmeis, Thomas (2016). Extensive regulation of diurnal transcription and metabolism by glucocorticoids. PLoS Genetics, 12 (12) e1006512, e1006512. doi: 10.1371/journal.pgen.1006512

Extensive regulation of diurnal transcription and metabolism by glucocorticoids

2016

Journal Article

Ferredoxin 1b (Fdx1b) is the essential mitochondrial redox partner for cortisol biosynthesis in zebrafish

Griffin, Aliesha, Parajes, Silvia, Weger, Meltem, Zaucker, Andreas, Taylor, Angela E., O'Neil, Donna M., Mueller, Ferenc and Krone, Nils (2016). Ferredoxin 1b (Fdx1b) is the essential mitochondrial redox partner for cortisol biosynthesis in zebrafish. Endocrinology, 157 (3), 1122-1134. doi: 10.1210/en.2015-1480

Ferredoxin 1b (Fdx1b) is the essential mitochondrial redox partner for cortisol biosynthesis in zebrafish

2013

Journal Article

Glycolysis supports embryonic muscle growth by promoting myoblast fusion

Tixier, Vanessa, Bataille, Laetitia, Etard, Christelle, Jagla, Teresa, Weger, Meltem, DaPonte, Jean Philippe, Straehle, Uwe, Dickmeis, Thomas and Jagla, Krzysztof (2013). Glycolysis supports embryonic muscle growth by promoting myoblast fusion. Proceedings of the National Academy of Sciences of the United States of America, 110 (47), 18982-18987. doi: 10.1073/pnas.1301262110

Glycolysis supports embryonic muscle growth by promoting myoblast fusion

Supervision

Availability

Dr Meltem Weger is:
Available for supervision

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Supervision history

Current supervision

Media

Enquiries

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