
Overview
Background
Educated at the University of Copenhagen, Denmark, and the Australian National University, Canberra. Career at the Université de Lausanne, Switzerland, and the Universität Marburg, Germany. Professor and Chair of Organic Chemistry and Head of the Organic Chemistry Section, The University of Queensland from 1985. Emeritus professor from 2008. Chair of the National Committee for Chemistry of the Australian Academy of Science 2009-2014. Editor-in-Chief, Australian Journal of Chemistry 2008-15. Editor, Journal of Analytical and Applied Pyrolysis (Elsevier, IF 3.65) 2016-. Visiting Professor Université de Pau, France, 2011-19; Visiting Professor University of Kuwait 2014-18; Visiting Professor / Special Appointed Professor Hiroshima University 2014-18. Fellow of the Australian Academy of Science. Centenary Medal of the Australian Commonwealth 2003 for research in organic and physical chemistry. David Craig Medal of the Academy of Science 2014 for research in chemistry. JSPS Fellowship (Japan) 2014. Honorary doctorate, University of Pau, France, 2014. A.J. Birch Medal of the Royal Australian Chemical Institute (RACI) for ecellence in research in organic chemistry, 2014. Leighton Medal of the RACI 2018.
Research on Unusual Molecules and Reactive Intermediates: Synthesis and Reaction Mechanism. Heterocyclic chemistry. Pyrolysis reactions. Photochemistry
Research in the Wentrup group is concerned with the discovery of novel types of molecules with new and unusual bonding patterns. Such molecules are mostly highly reactive, and special methods are required both for their generation and for their detection. The group has developed these methods over many years and acquired world-class equipment for these purposes, including flash vacuum thermolysis apparatus, cryostats for matrix isolation of reaction products at cryogenic temperatures (down to 7 K), matrix and solution photochemistry equipment, infrared, UV and mass spectrometers, as well as modern computational facilities.
This research has resulted in the synthesis and characterization of many novel compounds, including extended cumulenes of the types RN=C=C=C=X, which themselves are used in the synthesis of many novel types of molecules, some of them of potential pharmaceutical interest (quinolone antibiotics; diazepines).
The research group has a world reputation in the field of carbene and nitrene chemistry, involving reactive intermediates with sextet carbon or nitrogen. These species are also very useful in synthesis, for example in the preparation of diazepines and diazepinones, a family of pharmaceutically interesting compounds. Numerous mechanistic studies and synthetic applications of ketenes have been carried out in our group.
Active collaborations are ongoing with scientists in Australia (UQ and CSIRO), China (Suzhou), France (Pau), Germany (Oldenburg), Japan (Hiroshima), Spain (Donostia - San Sebastian), and Portugal (Coimbra).
Availability
- Emeritus Professor Curt Wentrup is:
- Not available for supervision
- Media expert
Fields of research
Qualifications
- Doctor of Philosophy, Australian National University
- Doctor of Philosophy of Science (Advanced), University of Copenhagen
- Doctoral Diploma, Institution to be confirmed
- Australian Academy of Science, Australian Academy of Science
- Royal Australian Chemical Institute, Royal Australian Chemical Institute
Research interests
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Organic, physical, and historical chemistry
Reactive intermediates, pyrolysis, photochemistry, reaction mechanism. History of science.
Research impacts
This research leads to the development of new pharmaceuticals, e.g. new antibiotics (quinolones and naphthyridones) and new leads towards a treatment for scizophrenia (diazepine molecules).
Chemical industry has used our pyrolysis techniques in specialized manufacturing processes.
Our analytical/spectroscopic work has led to cooperation with chemical and energy firms and agencies involved in forensic science, and our research has generated collaborations with many scientists at universities in Australia, Austria, Belgium, China, Denmark, France, Germany, Hungary, Japan, Portugal, Singapore, Switzerland, and USA.
Works
Search Professor Curt Wentrup’s works on UQ eSpace
2019
Journal Article
RACI Awards 2017-19
Wentrup, Curt (2019). RACI Awards 2017-19. Australian Journal of Chemistry, 72 (8), 561-562. doi: 10.1071/CHv72n8_FO
2018
Journal Article
Phenylnitrene radical cation rearrangements
Bégué, Didier, Dargelos, Alain and Wentrup, Curt (2018). Phenylnitrene radical cation rearrangements. Journal of Physical Chemistry A: Molecules, Spectroscopy, Kinetics, Environment and General Theory, 122 (43) acs.jpca.8b08480, 8490-8496. doi: 10.1021/acs.jpca.8b08480
2018
Journal Article
Triplet states of tetrazoles, nitrenes, and carbenes from matrix photolysis of tetrazoles, and phenylcyanamide as a source of phenylnitrene
Abe, Manabu, Bégué, Didier, Silva, Hugo Santos, Dargelos, Alain and Wentrup, Curt (2018). Triplet states of tetrazoles, nitrenes, and carbenes from matrix photolysis of tetrazoles, and phenylcyanamide as a source of phenylnitrene. Journal of Physical Chemistry A, 122 (37), 7276-7283. doi: 10.1021/acs.jpca.8b06960
2018
Journal Article
Carbene und Nitrene: aktuelle Entwicklungen in der Grundlagenchemie
Wentrup, Curt (2018). Carbene und Nitrene: aktuelle Entwicklungen in der Grundlagenchemie. Angewandte Chemie, 130 (36), 11680-11693. doi: 10.1002/ange.201804863
2018
Journal Article
Trimethylsilylnitrene and its surprising rearrangement to N-(Dimethylsilyl)methanimine via silaziridine and silaazomethine ylide
Wentrup, Curt, Lüerssen, Holger, Silva, Hugo Santos, Dargelos, Alain and Bégué, Didier (2018). Trimethylsilylnitrene and its surprising rearrangement to N-(Dimethylsilyl)methanimine via silaziridine and silaazomethine ylide. Chemistry: A European Journal, 24 (54), 14547-14553. doi: 10.1002/chem.201803245
2018
Journal Article
Direct observation of an imidoylnitrene: photochemical formation of PhC(=NMe)−N and Me−N from 1-methyl-5-phenyltetrazole
Abe, Manabu, Bégué, Didier, Santos-Silva, Hugo, Dargelos, Alain and Wentrup, Curt (2018). Direct observation of an imidoylnitrene: photochemical formation of PhC(=NMe)−N and Me−N from 1-methyl-5-phenyltetrazole. Angewandte Chemie, 130 (12), 3266-3270. doi: 10.1002/ange.201712689
2018
Journal Article
First Direct Observation of an Imidoylnitrene. Photochemical Formation of PhC(=NMe)-N and Me-N from 1-Methyl-5-phenyltetrazole
Wentrup, Curt, Abe, Manabu, Bégué, Didier, Santos-Silva, Hugo and Dargelos, Alain (2018). First Direct Observation of an Imidoylnitrene. Photochemical Formation of PhC(=NMe)-N and Me-N from 1-Methyl-5-phenyltetrazole. Angewandte Chemie (International ed. in English), 57 (12), 3212-3216. doi: 10.1002/anie.201712689
2018
Journal Article
From dipivaloylketene to tetraoxaadamantanes
Kollenz, Gert and Wentrup, Curt (2018). From dipivaloylketene to tetraoxaadamantanes. Beilstein Journal of Organic Chemistry, 14 (1), 1-10. doi: 10.3762/bjoc.14.1
2018
Journal Article
RACI and academy of science awards 2017-18
Wentrup, Curt (2018). RACI and academy of science awards 2017-18. Australian Journal of Chemistry, 71 (10), 721-722. doi: 10.1071/CHv71n10_FO
2018
Book Chapter
Flash vacuum pyrolysis
Wentrup, Curt (2018). Flash vacuum pyrolysis. Kirk-Othmer encyclopedia of chemical technology. (pp. 1-28) Hoboken, NJ, United States: John Wiley & Sons. doi: 10.1002/0471238961.flasmcna.a01.pub2
2017
Journal Article
Flash-Vakuumpyrolyse - Techniken und Reaktionen
Wentrup, Curt (2017). Flash-Vakuumpyrolyse - Techniken und Reaktionen. Angewandte Chemie, 129 (47), 15002-15031. doi: 10.1002/ange.201705118
2017
Journal Article
Pyrolysis of benzotriazoles. 1-Acyl- and 1-alkoxycarbonylbenzotriazoles: Hetero-Wolff rearrangement to N-acyl- and N-alkoxycarbonyl-fulvenimines and free radical routes to cyanocyclopentadienes
Wentrup, Curt, Freiermuth, Beat and Aylward, Nigel (2017). Pyrolysis of benzotriazoles. 1-Acyl- and 1-alkoxycarbonylbenzotriazoles: Hetero-Wolff rearrangement to N-acyl- and N-alkoxycarbonyl-fulvenimines and free radical routes to cyanocyclopentadienes. Journal of Analytical and Applied Pyrolysis, 128, 187-195. doi: 10.1016/j.jaap.2017.10.011
2017
Journal Article
Celebrating RACI and Academy of Science Awards
Wentrup, Curt (2017). Celebrating RACI and Academy of Science Awards. Australian Journal of Chemistry, 70 (11), 1159-1160. doi: 10.1071/CHv70n11_FO
2017
Journal Article
Imidoylnitrenes R'C(═NR)-N, Nitrile Imines, 1H-Diazirines, and Carbodiimides: Interconversions and Rearrangements, Structures, and Energies at DFT and CASPT2 Levels of Theory
Bégué, Didier, Santos-Silva, Hugo, Dargelos, Alain and Wentrup, Curt (2017). Imidoylnitrenes R'C(═NR)-N, Nitrile Imines, 1H-Diazirines, and Carbodiimides: Interconversions and Rearrangements, Structures, and Energies at DFT and CASPT2 Levels of Theory. The journal of physical chemistry. A, 121 (43), 8227-8235. doi: 10.1021/acs.jpca.7b08445
2017
Journal Article
Iminocyclohexadienylidenes: carbenes or diradicals? the hetero-Wolff rearrangement of benzotriazoles to cyanocyclopentadienes and 1H-benzo[b]azirines
Begue, Didier, Santos-Silva, Hugo, Dargelos, Alain and Wentrup, Curt (2017). Iminocyclohexadienylidenes: carbenes or diradicals? the hetero-Wolff rearrangement of benzotriazoles to cyanocyclopentadienes and 1H-benzo[b]azirines. Journal of Physical Chemistry A, 121 (32), 5998-6003. doi: 10.1021/acs.jpca.7b05325
2017
Conference Publication
7th Heron Island conference on reactive intermediates and unusual molecules
Wentrup, Curt and Williams, Craig M. (2017). 7th Heron Island conference on reactive intermediates and unusual molecules. Clayton, VIC, Australia: CSIRO. doi: 10.1071/CH17065
2017
Journal Article
Pyrolysis of hydrazine derivatives and related compounds with N-N single bonds
Gaber, Abdel-Aal M. and Wentrup, Curt (2017). Pyrolysis of hydrazine derivatives and related compounds with N-N single bonds. Journal of Analytical and Applied Pyrolysis, 125, 258-278. doi: 10.1016/j.jaap.2017.03.016
2017
Journal Article
New, simple and efficient method for the synthesis of imidazo-azines by flash vacuum thermolysis of tert-butylimines of pyrimidine-2-, pyrazine-2-, quinoline-2-, quinoxaline-2- and isoquinoline-1-carbaldehydes
Justyna, Katarzyna , Chrostowska, Anna , Leśniak, Stanisław , Darrigan, Clovis , Baylère, Patrick , Khayar, Saïd and Wentrup, Curt (2017). New, simple and efficient method for the synthesis of imidazo-azines by flash vacuum thermolysis of tert-butylimines of pyrimidine-2-, pyrazine-2-, quinoline-2-, quinoxaline-2- and isoquinoline-1-carbaldehydes. Journal of Analytical and Applied Pyrolysis, 125, 335-346. doi: 10.1016/j.jaap.2017.02.028
2016
Journal Article
A thermally populated, perpendicularly twisted alkene triplet diradical
Wentrup, Curt, Regimbald-Krnel, Michèle J., Müller, Dennis and Comba, Peter (2016). A thermally populated, perpendicularly twisted alkene triplet diradical. Angewandte Chemie, 128 (47), 14820-14825. doi: 10.1002/ange.201607415
2016
Journal Article
A Thermally Populated, Perpendicularly Twisted Alkene Triplet Diradical
Wentrup, Curt, Regimbald-Krnel, Michele J., Müller, Dennis and Comba, Peter (2016). A Thermally Populated, Perpendicularly Twisted Alkene Triplet Diradical. Angewandte Chemie, 55 (47), 14600-14605. doi: 10.1002/anie.201607415
Funding
Supervision
Availability
- Emeritus Professor Curt Wentrup is:
- Not available for supervision
Supervision history
Completed supervision
-
2006
Doctor Philosophy
SYNTHESES AND REACTIONS OF IMINOPROPADIENONES, SYDNONES AND OXAZINONES
Principal Advisor
Other advisors: Professor Craig Williams
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2002
Doctor Philosophy
HETEROCYCLIC SYNTHESIS BASED ON IMINOPROPADIENONES
Principal Advisor
-
2002
Doctor Philosophy
SYNTHESIS AND CHARACTERISATION OF 1,3- and 1,4- DIAZEPINES AND DERIVATIVES
Principal Advisor
-
Doctor Philosophy
NITRENES REARRANGEMENTS: FORMATION OF REACTIVE INTERMEDIATES AND UNUSUAL MOLECULES
Principal Advisor
Other advisors: Professor Craig Williams
Media
Enquiries
Contact Emeritus Professor Curt Wentrup directly for media enquiries about:
- Organic reaction mechanisms
- Photochemistry
- Pyrolysis
- Reactive intermediates
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