
Overview
Background
Educated at the University of Copenhagen, Denmark, and the Australian National University, Canberra. Career at the Université de Lausanne, Switzerland, and the Universität Marburg, Germany. Professor and Chair of Organic Chemistry and Head of the Organic Chemistry Section, The University of Queensland from 1985. Emeritus professor from 2008. Chair of the National Committee for Chemistry of the Australian Academy of Science 2009-2014. Editor-in-Chief, Australian Journal of Chemistry 2008-15. Editor, Journal of Analytical and Applied Pyrolysis (Elsevier, IF 3.65) 2016-. Visiting Professor Université de Pau, France, 2011-19; Visiting Professor University of Kuwait 2014-18; Visiting Professor / Special Appointed Professor Hiroshima University 2014-18. Fellow of the Australian Academy of Science. Centenary Medal of the Australian Commonwealth 2003 for research in organic and physical chemistry. David Craig Medal of the Academy of Science 2014 for research in chemistry. JSPS Fellowship (Japan) 2014. Honorary doctorate, University of Pau, France, 2014. A.J. Birch Medal of the Royal Australian Chemical Institute (RACI) for ecellence in research in organic chemistry, 2014. Leighton Medal of the RACI 2018.
Research on Unusual Molecules and Reactive Intermediates: Synthesis and Reaction Mechanism. Heterocyclic chemistry. Pyrolysis reactions. Photochemistry
Research in the Wentrup group is concerned with the discovery of novel types of molecules with new and unusual bonding patterns. Such molecules are mostly highly reactive, and special methods are required both for their generation and for their detection. The group has developed these methods over many years and acquired world-class equipment for these purposes, including flash vacuum thermolysis apparatus, cryostats for matrix isolation of reaction products at cryogenic temperatures (down to 7 K), matrix and solution photochemistry equipment, infrared, UV and mass spectrometers, as well as modern computational facilities.
This research has resulted in the synthesis and characterization of many novel compounds, including extended cumulenes of the types RN=C=C=C=X, which themselves are used in the synthesis of many novel types of molecules, some of them of potential pharmaceutical interest (quinolone antibiotics; diazepines).
The research group has a world reputation in the field of carbene and nitrene chemistry, involving reactive intermediates with sextet carbon or nitrogen. These species are also very useful in synthesis, for example in the preparation of diazepines and diazepinones, a family of pharmaceutically interesting compounds. Numerous mechanistic studies and synthetic applications of ketenes have been carried out in our group.
Active collaborations are ongoing with scientists in Australia (UQ and CSIRO), China (Suzhou), France (Pau), Germany (Oldenburg), Japan (Hiroshima), Spain (Donostia - San Sebastian), and Portugal (Coimbra).
Availability
- Emeritus Professor Curt Wentrup is:
- Not available for supervision
- Media expert
Fields of research
Qualifications
- Doctor of Philosophy, Australian National University
- Doctor of Philosophy of Science (Advanced), University of Copenhagen
- Doctoral Diploma, Institution to be confirmed
- Australian Academy of Science, Australian Academy of Science
- Royal Australian Chemical Institute, Royal Australian Chemical Institute
Research interests
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Organic, physical, and historical chemistry
Reactive intermediates, pyrolysis, photochemistry, reaction mechanism. History of science.
Research impacts
This research leads to the development of new pharmaceuticals, e.g. new antibiotics (quinolones and naphthyridones) and new leads towards a treatment for scizophrenia (diazepine molecules).
Chemical industry has used our pyrolysis techniques in specialized manufacturing processes.
Our analytical/spectroscopic work has led to cooperation with chemical and energy firms and agencies involved in forensic science, and our research has generated collaborations with many scientists at universities in Australia, Austria, Belgium, China, Denmark, France, Germany, Hungary, Japan, Portugal, Singapore, Switzerland, and USA.
Works
Search Professor Curt Wentrup’s works on UQ eSpace
2013
Journal Article
Photolysis of dimethylcarbamoyl azide in an argon matrix: Spectroscopic identification of dimethylamino isocyanate and 1,1-dimethyldiazene
Pasinszki, Tibor, Krebsz, Melinda, Tarczay, György and Wentrup, Curt (2013). Photolysis of dimethylcarbamoyl azide in an argon matrix: Spectroscopic identification of dimethylamino isocyanate and 1,1-dimethyldiazene. Journal of Organic Chemistry, 78 (23), 11985-11991. doi: 10.1021/jo402023m
2013
Journal Article
Matrix-IR spectroscopic investigations of the thermolysis and photolysis of diazoamides
Wentrup, Curt, Bibas, Herve, Kuhn, Arvid, Mitschke, Ullrich and McMills, Mark C. (2013). Matrix-IR spectroscopic investigations of the thermolysis and photolysis of diazoamides. Journal of Organic Chemistry, 78 (21), 10705-10717. doi: 10.1021/jo401695x
2013
Journal Article
Iminopropadienones RN=C=C=C=O and bisiminopropadienes RN=C=C=C=NR: Matrix infrared spectra and anharmonic frequency calculations
Begue, Didier, Baraille, Isabelle, Andersen, Heidi Gade and Wentrup, Curt (2013). Iminopropadienones RN=C=C=C=O and bisiminopropadienes RN=C=C=C=NR: Matrix infrared spectra and anharmonic frequency calculations. Journal of Chemical Physics, 139 (16) 164314, 164314.1-164314.9. doi: 10.1063/1.4826647
2013
Journal Article
New reactions of N-tert-butylimines; formation of N-heterocycles by methyl radical elimination on flash vacuum thermolysis of N-benzylidene- and N-(2-pyridyl-methylidene)-tert-butylamines
Vu, Thien Y, Chrostowska, Anna, Huynh, Thi Kieu Xuan, Khayar, Saïd, Dargelos, Alain, Justyna, Katarzyna, Pasternak, Beata, Leśniak, Stanisław and Wentrup, Curt (2013). New reactions of N-tert-butylimines; formation of N-heterocycles by methyl radical elimination on flash vacuum thermolysis of N-benzylidene- and N-(2-pyridyl-methylidene)-tert-butylamines. Chemistry: A European Journal, 19 (44), 14983-14988. doi: 10.1002/chem.201301663
2013
Journal Article
Zwitterionic 1,3-shift intermediates in the interconversions of (thio)carbamoyl isocyanates and carbamoyl iso(thio)cyanates, R2N–CX–NCO ⇌ R2N–CO–NCX, and in carbamoylketenes R2N–CO–CH=C=O
Koch, Rainer and Wentrup, Curt (2013). Zwitterionic 1,3-shift intermediates in the interconversions of (thio)carbamoyl isocyanates and carbamoyl iso(thio)cyanates, R2N–CX–NCO ⇌ R2N–CO–NCX, and in carbamoylketenes R2N–CO–CH=C=O. European Journal of Organic Chemistry, Early View (35), 1-9. doi: 10.1002/ejoc.201300975
2013
Journal Article
Laser-induced carbene-carbene rearrangement in solution: the diphenylcarbene-fluorene rearrangement
Régimbald-Krnel, Michèle J. and Wentrup, Curt (2013). Laser-induced carbene-carbene rearrangement in solution: the diphenylcarbene-fluorene rearrangement. Journal of Organic Chemistry, 78 (17), 8789–8795-8789–8795. doi: 10.1021/jo401607m
2013
Journal Article
Mechanistic diversity in thermal fragmentation reactions: a computational exploration of CO and CO2 extrusions from five-membered rings
Rzepa, Henry S. and Wentrup, Curt (2013). Mechanistic diversity in thermal fragmentation reactions: a computational exploration of CO and CO2 extrusions from five-membered rings. Journal of Organic Chemistry, 78 (15), 7565-7574. doi: 10.1021/jo401146k
2013
Journal Article
4-Pyridylnitrene and 2-pyrazinylcarbene
Wentrup, Curt, Reisinger, Ales and Kvaskoff, David (2013). 4-Pyridylnitrene and 2-pyrazinylcarbene. Beilstein Journal of Organic Chemistry, 9 (23), 754-760. doi: 10.3762/bjoc.9.85
2013
Journal Article
3-Pyridylnitrene, 2-and 4-pyrimidinylcarbenes, 3-quinolylnitrenes, and 4-quinazolinylcarbenes. Interconversion, ring expansion to diazacycloheptatetraenes, ring opening to nitrile ylides, and ring contraction to cyanopyrroles and cyanoindoles
Wentrup, Curt, Lan, Nguyen Mong, Lukosch, Adelheid, Bednarek, Pawel and Kvaskoff, David (2013). 3-Pyridylnitrene, 2-and 4-pyrimidinylcarbenes, 3-quinolylnitrenes, and 4-quinazolinylcarbenes. Interconversion, ring expansion to diazacycloheptatetraenes, ring opening to nitrile ylides, and ring contraction to cyanopyrroles and cyanoindoles. Beilstein Journal of Organic Chemistry, 9 (5), 743-753. doi: 10.3762/bjoc.9.84
2013
Journal Article
Rearrangements of Acyl, Thioacyl, and Imidoyl (Thio)cyanates to Iso(thio)cyanates, Acyl Iso(thio)cyanates to (Thio)acyl Isocyanates, and Imidoyl Iso(thio)cyanates to (Thio)acyl Carbodiimides, RCX-YCN reversible arrow RCX-NCY reversible arrow RCY-NCX rever
Koch, Rainer and Wentrup, Curt (2013). Rearrangements of Acyl, Thioacyl, and Imidoyl (Thio)cyanates to Iso(thio)cyanates, Acyl Iso(thio)cyanates to (Thio)acyl Isocyanates, and Imidoyl Iso(thio)cyanates to (Thio)acyl Carbodiimides, RCX-YCN reversible arrow RCX-NCY reversible arrow RCY-NCX rever. Journal of Organic Chemistry, 78 (5), 1802-1810. doi: 10.1021/jo3013786
2013
Journal Article
Chemical activation in azide and nitrene chemistry: methyl azide, phenyl azide, naphthyl azides, pyridyl azides, benzotriazoles, and triazolopyridines
Wentrup, Curt (2013). Chemical activation in azide and nitrene chemistry: methyl azide, phenyl azide, naphthyl azides, pyridyl azides, benzotriazoles, and triazolopyridines. Australian Journal of Chemistry, 66 (8), 852-863. doi: 10.1071/CH13283
2013
Journal Article
1,5-(1,7)-biradicals and nitrenes formed by ring opening of hetarylnitrenes
Wentrup, Curt and Kvaskoff, David (2013). 1,5-(1,7)-biradicals and nitrenes formed by ring opening of hetarylnitrenes. Australian Journal of Chemistry, 66 (3), 286-296. doi: 10.1071/CH12502
2013
Journal Article
New Year Editorial 2013
Wentrup, Curt (2013). New Year Editorial 2013. Australian Journal of Chemistry, 66 (1), 1-2. doi: 10.1071/CH12554
2013
Book Chapter
Matrix studies on aromatic and heteroaromatic nitrenes and their rearrangements
Wentrup, Curt (2013). Matrix studies on aromatic and heteroaromatic nitrenes and their rearrangements. Nitrenes and nitrenium ions. (pp. 273-315) edited by Daniel E. Falvey and Anna D. Gudmundsdottir. Hoboken NJ, United States: John Wiley and Sons Inc.. doi: 10.1002/9781118560907.ch8
2012
Journal Article
Mass spectrometry of cyclopentadienylideneketene: differentiation of isomeric ion structures by means of ion/molecule reactions
Gerbaux, Pascal and Wentrup, Curt (2012). Mass spectrometry of cyclopentadienylideneketene: differentiation of isomeric ion structures by means of ion/molecule reactions. Australian Journal of Chemistry, 65 (12), 1655-1661. doi: 10.1071/CH12327
2012
Journal Article
12th Eurasia conference on chemical sciences
Hadjiliadis, Nick and Wentrup, Curt (2012). 12th Eurasia conference on chemical sciences. Australian Journal of Chemistry, 65 (12), 1561-1563. doi: 10.1071/CH12478
2012
Journal Article
Methyliminopropadienone CH3-N═C═C═C═O: photoelectron spectrum and electronic structure
Chrostowska, Anna, Dargelos, Alain, Khayar, Said and Wentrup, Curt (2012). Methyliminopropadienone CH3-N═C═C═C═O: photoelectron spectrum and electronic structure. Journal of Physical Chemistry A, 116 (37), 9315-9320. doi: 10.1021/jp307916p
2012
Journal Article
Synthesis and chemistry of a very stable but reactive diisocyanate, trioxabicyclo[3.3.1]nonadiene diisocyanate
Smounig, Ralph, Leber, Sabine, Kvaskoff, David, Kollenz, Gert and Wentrup, Curt (2012). Synthesis and chemistry of a very stable but reactive diisocyanate, trioxabicyclo[3.3.1]nonadiene diisocyanate. Rsc Advances, 2 (20), 7743-7746. doi: 10.1039/c2ra21073h
2012
Journal Article
Synthesis of functionalized macrocyclic derivatives of trioxabicyclo[3.3.0]nonadiene
Leber, Sabine, Kollenz, Gert and Wentrup, Curt (2012). Synthesis of functionalized macrocyclic derivatives of trioxabicyclo[3.3.0]nonadiene. Beilstein Journal of Organic Chemistry, 8 (1), 738-743. doi: 10.3762/bjoc.8.83
2012
Journal Article
Synthesis and structure of a new 1,2-bridged calix[6]arene
Haberz, Peter, Belaj, Ferdinand, Gloe, Karsten, Wentrup, Curt and Kollenz, Gert (2012). Synthesis and structure of a new 1,2-bridged calix[6]arene. Supramolecular Chemistry, 24 (4), 279-284. doi: 10.1080/10610278.2012.658393
Funding
Supervision
Availability
- Emeritus Professor Curt Wentrup is:
- Not available for supervision
Supervision history
Completed supervision
-
2006
Doctor Philosophy
SYNTHESES AND REACTIONS OF IMINOPROPADIENONES, SYDNONES AND OXAZINONES
Principal Advisor
Other advisors: Professor Craig Williams
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2002
Doctor Philosophy
HETEROCYCLIC SYNTHESIS BASED ON IMINOPROPADIENONES
Principal Advisor
-
2002
Doctor Philosophy
SYNTHESIS AND CHARACTERISATION OF 1,3- and 1,4- DIAZEPINES AND DERIVATIVES
Principal Advisor
-
Doctor Philosophy
NITRENES REARRANGEMENTS: FORMATION OF REACTIVE INTERMEDIATES AND UNUSUAL MOLECULES
Principal Advisor
Other advisors: Professor Craig Williams
Media
Enquiries
Contact Emeritus Professor Curt Wentrup directly for media enquiries about:
- Organic reaction mechanisms
- Photochemistry
- Pyrolysis
- Reactive intermediates
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