
Overview
Background
Educated at the University of Copenhagen, Denmark, and the Australian National University, Canberra. Career at the Université de Lausanne, Switzerland, and the Universität Marburg, Germany. Professor and Chair of Organic Chemistry and Head of the Organic Chemistry Section, The University of Queensland from 1985. Emeritus professor from 2008. Chair of the National Committee for Chemistry of the Australian Academy of Science 2009-2014. Editor-in-Chief, Australian Journal of Chemistry 2008-15. Editor, Journal of Analytical and Applied Pyrolysis (Elsevier, IF 3.65) 2016-. Visiting Professor Université de Pau, France, 2011-19; Visiting Professor University of Kuwait 2014-18; Visiting Professor / Special Appointed Professor Hiroshima University 2014-18. Fellow of the Australian Academy of Science. Centenary Medal of the Australian Commonwealth 2003 for research in organic and physical chemistry. David Craig Medal of the Academy of Science 2014 for research in chemistry. JSPS Fellowship (Japan) 2014. Honorary doctorate, University of Pau, France, 2014. A.J. Birch Medal of the Royal Australian Chemical Institute (RACI) for ecellence in research in organic chemistry, 2014. Leighton Medal of the RACI 2018.
Research on Unusual Molecules and Reactive Intermediates: Synthesis and Reaction Mechanism. Heterocyclic chemistry. Pyrolysis reactions. Photochemistry
Research in the Wentrup group is concerned with the discovery of novel types of molecules with new and unusual bonding patterns. Such molecules are mostly highly reactive, and special methods are required both for their generation and for their detection. The group has developed these methods over many years and acquired world-class equipment for these purposes, including flash vacuum thermolysis apparatus, cryostats for matrix isolation of reaction products at cryogenic temperatures (down to 7 K), matrix and solution photochemistry equipment, infrared, UV and mass spectrometers, as well as modern computational facilities.
This research has resulted in the synthesis and characterization of many novel compounds, including extended cumulenes of the types RN=C=C=C=X, which themselves are used in the synthesis of many novel types of molecules, some of them of potential pharmaceutical interest (quinolone antibiotics; diazepines).
The research group has a world reputation in the field of carbene and nitrene chemistry, involving reactive intermediates with sextet carbon or nitrogen. These species are also very useful in synthesis, for example in the preparation of diazepines and diazepinones, a family of pharmaceutically interesting compounds. Numerous mechanistic studies and synthetic applications of ketenes have been carried out in our group.
Active collaborations are ongoing with scientists in Australia (UQ and CSIRO), China (Suzhou), France (Pau), Germany (Oldenburg), Japan (Hiroshima), Spain (Donostia - San Sebastian), and Portugal (Coimbra).
Availability
- Emeritus Professor Curt Wentrup is:
- Not available for supervision
- Media expert
Fields of research
Qualifications
- Doctor of Philosophy, Australian National University
- Doctor of Philosophy of Science (Advanced), University of Copenhagen
- Doctoral Diploma, Institution to be confirmed
- Australian Academy of Science, Australian Academy of Science
- Royal Australian Chemical Institute, Royal Australian Chemical Institute
Research interests
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Organic, physical, and historical chemistry
Reactive intermediates, pyrolysis, photochemistry, reaction mechanism. History of science.
Research impacts
This research leads to the development of new pharmaceuticals, e.g. new antibiotics (quinolones and naphthyridones) and new leads towards a treatment for scizophrenia (diazepine molecules).
Chemical industry has used our pyrolysis techniques in specialized manufacturing processes.
Our analytical/spectroscopic work has led to cooperation with chemical and energy firms and agencies involved in forensic science, and our research has generated collaborations with many scientists at universities in Australia, Austria, Belgium, China, Denmark, France, Germany, Hungary, Japan, Portugal, Singapore, Switzerland, and USA.
Works
Search Professor Curt Wentrup’s works on UQ eSpace
2015
Journal Article
Sir John Cornforth Memorial Issue
Wentrup, Curt (2015). Sir John Cornforth Memorial Issue. Australian Journal of Chemistry, 68 (4), 519-520. doi: 10.1071/CH15100
2015
Journal Article
RACI Congress Adelaide
Wentrup, Curt (2015). RACI Congress Adelaide. Australian Journal of Chemistry, 68 (9), 1317-1318. doi: 10.1071/CH15508
2015
Journal Article
New Year Editorial 2015
Wentrup, Curt (2015). New Year Editorial 2015. Australian Journal of Chemistry, 68 (1), 1-2. doi: 10.1071/CH14678
2014
Journal Article
Phenylnitrene, phenylcarbene, and pyridylcarbenes. Rearrangements to cyanocyclopentadiene and fulvenallene.
Kvaskoff, David, Lüerssen, Holger, Bednarek, Pawel and Wentrup, Curt (2014). Phenylnitrene, phenylcarbene, and pyridylcarbenes. Rearrangements to cyanocyclopentadiene and fulvenallene.. Journal of the American Chemical Society, 136 (43), 15203-15214. doi: 10.1021/ja506151p
2014
Journal Article
Flash (vacuum) pyrolysis apparatus and methods
Wentrup, Curt (2014). Flash (vacuum) pyrolysis apparatus and methods. Australian Journal of Chemistry, 67 (9), 1150-1165. doi: 10.1071/CH14096
2014
Journal Article
Ketene-Ketene interconversion. 6-Carbonylcyclohexa-2,4-dienone-hepta-1,2,4, 6-tetraene-1,7-dione-6-oxocyclohexa-2,4-dienylidene and wolff rearrangement to fulven-6-one
Koch, Rainer, Blanch, Rodney J. and Wentrup, Curt (2014). Ketene-Ketene interconversion. 6-Carbonylcyclohexa-2,4-dienone-hepta-1,2,4, 6-tetraene-1,7-dione-6-oxocyclohexa-2,4-dienylidene and wolff rearrangement to fulven-6-one. Journal of Organic Chemistry, 79 (15), 6978-6986. doi: 10.1021/jo5011087
2014
Journal Article
Comment on "Computational Study on the Vinyl Azide Decomposition"
Wentrup, Curt, Nunes, Claudio M and Reva, Igor (2014). Comment on "Computational Study on the Vinyl Azide Decomposition". Journal of Physical Chemistry A, 118 (27), 5122-5123. doi: 10.1021/jp503958z
2014
Journal Article
Flash vacuum thermolysis of N-(3- and 4-pyridylmethylidene)-tert-butylamines: mechanisms of formation of pyrrolopyridines and naphthyridines
Justyna, Katarzyna, Leśniak, Stanisław, Nazarski, Ryszard B., Rachwalski, Michał, Vu, Thien Y., Huynh, Thi Kieu Xuan, Khayar, Saïd, Dargelos, Alain, Chrostowska, Anna and Wentrup, Curt (2014). Flash vacuum thermolysis of N-(3- and 4-pyridylmethylidene)-tert-butylamines: mechanisms of formation of pyrrolopyridines and naphthyridines. European Journal of Organic Chemistry, 2014 (14), 3020-3027. doi: 10.1002/ejoc.201400112
2014
Journal Article
6th Heron Island conference on reactive intermediates and unusual molecules
Wentrup, Curt and Williams, Craig (2014). 6th Heron Island conference on reactive intermediates and unusual molecules. Australian Journal of Chemistry, 67 (3), 317-319. doi: 10.1071/CH14041
2014
Journal Article
Nitrile ylides: allenic and propargylic structures from pyrazinylnitrenes. Experimental and theoretical characterization
Begue, Didier, Addicott, Chris, Burgard, Riko, Bednarek, Pawel, Guille, Emilie, Baraille, Isabelle and Wentrup, Curt (2014). Nitrile ylides: allenic and propargylic structures from pyrazinylnitrenes. Experimental and theoretical characterization. Journal of Organic Chemistry, 79 (5), 2148-2155. doi: 10.1021/jo500002r
2014
Journal Article
3-pyridazinylnitrenes and 2-pyrimidinylnitrenes
Torker, Sebastian, Kvaskoff, David and Wentrup, Curt (2014). 3-pyridazinylnitrenes and 2-pyrimidinylnitrenes. Journal of Organic Chemistry, 79 (4), 1758-1770. doi: 10.1021/jo4027897
2014
Journal Article
Nitrile imines and nitrile ylides: Rearrangements of benzonitrile N-methylimine and benzonitrile dimethylmethylide to azabutadienes, carbodiimides, and ketenimines. chemical activation in thermolysis of azirenes, tetrazoles, oxazolones, isoxazolones, and
Begue, Didier, Dargelos, Alain, Berstermann, Hans M., Netsch, Klaus P., Bednarek, Pawel and Wentrup, Curt (2014). Nitrile imines and nitrile ylides: Rearrangements of benzonitrile N-methylimine and benzonitrile dimethylmethylide to azabutadienes, carbodiimides, and ketenimines. chemical activation in thermolysis of azirenes, tetrazoles, oxazolones, isoxazolones, and. Journal of Organic Chemistry, 79 (3), 1247-1253. doi: 10.1021/jo402667y
2014
Journal Article
Carbenic nitrile imines: Properties and reactivity
Begue, Didier and Wentrup, Curt (2014). Carbenic nitrile imines: Properties and reactivity. Journal of Organic Chemistry, 79 (3), 1418-1426. doi: 10.1021/jo402875c
2014
Journal Article
New year editorial 2014
Wentrup, Curt (2014). New year editorial 2014. Australian Journal of Chemistry, 67 (1), 1-2. doi: 10.1071/CH13677
2014
Journal Article
Nitrene-carbene-carbene rearrangement. photolysis and thermolysis of tetrazolo[5,1- a ]phthalazine with formation of 1-phthalazinylnitrene, o-cyanophenylcarbene, and phenylcyanocarbene
Hoj, Martin, Kvaskoff, David and Wentrup, Curt (2014). Nitrene-carbene-carbene rearrangement. photolysis and thermolysis of tetrazolo[5,1- a ]phthalazine with formation of 1-phthalazinylnitrene, o-cyanophenylcarbene, and phenylcyanocarbene. Journal of Organic Chemistry, 79 (1), 307-313. doi: 10.1021/jo402448u
2014
Journal Article
Formation of allenyl ketones, 3-ethynylcoumarins, and arylfurans, furylfurans, and furylthiophenes by flash vacuum thermolysis of 3-methylidenefuran-2(3 H)-ones
Koch, Rainer, Berstermann, Hans Michael and Wentrup, Curt (2014). Formation of allenyl ketones, 3-ethynylcoumarins, and arylfurans, furylfurans, and furylthiophenes by flash vacuum thermolysis of 3-methylidenefuran-2(3 H)-ones. Journal of Organic Chemistry, 79 (1), 65-71. doi: 10.1021/jo402139a
2014
Conference Publication
Sydnone photochemistry: Direct observation of earl's bicyclic lactone valence isomers (oxadiazabicyclo[2.1.0] pentanones), formation of carbodiimides, reaction mechanism, and photochromism
Veedu, Rakesh N., Kvaskoff, David and Wentrup, Curt (2014). Sydnone photochemistry: Direct observation of earl's bicyclic lactone valence isomers (oxadiazabicyclo[2.1.0] pentanones), formation of carbodiimides, reaction mechanism, and photochromism. 6th Heron Island Conference on Reactive Intermediates and Unusual Molecules, Heron Island, Qld, Australia, 7 - 13 July 2013. Collingwood, VIC Australia: CSIRO. doi: 10.1071/CH13536
2014
Journal Article
C8H6 thermal chemistry. 7-Methylenecyclohepta-1,3,5- dienyne (heptafulvyne) by flash vacuum thermolysis]matrix isolation. Chemical activation in the rearrangements of phenylenedicarbenes and of benzocyclobutadiene to phenylacetylene
Kuhn, Arvid, Miura, Daisuke, Tomioka, Hideo and Wentrup, Curt (2014). C8H6 thermal chemistry. 7-Methylenecyclohepta-1,3,5- dienyne (heptafulvyne) by flash vacuum thermolysis]matrix isolation. Chemical activation in the rearrangements of phenylenedicarbenes and of benzocyclobutadiene to phenylacetylene. Australian Journal of Chemistry, 67 (8-9), 1174-1179. doi: 10.1071/CH13670
2014
Conference Publication
Reactions of adamantanethione with ketenes: Formation of a 1,3,5-dioxathiane
Drinnan, Nicholas and Wentrup, Curt (2014). Reactions of adamantanethione with ketenes: Formation of a 1,3,5-dioxathiane. 6th Heron Island Conference on Reactive Intermediates and Unusual Molecules, Heron Island, QLD, Australia, 7-13 July 2013. Collingwood, VIC Australia: CSIRO. doi: 10.1071/CH13449
2014
Journal Article
Roger F. C. Brown Memorial Issue
Wentrup, Curt (2014). Roger F. C. Brown Memorial Issue. Australian Journal of Chemistry, 67 (8-9), 1139-1141. doi: 10.1071/CH14419
Funding
Supervision
Availability
- Emeritus Professor Curt Wentrup is:
- Not available for supervision
Supervision history
Completed supervision
-
2006
Doctor Philosophy
SYNTHESES AND REACTIONS OF IMINOPROPADIENONES, SYDNONES AND OXAZINONES
Principal Advisor
Other advisors: Professor Craig Williams
-
2002
Doctor Philosophy
HETEROCYCLIC SYNTHESIS BASED ON IMINOPROPADIENONES
Principal Advisor
-
2002
Doctor Philosophy
SYNTHESIS AND CHARACTERISATION OF 1,3- and 1,4- DIAZEPINES AND DERIVATIVES
Principal Advisor
-
Doctor Philosophy
NITRENES REARRANGEMENTS: FORMATION OF REACTIVE INTERMEDIATES AND UNUSUAL MOLECULES
Principal Advisor
Other advisors: Professor Craig Williams
Media
Enquiries
Contact Emeritus Professor Curt Wentrup directly for media enquiries about:
- Organic reaction mechanisms
- Photochemistry
- Pyrolysis
- Reactive intermediates
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