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Dr Alex Smith
Dr

Alex Smith

Email: 

Overview

Background

Dr. Alex Smith is a Research Fellow at UQ's School of Chemical Engineering. His interests are in understanding structure: function relationships between complex carbohydrates (such as heparan sulphate) and proteins, and how these interactions can inform the development of glycotherapeutic agents to treat a wide variety of injuries and diseases.

Availability

Dr Alex Smith is:
Available for supervision

Research interests

  • Heparan sulphate and other glycosaminoglycans

    Understanding structure: function relationships between complex carbohydrates such as heparan sulphate and the myriad of proteins to which heparan sulphate binds. Specifically, assessing interactions between heparan sulphate and proteins involved in wound healing, inflammation, cell survival, and differentiation.

  • Cell membrane engineering

    Developing novel strategies for cell membrane engineering using glycoconjugates to influence cell behaviour.

  • Glycotherapeutics

    Assessing the potential of using heparan sulphate and synthetic heparan sulphate mimetics in the treatment of numerous diseases, injuries, and as media additives in the expansion of therapeutically relevant cell types.

Works

Search Professor Alex Smith’s works on UQ eSpace

32 works between 2011 and 2024

1 - 20 of 32 works

Featured

2023

Journal Article

Enhancing BMP-2-mediated osteogenesis with a synthetic heparan sulfate mimetic

Smith, Raymond A. A., Luo, Xiaoman, Lu, Xiaohua, Tan, Tuan Chun, Le, Bach Q., Zubkova, Olga V., Tyler, Peter C., Nurcombe, Victor and Cool, Simon M. (2023). Enhancing BMP-2-mediated osteogenesis with a synthetic heparan sulfate mimetic. Biomaterials Advances, 155 213671, 1-17. doi: 10.1016/j.bioadv.2023.213671

Enhancing BMP-2-mediated osteogenesis with a synthetic heparan sulfate mimetic

Featured

2020

Journal Article

Heparan sulfate proteoglycans: key mediators of stem cell function

Ravikumar, Maanasa, Smith, Raymond Alexander Alfred, Nurcombe, Victor and Cool, Simon M. (2020). Heparan sulfate proteoglycans: key mediators of stem cell function. Frontiers in Cell and Developmental Biology, 8 581213, 581213. doi: 10.3389/fcell.2020.581213

Heparan sulfate proteoglycans: key mediators of stem cell function

Featured

2018

Journal Article

Minimum structural requirements for BMP-2-binding of heparin oligosaccharides

Smith, Raymond A.A., Murali, Sadasivam, Rai, Bina, Lu, Xiaohua, Lim, Zophia Xue Hui, Lee, Jaslyn J.L., Nurcombe, Victor and Cool, Simon M. (2018). Minimum structural requirements for BMP-2-binding of heparin oligosaccharides. Biomaterials, 184, 41-55. doi: 10.1016/j.biomaterials.2018.08.056

Minimum structural requirements for BMP-2-binding of heparin oligosaccharides

Featured

2014

Journal Article

Glycocalyx remodeling with proteoglycan mimetics promotes neural specification in embryonic stem cells

Huang, Mia L., Smith, Raymond A. A., Trieger, Greg W. and Godula, Kamil (2014). Glycocalyx remodeling with proteoglycan mimetics promotes neural specification in embryonic stem cells. Journal of the American Chemical Society, 136 (30), 10565-10568. doi: 10.1021/ja505012a

Glycocalyx remodeling with proteoglycan mimetics promotes neural specification in embryonic stem cells

2024

Journal Article

Amphiphilic heparinoids as potent antiviral agents against SARS-CoV-2

Chhabra, Mohit, Shanthamurthy, Chethan D., Kumar, Nanjudaswamy Vijendra, Mardhekar, Sandhya, Vishweshwara, Sharath S., Wimmer, Norbert, Modhiran, Naphak, Watterson, Daniel, Amarilla, Alberto A., Cha, Jonathan S., Beckett, James R., De Voss, James J., Kayal, Yasmin, Vlodavsky, Israel, Dorsett, Lauren R., Smith, Raymond A. A., Gandhi, Neha S., Kikkeri, Raghavendra and Ferro, Vito (2024). Amphiphilic heparinoids as potent antiviral agents against SARS-CoV-2. Journal of Medicinal Chemistry, 67 (14), 11885-11916. doi: 10.1021/acs.jmedchem.4c00487

Amphiphilic heparinoids as potent antiviral agents against SARS-CoV-2

2024

Conference Publication

Preserving clinical efficacy of mesenchymal stem cells with glycosaminoglycan additives

Shokoohmand, A., Srinivasan, A., Ling, L., Silva, F. Rodrigues de Oliveira, Eio, M.Y., Lu, X., Loberas, M., Tao, K., Tan, C., Nurcombe, V., Hui, J., Smith, R. and Cool, S. (2024). Preserving clinical efficacy of mesenchymal stem cells with glycosaminoglycan additives. 30th Annual ISCT Meeting, Vancouver, BC, Canada, 29 May - 1 June 2024. Oxford, United Kingdom: Elsevier. doi: 10.1016/j.jcyt.2024.03.116

Preserving clinical efficacy of mesenchymal stem cells with glycosaminoglycan additives

2024

Journal Article

Rational synthesis of a heparan sulfate saccharide that promotes the activity of BMP2

Shaffer, Karl J., Smith, Raymond A. A., Daines, Alison M., Luo, Xiaoman, Lu, Xiaohua, Tan, Tuan Chun, Le, Bach Q., Schwörer, Ralf, Hinkley, Simon F. R., Tyler, Peter C., Nurcombe, Victor and Cool, Simon M. (2024). Rational synthesis of a heparan sulfate saccharide that promotes the activity of BMP2. Carbohydrate Polymers, 333 121979, 121979. doi: 10.1016/j.carbpol.2024.121979

Rational synthesis of a heparan sulfate saccharide that promotes the activity of BMP2

2023

Journal Article

Affinity-selected heparan sulfate collagen device promotes periodontal regeneration in an intrabony defect model in Macaca fascicularis

Luo, Xiaoman, Lau, Chau Sang, Le, Bach Quang, Tan, Tuan Chun, Too, Jian Hui, Smith, Raymond Alexander Alfred, Yu, Na and Cool, Simon M. (2023). Affinity-selected heparan sulfate collagen device promotes periodontal regeneration in an intrabony defect model in Macaca fascicularis. Scientific Reports, 13 (1) 11774, 1-15. doi: 10.1038/s41598-023-38818-y

Affinity-selected heparan sulfate collagen device promotes periodontal regeneration in an intrabony defect model in Macaca fascicularis

2023

Journal Article

Bioactive polyethylene by ring opening metathesis polymerization for potential orthopaedic applications

Guo, Jiayi, Park, Eun Ju, Teo, Yew Chin, Abbas, Asyraf, Goh, Denise, Smith, Raymond Alexander Alfred, Nie, Yuntong, Nguyen, Hang T. L., Yeong, Joe Poh Sheng, Cool, Simon, Haruyuki, Makio and Teo, Peili (2023). Bioactive polyethylene by ring opening metathesis polymerization for potential orthopaedic applications. Polymer Chemistry, 14 (15), 1743-1751. doi: 10.1039/d2py01545e

Bioactive polyethylene by ring opening metathesis polymerization for potential orthopaedic applications

2022

Journal Article

Bioactive PCL-peptide and PLA-peptide brush copolymers for bone tissue engineering

Teo, Yew Chin, Park, Eun Ju, Guo, Jiayi, Abbas, Asyraf, Smith, Raymond Alexander Alfred, Goh, Denise, Yeong, Joe Poh Sheng, Cool, Simon and Teo, Peili (2022). Bioactive PCL-peptide and PLA-peptide brush copolymers for bone tissue engineering. ACS Applied Bio Materials, 5 (10), 4770-4778. doi: 10.1021/acsabm.2c00455

Bioactive PCL-peptide and PLA-peptide brush copolymers for bone tissue engineering

2022

Journal Article

Strategies to enhance immunomodulatory properties and reduce heterogeneity in mesenchymal stromal cells during ex vivo expansion

Srinivasan, Akshaya, Sathiyanathan, Padmapriya, Yin, Lu, Liu, Tong Ming, Lam, Alan, Ravikumar, Maanasa, Smith, Raymond Alexander Alfred, Loh, Han Ping, Zhang, Ying, Ling, Ling, Ng, Say Kong, Yang, Yuan Sheng, Lezhava, Alexander, Hui, James, Oh, Steve and Cool, Simon M. (2022). Strategies to enhance immunomodulatory properties and reduce heterogeneity in mesenchymal stromal cells during ex vivo expansion. Cytotherapy, 24 (5), 456-472. doi: 10.1016/j.jcyt.2021.11.009

Strategies to enhance immunomodulatory properties and reduce heterogeneity in mesenchymal stromal cells during ex vivo expansion

2022

Journal Article

Variability in the composition of porcine mucosal heparan sulfates

Sargison, Liam, Smith, Raymond A A, Carnachan, Susan M, Daines, Alison M, Brackovic, Amira, Kidgell, Joel T, Nurcombe, Victor, Cool, Simon M, Sims, Ian M and Hinkley, Simon F R (2022). Variability in the composition of porcine mucosal heparan sulfates. Carbohydrate Polymers, 282 119081, 119081. doi: 10.1016/j.carbpol.2021.119081

Variability in the composition of porcine mucosal heparan sulfates

2021

Journal Article

Application of a BMP2-binding heparan sulphate to promote periodontal regeneration

Le, B. Q., Too, J. H., Tan, T. C., Smith, R. A. A., Nurcombe, , Cool, S. M. and Yu, N. (2021). Application of a BMP2-binding heparan sulphate to promote periodontal regeneration. European Cells and Materials, 42, 139-153. doi: 10.22203/eCM.v042a10

Application of a BMP2-binding heparan sulphate to promote periodontal regeneration

2020

Journal Article

Vascular endothelial growth factor 165-binding heparan sulfate promotes functional recovery from cerebral ischemia

Chan, Su Jing, Esposito, Elga, Hayakawa, Kazuhide, Mandaville, Emiri, Smith, Raymond A. A., Guo, Shuzhen, Niu, Wanting, Wong, Peter Tsun-Hong, Cool, Simon M., Lo, Eng H. and Nurcombe, Victor (2020). Vascular endothelial growth factor 165-binding heparan sulfate promotes functional recovery from cerebral ischemia. Stroke, 51 (9), 2844-2853. doi: 10.1161/STROKEAHA.119.025304

Vascular endothelial growth factor 165-binding heparan sulfate promotes functional recovery from cerebral ischemia

2020

Journal Article

A synthetic heparan sulphate mimetic for enhancing BMP-2-mediated osteogenesis and bone regeneration

Smith, R.A., Lu, X., Tan, T., Luo, X., Le, B.Q., Zubkova, O.V., Cool, S. and Nurcombe, V. (2020). A synthetic heparan sulphate mimetic for enhancing BMP-2-mediated osteogenesis and bone regeneration. Cytotherapy, 22 (5), S32-S32. doi: 10.1016/j.jcyt.2020.03.017

A synthetic heparan sulphate mimetic for enhancing BMP-2-mediated osteogenesis and bone regeneration

2020

Journal Article

Enhancing the efficacy of stem cell therapy with glycosaminoglycans

Ling, Ling, Ren, Xiafei, Cao, Xue, Hassan, Afizah Binte Mohd, Mah, Sophia, Sathiyanathan, Padmapriya, Smith, Raymond A. A., Tan, Clarissa L. L., Eio, Michelle, Samsonraj, Rebekah M., Van Wijnen, Andre J., Raghunath, Michael, Nurcombe, Victor, Hui, James H. and Cool, Simon M. (2020). Enhancing the efficacy of stem cell therapy with glycosaminoglycans. Stem Cell Reports, 14 (1), 105-121. doi: 10.1016/j.stemcr.2019.12.003

Enhancing the efficacy of stem cell therapy with glycosaminoglycans

2019

Journal Article

Bringing heparan sulfate glycomics together with proteomics for the design of novel therapeutics: A historical perspective

Nurcombe, Victor, Ling, Ling, Hondermarck, Hubert, Cool, Simon M. and Smith, Raymond A. A. (2019). Bringing heparan sulfate glycomics together with proteomics for the design of novel therapeutics: A historical perspective. Proteomics, 19 (21-22) 1800466, 1800466. doi: 10.1002/pmic.201800466

Bringing heparan sulfate glycomics together with proteomics for the design of novel therapeutics: A historical perspective

2019

Conference Publication

Biomimicry of glycosaminoglycans in the bone marrow microenvironment favour the expansion of highly potent human mesenchymal stem cells

Ling, L., Ren, X., Hassan, A. Binte Mohd, Mah, S., Smith, R. A., Tan, C., van Wijnen, A., Raghunath, M., Nurcombe, V., Hui, J. and Cool, S. (2019). Biomimicry of glycosaminoglycans in the bone marrow microenvironment favour the expansion of highly potent human mesenchymal stem cells. ISCT 2019, Melbourne, VIC, Australia, 29 May - 1 June 2019. Oxford, United Kingdom: Elsevier. doi: 10.1016/j.jcyt.2019.03.463

Biomimicry of glycosaminoglycans in the bone marrow microenvironment favour the expansion of highly potent human mesenchymal stem cells

2019

Journal Article

A heparan sulfate device for the regeneration of osteochondral defects

Lee, Jonathan H., Luo, Xiaoman, Ren, Xiafei, Tan, Tuan Chun, Smith, Raymond A.A., Swaminathan, Kunchithapadam, Sekar, Sakthivel, Bhakoo, Kishore, Nurcombe, Victor, Hui, James H. and Cool, Simon M. (2019). A heparan sulfate device for the regeneration of osteochondral defects. Tissue Engineering - Part A, 25 (5-6), 352-363. doi: 10.1089/ten.tea.2018.0171

A heparan sulfate device for the regeneration of osteochondral defects

2018

Journal Article

Dendrimer heparan sulfate glycomimetics: potent heparanase inhibitors for anticancer therapy

Zubkova, Olga V., Ahmed, Yassir A., Guimond, Scott E., Noble, Sophia-Louise, Miller, John Holmes, Smith, Raymond Alexander Alfred, Nurcombe, Victor, Tyler, Peter C., Weissmann, Marina, Vlodavsky, Israel and Turnbull, Jeremy E. (2018). Dendrimer heparan sulfate glycomimetics: potent heparanase inhibitors for anticancer therapy. ACS Chemical Biology, 13 (12), 3236-3242. doi: 10.1021/acschembio.8b00909

Dendrimer heparan sulfate glycomimetics: potent heparanase inhibitors for anticancer therapy

Funding

Past funding

  • 2023
    Developing good manufacturing practice (GMP) methods for the isolation and characterisation of glycotherapeutics for clinical translation (MTPConnect REDI Program grant administered by MTP-IIGC)
    MTPConnect
    Open grant

Supervision

Availability

Dr Alex Smith is:
Available for supervision

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Supervision history

Current supervision

Media

Enquiries

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communications@uq.edu.au