Overview
Background
Dr. Alex Smith is a Research Fellow at UQ's School of Chemical Engineering. His interests are in understanding structure: function relationships between complex carbohydrates (such as heparan sulphate) and proteins, and how these interactions can inform the development of glycotherapeutic agents to treat a wide variety of injuries and diseases.
Availability
- Dr Alex Smith is:
- Available for supervision
Fields of research
Research interests
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Heparan sulphate and other glycosaminoglycans
Understanding structure: function relationships between complex carbohydrates such as heparan sulphate and the myriad of proteins to which heparan sulphate binds. Specifically, assessing interactions between heparan sulphate and proteins involved in wound healing, inflammation, cell survival, and differentiation.
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Cell membrane engineering
Developing novel strategies for cell membrane engineering using glycoconjugates to influence cell behaviour.
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Glycotherapeutics
Assessing the potential of using heparan sulphate and synthetic heparan sulphate mimetics in the treatment of numerous diseases, injuries, and as media additives in the expansion of therapeutically relevant cell types.
Works
Search Professor Alex Smith’s works on UQ eSpace
2018
Journal Article
Dendrimer heparan sulfate glycomimetics: potent heparanase inhibitors for anticancer therapy
Zubkova, Olga V., Ahmed, Yassir A., Guimond, Scott E., Noble, Sophia-Louise, Miller, John Holmes, Smith, Raymond Alexander Alfred, Nurcombe, Victor, Tyler, Peter C., Weissmann, Marina, Vlodavsky, Israel and Turnbull, Jeremy E. (2018). Dendrimer heparan sulfate glycomimetics: potent heparanase inhibitors for anticancer therapy. ACS Chemical Biology, 13 (12), 3236-3242. doi: 10.1021/acschembio.8b00909
2018
Journal Article
Improved recovery from limb ischaemia by delivery of an affinity-isolated heparan sulphate
Poon, Selina, Lu, Xiaohua, Smith, Raymond A. A., Ho, Pei, Bhakoo, Kishore, Nurcombe, Victor and Cool, Simon M. (2018). Improved recovery from limb ischaemia by delivery of an affinity-isolated heparan sulphate. Angiogenesis, 21 (4), 777-791. doi: 10.1007/s10456-018-9622-9
2018
Journal Article
Retention of the structure and function of heparan sulfate biomaterials after gamma irradiation
Smith, Raymond A. A., Chua, R. J. E., Carnachan, Susan M., Tan, Clarissa L. L., Sims, Ian M., Hinkley, Simon F. R., Nurcombe, Victor and Cool, Simon M. (2018). Retention of the structure and function of heparan sulfate biomaterials after gamma irradiation. Tissue Engineering - Part A, 24 (9-10), 729-739. doi: 10.1089/ten.tea.2017.0263
2018
Conference Publication
Harnessing glycocalyx interactions to modulate differentiation and development
Huang, Mia L., Michalak, Austen L., Tota, Ember M., Smith, Raymond Alexander, Trieger, Greg W. and Godula, Kamil (2018). Harnessing glycocalyx interactions to modulate differentiation and development. Experimental Biology 2018 Meeting, San Diego, CA United States, 21-25 April 2018. Hoboken, NJ United States: John Wiley & Sons. doi: 10.1096/fasebj.2018.32.1_supplement.673.16
2018
Journal Article
Small molecule antagonist of cell surface glycosaminoglycans restricts mouse embryonic stem cells in a pluripotent state
Huang, Mia L., Michalak, Austen L., Fisher, Christopher J., Christy, Mitchell, Smith, Raymond A. A. and Godula, Kamil (2018). Small molecule antagonist of cell surface glycosaminoglycans restricts mouse embryonic stem cells in a pluripotent state. Stem Cells, 36 (1), 45-54. doi: 10.1002/stem.2714
2017
Journal Article
Growth differentiation factor 5-mediated enhancement of chondrocyte phenotype is inhibited by heparin: implications for the use of heparin in the clinic and in tissue engineering applications
Ayerst, Bethanie I., Smith, Raymond A.A., Nurcombe, Victor, Day, Anthony J., Merry, Catherine L.R. and Cool, Simon M. (2017). Growth differentiation factor 5-mediated enhancement of chondrocyte phenotype is inhibited by heparin: implications for the use of heparin in the clinic and in tissue engineering applications. Tissue Engineering - Part A, 23 (7-8), 275-292. doi: 10.1089/ten.tea.2016.0364
2016
Journal Article
Determining the extent of heparan sulfate depolymerisation following heparin lyase treatment
Carnachan, Susan M., Bell, Tracey J., Sims, Ian M., Smith, Raymond A.A., Nurcombe, Victor, Cool, Simon M. and Hinkley, Simon F.R. (2016). Determining the extent of heparan sulfate depolymerisation following heparin lyase treatment. Carbohydrate Polymers, 152, 592-597. doi: 10.1016/j.carbpol.2016.07.024
2016
Conference Publication
Glycocalyx based strategies to modulate embryonic stem cell fates
Huang, Mia, Godula, Kamil, Smith, Raymond, Christy, Mitchell, Fisher, Christopher and Michalak, Austen (2016). Glycocalyx based strategies to modulate embryonic stem cell fates. ACS Spring 2016 Meeting, San Diego, CA United States, 13 - 17 March 2016. Washington, DC United States: American Chemical Society.
2016
Book Chapter
Glycocalyx remodeling with glycopolymer-based proteoglycan mimetics
Huang, Mia L., Smith, Raymond A. A., Trieger, Greg W. and Godula, Kamil (2016). Glycocalyx remodeling with glycopolymer-based proteoglycan mimetics. Macro-glycoligands: methods and protocols. (pp. 207-224) edited by Xue-Long Sun. New York, NY, United States: Humana Press. doi: 10.1007/978-1-4939-3130-9_17
2015
Journal Article
Structural determinants of heparin-transforming growth factor-β1 interactions and their effects on signaling
Lee, Jonathan, Wee, Sheena, Gunaratne, Jayantha, Chua, R. J. E., Smith, Raymond A. A., Ling, Ling, Fernig, David G., Swaminathan, Kunchithapadam, Nurcombe, Victor and Cool, Simon M. (2015). Structural determinants of heparin-transforming growth factor-β1 interactions and their effects on signaling. Glycobiology, 25 (12), 1491-1504. doi: 10.1093/glycob/cwv064
2015
Journal Article
Use of flow cytometry for characterization and fractionation of cell populations based on their expression of heparan sulfate epitopes
Holley, Rebecca J., Smith, Raymond A., van de Westerlo, Els M. A., Pickford, Claire E., Merry, C. L. R. and van Kuppevelt, Toin H. (2015). Use of flow cytometry for characterization and fractionation of cell populations based on their expression of heparan sulfate epitopes. Glycosaminoglycans: Chemistry and Biology, 1229, 239-251. doi: 10.1007/978-1-4939-1714-3_21
2014
Conference Publication
Glycocalyx remodeling with synthetic proteoglycan mimetics promotes neural specification in embryonic stem cells
Godula, Kamil, Huang, Mia, Smith, Raymond and Trieger, Greg (2014). Glycocalyx remodeling with synthetic proteoglycan mimetics promotes neural specification in embryonic stem cells. Joint Meeting of the Society-for-Glycobiology (SFG) and the Japanese-Society-of-Carbohydrate-Research (JSCR), Honolulu, HI, United States, 16-19 November 2014. Cary, NC, United States: Oxford University Press.
2011
Journal Article
Glycosaminoglycans as regulators of stem cell differentiation
Smith, Raymond A. A., Meade, Kate, Pickford, Claire E., Holley, Rebecca J. and Merry, Catherine L. R. (2011). Glycosaminoglycans as regulators of stem cell differentiation. Biochemical Society Transactions, 39 (1), 383-387. doi: 10.1042/bst0390383
Funding
Past funding
Supervision
Availability
- Dr Alex Smith is:
- Available for supervision
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Supervision history
Current supervision
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Doctor Philosophy
Elucidating the effects of potency biomarkers on cellular reprogramming and differentiation in adult stem cells
Associate Advisor
Other advisors: Professor Nathan Palpant, Professor Simon Cool
Media
Enquiries
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