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Dr Philip Mosley
Dr

Philip Mosley

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Overview

Background

Dr Philip Mosley studied at the University of Oxford and obtained a masters degree in physiological sciences and a degree in medicine. He was also captain of the university boxing team and was awarded two full 'Blues'. He worked as a junior doctor in Manchester before moving to Australia to complete his specialist training in psychiatry.

Dr Mosley is a Fellow of the Royal Australian and New Zealand College of Psychiatry (RANZCP) and has completed an advanced certificate in Consultation-Liaison Psychiatry. As part of his training he also undertook a 2-year neuropsychiatry fellowship at the Royal Brisbane and Women’s Hospital (RBWH) and the Asia-Pacific Centre for Neuromodulation (APCN) at the University of Queensland. Currently, Dr Mosley works as a member of the deep brain stimulation (DBS) team at St Andrew's War Memorial Hospital, Brisbane, runs a private neuropsychiatry practice and also provides a consultation-liaison psychiatry service to the neurology, medical and surgical wards. Dr Mosley's private practice is focussed on neurodegenerative disease, movement disorders and head injury.

Dr Mosley is an active clinician-scientist with appointments at the QIMR Berghofer Medical Research Institute, Queensland Brain Institute and CSIRO. He completed his PhD in neuroscience in 2019 under the supervision of Professor Michael Breakspear. He published eleven peer-reviewed manuscripts and received the UQ Dean's Award for outstanding thesis. Dr Mosley has been the chief investigator in a study of the neuropsychiatric effects of DBS for Parkinson’s disease, in a study of medicinal cannabis for Tourette’s syndrome, a lead investigator in a clinical trial of DBS for obsessive-compulsive disorder and anorexia nervosa, as well as a clinical fellow in a neuroimaging study of Alzheimer’s disease. He has won prizes from the RANZCP in Old Age Psychiatry and Consultation-Liaison Psychiatry, and he has received research funding from the RBWH Foundation, the RANZCP Young Investigator Grant, Parkinson’s Queensland and Wesley Medical Research. Dr Mosley was awarded an ‘Advance Queensland’ Early Career Fellowship for his Parkinson's disease research and won the postgraduate medal from the Australian Society for Medical Research for findings arising from this project. In 2020, he won the Early Career Psychiatrist award from the RANZCP, which is presented to the fellow producing the most significant piece of research in the five years since fellowship. Currently Dr Mosley's research is funded by the National Health and Medical Research Council (NHMRC) and the Medical Research Future Fund.

If you wish to contact Dr Mosley regarding a clinical matter, please do so via his neuropsychiatry clinic (Neurosciences Queensland) telephone: 07 3839 3688 or email: admin@nsqld.com.au.

Availability

Dr Philip Mosley is:
Available for supervision

Research impacts

Dr Mosley is one of the most experienced psychiatrists in the world with regards to the practice of deep brain stimulation (DBS) and has been embedded as a psychiatrist in the DBS service in Brisbane since 2013. This centre is the largest in Australia and one of the largest worldwide (1200 devices implanted). Dr Mosley has improved the neuropsychiatric safety of DBS for Parkinson’s disease through individualised assessments of brain connectivity and stimulation field distribution. His rich dataset has been shared with European and US collaborators. During his PhD in neuroscience, Dr Mosley demarcated brain networks responsible for changes in mood after DBS and used mathematical modelling of human behaviour to discriminate those at risk of postoperative psychiatric complications. His work translates clinically to more accurate and effective use of neuromodulation, based on targeted recruitment of key neuronal pathways. Applying these methods to treatment-resistant obsessive-compulsive disorder, Dr Mosley characterised a brain connectivity fingerprint associated with clinically-significant response to DBS. This was a landmark Australian trial (Reg. U1111-1146-0992), establishing DBS as a viable treatment option for those with intractable symptoms. Positive outcomes from this sham-controlled trial have led to the first Australian trial of DBS for severe and enduring anorexia nervosa (Reg. U1111-1219-9348).

Completed Projects:

  1. Defining brain networks mediating psychiatric symptoms after subthalamic deep brain stimulation for Parkinson's disease.
  2. Predictors of caregiver burden after subthalamic deep brain stimulation for Parkinson's disease.
  3. Psychological interventions for caregivers after subthalamic deep brain stimulation for Parkinson's disease.
  4. Deep brain stimulation of the nucleus accumbens for severe, treatment-resistant, obsessive-compulsive disorder.
  5. A randomised, double-blind, placebo-controlled crossover trial of medicinal cannabis for Tourette's syndrome.
  6. Neuroimaging biomarkers of early Alzheimer's disease.

Current Projects:

  1. Deep brain stimulation of the bed nucleus of the stria terminalis for severe obsessive-compulsive disorder (recruiting).
  2. Transcranial focussed ultrasound for severe obsessive-compulsive disorder (recruiting).

Works

Search Professor Philip Mosley’s works on UQ eSpace

52 works between 2009 and 2024

1 - 20 of 52 works

2024

Journal Article

Markers of positive affect and brain state synchrony discriminate melancholic from non-melancholic depression using naturalistic stimuli

Mosley, Philip E., van der Meer, Johan N., Hamilton, Lachlan H. W., Fripp, Jurgen, Parker, Stephen, Jeganathan, Jayson, Breakspear, Michael, Parker, Richard, Holland, Rebecca, Mitchell, Brittany L., Byrne, Enda, Hickie, Ian B., Medland, Sarah E., Martin, Nicholas G. and Cocchi, Luca (2024). Markers of positive affect and brain state synchrony discriminate melancholic from non-melancholic depression using naturalistic stimuli. Molecular Psychiatry. doi: 10.1038/s41380-024-02699-y

Markers of positive affect and brain state synchrony discriminate melancholic from non-melancholic depression using naturalistic stimuli

2024

Journal Article

Tractography-Based Deep Brain Stimulation for Obsessive-Compulsive Disorder

Meyer, Garance M. and Mosley, Philip E. (2024). Tractography-Based Deep Brain Stimulation for Obsessive-Compulsive Disorder. Biological Psychiatry, 96 (2), 80-81. doi: 10.1016/j.biopsych.2024.05.009

Tractography-Based Deep Brain Stimulation for Obsessive-Compulsive Disorder

2024

Journal Article

Caregiver burden in Parkinson disease: a scoping review of the literature from 2017-2022

Aamodt, Whitley W., Kluger, Benzi M., Mirham, Miray, Job, Anna, Lettenberger, Samantha E., Mosley, Philip E. and Seshadri, Sandhya (2024). Caregiver burden in Parkinson disease: a scoping review of the literature from 2017-2022. Journal of Geriatric Psychiatry and Neurology, 37 (2), 96-113. doi: 10.1177/08919887231195219

Caregiver burden in Parkinson disease: a scoping review of the literature from 2017-2022

2024

Journal Article

Generation of novel ideas: creativity in Alzheimer’s disease, mild cognitive impairment, and healthy older adults

Marsh, Georgia, Aung, Ohnmar, Ceslis, Amelia, Adam, Robert, Mosley, Philip, Fripp, Jurgen and Robinson, Gail A. (2024). Generation of novel ideas: creativity in Alzheimer’s disease, mild cognitive impairment, and healthy older adults. Creativity Research Journal, 1-16. doi: 10.1080/10400419.2024.2304498

Generation of novel ideas: creativity in Alzheimer’s disease, mild cognitive impairment, and healthy older adults

2024

Journal Article

Deep Brain Stimulation for Obsessive-Compulsive Disorder: Optimal Stimulation Sites

Meyer, Garance M., Hollunder, Barbara, Li, Ningfei, Butenko, Konstantin, Dembek, Till A., Hart, Lauren, Nombela, Cristina, Mosley, Philip, Akram, Harith, Acevedo, Nicola, Borron, Benjamin M., Chou, Tina, Castaño Montoya, Juan Pablo, Strange, Bryan, Barcia, Juan A., Tyagi, Himanshu, Castle, David J., Smith, Andrew H., Choi, Ki Sueng, Kopell, Brian H., Mayberg, Helen S., Sheth, Sameer A., Goodman, Wayne, Leentjens, Albert F.G., Richardson, R. Mark, Rossell, Susan L., Bosanac, Peter, Cosgrove, G. Rees, Kuhn, Jens ... Horn, Andreas (2024). Deep Brain Stimulation for Obsessive-Compulsive Disorder: Optimal Stimulation Sites. Biological Psychiatry, 96 (2), 101-113. doi: 10.1016/j.biopsych.2023.12.010

Deep Brain Stimulation for Obsessive-Compulsive Disorder: Optimal Stimulation Sites

2023

Journal Article

Cerebellar volume and disease staging in Parkinson's disease: an ENIGMA-PD study

Kerestes, Rebecca, Laansma, Max A., Owens-Walton, Conor, Perry, Andrew, van Heese, Eva M., Al-Bachari, Sarah, Anderson, Tim J., Assogna, Francesca, Aventurato, Ítalo K., van Balkom, Tim D., Berendse, Henk W., van den Berg, Kevin R.E., Betts, Rebecca, Brioschi, Ricardo, Carr, Jonathan, Cendes, Fernando, Clark, Lyles R., Dalrymple-Alford, John C., Dirkx, Michiel F., Druzgal, Jason, Durrant, Helena, Emsley, Hedley C.A., Garraux, Gaëtan, Haroon, Hamied A., Helmich, Rick C., van den Heuvel, Odile A., João, Rafael B., Johansson, Martin E., Khachatryan, Samson G. ... Harding, Ian H. (2023). Cerebellar volume and disease staging in Parkinson's disease: an ENIGMA-PD study. Movement Disorders, 38 (12), 2269-2281. doi: 10.1002/mds.29611

Cerebellar volume and disease staging in Parkinson's disease: an ENIGMA-PD study

2023

Journal Article

The Role of Apathy in Spontaneous Verbal and Nonverbal Behaviors: A Transdiagnostic Pilot Study in Neurodegeneration

Horne, Kristina S., Ceslis, Amelia, Mosley, Philip, Adam, Robert and Robinson, Gail A. (2023). The Role of Apathy in Spontaneous Verbal and Nonverbal Behaviors: A Transdiagnostic Pilot Study in Neurodegeneration. Cognitive and Behavioral Neurology, Publish Ahead of Print (3), 178-193. doi: 10.1097/wnn.0000000000000345

The Role of Apathy in Spontaneous Verbal and Nonverbal Behaviors: A Transdiagnostic Pilot Study in Neurodegeneration

2023

Journal Article

Tetrahydrocannabinol and cannabidiol in Tourette Syndrome

Mosley, Philip E., Webb, Lachlan, Suraev, Anastasia, Hingston, Leah, Turnbull, Tracy, Foster, Kelley, Ballard, Emma, Gomes, Lauren, Mohan, Adith, Sachdev, Perminder S., Kevin, Richard, Gordon, Rebecca, Benson, Melissa and McGregor, Iain S. (2023). Tetrahydrocannabinol and cannabidiol in Tourette Syndrome. NEJM Evidence, 2 (9). doi: 10.1056/evidoa2300012

Tetrahydrocannabinol and cannabidiol in Tourette Syndrome

2023

Journal Article

Functional network reorganization precedes apathy in Parkinson’s disease: a neural marker of risk?

Mosley, Philip E and Robinson, Gail A (2023). Functional network reorganization precedes apathy in Parkinson’s disease: a neural marker of risk?. Brain, 146 (7), 2661-2662. doi: 10.1093/brain/awad180

Functional network reorganization precedes apathy in Parkinson’s disease: a neural marker of risk?

2023

Journal Article

Evaluation of brain-body health in individuals with common neuropsychiatric disorders

Tian, Ye Ella, Di Biase, Maria A., Mosley, Philip E., Lupton, Michelle K., Xia, Ying, Fripp, Jurgen, Breakspear, Michael, Cropley, Vanessa and Zalesky, Andrew (2023). Evaluation of brain-body health in individuals with common neuropsychiatric disorders. JAMA Psychiatry, 80 (6), 567-576. doi: 10.1001/jamapsychiatry.2023.0791

Evaluation of brain-body health in individuals with common neuropsychiatric disorders

2022

Journal Article

Clinical recommendations for the care of people with treatment-refractory obsessive-compulsive disorder when undergoing deep brain stimulation

Acevedo, Nicola, Castle, David, Groves, Clare, Bosanac, Peter, Mosley, Philip E. and Rossell, Susan (2022). Clinical recommendations for the care of people with treatment-refractory obsessive-compulsive disorder when undergoing deep brain stimulation. Australian and New Zealand Journal of Psychiatry, 56 (10) ARTN 00048674221100947, 1219-1225. doi: 10.1177/00048674221100947

Clinical recommendations for the care of people with treatment-refractory obsessive-compulsive disorder when undergoing deep brain stimulation

2022

Journal Article

Deep brain stimulation for treatment-refractory obsessive-compulsive disorder: Opportunities and challenges

Mosley, Philip E., Velakoulis, Dennis, Farrand, Sarah, Marsh, Rodney, Mohan, Adith, Castle, David and Sachdev, Perminder (2022). Deep brain stimulation for treatment-refractory obsessive-compulsive disorder: Opportunities and challenges. Australian and New Zealand Journal of Psychiatry, 56 (11), 1523-1524. doi: 10.1177/00048674221109008

Deep brain stimulation for treatment-refractory obsessive-compulsive disorder: Opportunities and challenges

2022

Journal Article

Australian Parkinson’s Genetics Study (APGS): pilot (n=1532)

Bivol, Svetlana, Mellick, George D., Gratten, Jacob, Parker, Richard, Mulcahy, Aoibhe, Mosley, Philip E., Poortvliet, Peter C., Campos, Adrian I., Mitchell, Brittany L., Garcia-Marin, Luis M., Cross, Simone, Ferguson, Mary, Lind, Penelope A., Loesch, Danuta Z., Visscher, Peter M., Medland, Sarah E., Scherzer, Clemens R., Martin, Nicholas G. and Rentería, Miguel E. (2022). Australian Parkinson’s Genetics Study (APGS): pilot (n=1532). BMJ Open, 12 (2) e052032, e052032. doi: 10.1136/bmjopen-2021-052032

Australian Parkinson’s Genetics Study (APGS): pilot (n=1532)

2022

Journal Article

A snapshot of brain and cognition in healthy mid-life and older adults

Borne, Léonie, Lupton, Michelle K., Guo, Christine, Mosley, Philip, Adam, Robert, Ceslis, Amelia, Bourgeat, Pierrick, Fazlollahi, Amir , Maruff, Paul, Rowe, Christopher C., Masters, Colin L., Fripp, Jurgen , Robinson, Gail A. and Breakspear, Michael (2022). A snapshot of brain and cognition in healthy mid-life and older adults. bioRxiv. doi: 10.1101/2022.01.20.476706

A snapshot of brain and cognition in healthy mid-life and older adults

2022

Journal Article

Deep brain stimulation for obsessive–compulsive disorder: a crisis of access

Visser-Vandewalle, Veerle, Andrade, Pablo, Mosley, Philip E., Greenberg, Benjamin D., Schuurman, Rick, McLaughlin, Nicole C., Voon, Valerie, Krack, Paul, Foote, Kelly D., Mayberg, Helen S., Figee, Martijn, Kopell, Brian H., Polosan, Mircea, Joyce, Eileen M., Chabardes, Stephan, Matthews, Keith, Baldermann, Juan C., Tyagi, Himanshu, Holtzheimer, Paul E., Bervoets, Chris, Hamani, Clement, Karachi, Carine, Denys, Damiaan, Zrinzo, Ludvic, Blomstedt, Patric, Naesström, Matilda, Abosch, Aviva, Rasmussen, Steven, Coenen, Volker A. ... Okun, Michael S. (2022). Deep brain stimulation for obsessive–compulsive disorder: a crisis of access. Nature Medicine, 28 (8), 1529-1532. doi: 10.1038/s41591-022-01879-z

Deep brain stimulation for obsessive–compulsive disorder: a crisis of access

2021

Journal Article

Connectomic deep brain stimulation for obsessive-compulsive disorder

Baldermann, Juan Carlos, Schueller, Thomas, Kohl, Sina, Voon, Valerie, Li, Ningfei, Hollunder, Barbara, Figee, Martijn, Haber, Suzanne N., Sheth, Sameer A., Mosley, Philip E., Huys, Daniel, Johnson, Kara A., Butson, Christopher, Ackermans, Linda, Vlis, Tim Bouwens van der, Leentjens, Albert F. G., Barbe, Michael, Visser-Vandewalle, Veerle, Kuhn, Jens and Horn, Andreas (2021). Connectomic deep brain stimulation for obsessive-compulsive disorder. Biological Psychiatry, 90 (10), 678-688. doi: 10.1016/j.biopsych.2021.07.010

Connectomic deep brain stimulation for obsessive-compulsive disorder

2021

Journal Article

Deep brain stimulation for treatment-refractory obsessive-compulsive disorder should be an accepted therapy in Australia

Mosley, Philip E., Velakoulis, Dennis, Farrand, Sarah, Marsh, Rodney, Mohan, Adith, Castle, David and Sachdev, Perminder S. (2021). Deep brain stimulation for treatment-refractory obsessive-compulsive disorder should be an accepted therapy in Australia. Australian & New Zealand Journal of Psychiatry, 56 (5), 000486742110314-436. doi: 10.1177/00048674211031482

Deep brain stimulation for treatment-refractory obsessive-compulsive disorder should be an accepted therapy in Australia

2021

Journal Article

Welcome to the Breakfast Club: Building academic psychiatry capacity in Queensland

Suetani, Shuichi, Burgher, Bjorn, Mosley, Phil and Parker, Stephen (2021). Welcome to the Breakfast Club: Building academic psychiatry capacity in Queensland. Australian and New Zealand Journal of Psychiatry, 55 (11), 48674211025630-1032. doi: 10.1177/00048674211025630

Welcome to the Breakfast Club: Building academic psychiatry capacity in Queensland

2021

Journal Article

A randomised, double-blind, sham-controlled trial of deep brain stimulation of the bed nucleus of the stria terminalis for treatment-resistant obsessive-compulsive disorder

Mosley, Philip E., Windels, François, Morris, John, Coyne, Terry, Marsh, Rodney, Giorni, Andrea, Mohan, Adith, Sachdev, Perminder, O’Leary, Emily, Boschen, Mark, Sah, Pankaj and Silburn, Peter A. (2021). A randomised, double-blind, sham-controlled trial of deep brain stimulation of the bed nucleus of the stria terminalis for treatment-resistant obsessive-compulsive disorder. Translational Psychiatry, 11 (1) 190, 190. doi: 10.1038/s41398-021-01307-9

A randomised, double-blind, sham-controlled trial of deep brain stimulation of the bed nucleus of the stria terminalis for treatment-resistant obsessive-compulsive disorder

2021

Journal Article

Deep brain stimulation for refractory obsessive-compulsive disorder (OCD): emerging or established therapy?

Wu, Hemmings, Hariz, Marwan, Visser-Vandewalle, Veerle, Zrinzo, Ludvic, Coenen, Volker A., Sheth, Sameer A., Bervoets, Chris, Naesström, Matilda, Blomstedt, Patric, Coyne, Terry, Hamani, Clement, Slavin, Konstantin, Krauss, Joachim K., Kahl, Kai G., Taira, Takaomi, Zhang, Chencheng, Sun, Bomin, Toda, Hiroki, Schlaepfer, Thomas, Chang, Jin Woo, Régis, Jean, Schuurman, Rick, Schulder, Michael, Doshi, Paresh, Mosley, Philip, Poologaindran, Anujan, Lázaro-Muñoz, Gabriel, Pepper, Joshua, Schechtmann, Gaston ... Nuttin, Bart (2021). Deep brain stimulation for refractory obsessive-compulsive disorder (OCD): emerging or established therapy?. Molecular Psychiatry, 26 (1), 60-65. doi: 10.1038/s41380-020-00933-x

Deep brain stimulation for refractory obsessive-compulsive disorder (OCD): emerging or established therapy?

Supervision

Availability

Dr Philip Mosley is:
Available for supervision

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Media

Enquiries

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