
Overview
Background
Dr Philip Mosley studied at the University of Oxford and obtained a masters degree in physiological sciences and a degree in medicine. He was also captain of the university boxing team and was awarded two full 'Blues'. He worked as a junior doctor in Manchester before moving to Australia to complete his specialist training in psychiatry.
Dr Mosley is a Fellow of the Royal Australian and New Zealand College of Psychiatry (RANZCP) and has completed an advanced certificate in Consultation-Liaison Psychiatry. As part of his training he also undertook a 2-year neuropsychiatry fellowship at the Royal Brisbane and Women’s Hospital (RBWH) and the Asia-Pacific Centre for Neuromodulation (APCN) at the University of Queensland. Currently, Dr Mosley works as a member of the deep brain stimulation (DBS) team at St Andrew's War Memorial Hospital, Brisbane, runs a private neuropsychiatry practice and also provides a consultation-liaison psychiatry service to the neurology, medical and surgical wards. Dr Mosley's private practice is focussed on neurodegenerative disease, movement disorders and head injury.
Dr Mosley is an active clinician-scientist with appointments at the QIMR Berghofer Medical Research Institute, Queensland Brain Institute and CSIRO. He completed his PhD in neuroscience in 2019 under the supervision of Professor Michael Breakspear. He published eleven peer-reviewed manuscripts and received the UQ Dean's Award for outstanding thesis. Dr Mosley has been the chief investigator in a study of the neuropsychiatric effects of DBS for Parkinson’s disease, in a study of medicinal cannabis for Tourette’s syndrome, a lead investigator in a clinical trial of DBS for obsessive-compulsive disorder and anorexia nervosa, as well as a clinical fellow in a neuroimaging study of Alzheimer’s disease. He has won prizes from the RANZCP in Old Age Psychiatry and Consultation-Liaison Psychiatry, and he has received research funding from the RBWH Foundation, the RANZCP Young Investigator Grant, Parkinson’s Queensland and Wesley Medical Research. Dr Mosley was awarded an ‘Advance Queensland’ Early Career Fellowship for his Parkinson's disease research and won the postgraduate medal from the Australian Society for Medical Research for findings arising from this project. In 2020, he won the Early Career Psychiatrist award from the RANZCP, which is presented to the fellow producing the most significant piece of research in the five years since fellowship. Currently Dr Mosley's research is funded by the National Health and Medical Research Council (NHMRC) and the Medical Research Future Fund.
If you wish to contact Dr Mosley regarding a clinical matter, please do so via his neuropsychiatry clinic (Neurosciences Queensland) telephone: 07 3839 3688 or email: admin@nsqld.com.au.
Availability
- Dr Philip Mosley is:
- Available for supervision
Fields of research
Research impacts
Dr Mosley is one of the most experienced psychiatrists in the world with regards to the practice of deep brain stimulation (DBS) and has been embedded as a psychiatrist in the DBS service in Brisbane since 2013. This centre is the largest in Australia and one of the largest worldwide (1200 devices implanted). Dr Mosley has improved the neuropsychiatric safety of DBS for Parkinson’s disease through individualised assessments of brain connectivity and stimulation field distribution. His rich dataset has been shared with European and US collaborators. During his PhD in neuroscience, Dr Mosley demarcated brain networks responsible for changes in mood after DBS and used mathematical modelling of human behaviour to discriminate those at risk of postoperative psychiatric complications. His work translates clinically to more accurate and effective use of neuromodulation, based on targeted recruitment of key neuronal pathways. Applying these methods to treatment-resistant obsessive-compulsive disorder, Dr Mosley characterised a brain connectivity fingerprint associated with clinically-significant response to DBS. This was a landmark Australian trial (Reg. U1111-1146-0992), establishing DBS as a viable treatment option for those with intractable symptoms. Positive outcomes from this sham-controlled trial have led to the first Australian trial of DBS for severe and enduring anorexia nervosa (Reg. U1111-1219-9348).
Completed Projects:
- Defining brain networks mediating psychiatric symptoms after subthalamic deep brain stimulation for Parkinson's disease.
- Predictors of caregiver burden after subthalamic deep brain stimulation for Parkinson's disease.
- Psychological interventions for caregivers after subthalamic deep brain stimulation for Parkinson's disease.
- Deep brain stimulation of the nucleus accumbens for severe, treatment-resistant, obsessive-compulsive disorder.
- A randomised, double-blind, placebo-controlled crossover trial of medicinal cannabis for Tourette's syndrome.
- Neuroimaging biomarkers of early Alzheimer's disease.
Current Projects:
- Deep brain stimulation of the bed nucleus of the stria terminalis for severe obsessive-compulsive disorder (recruiting).
- Transcranial focussed ultrasound for severe obsessive-compulsive disorder (recruiting).
Works
Search Professor Philip Mosley’s works on UQ eSpace
2024
Journal Article
The interplay of age, gender and amyloid on brain and cognition in mid-life and older adults
Borne, Léonie, Thienel, Renate, Lupton, Michelle K., Guo, Christine, Mosley, Philip, Behler, Anna, Giorgio, Joseph, Adam, Robert, Ceslis, Amelia, Bourgeat, Pierrick, Fazlollahi, Amir, Maruff, Paul, Rowe, Christopher C., Masters, Colin L., Fripp, Jurgen, Robinson, Gail A. and Breakspear, Michael (2024). The interplay of age, gender and amyloid on brain and cognition in mid-life and older adults. Scientific Reports, 14 (1) 27207, 1-15. doi: 10.1038/s41598-024-78308-3
2024
Journal Article
Markers of positive affect and brain state synchrony discriminate melancholic from non-melancholic depression using naturalistic stimuli
Mosley, Philip E., van der Meer, Johan N., Hamilton, Lachlan H. W., Fripp, Jurgen, Parker, Stephen, Jeganathan, Jayson, Breakspear, Michael, Parker, Richard, Holland, Rebecca, Mitchell, Brittany L., Byrne, Enda, Hickie, Ian B., Medland, Sarah E., Martin, Nicholas G. and Cocchi, Luca (2024). Markers of positive affect and brain state synchrony discriminate melancholic from non-melancholic depression using naturalistic stimuli. Molecular Psychiatry, 30 (3) 11605, 848-860. doi: 10.1038/s41380-024-02699-y
2024
Journal Article
Tractography-Based Deep Brain Stimulation for Obsessive-Compulsive Disorder
Meyer, Garance M. and Mosley, Philip E. (2024). Tractography-Based Deep Brain Stimulation for Obsessive-Compulsive Disorder. Biological Psychiatry, 96 (2), 80-81. doi: 10.1016/j.biopsych.2024.05.009
2024
Journal Article
Deep brain stimulation for obsessive-compulsive disorder: optimal stimulation sites
Meyer, Garance M., Hollunder, Barbara, Li, Ningfei, Butenko, Konstantin, Dembek, Till A., Hart, Lauren, Nombela, Cristina, Mosley, Philip, Akram, Harith, Acevedo, Nicola, Borron, Benjamin M., Chou, Tina, Castaño Montoya, Juan Pablo, Strange, Bryan, Barcia, Juan A., Tyagi, Himanshu, Castle, David J., Smith, Andrew H., Choi, Ki Sueng, Kopell, Brian H., Mayberg, Helen S., Sheth, Sameer A., Goodman, Wayne, Leentjens, Albert F.G., Richardson, R. Mark, Rossell, Susan L., Bosanac, Peter, Cosgrove, G. Rees, Kuhn, Jens ... Horn, Andreas (2024). Deep brain stimulation for obsessive-compulsive disorder: optimal stimulation sites. Biological Psychiatry, 96 (2), 101-113. doi: 10.1016/j.biopsych.2023.12.010
2024
Journal Article
Caregiver burden in Parkinson disease: a scoping review of the literature from 2017-2022
Aamodt, Whitley W., Kluger, Benzi M., Mirham, Miray, Job, Anna, Lettenberger, Samantha E., Mosley, Philip E. and Seshadri, Sandhya (2024). Caregiver burden in Parkinson disease: a scoping review of the literature from 2017-2022. Journal of Geriatric Psychiatry and Neurology, 37 (2), 96-113. doi: 10.1177/08919887231195219
2024
Journal Article
Generation of novel ideas: creativity in Alzheimer’s disease, mild cognitive impairment, and healthy older adults
Marsh, Georgia, Aung, Ohnmar, Ceslis, Amelia, Adam, Robert, Mosley, Philip, Fripp, Jurgen and Robinson, Gail A. (2024). Generation of novel ideas: creativity in Alzheimer’s disease, mild cognitive impairment, and healthy older adults. Creativity Research Journal, 1-16. doi: 10.1080/10400419.2024.2304498
2023
Journal Article
Cerebellar volume and disease staging in Parkinson's disease: an ENIGMA-PD study
Kerestes, Rebecca, Laansma, Max A., Owens-Walton, Conor, Perry, Andrew, van Heese, Eva M., Al-Bachari, Sarah, Anderson, Tim J., Assogna, Francesca, Aventurato, Ítalo K., van Balkom, Tim D., Berendse, Henk W., van den Berg, Kevin R.E., Betts, Rebecca, Brioschi, Ricardo, Carr, Jonathan, Cendes, Fernando, Clark, Lyles R., Dalrymple-Alford, John C., Dirkx, Michiel F., Druzgal, Jason, Durrant, Helena, Emsley, Hedley C.A., Garraux, Gaëtan, Haroon, Hamied A., Helmich, Rick C., van den Heuvel, Odile A., João, Rafael B., Johansson, Martin E., Khachatryan, Samson G. ... Harding, Ian H. (2023). Cerebellar volume and disease staging in Parkinson's disease: an ENIGMA-PD study. Movement Disorders, 38 (12), 2269-2281. doi: 10.1002/mds.29611
2023
Journal Article
The Role of Apathy in Spontaneous Verbal and Nonverbal Behaviors: A Transdiagnostic Pilot Study in Neurodegeneration
Horne, Kristina S., Ceslis, Amelia, Mosley, Philip, Adam, Robert and Robinson, Gail A. (2023). The Role of Apathy in Spontaneous Verbal and Nonverbal Behaviors: A Transdiagnostic Pilot Study in Neurodegeneration. Cognitive and Behavioral Neurology, 36 (3), 178-193. doi: 10.1097/wnn.0000000000000345
2023
Journal Article
Tetrahydrocannabinol and cannabidiol in Tourette Syndrome
Mosley, Philip E., Webb, Lachlan, Suraev, Anastasia, Hingston, Leah, Turnbull, Tracy, Foster, Kelley, Ballard, Emma, Gomes, Lauren, Mohan, Adith, Sachdev, Perminder S., Kevin, Richard, Gordon, Rebecca, Benson, Melissa and McGregor, Iain S. (2023). Tetrahydrocannabinol and cannabidiol in Tourette Syndrome. NEJM Evidence, 2 (9). doi: 10.1056/evidoa2300012
2023
Journal Article
Functional network reorganization precedes apathy in Parkinson’s disease: a neural marker of risk?
Mosley, Philip E and Robinson, Gail A (2023). Functional network reorganization precedes apathy in Parkinson’s disease: a neural marker of risk?. Brain, 146 (7), 2661-2662. doi: 10.1093/brain/awad180
2023
Journal Article
Evaluation of brain-body health in individuals with common neuropsychiatric disorders
Tian, Ye Ella, Di Biase, Maria A., Mosley, Philip E., Lupton, Michelle K., Xia, Ying, Fripp, Jurgen, Breakspear, Michael, Cropley, Vanessa and Zalesky, Andrew (2023). Evaluation of brain-body health in individuals with common neuropsychiatric disorders. JAMA Psychiatry, 80 (6), 567-576. doi: 10.1001/jamapsychiatry.2023.0791
2022
Journal Article
Clinical recommendations for the care of people with treatment-refractory obsessive-compulsive disorder when undergoing deep brain stimulation
Acevedo, Nicola, Castle, David, Groves, Clare, Bosanac, Peter, Mosley, Philip E. and Rossell, Susan (2022). Clinical recommendations for the care of people with treatment-refractory obsessive-compulsive disorder when undergoing deep brain stimulation. Australian and New Zealand Journal of Psychiatry, 56 (10) 00048674221100947, 1219-1225. doi: 10.1177/00048674221100947
2022
Journal Article
Deep brain stimulation for treatment-refractory obsessive-compulsive disorder: Opportunities and challenges
Mosley, Philip E., Velakoulis, Dennis, Farrand, Sarah, Marsh, Rodney, Mohan, Adith, Castle, David and Sachdev, Perminder (2022). Deep brain stimulation for treatment-refractory obsessive-compulsive disorder: Opportunities and challenges. Australian and New Zealand Journal of Psychiatry, 56 (11), 1523-1524. doi: 10.1177/00048674221109008
2022
Journal Article
Australian Parkinson’s Genetics Study (APGS): pilot (n=1532)
Bivol, Svetlana, Mellick, George D., Gratten, Jacob, Parker, Richard, Mulcahy, Aoibhe, Mosley, Philip E., Poortvliet, Peter C., Campos, Adrian I., Mitchell, Brittany L., Garcia-Marin, Luis M., Cross, Simone, Ferguson, Mary, Lind, Penelope A., Loesch, Danuta Z., Visscher, Peter M., Medland, Sarah E., Scherzer, Clemens R., Martin, Nicholas G. and Rentería, Miguel E. (2022). Australian Parkinson’s Genetics Study (APGS): pilot (n=1532). BMJ Open, 12 (2) e052032, e052032. doi: 10.1136/bmjopen-2021-052032
2022
Journal Article
A snapshot of brain and cognition in healthy mid-life and older adults
Borne, Léonie, Lupton, Michelle K., Guo, Christine, Mosley, Philip, Adam, Robert, Ceslis, Amelia, Bourgeat, Pierrick, Fazlollahi, Amir , Maruff, Paul, Rowe, Christopher C., Masters, Colin L., Fripp, Jurgen , Robinson, Gail A. and Breakspear, Michael (2022). A snapshot of brain and cognition in healthy mid-life and older adults. bioRxiv. doi: 10.1101/2022.01.20.476706
2022
Journal Article
Deep brain stimulation for obsessive–compulsive disorder: a crisis of access
Visser-Vandewalle, Veerle, Andrade, Pablo, Mosley, Philip E., Greenberg, Benjamin D., Schuurman, Rick, McLaughlin, Nicole C., Voon, Valerie, Krack, Paul, Foote, Kelly D., Mayberg, Helen S., Figee, Martijn, Kopell, Brian H., Polosan, Mircea, Joyce, Eileen M., Chabardes, Stephan, Matthews, Keith, Baldermann, Juan C., Tyagi, Himanshu, Holtzheimer, Paul E., Bervoets, Chris, Hamani, Clement, Karachi, Carine, Denys, Damiaan, Zrinzo, Ludvic, Blomstedt, Patric, Naesström, Matilda, Abosch, Aviva, Rasmussen, Steven, Coenen, Volker A. ... Okun, Michael S. (2022). Deep brain stimulation for obsessive–compulsive disorder: a crisis of access. Nature Medicine, 28 (8), 1529-1532. doi: 10.1038/s41591-022-01879-z
2021
Journal Article
Connectomic deep brain stimulation for obsessive-compulsive disorder
Baldermann, Juan Carlos, Schueller, Thomas, Kohl, Sina, Voon, Valerie, Li, Ningfei, Hollunder, Barbara, Figee, Martijn, Haber, Suzanne N., Sheth, Sameer A., Mosley, Philip E., Huys, Daniel, Johnson, Kara A., Butson, Christopher, Ackermans, Linda, Vlis, Tim Bouwens van der, Leentjens, Albert F. G., Barbe, Michael, Visser-Vandewalle, Veerle, Kuhn, Jens and Horn, Andreas (2021). Connectomic deep brain stimulation for obsessive-compulsive disorder. Biological Psychiatry, 90 (10), 678-688. doi: 10.1016/j.biopsych.2021.07.010
2021
Journal Article
Deep brain stimulation for treatment-refractory obsessive-compulsive disorder should be an accepted therapy in Australia
Mosley, Philip E., Velakoulis, Dennis, Farrand, Sarah, Marsh, Rodney, Mohan, Adith, Castle, David and Sachdev, Perminder S. (2021). Deep brain stimulation for treatment-refractory obsessive-compulsive disorder should be an accepted therapy in Australia. Australian & New Zealand Journal of Psychiatry, 56 (5), 000486742110314-436. doi: 10.1177/00048674211031482
2021
Journal Article
Welcome to the Breakfast Club: Building academic psychiatry capacity in Queensland
Suetani, Shuichi, Burgher, Bjorn, Mosley, Phil and Parker, Stephen (2021). Welcome to the Breakfast Club: Building academic psychiatry capacity in Queensland. Australian and New Zealand Journal of Psychiatry, 55 (11), 48674211025630-1032. doi: 10.1177/00048674211025630
2021
Journal Article
A randomised, double-blind, sham-controlled trial of deep brain stimulation of the bed nucleus of the stria terminalis for treatment-resistant obsessive-compulsive disorder
Mosley, Philip E., Windels, François, Morris, John, Coyne, Terry, Marsh, Rodney, Giorni, Andrea, Mohan, Adith, Sachdev, Perminder, O’Leary, Emily, Boschen, Mark, Sah, Pankaj and Silburn, Peter A. (2021). A randomised, double-blind, sham-controlled trial of deep brain stimulation of the bed nucleus of the stria terminalis for treatment-resistant obsessive-compulsive disorder. Translational Psychiatry, 11 (1) 190, 190. doi: 10.1038/s41398-021-01307-9
Supervision
Availability
- Dr Philip Mosley is:
- Available for supervision
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Media
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