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Dr Philip Mosley
Dr

Philip Mosley

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Overview

Background

Dr Philip Mosley studied at the University of Oxford and obtained a masters degree in physiological sciences and a degree in medicine. He was also captain of the university boxing team and was awarded two full 'Blues'. He worked as a junior doctor in Manchester before moving to Australia to complete his specialist training in psychiatry.

Dr Mosley is a Fellow of the Royal Australian and New Zealand College of Psychiatry (RANZCP) and has completed an advanced certificate in Consultation-Liaison Psychiatry. As part of his training he also undertook a 2-year neuropsychiatry fellowship at the Royal Brisbane and Women’s Hospital (RBWH) and the Asia-Pacific Centre for Neuromodulation (APCN) at the University of Queensland. Currently, Dr Mosley works as a member of the deep brain stimulation (DBS) team at St Andrew's War Memorial Hospital, Brisbane, runs a private neuropsychiatry practice and also provides a consultation-liaison psychiatry service to the neurology, medical and surgical wards. Dr Mosley's private practice is focussed on neurodegenerative disease, movement disorders and head injury.

Dr Mosley is an active clinician-scientist with appointments at the QIMR Berghofer Medical Research Institute, Queensland Brain Institute and CSIRO. He completed his PhD in neuroscience in 2019 under the supervision of Professor Michael Breakspear. He published eleven peer-reviewed manuscripts and received the UQ Dean's Award for outstanding thesis. Dr Mosley has been the chief investigator in a study of the neuropsychiatric effects of DBS for Parkinson’s disease, in a study of medicinal cannabis for Tourette’s syndrome, a lead investigator in a clinical trial of DBS for obsessive-compulsive disorder and anorexia nervosa, as well as a clinical fellow in a neuroimaging study of Alzheimer’s disease. He has won prizes from the RANZCP in Old Age Psychiatry and Consultation-Liaison Psychiatry, and he has received research funding from the RBWH Foundation, the RANZCP Young Investigator Grant, Parkinson’s Queensland and Wesley Medical Research. Dr Mosley was awarded an ‘Advance Queensland’ Early Career Fellowship for his Parkinson's disease research and won the postgraduate medal from the Australian Society for Medical Research for findings arising from this project. In 2020, he won the Early Career Psychiatrist award from the RANZCP, which is presented to the fellow producing the most significant piece of research in the five years since fellowship. Currently Dr Mosley's research is funded by the National Health and Medical Research Council (NHMRC) and the Medical Research Future Fund.

If you wish to contact Dr Mosley regarding a clinical matter, please do so via his neuropsychiatry clinic (Neurosciences Queensland) telephone: 07 3839 3688 or email: admin@nsqld.com.au.

Availability

Dr Philip Mosley is:
Available for supervision

Research impacts

Dr Mosley is one of the most experienced psychiatrists in the world with regards to the practice of deep brain stimulation (DBS) and has been embedded as a psychiatrist in the DBS service in Brisbane since 2013. This centre is the largest in Australia and one of the largest worldwide (1200 devices implanted). Dr Mosley has improved the neuropsychiatric safety of DBS for Parkinson’s disease through individualised assessments of brain connectivity and stimulation field distribution. His rich dataset has been shared with European and US collaborators. During his PhD in neuroscience, Dr Mosley demarcated brain networks responsible for changes in mood after DBS and used mathematical modelling of human behaviour to discriminate those at risk of postoperative psychiatric complications. His work translates clinically to more accurate and effective use of neuromodulation, based on targeted recruitment of key neuronal pathways. Applying these methods to treatment-resistant obsessive-compulsive disorder, Dr Mosley characterised a brain connectivity fingerprint associated with clinically-significant response to DBS. This was a landmark Australian trial (Reg. U1111-1146-0992), establishing DBS as a viable treatment option for those with intractable symptoms. Positive outcomes from this sham-controlled trial have led to the first Australian trial of DBS for severe and enduring anorexia nervosa (Reg. U1111-1219-9348).

Completed Projects:

  1. Defining brain networks mediating psychiatric symptoms after subthalamic deep brain stimulation for Parkinson's disease.
  2. Predictors of caregiver burden after subthalamic deep brain stimulation for Parkinson's disease.
  3. Psychological interventions for caregivers after subthalamic deep brain stimulation for Parkinson's disease.
  4. Deep brain stimulation of the nucleus accumbens for severe, treatment-resistant, obsessive-compulsive disorder.
  5. A randomised, double-blind, placebo-controlled crossover trial of medicinal cannabis for Tourette's syndrome.
  6. Neuroimaging biomarkers of early Alzheimer's disease.

Current Projects:

  1. Deep brain stimulation of the bed nucleus of the stria terminalis for severe obsessive-compulsive disorder (recruiting).
  2. Transcranial focussed ultrasound for severe obsessive-compulsive disorder (recruiting).

Works

Search Professor Philip Mosley’s works on UQ eSpace

52 works between 2009 and 2024

21 - 40 of 52 works

2021

Book Chapter

Neuropsychiatric effects of subthalamic deep brain stimulation

Mosley, Philip E. and Akram, Harith (2021). Neuropsychiatric effects of subthalamic deep brain stimulation. Human hypothalamus : middle and posterior region. (pp. 417-431) edited by Dick F. Swaab, Felix Kreier, Paul J. Lucassen, Ahmad Salehi and Ruud M. Buijs. Amsterdam, Netherlands: Elsevier. doi: 10.1016/B978-0-12-820107-7.00026-4

Neuropsychiatric effects of subthalamic deep brain stimulation

2020

Journal Article

Subthalamic deep brain stimulation identifies frontal networks supporting initiation, inhibition and strategy use in Parkinson's disease

Mosley, Philip E., Robinson, Katherine, Coyne, Terry, Silburn, Peter, Barker, Megan S., Breakspear, Michael, Robinson, Gail A. and Perry, Alistair (2020). Subthalamic deep brain stimulation identifies frontal networks supporting initiation, inhibition and strategy use in Parkinson's disease. NeuroImage, 223 117352, 1-19. doi: 10.1016/j.neuroimage.2020.117352

Subthalamic deep brain stimulation identifies frontal networks supporting initiation, inhibition and strategy use in Parkinson's disease

2020

Journal Article

A prospective cohort study of prodromal Alzheimer’s disease: Prospective Imaging Study of Ageing: genes, brain and behaviour (PISA)

Lupton, Michelle K., Robinson, Gail A., Adam, Robert J, Rose, Stephen, Byrne, Gerard J., Salvado, Olivier, Pachana, Nancy A., Almeida, Osvaldo P., McAloney, Kerrie, Gordon, Scott D., Raniga, Parnesh, Fazlollahi, Amir, Xia, Ying, Ceslis, Amelia, Sonkusare, Saurabh, Zhang, Qing, Kholghi, Mahnoosh, Karunanithi, Mohan, Mosley, Philip E., Lv, Jinglei, Borne, Léonie, Adsett, Jessica, Garden, Natalie, Fripp, Jurgen, Martin, Nicholas G., Guo, Christine C. and Breakspear, Michael (2020). A prospective cohort study of prodromal Alzheimer’s disease: Prospective Imaging Study of Ageing: genes, brain and behaviour (PISA). NeuroImage: Clinical, 29 102527, 102527. doi: 10.1016/j.nicl.2020.102527

A prospective cohort study of prodromal Alzheimer’s disease: Prospective Imaging Study of Ageing: genes, brain and behaviour (PISA)

2020

Journal Article

The structural connectivity of subthalamic deep brain stimulation correlates with impulsivity in Parkinson’s

Mosley, Philip E., Paliwal, Saee, Robinson, Katherine, Coyne, Terry, Silburn, Peter, Tittgemeyer, Marc, Stephan, Klaas E., Perry, Alistair and Breakspear, Michael (2020). The structural connectivity of subthalamic deep brain stimulation correlates with impulsivity in Parkinson’s. Brain, 143 (7), 2235-2254. doi: 10.1093/brain/awaa148

The structural connectivity of subthalamic deep brain stimulation correlates with impulsivity in Parkinson’s

2020

Journal Article

A pilot trial of cognitive behavioral therapy for caregivers after deep brain stimulation for Parkinson's Disease

Mosley, Philip E., Robinson, Katherine, Dissanayaka, Nadeeka N., Coyne, Terry, Silburn, Peter, Marsh, Rodney and Pye, Deidre (2020). A pilot trial of cognitive behavioral therapy for caregivers after deep brain stimulation for Parkinson's Disease. Journal of Geriatric Psychiatry and Neurology, 34 (5), 891988720924720-465. doi: 10.1177/0891988720924720

A pilot trial of cognitive behavioral therapy for caregivers after deep brain stimulation for Parkinson's Disease

2020

Journal Article

Left prefrontal connectivity links subthalamic stimulation with depressive symptoms

Irmen, Friederike, Horn, Andreas, Mosley, Philip, Perry, Alistair, Petry‐Schmelzer, Jan Niklas, Dafsari, Haidar S., Barbe, Michael, Visser‐Vandewalle, Veerle, Schneider, Gerd‐Helge, Li, Ningfei, Kübler, Dorothee, Wenzel, Gregor and Kühn, Andrea A. (2020). Left prefrontal connectivity links subthalamic stimulation with depressive symptoms. Annals of Neurology, 87 (6) ana.25734, 962-975. doi: 10.1002/ana.25734

Left prefrontal connectivity links subthalamic stimulation with depressive symptoms

2020

Other Outputs

Impulsivity and Caregiver Burden after Deep Brain Stimulation for Parkinson’s Disease

Mosley, Philip (2020). Impulsivity and Caregiver Burden after Deep Brain Stimulation for Parkinson’s Disease. PhD Thesis, Faculty of Medicine, The University of Queensland. doi: 10.14264/uql.2020.233

Impulsivity and Caregiver Burden after Deep Brain Stimulation for Parkinson’s Disease

2019

Journal Article

The structural connectivity of discrete networks underlies impulsivity and gambling in Parkinson's disease

Mosley, Philip E., Paliwal, Saee, Robinson, Katherine, Coyne, Terry, Silburn, Peter, Tittgemeyer, Marc, Stephan, Klaas E., Breakspear, Michael and Perry, Alistair (2019). The structural connectivity of discrete networks underlies impulsivity and gambling in Parkinson's disease. Brain, 142 (12), 3917-3935. doi: 10.1093/brain/awz327

The structural connectivity of discrete networks underlies impulsivity and gambling in Parkinson's disease

2019

Journal Article

Subjective estimates of uncertainty during gambling and impulsivity after subthalamic deep brain stimulation for Parkinson’s disease

Paliwal, Saee, Mosley, Philip E., Breakspear, Michael, Coyne, Terry, Silburn, Peter, Aponte, Eduardo, Mathys, Christoph and Stephan, Klaas E. (2019). Subjective estimates of uncertainty during gambling and impulsivity after subthalamic deep brain stimulation for Parkinson’s disease. Scientific Reports, 9 (1) 14795, 14795. doi: 10.1038/s41598-019-51164-2

Subjective estimates of uncertainty during gambling and impulsivity after subthalamic deep brain stimulation for Parkinson’s disease

2019

Journal Article

‘Woe betides anybody who tries to turn me down.’ A qualitative analysis of neuropsychiatric symptoms following subthalamic deep brain stimulation for Parkinson’s disease

Mosley, Philip E., Robinson, Katherine, Coyne, Terry, Silburn, Peter, Breakspear, Michael and Carter, Adrian (2019). ‘Woe betides anybody who tries to turn me down.’ A qualitative analysis of neuropsychiatric symptoms following subthalamic deep brain stimulation for Parkinson’s disease. Neuroethics, 14 (S1), 47-63. doi: 10.1007/s12152-019-09410-x

‘Woe betides anybody who tries to turn me down.’ A qualitative analysis of neuropsychiatric symptoms following subthalamic deep brain stimulation for Parkinson’s disease

2019

Conference Publication

Neurosurgery for psychiatric disorders: an update

Mosley, P., Silburn, P., Coyne, T. and Marsh, R. (2019). Neurosurgery for psychiatric disorders: an update. RANZCP, Cairns, QLD, Australia, 12-16 May 2019. London, United Kingdom: Sage Publications.

Neurosurgery for psychiatric disorders: an update

2019

Conference Publication

Deep brain simulation of the nucleus accumbens for severe, treatment-resistant obsessive-compulsive disorder

Mosley, P. (2019). Deep brain simulation of the nucleus accumbens for severe, treatment-resistant obsessive-compulsive disorder. RANZCP, Cairns, QLD, Australia, 12-16 May 2019. London, United Kingdom: Sage Publications.

Deep brain simulation of the nucleus accumbens for severe, treatment-resistant obsessive-compulsive disorder

2018

Journal Article

Caregiver burden and caregiver appraisal of psychiatric symptoms are not modulated by subthalamic deep brain stimulation for Parkinson's disease

Mosley, Philip E., Breakspear, Michael, Coyne, Terry, Silburn, Peter and Smith, David (2018). Caregiver burden and caregiver appraisal of psychiatric symptoms are not modulated by subthalamic deep brain stimulation for Parkinson's disease. NPJ Parkinson's disease, 4 (1) 12, 12. doi: 10.1038/s41531-018-0048-2

Caregiver burden and caregiver appraisal of psychiatric symptoms are not modulated by subthalamic deep brain stimulation for Parkinson's disease

2018

Journal Article

The site of stimulation moderates neuropsychiatric symptoms after subthalamic deep brain stimulation for Parkinson's disease

Mosley, Philip E., Smith, David, Coyne, Terry, Silburn, Peter, Breakspear, Michael and Perry, Alistair (2018). The site of stimulation moderates neuropsychiatric symptoms after subthalamic deep brain stimulation for Parkinson's disease. NeuroImage: Clinical, 18, 996-1006. doi: 10.1016/j.nicl.2018.03.009

The site of stimulation moderates neuropsychiatric symptoms after subthalamic deep brain stimulation for Parkinson's disease

2018

Journal Article

Persistence of mania after cessation of stimulation following subthalamic deep brain stimulation

Mosley, Philip E., Marsh, Rodney, Perry, Alistair, Coyne, Terry and Silburn, Peter (2018). Persistence of mania after cessation of stimulation following subthalamic deep brain stimulation. The Journal of Neuropsychiatry and Clinical Neurosciences, 30 (3), 246-249. doi: 10.1176/appi.neuropsych.17060129

Persistence of mania after cessation of stimulation following subthalamic deep brain stimulation

2017

Journal Article

Caregiver burden in Parkinson disease: a critical review of recent literature

Mosley, Philip E., Moodie, Rebecca and Dissanayaka, Nadeeka (2017). Caregiver burden in Parkinson disease: a critical review of recent literature. Journal of Geriatric Psychiatry and Neurology, 30 (5), 235-252. doi: 10.1177/0891988717720302

Caregiver burden in Parkinson disease: a critical review of recent literature

2017

Conference Publication

Predicting psychiatric symptoms after subthalamic deep brain stimulation for Parkinson's disease

Mosley, Philip, Smith, David, Perry, Alistair, Silburn, Peter, Coyne, Terry and Breakspear, Michael (2017). Predicting psychiatric symptoms after subthalamic deep brain stimulation for Parkinson's disease. 17th Quadrennial Meeting of the World Society for Stereotactic and Functional Neurosurgery, Berlin, Germany, June 26-29, 2017. Stereotactic and Functional Neurosurgery: Karger. doi: 10.1159/000478281

Predicting psychiatric symptoms after subthalamic deep brain stimulation for Parkinson's disease

2016

Journal Article

Talking with Dr Philip Mosley

Mosley, Philip (2016). Talking with Dr Philip Mosley. Australasian Psychiatry, 24 (5), 516-517. doi: 10.1177/1039856216668252b

Talking with Dr Philip Mosley

2016

Journal Article

Management of impulse control disorders in Parkinson's disease

Zhang, Susan, Dissanayaka, Nadeeka N., Dawson, Andrew, O’Sullivan, John D., Mosley, Philip, Hall, Wayne and Carter, Adrian (2016). Management of impulse control disorders in Parkinson's disease. International Psychogeriatrics, 28 (10), 1597-1614. doi: 10.1017/S104161021600096X

Management of impulse control disorders in Parkinson's disease

2015

Journal Article

Deep brain stimulation for depression: Scientific issues and future directions

Mosley, Philip E., Marsh, Rodney and Carter, Adrian (2015). Deep brain stimulation for depression: Scientific issues and future directions. Australian and New Zealand Journal of Psychiatry, 49 (11), 967-978. doi: 10.1177/0004867415599845

Deep brain stimulation for depression: Scientific issues and future directions

Supervision

Availability

Dr Philip Mosley is:
Available for supervision

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Media

Enquiries

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communications@uq.edu.au