Overview
Background
Dr Philip Mosley studied at the University of Oxford and obtained a master’s degree in physiological sciences and a degree in medicine. He was also captain of the university boxing team and was awarded two full 'Blues'. He worked as a junior doctor in Manchester before moving to Australia to complete his specialist training in psychiatry, which he undertook at the Royal brisbane and Women's Hospital.
Dr Mosley is a Fellow of the Royal Australian and New Zealand College of Psychiatry (RANZCP) and halso holds an advanced certificate in Consultation-Liaison Psychiatry. As part of his training, Dr Mosley undertook a 2-year neuropsychiatry fellowship at the Royal Brisbane and Women’s Hospital (RBWH) and the Asia-Pacific Centre for Neuromodulation (APCN), an active research entity of the Queensland Brain Institute.
Currently, Dr Mosley works as a specialist neuropsychiatrist in a deep brain stimulation team, runs a private neuropsychiatry practice and also provides a consultation-liaison psychiatry service to the neurology, medical and surgical wards of the general hospital. Dr Mosley's private practice is focussed on neurodegenerative disease, movement disorders and head injury.
Dr Mosley remains an active clinician-scientist with appointments at the QIMR Berghofer Medical Research Institute and the Queensland Brain Institute. He completed his PhD in neuroscience in 2019 under the supervision of Professor Michael Breakspear. He published eleven peer-reviewed manuscripts from his thesis alone, and received the UQ Dean's Award for outstanding thesis.
Dr Mosley has been the chief investigator in a study of the neuropsychiatric effects of DBS for Parkinson’s disease, in a study of medicinal cannabis for Tourette’s syndrome, a lead investigator in a clinical trial of DBS for obsessive-compulsive disorder and anorexia nervosa, as well as a clinical fellow in a neuroimaging study of Alzheimer’s disease. He has won prizes from the RANZCP in Old Age Psychiatry and Consultation-Liaison Psychiatry, and he has received research funding from the RBWH Foundation, the RANZCP Young Investigator Grant, Parkinson’s Queensland and Wesley Medical Research. Dr Mosley was awarded an ‘Advance Queensland’ Early Career Fellowship for his Parkinson's disease research and won the postgraduate medal from the Australian Society for Medical Research for findings arising from this project. In 2020, he won the Early Career Psychiatrist award from the RANZCP, which is presented to the fellow producing the most significant piece of research in the five years since fellowship. Currently Dr Mosley's research is funded by the National Health and Medical Research Council (NHMRC) and the Medical Research Future Fund (MRFF).
Availability
- Dr Philip Mosley is:
- Available for supervision
Fields of research
Research impacts
Dr Mosley is one of the most experienced psychiatrists in the world with regards to the practice of deep brain stimulation (DBS) and has been embedded as a psychiatrist within a DBS service in Brisbane since 2013. Dr Mosley has improved the neuropsychiatric safety of DBS for Parkinson’s disease through individualised assessments of brain connectivity and stimulation field distribution. His rich dataset has been shared with European and US collaborators. During his PhD in neuroscience, Dr Mosley demarcated brain networks responsible for changes in mood after DBS and used mathematical modelling of human behaviour to discriminate those at risk of postoperative psychiatric complications. His work translates clinically to more accurate and effective use of neuromodulation, based on targeted recruitment of key neuronal pathways.
Applying these methods to treatment-resistant obsessive-compulsive disorder, Dr Mosley characterised a brain connectivity fingerprint associated with clinically-significant response to DBS. This was a landmark Australian trial (Reg. U1111-1146-0992), establishing DBS as a viable treatment option for those with intractable symptoms. Dr Mosley extended this work in a second trial, and then became one of the first clinical researchers in the world to adapt non-invasive deep brain ultrasound for OCD - using precisely-focussed, high-frequency sound wave energy, to change the activity of deep brain regions, without surgical ablation of brain tissue or the implantation of medical devices.Manuscripts from these trials are currently being peer-reviewed for publication in the scientific literature.
Completed Projects:
- Defining brain networks mediating psychiatric symptoms after subthalamic deep brain stimulation for Parkinson's disease.
- Predictors of caregiver burden after subthalamic deep brain stimulation for Parkinson's disease.
- Psychological interventions for caregivers after subthalamic deep brain stimulation for Parkinson's disease.
- Deep brain stimulation of the nucleus accumbens for severe, treatment-resistant, obsessive-compulsive disorder.
- A randomised, double-blind, placebo-controlled, crossover trial of medicinal cannabis for Tourette's syndrome.
- Neuroimaging biomarkers of early Alzheimer's disease.
- 7. Discriminating between melancholic and non-melancholic depression using analyses of facial expressivity and functional brain imaging.
- 8. Focussed ultrasound stimulation of the nucleus accumbens and the basolateral nucleus of the amygdala for severe iobsessive-compulsive disorder (manuscript under review)
Works
Search Professor Philip Mosley’s works on UQ eSpace
2022
Journal Article
Deep brain stimulation for treatment-refractory obsessive-compulsive disorder: Opportunities and challenges
Mosley, Philip E., Velakoulis, Dennis, Farrand, Sarah, Marsh, Rodney, Mohan, Adith, Castle, David and Sachdev, Perminder (2022). Deep brain stimulation for treatment-refractory obsessive-compulsive disorder: Opportunities and challenges. Australian and New Zealand Journal of Psychiatry, 56 (11), 1523-1524. doi: 10.1177/00048674221109008
2022
Journal Article
Australian Parkinson’s Genetics Study (APGS): pilot (n=1532)
Bivol, Svetlana, Mellick, George D., Gratten, Jacob, Parker, Richard, Mulcahy, Aoibhe, Mosley, Philip E., Poortvliet, Peter C., Campos, Adrian I., Mitchell, Brittany L., Garcia-Marin, Luis M., Cross, Simone, Ferguson, Mary, Lind, Penelope A., Loesch, Danuta Z., Visscher, Peter M., Medland, Sarah E., Scherzer, Clemens R., Martin, Nicholas G. and Rentería, Miguel E. (2022). Australian Parkinson’s Genetics Study (APGS): pilot (n=1532). BMJ Open, 12 (2) e052032, e052032. doi: 10.1136/bmjopen-2021-052032
2022
Journal Article
A snapshot of brain and cognition in healthy mid-life and older adults
Borne, Léonie, Lupton, Michelle K., Guo, Christine, Mosley, Philip, Adam, Robert, Ceslis, Amelia, Bourgeat, Pierrick, Fazlollahi, Amir , Maruff, Paul, Rowe, Christopher C., Masters, Colin L., Fripp, Jurgen , Robinson, Gail A. and Breakspear, Michael (2022). A snapshot of brain and cognition in healthy mid-life and older adults. bioRxiv. doi: 10.1101/2022.01.20.476706
2022
Journal Article
Deep brain stimulation for obsessive–compulsive disorder: a crisis of access
Visser-Vandewalle, Veerle, Andrade, Pablo, Mosley, Philip E., Greenberg, Benjamin D., Schuurman, Rick, McLaughlin, Nicole C., Voon, Valerie, Krack, Paul, Foote, Kelly D., Mayberg, Helen S., Figee, Martijn, Kopell, Brian H., Polosan, Mircea, Joyce, Eileen M., Chabardes, Stephan, Matthews, Keith, Baldermann, Juan C., Tyagi, Himanshu, Holtzheimer, Paul E., Bervoets, Chris, Hamani, Clement, Karachi, Carine, Denys, Damiaan, Zrinzo, Ludvic, Blomstedt, Patric, Naesström, Matilda, Abosch, Aviva, Rasmussen, Steven, Coenen, Volker A. ... Okun, Michael S. (2022). Deep brain stimulation for obsessive–compulsive disorder: a crisis of access. Nature Medicine, 28 (8), 1529-1532. doi: 10.1038/s41591-022-01879-z
2021
Journal Article
Connectomic deep brain stimulation for obsessive-compulsive disorder
Baldermann, Juan Carlos, Schueller, Thomas, Kohl, Sina, Voon, Valerie, Li, Ningfei, Hollunder, Barbara, Figee, Martijn, Haber, Suzanne N., Sheth, Sameer A., Mosley, Philip E., Huys, Daniel, Johnson, Kara A., Butson, Christopher, Ackermans, Linda, Vlis, Tim Bouwens van der, Leentjens, Albert F. G., Barbe, Michael, Visser-Vandewalle, Veerle, Kuhn, Jens and Horn, Andreas (2021). Connectomic deep brain stimulation for obsessive-compulsive disorder. Biological Psychiatry, 90 (10), 678-688. doi: 10.1016/j.biopsych.2021.07.010
2021
Journal Article
Deep brain stimulation for treatment-refractory obsessive-compulsive disorder should be an accepted therapy in Australia
Mosley, Philip E., Velakoulis, Dennis, Farrand, Sarah, Marsh, Rodney, Mohan, Adith, Castle, David and Sachdev, Perminder S. (2021). Deep brain stimulation for treatment-refractory obsessive-compulsive disorder should be an accepted therapy in Australia. Australian & New Zealand Journal of Psychiatry, 56 (5), 000486742110314-436. doi: 10.1177/00048674211031482
2021
Journal Article
Welcome to the Breakfast Club: Building academic psychiatry capacity in Queensland
Suetani, Shuichi, Burgher, Bjorn, Mosley, Phil and Parker, Stephen (2021). Welcome to the Breakfast Club: Building academic psychiatry capacity in Queensland. Australian and New Zealand Journal of Psychiatry, 55 (11), 48674211025630-1032. doi: 10.1177/00048674211025630
2021
Journal Article
A randomised, double-blind, sham-controlled trial of deep brain stimulation of the bed nucleus of the stria terminalis for treatment-resistant obsessive-compulsive disorder
Mosley, Philip E., Windels, François, Morris, John, Coyne, Terry, Marsh, Rodney, Giorni, Andrea, Mohan, Adith, Sachdev, Perminder, O’Leary, Emily, Boschen, Mark, Sah, Pankaj and Silburn, Peter A. (2021). A randomised, double-blind, sham-controlled trial of deep brain stimulation of the bed nucleus of the stria terminalis for treatment-resistant obsessive-compulsive disorder. Translational Psychiatry, 11 (1) 190, 190. doi: 10.1038/s41398-021-01307-9
2021
Journal Article
Deep brain stimulation for refractory obsessive-compulsive disorder (OCD): emerging or established therapy?
Wu, Hemmings, Hariz, Marwan, Visser-Vandewalle, Veerle, Zrinzo, Ludvic, Coenen, Volker A., Sheth, Sameer A., Bervoets, Chris, Naesström, Matilda, Blomstedt, Patric, Coyne, Terry, Hamani, Clement, Slavin, Konstantin, Krauss, Joachim K., Kahl, Kai G., Taira, Takaomi, Zhang, Chencheng, Sun, Bomin, Toda, Hiroki, Schlaepfer, Thomas, Chang, Jin Woo, Régis, Jean, Schuurman, Rick, Schulder, Michael, Doshi, Paresh, Mosley, Philip, Poologaindran, Anujan, Lázaro-Muñoz, Gabriel, Pepper, Joshua, Schechtmann, Gaston ... Nuttin, Bart (2021). Deep brain stimulation for refractory obsessive-compulsive disorder (OCD): emerging or established therapy?. Molecular Psychiatry, 26 (1), 60-65. doi: 10.1038/s41380-020-00933-x
2021
Book Chapter
Neuropsychiatric effects of subthalamic deep brain stimulation
Mosley, Philip E. and Akram, Harith (2021). Neuropsychiatric effects of subthalamic deep brain stimulation. Human hypothalamus : middle and posterior region. (pp. 417-431) edited by Dick F. Swaab, Felix Kreier, Paul J. Lucassen, Ahmad Salehi and Ruud M. Buijs. Amsterdam, Netherlands: Elsevier. doi: 10.1016/B978-0-12-820107-7.00026-4
2020
Journal Article
Subthalamic deep brain stimulation identifies frontal networks supporting initiation, inhibition and strategy use in Parkinson's disease
Mosley, Philip E., Robinson, Katherine, Coyne, Terry, Silburn, Peter, Barker, Megan S., Breakspear, Michael, Robinson, Gail A. and Perry, Alistair (2020). Subthalamic deep brain stimulation identifies frontal networks supporting initiation, inhibition and strategy use in Parkinson's disease. NeuroImage, 223 117352, 1-19. doi: 10.1016/j.neuroimage.2020.117352
2020
Journal Article
A prospective cohort study of prodromal Alzheimer’s disease: Prospective Imaging Study of Ageing: genes, brain and behaviour (PISA)
Lupton, Michelle K., Robinson, Gail A., Adam, Robert J, Rose, Stephen, Byrne, Gerard J., Salvado, Olivier, Pachana, Nancy A., Almeida, Osvaldo P., McAloney, Kerrie, Gordon, Scott D., Raniga, Parnesh, Fazlollahi, Amir, Xia, Ying, Ceslis, Amelia, Sonkusare, Saurabh, Zhang, Qing, Kholghi, Mahnoosh, Karunanithi, Mohan, Mosley, Philip E., Lv, Jinglei, Borne, Léonie, Adsett, Jessica, Garden, Natalie, Fripp, Jurgen, Martin, Nicholas G., Guo, Christine C. and Breakspear, Michael (2020). A prospective cohort study of prodromal Alzheimer’s disease: Prospective Imaging Study of Ageing: genes, brain and behaviour (PISA). NeuroImage: Clinical, 29 102527, 102527. doi: 10.1016/j.nicl.2020.102527
2020
Journal Article
The structural connectivity of subthalamic deep brain stimulation correlates with impulsivity in Parkinson’s
Mosley, Philip E., Paliwal, Saee, Robinson, Katherine, Coyne, Terry, Silburn, Peter, Tittgemeyer, Marc, Stephan, Klaas E., Perry, Alistair and Breakspear, Michael (2020). The structural connectivity of subthalamic deep brain stimulation correlates with impulsivity in Parkinson’s. Brain, 143 (7), 2235-2254. doi: 10.1093/brain/awaa148
2020
Journal Article
A pilot trial of cognitive behavioral therapy for caregivers after deep brain stimulation for Parkinson's Disease
Mosley, Philip E., Robinson, Katherine, Dissanayaka, Nadeeka N., Coyne, Terry, Silburn, Peter, Marsh, Rodney and Pye, Deidre (2020). A pilot trial of cognitive behavioral therapy for caregivers after deep brain stimulation for Parkinson's Disease. Journal of Geriatric Psychiatry and Neurology, 34 (5), 891988720924720-465. doi: 10.1177/0891988720924720
2020
Journal Article
Left prefrontal connectivity links subthalamic stimulation with depressive symptoms
Irmen, Friederike, Horn, Andreas, Mosley, Philip, Perry, Alistair, Petry‐Schmelzer, Jan Niklas, Dafsari, Haidar S., Barbe, Michael, Visser‐Vandewalle, Veerle, Schneider, Gerd‐Helge, Li, Ningfei, Kübler, Dorothee, Wenzel, Gregor and Kühn, Andrea A. (2020). Left prefrontal connectivity links subthalamic stimulation with depressive symptoms. Annals of Neurology, 87 (6) ana.25734, 962-975. doi: 10.1002/ana.25734
2020
Other Outputs
Impulsivity and Caregiver Burden after Deep Brain Stimulation for Parkinson’s Disease
Mosley, Philip (2020). Impulsivity and Caregiver Burden after Deep Brain Stimulation for Parkinson’s Disease. PhD Thesis, Faculty of Medicine, The University of Queensland. doi: 10.14264/uql.2020.233
2019
Journal Article
The structural connectivity of discrete networks underlies impulsivity and gambling in Parkinson's disease
Mosley, Philip E., Paliwal, Saee, Robinson, Katherine, Coyne, Terry, Silburn, Peter, Tittgemeyer, Marc, Stephan, Klaas E., Breakspear, Michael and Perry, Alistair (2019). The structural connectivity of discrete networks underlies impulsivity and gambling in Parkinson's disease. Brain, 142 (12), 3917-3935. doi: 10.1093/brain/awz327
2019
Journal Article
Subjective estimates of uncertainty during gambling and impulsivity after subthalamic deep brain stimulation for Parkinson’s disease
Paliwal, Saee, Mosley, Philip E., Breakspear, Michael, Coyne, Terry, Silburn, Peter, Aponte, Eduardo, Mathys, Christoph and Stephan, Klaas E. (2019). Subjective estimates of uncertainty during gambling and impulsivity after subthalamic deep brain stimulation for Parkinson’s disease. Scientific Reports, 9 (1) 14795, 14795. doi: 10.1038/s41598-019-51164-2
2019
Journal Article
‘Woe betides anybody who tries to turn me down.’ A qualitative analysis of neuropsychiatric symptoms following subthalamic deep brain stimulation for Parkinson’s disease
Mosley, Philip E., Robinson, Katherine, Coyne, Terry, Silburn, Peter, Breakspear, Michael and Carter, Adrian (2019). ‘Woe betides anybody who tries to turn me down.’ A qualitative analysis of neuropsychiatric symptoms following subthalamic deep brain stimulation for Parkinson’s disease. Neuroethics, 14 (S1), 47-63. doi: 10.1007/s12152-019-09410-x
2019
Conference Publication
Deep brain simulation of the nucleus accumbens for severe, treatment-resistant obsessive-compulsive disorder
Mosley, P. (2019). Deep brain simulation of the nucleus accumbens for severe, treatment-resistant obsessive-compulsive disorder. RANZCP, Cairns, QLD, Australia, 12-16 May 2019. London, United Kingdom: Sage Publications.
Supervision
Availability
- Dr Philip Mosley is:
- Available for supervision
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Media
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