Dr Randal Moldrich
Dr

Randal Moldrich

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Availability

Dr Randal Moldrich is:
Available for supervision
Media expert

Fields of research

Basic pharmacology Biological Sciences Biomedical and Clinical Sciences Developmental genetics (incl. sex determination) Epigenetics (incl. genome methylation and epigenomics) Genetics Neurogenetics Neurosciences Paediatrics Pharmacology and pharmaceutical sciences

Research interests

  • Neurodevelopmental disorders

    From bench to bedside

Search Professor Randal Moldrich’s works on UQ eSpace

46 works between 1999 and 2017
All (46) Journal Article (38) Conference Publication (8)

1 - 20 of 46 works

2017

Journal Article

Validation of an MRI brain injury and growth scoring system in very preterm infants scanned at 29-to 35-week postmenstrual age

George, J. M., Fiori, S., Fripp, J., Pannek, K., Bursle, J., Moldrich, R. X., Guzzetta, A., Coulthard, A., Ware, R. S., Rose, S. E., Colditz, P. B. and Boyd, R. N. (2017). Validation of an MRI brain injury and growth scoring system in very preterm infants scanned at 29-to 35-week postmenstrual age. American Journal of Neuroradiology, 38 (7), 1435-1442. doi: 10.3174/ajnr.A5191

Validation of an MRI brain injury and growth scoring system in very preterm infants scanned at 29-to 35-week postmenstrual age

2015

Journal Article

EMX1 regulates NRP1-mediated wiring of the mouse anterior cingulate cortex

Lim, Jonathan W. C., Donahoo, Amber-Lee S., Bunt, Jens, Edwards, Timothy J., Fenlon, Laura R., Liu, Ying, Zhou, Jing, Moldrich, Randal X., Piper, Michael, Gobius, Ilan, Bailey, Timothy L., Wray, Naomi R., Kessaris, Nicoletta, Poo, Mu-Ming, Rubenstein, John L. R. and Richards, Linda J. (2015). EMX1 regulates NRP1-mediated wiring of the mouse anterior cingulate cortex. Development, 142 (21), 3746-3757. doi: 10.1242/dev.119909

EMX1 regulates NRP1-mediated wiring of the mouse anterior cingulate cortex

2015

Journal Article

A familial 7q36.3 duplication associated with agenesis of the corpus callosum

Wong, Keith, Moldrich, Randal, Hunter, Matthew, Edwards, Matthew, Finlay, David, O'Donnell, Sheridan, Macdougall, Tom, Bain, Nicole and Kamien, Benjamin (2015). A familial 7q36.3 duplication associated with agenesis of the corpus callosum. American Journal of Medical Genetics, Part A, 167 (9), 2201-2208. doi: 10.1002/ajmg.a.37143

A familial 7q36.3 duplication associated with agenesis of the corpus callosum

2015

Journal Article

Formation of functional areas in the cerebral cortex is disrupted in a mouse model of autism spectrum disorder

Fenlon, Laura R., Liu, Sha, Gobius, Ilan, Kurniawan, Nyoman D., Murphy, Skyle, Moldrich, Randal X. and Richards, Linda J. (2015). Formation of functional areas in the cerebral cortex is disrupted in a mouse model of autism spectrum disorder. Neural Development, 10 (10) 10, 1-14. doi: 10.1186/s13064-015-0033-y

Formation of functional areas in the cerebral cortex is disrupted in a mouse model of autism spectrum disorder

2014

Journal Article

Prenatal pharmacotherapy rescues brain development in a Down's syndrome mouse model

Guidi, Sandra, Stagni, Fiorenza, Bianchi, Patrizia, Ciani, Elisabetta, Giacomini, Andrea, De Franceschi, Marianna, Moldrich, Randal, Kurniawan, Nyoman, Mardon, Karine, Giuliani, Alessandro, Calzà, Laura and Bartesaghi, Renata (2014). Prenatal pharmacotherapy rescues brain development in a Down's syndrome mouse model. Brain, 137 (2), 380-401. doi: 10.1093/brain/awt340

Prenatal pharmacotherapy rescues brain development in a Down's syndrome mouse model

2014

Journal Article

Visualization of mouse barrel cortex using ex-vivo track density imaging

Kurniawan, Nyoman D., Richards, Kay L., Yang, Zhengyi, She, David, Ullmann, Jeremy F. P., Moldrich, Randal X., Liu, Sha, Yaksic, Javier Urriola, Leanage, Gayeshika, Kharatishvilia, Irina, Wimmer, Verena, Calamante, Fernando, Galloway, Graham J., Petrou, Steven and Reutens, David C. (2014). Visualization of mouse barrel cortex using ex-vivo track density imaging. NeuroImage, 87, 465-475. doi: 10.1016/j.neuroimage.2013.09.030

Visualization of mouse barrel cortex using ex-vivo track density imaging

2013

Journal Article

X-linked microtubule-associated protein, Mid1, regulates axon development

Lu, Tingjia, Chen, Renchao, Cox, Timothy C., Moldrich, Randal X., Kurniawan, Nyoman, Tan, Guohe, Perry, Jo K., Ashworth, Alan, Bartlett, Perry F., Xu, Li, Zhang, Jing, Lu, Bin, Wu, Mingyue, Shen, Qi, Liu, Yuanyuan, Richards, Linda J. and Xiong, Zhiqi (2013). X-linked microtubule-associated protein, Mid1, regulates axon development. Proceedings of the National Academy of Sciences of the United States of America, 110 (47), 19131-19136. doi: 10.1073/pnas.1303687110

X-linked microtubule-associated protein, Mid1, regulates axon development

2013

Journal Article

Inhibition of histone deacetylase in utero causes sociability deficits in postnatal mice

Moldrich, Randal X., Leanage, Gayeshika, She, David, Dolan-Evans, Elliot, Nelson, Michael, Reza, Nargis and Reutens, David C. (2013). Inhibition of histone deacetylase in utero causes sociability deficits in postnatal mice. Behavioural Brain Research, 257, 253-264. doi: 10.1016/j.bbr.2013.09.049

Inhibition of histone deacetylase in utero causes sociability deficits in postnatal mice

2012

Journal Article

Multiple Slits regulate the development of midline glial populations and the corpus callosum

Unni, Divya K., Piper, Michael, Moldrich, Randal X., Gobius, Ilan, Liu, Sha, Fothergill, Thomas, Donahoo, Amber-Lee S., Baisden, John M., Cooper, Helen M. and Richards, Linda J. (2012). Multiple Slits regulate the development of midline glial populations and the corpus callosum. Developmental Biology, 365 (1), 36-49. doi: 10.1016/j.ydbio.2012.02.004

Multiple Slits regulate the development of midline glial populations and the corpus callosum

2012

Journal Article

Loss of neuronal potassium/chloride cotransporter 3 (KCC3) is responsible for the degenerative phenotype in a conditional mouse model of hereditary motor and sensory neuropathy associated with agenesis of the corpus callosum

Shekarabi, Masoud, Moldrich, Randal X., Rasheed, Sarah, Salin-Cantegrel, Adele, Laganiere, Janet, Rochefort, Daniel, Hince, Pascale, Huot, Karine, Gaudet, Rebecca, Kurniawan, Nyoman, Sotocinal, Susana G., Ritchie, Jennifer, Dion, Patrick A., Mogil, Jeffrey S., Richards, Linda J. and Rouleau, Guy A. (2012). Loss of neuronal potassium/chloride cotransporter 3 (KCC3) is responsible for the degenerative phenotype in a conditional mouse model of hereditary motor and sensory neuropathy associated with agenesis of the corpus callosum. Journal of Neuroscience, 32 (11), 3865-3876. doi: 10.1523/JNEUROSCI.3679-11.2012

Loss of neuronal potassium/chloride cotransporter 3 (KCC3) is responsible for the degenerative phenotype in a conditional mouse model of hereditary motor and sensory neuropathy associated with agenesis of the corpus callosum

2012

Conference Publication

How sodium valproate causes language delay and autism - a molecular study

Moldrich, R., Leanage, G. and Reutens, D. (2012). How sodium valproate causes language delay and autism - a molecular study. 10th European Congress on Epileptology, London, United Kingdom, 30 September-4 October 2012. Hoboken, NJ, United States: Wiley-Blackwell Publishing. doi: 10.1111/j.1528-1167.2012.03677.x

How sodium valproate causes language delay and autism - a molecular study

2011

Journal Article

Fgfr3 regulates development of the caudal telencephalon

Moldrich, Randal X., Mezzera, Cecilia, Holmes, William M., Goda, Sailaja, Brookfield, Sam J., Rankin, Alastair J., Barr, Emily, Kurniawan, Nyoman, Dewar, Deborah, Richards, Linda J., López-Bendito, Guillermina and Iwata, Tomoko (2011). Fgfr3 regulates development of the caudal telencephalon. Developmental Dynamics, 240 (6), 1586-1599. doi: 10.1002/dvdy.22636

Fgfr3 regulates development of the caudal telencephalon

2010

Journal Article

Molecular regulation of the developing commissural plate

Moldrich, Randal X., Gobius, Ilan, Pollak, Thomas, Zhang, Jiangyang, Ren, Tianbo, Brown, Lucia, Mori, Susumu, Romero, Camino De Juan, Britanova, Olga, Tarabykin, Victor and Richards, Linda J. (2010). Molecular regulation of the developing commissural plate. Journal of Comparative Neurology, 518 (18), 3645-3661. doi: 10.1002/cne.22445

Molecular regulation of the developing commissural plate

2010

Journal Article

Clathrin-dependent APP endocytosis and Abeta secretion are highly sensitive to the level of plasma membrane cholesterol

Cossec, Jack-Christophe, Simon, Anne, Marquer, Catherine, Moldrich, Randal X., Leterrier, Christophe, Rossier, Jean, Duykaerts, Charles, Lenkei, Zsolt and Potier, Marie-Claude (2010). Clathrin-dependent APP endocytosis and Abeta secretion are highly sensitive to the level of plasma membrane cholesterol. BBA - Molecular and Cell Biology of Lipids, 1801 (8), 846-852. doi: 10.1016/j.bbalip.2010.05.010

Clathrin-dependent APP endocytosis and Abeta secretion are highly sensitive to the level of plasma membrane cholesterol

2010

Journal Article

Comparative mouse brain tractography of diffusion magnetic resonance imaging

Moldrich, Randal X., Pannek, Kerstin, Hoch, Renee, Rubenstein, John L., Kurniawan, Nyoman D. and Richards, Linda J. (2010). Comparative mouse brain tractography of diffusion magnetic resonance imaging. NeuroImage, 51 (3), 1027-1036. doi: 10.1016/j.neuroimage.2010.03.035

Comparative mouse brain tractography of diffusion magnetic resonance imaging

2010

Journal Article

NFIA controls telencephalic progenitor cell differentiation through repression of the Notch effector Hes1

Piper, Michael, Barry, Guy, Hawkins, John, Mason, Sharon, Lindwall, Charlotta, Little, Erica, Sarkar, Anindita, Smith, Aaron G., Moldrich, Randal X., Boyle, Glen M., Tole, Shubjha, Gronostajski, Richard M., Bailey, Timothy L. and Richards, Linda J. (2010). NFIA controls telencephalic progenitor cell differentiation through repression of the Notch effector Hes1. Journal of Neuroscience, 30 (27), 9127-9139. doi: 10.1523/JNEUROSCI.6167-09.2010

NFIA controls telencephalic progenitor cell differentiation through repression of the Notch effector Hes1

2009

Journal Article

Multiple non-cell-autonomous defects underlie neocortical callosal dysgenesis in Nfib-deficient mice

Piper, Michael, Moldrich, Randal, Lindwall, Charlotta, Little, Erica, Barry, Guy, Mason, Sharon, Sunn, Nana, Kurniawan, Nyoman D., Gronostajski, Richard M. and Richards, Linda J. (2009). Multiple non-cell-autonomous defects underlie neocortical callosal dysgenesis in Nfib-deficient mice. Neural Development, 4 (Article # 43) 43, 1-16. doi: 10.1186/1749-8104-4-43

Multiple non-cell-autonomous defects underlie neocortical callosal dysgenesis in Nfib-deficient mice

2009

Journal Article

Proliferation deficits and gene expression dysregulation in Down's syndrome (Ts1Cje) neural progenitor cells cultured from neurospheres

Moldrich, Randal X., Dauphinot, Luce, Laffaire, Julien, Vitalis, Tania, Herault, Yann, Beart, Philip M., Rossier, Jean, Vivien, Denis, Gehrig, Corinne, Antonarakis, Stylianos E., Lyle, Robert and Potier, Marie-Claude (2009). Proliferation deficits and gene expression dysregulation in Down's syndrome (Ts1Cje) neural progenitor cells cultured from neurospheres. Journal of Neuroscience Research, 87 (14), 3143-3152. doi: 10.1002/jnr.22131

Proliferation deficits and gene expression dysregulation in Down's syndrome (Ts1Cje) neural progenitor cells cultured from neurospheres

2009

Journal Article

Gene expression signature of cerebellar hypoplasia in a mouse model of Down syndrome during postnatal development

Laffaire, Julien, Rivals, Isabelle, Dauphinot, Luce, Pasteau, Fabien, Wehrle, Rosine, Larrat, Benoit, Vitalis, Tania, Moldrich, Randal X., Rossier, Jean, Sinkus, Ralph, Herault, Yann, Dusart, Isabelle and Potier, Marie-Claude (2009). Gene expression signature of cerebellar hypoplasia in a mouse model of Down syndrome during postnatal development. BMC Genomics, 10 (9) 138, 138.1-138.15. doi: 10.1186/1471-2164-10-138

Gene expression signature of cerebellar hypoplasia in a mouse model of Down syndrome during postnatal development

2008

Journal Article

Specific glial populations regulate hippocampal morphogenesis

Barry, Guy, Michael Piper, Lindwall, Charlotta, Moldrich, Randal, Mason, Sharon, Little, Erica, Sarkar, Anindita, Tole, Shubha, Gronostajski, Richard M. and Richards, Linda J. (2008). Specific glial populations regulate hippocampal morphogenesis. The Journal of Neuroscience, 28 (47), 12328-12340. doi: 10.1523/JNEUROSCI.4000-08.2008

Specific glial populations regulate hippocampal morphogenesis

Past funding

  • 2015 - 2022
    Neurodevelopment of the preterm infant
    NHMRC Project Grant
    Open grant
  • 2012 - 2015
    Mapping cerebral circuits in Down syndrome
    Fondation Jerome Lejeune
    Open grant
  • 2012
    The role of epigenetics in epilepsy
    RL Cooper Medical Research Foundation Limited
    Open grant
  • 2009
    The role of the Son gene in the developing brain and Down syndrome
    UQ Early Career Researcher
    Open grant
  • 2008 - 2009
    Down Syndrome candidate gene, Son, in the developing brain
    Fondation Jerome Lejeune
    Open grant
  • 2008
    UQ Travel Awards Category 2 - Randal Moldrich
    UQ Travel Grants Scheme
    Open grant
  • 2007 - 2008
    Down syndrome gene regulation of the proliferation rate of neural precursor cells
    UQ New Staff Research Start-Up Fund
    Open grant
  • 2007 - 2009
    NHMRC CJ Martin Fellowship: Understanding the neuropathy of Down Syndrome and identification of molecular targets for therapeutic intervention
    NHMRC Training (Postdoctoral) Fellowship
    Open grant

Availability

Dr Randal Moldrich is:
Available for supervision

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Enquiries

Contact Dr Randal Moldrich directly for media enquiries about:

  • Angelman Syndrome

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