Overview
Background
Dr. Zoe West, a Research Fellow at the Queensland Centre for Gynaecological Cancer within UQ's Centre for Clinical Research, specialising in vulvar cancer. Her primary objective is to minimise surgical interventions and enhance patient outcomes. Dr. West employs state-of-the-art three-dimensional imaging in her research to gain deeper insights into the intricacies of vulvar cancer.
Availability
- Dr Zoe West is:
- Available for supervision
Qualifications
- Doctor of Philosophy of Cellular Immunology, Queensland University of Technology
Research interests
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Vulvar Cancer
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Gynaecological Cancers
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3D imaging
iDISCO - DIPCO
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Tumour microenvironment
Immune-oncology - Cellular interactions
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Microscopy
Light sheet - Confocal - AI segmentation
Works
Search Professor Zoe West’s works on UQ eSpace
2024
Journal Article
Whole-brain spatial transcriptional analysis at cellular resolution
Kanatani, Shigeaki, Kreutzmann, Judith C., Li, Yue, West, Zoe, Larsen, Lea Lydolph, Nikou, Danai Vougesi, Eidhof, Ilse, Walton, Abigail, Zhang, Songbai, Rodríguez-Kirby, Leslie Rubio, Skytte, Jacob Lercke, Salinas, Casper Gravesen, Takamatsu, Kimiharu, Li, Xiaofei, Tanaka, Daisuke H., Kaczynska, Dagmara, Fukumoto, Keishiro, Karamzadeh, Razieh, Xiang, Yujiao, Uesaka, Naofumi, Tanabe, Tsutomu, Adner, Mikael, Hartman, Johan, Miyakawa, Ayako, Sundström, Erik, Castelo-Branco, Gonçalo, Roostalu, Urmas, Hecksher-Sørensen, Jacob and Uhlén, Per (2024). Whole-brain spatial transcriptional analysis at cellular resolution. Science, 386 (6724), 907-915. doi: 10.1126/science.adn9947
2024
Conference Publication
EV430/#358 Benefit-harm trade-off for groin node dissection versus groin ultrasound monitoring to reduce the risk of surgery-related morbidity in vulvar cancer – a decision-tree analysis
Obermair, Andreas, West, Zoe, Baxter, Eva, Condous, George, Hacker, Neville, Lord, Sally, Mccarthy, Sandie, Janda, Monika, Tuffaha, Haitham, Hayes, Sandi, Disipio, Tracey, Mellon, Anne, Gebski, Val, Mcnally, Orla and Martin, Andrew (2024). EV430/#358 Benefit-harm trade-off for groin node dissection versus groin ultrasound monitoring to reduce the risk of surgery-related morbidity in vulvar cancer – a decision-tree analysis. IGCS 2024 Annual Meeting, Dublin, Ireland, 16-18 October 2024. London, United Kingdom: BMJ Group. doi: 10.1136/ijgc-2024-igcs.551
2024
Journal Article
Three-dimensional imaging of upper tract urothelial carcinoma improves diagnostic yield and accuracy
Fukumoto, Keishiro, Kanatani, Shigeaki, Jaremko, Georg, West, Zoe, Li, Yue, Takamatsu, Kimiharu, Al Rayyes, Ibrahim, Mikami, Shuji, Niwa, Naoya, Axelsson, Tomas Andri, Tanaka, Nobuyuki, Oya, Mototsugu, Miyakawa, Ayako, Brehmer, Marianne and Uhlén, Per (2024). Three-dimensional imaging of upper tract urothelial carcinoma improves diagnostic yield and accuracy. JCI Insight, 9 (14) e175751, 14. doi: 10.1172/jci.insight.175751
2022
Journal Article
Disrupted Cacna1c gene expression perturbs spontaneous Ca <sup>2+</sup> activity causing abnormal brain development and increased anxiety
Smedler, Erik, Louhivuori, Lauri, Romanov, Roman A., Masini, Débora, Dehnisch Ellström, Ivar, Wang, Chungliang, Caramia, Martino, West, Zoe, Zhang, Songbai, Rebellato, Paola, Malmersjö, Seth, Brusini, Irene, Kanatani, Shigeaki, Fisone, Gilberto, Harkany, Tibor and Uhlén, Per (2022). Disrupted Cacna1c gene expression perturbs spontaneous Ca 2+ activity causing abnormal brain development and increased anxiety. Proceedings of the National Academy of Sciences, 119 (7) e2108768119. doi: 10.1073/pnas.2108768119
2021
Journal Article
The trans-SNARE complex VAMP4/Stx6/Stx7/Vti1b is a key regulator of Golgi to late endosome MT1-MMP transport in macrophages
West, Zoe Elizabeth, Aitcheson, Savannah Margaret, Semmler, Annalese Barbara Trudy and Murray, Rachael Zoe (2021). The trans-SNARE complex VAMP4/Stx6/Stx7/Vti1b is a key regulator of Golgi to late endosome MT1-MMP transport in macrophages. Traffic, 22 (11), 368-376. doi: 10.1111/tra.12813
2019
Journal Article
Development and use of biomaterials as wound healing therapies
Murray, Rachael Zoe, West, Zoe Elizabeth, Cowin, Allison June and Farrugia, Brooke Louise (2019). Development and use of biomaterials as wound healing therapies. Burns & Trauma, 7, 1-9. doi: 10.1186/s41038-018-0139-7
2019
Journal Article
Invasion by activated macrophages requires delivery of nascent membrane-type-1 matrix metalloproteinase through late endosomes/lysosomes to the cell surface
Röhl, Joan, West, Zoe E., Rudolph, Maren, Zaharia, Andreea, Van Lonkhuyzen, Derek, Hickey, Danica K., Semmler, Annalese B. T. and Murray, Rachael Z. (2019). Invasion by activated macrophages requires delivery of nascent membrane-type-1 matrix metalloproteinase through late endosomes/lysosomes to the cell surface. Traffic, 20 (9) tra.12675, 661-673. doi: 10.1111/tra.12675
2017
Journal Article
Macrophage phenotypes regulate scar formation and chronic wound healing
Hesketh, Mark, Sahin, Katherine B., West, Zoe E. and Murray, Rachael Z. (2017). Macrophage phenotypes regulate scar formation and chronic wound healing. International Journal of Molecular Sciences, 18 (7) 1545, 1-10. doi: 10.3390/ijms18071545
Funding
Current funding
Supervision
Availability
- Dr Zoe West is:
- Available for supervision
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Available projects
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Biomarkers in Gynaecological Cancer
Gynaecological cancers are the third most common cancer type diagnosed in Australian women. Each year over 6,700 Australian women and girls are diagnosed with gynaecological cancer and almost a third will not survive their disease.
We have a full-time PhD opportunity available at QCGC Research focusing on discovering and validating biomarkers that improve outcomes for women with gynaecological cancer. This project will involve working with clinical samples, conducting laboratory work, and analysing data.
The successful applicant will work as part of the QCGC Research team at UQCCR, as well as collaborate with researchers, clinicians, consumers, and stakeholders from other organisations, including hospitals, pathology providers and the community.
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Improving Outcomes for women experiencing gynaecological cancer
Endometrial cancer originates from the inner layer of the uterus and is the fifth most common cancer in women. In Australia, the incidence is >3,000 cases per year and this is rising at a rate of 1% year on year, while globally over 400,000 patients are diagnosed annually. Current standard treatment requires surgical removal of the uterus, tubes, and ovaries (hysterectomy). Clinical management guidelines for early-stage endometrial cancer also prescribe lymph node dissection to determine (via histopathology) the extent of the disease, however, this may lead to treatment that is more extensive than necessary.
We are currently running a phase III randomised clinical trial exploring the risks and benefits of lymph node dissection in clinical stage I endometrial cancer. The primary outcome of the trial is to determine the probability of disease-free survival at 4 years.
This project focuses on assessing:
- Patient-reported outcome measures, including health-related quality of life and fear of cancer recurrence
- Perioperative outcomes, including intra- and postoperative adverse events
- Lower-limb lymphoedema
- Requirements for adjuvant treatment
- Biomarkers to improve outcomes for patients
Supervision history
Current supervision
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Doctor Philosophy
Advanced methods for biomarker informed endometrial cancer
Associate Advisor
Other advisors: Dr Eva Baxter, Professor Andrew Martin, Professor Andreas Obermair
Media
Enquiries
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