Associate Professor Paul Ebert
Associate Professor

Paul Ebert

Email: 
Phone: 
+61 7 336 52973

Background

Genetics of mental health (new research)

We are using the genetic model organism, C. elegans, do investigate the genetic basis of both normal and disordered behaviour. Our current interests are identifying the genes responsible for anxiety and depression as well as the genes for eating disoders and addiction. Using C. elegans as a model organism will also allow us to study gene function as it relates to behaviour.

Molecular mechanisms of phosphine resistance (other research)

Genetic mapping of oxidative stress resistance genes. The fumigant phosphine disrupts oxidative metabolism, resulting in the production of reactive oxygen intermediates. This causes the premature ageing and death of targeted pests. Insect pests of stored grain in Australia now exhibit resistance to phosphine at levels more than 200 times the normal lethal dose.

We have genetically mappedf and identified the genes responsible for phosphine resistance in tall major insect pests of stored grain. We are using a systems biology approach in the model organism C. elegans to understand the molecular basis of phosphine action. Our genetic studies have recently shown that resistance to phosphine is associated with an extension of lifespan

Availability

Associate Professor Paul Ebert is:
Available for supervision
Media expert

Fields of research

Agricultural, Veterinary and Food Sciences Behavioural genetics Behavioural neuroscience Biological Sciences Biological psychology Biomedical and Clinical Sciences Crop and pasture post harvest technologies (incl. transportation and storage) Crop and pasture production Evolutionary psychological studies Gene expression (incl. microarray and other genome-wide approaches) Gene mapping Genetics Genomics Invertebrate biology Medical biochemistry - amino acids and metabolites Medical biochemistry and metabolomics Molecular evolution Neurogenetics Pharmacology and pharmaceutical sciences Psychology Psychopharmacology Zoology

Qualifications

  • Bachelor (Honours) of Science (Advanced), University of California-Riverside
  • Masters (Coursework) of Science, University of Washington
  • Doctor of Philosophy, Washington State University

Research interests

  • Genetics of mental health

    The genetics of mental health is notoriously difficult to study. I am developing behavioural assays in the model organism, Caenorhabditis elegans to study the genetics and neuropharmacology of anxiety and depression as well as anorexia and addiction.

  • Metabolic toxicology - fumigant toxicology

    I am interested in energy metabolism and mitochondrial function. My work is based around the toxicology of the agricultural fumigant, phosphine. The phosphine resistance gene, dld, not only results in phosphine resistance, but also modulates cellular energy metabolism.

Research impacts

Mental health

Anxiety is the most common mental health condition. Hundreds of candidate anxiety genes have been identified by human Genome Wide Association Studies (GWAS), but the functions of these genes are difficult to study in humans or mammalian model organisms. We have developed behavioural assays using C. elegans that are allowing us to confirm the role in anxiety of the candidate genes identified by GWAS.

We have also identified a suite of compounds that can induce anorexia in C. elegans. This system is allowing us to test the limited number of candidate anorexia genes that have been identified by GWAS and to identify new genes by genetic screens.

Other research

Our discovery of the economically important phosphine resistance gene has allowed us to characterise resistance across Australia and India. It is now being use to monitor resistance management strategies in collaboration with major grain handling companies to improve commercial practice in Australia and India. This is the subject of a recent Australia-India AISRF project on which I was the UQ lead investigator. We have also used the gene marker to characterise resistance in Vietnam, China, Turkey. Others have used our work to characterise resistance in the USA and Brazil.

We have also sought to use our understanding of how phosphine works to identify synergistic gases that might be used to extend the useful life of phosphine as a grain fumigant. This work was supported by an ARC Discovery grant and a research grant from the Plant Biosecurity CRC.

We have also discovered the the phosphine resistance gene, dld, is a lifespan extending factor. Interestingly, it also protects against pathology in a C. elegans model of Alzheimer's disease, a serious ageing associated disease. Alzheimer's disease is a major disease of global importance with huge economic ramifications due to the level of care required by people who suffer from dementia. Our system allows us to explore the metabolic basis of the disease, an aspect that has until recently been largely neglected.

Search Professor Paul Ebert’s works on UQ eSpace

97 works between 1986 and 2024
All (97) Journal Article (78) Book Chapter (5) Conference Publication (12) Other Outputs (1) Edited Outputs (1)

81 - 97 of 97 works

1999

Conference Publication

A unique D1-like dopamine receptor gene in honey bees shows age related expression in mushroom body intrinsic cells

Humphries, M. and Ebert, P. R. (1999). A unique D1-like dopamine receptor gene in honey bees shows age related expression in mushroom body intrinsic cells. XIII International Congress of IUSSI: IUSSI 1999, Adelaide, S. Aust., 29 December, 1998 - 4 January, 1999. America: IUSSI.

A unique D1-like dopamine receptor gene in honey bees shows age related expression in mushroom body intrinsic cells

1999

Conference Publication

Comparative genomic and detailed structural analysis of the GABA neurotransmitter transporter gene family between vertebrates and the invertebrates, Apis Mellifera and C.elegans

Dutton, P., Mccart, A., Whitehall, V. L. and Ebert, P. R. (1999). Comparative genomic and detailed structural analysis of the GABA neurotransmitter transporter gene family between vertebrates and the invertebrates, Apis Mellifera and C.elegans. ComBio 99, Conrad Jupiters, Gold Coast, 27-30 September, 1999. Kent Town, SA: Aust. Society for Biochemistry and Molecular Biology.

Comparative genomic and detailed structural analysis of the GABA neurotransmitter transporter gene family between vertebrates and the invertebrates, Apis Mellifera and C.elegans

1999

Conference Publication

Structural features of the biogenic amine receptor genes

Ebert, P. R., Meadows, B., Humphries, M., Swasdipan, N., Whitehall, V. L. and Doan, T. (1999). Structural features of the biogenic amine receptor genes. XIII International Congress of IUSSI: IUSSI 1999, Adelaide, SA, Australia, 29 December 1998 - 4 January 1999. United States: IUSSI.

Structural features of the biogenic amine receptor genes

1998

Journal Article

Isolation of seven unique biogenic amine receptor clones from the honey bee by library scanning

Ebert, P. R., Rowland, J. E. and Toma, D. P. (1998). Isolation of seven unique biogenic amine receptor clones from the honey bee by library scanning. Insect Molecular Biology, 7 (2), 151-162. doi: 10.1046/j.1365-2583.1998.72059.x

Isolation of seven unique biogenic amine receptor clones from the honey bee by library scanning

1996

Journal Article

Isolation of megabase-sized DNA fragments from the honey bee (Apis mellifera) genome

Ebert, Paul R. (1996). Isolation of megabase-sized DNA fragments from the honey bee (Apis mellifera) genome. Journal of Apicultural Research, 35 (3-4), 124-125. doi: 10.1080/00218839.1996.11100924

Isolation of megabase-sized DNA fragments from the honey bee (Apis mellifera) genome

1995

Journal Article

An S-RNase promoter from Nicotiana alata functions in transgenic N. alata plants but not Nicotiana tabacum

Murfett, Jane, Ebert, Paul R., Haring, Volker and Clarke, Adrienne E. (1995). An S-RNase promoter from Nicotiana alata functions in transgenic N. alata plants but not Nicotiana tabacum. Plant Molecular Biology, 28 (5), 957-963. doi: 10.1007/bf00042080

An S-RNase promoter from Nicotiana alata functions in transgenic N. alata plants but not Nicotiana tabacum

1995

Journal Article

Primary sequence, copy number, and distribution of mariner transposons in the honey bee

Ebert, P. R., Hileman, J. P. and Nguyen, H. T. (1995). Primary sequence, copy number, and distribution of mariner transposons in the honey bee. Insect Molecular Biology, 4 (2), 69-78. doi: 10.1111/j.1365-2583.1995.tb00010.x

Primary sequence, copy number, and distribution of mariner transposons in the honey bee

1992

Journal Article

Expression of a self-incompatibility glycoprotein (S2-Ribonuclease) from Nicotiana alata in transgenic Nicotiana tabacum

Murfett, Jane, Cornish, Edwina C., Ebert, Paul R., Bonig, Ingrid, McClure, Bruce A. and Clarke, Adrienne E. (1992). Expression of a self-incompatibility glycoprotein (S2-Ribonuclease) from Nicotiana alata in transgenic Nicotiana tabacum. The Plant Cell, 4 (9), 1063-1074. doi: 10.2307/3869475

Expression of a self-incompatibility glycoprotein (S2-Ribonuclease) from Nicotiana alata in transgenic Nicotiana tabacum

1990

Journal Article

Molecular genetics and biology of self-incompatibility in Nicotiana alata, an ornamental tobacco

Mcclure, B.A., Haring, V., Ebert, P.R., Anderson, M.A., Bacic, A. and Clarke, A.E. (1990). Molecular genetics and biology of self-incompatibility in Nicotiana alata, an ornamental tobacco. Australian Journal of Plant Physiology, 17 (3), 345-353. doi: 10.1071/pp9900345

Molecular genetics and biology of self-incompatibility in Nicotiana alata, an ornamental tobacco

1990

Journal Article

Transformation and regeneration of the self-incompatible species Nicotiana alata Link & Otto

Ebert, Paul R. and Clarke, Adrienne E. (1990). Transformation and regeneration of the self-incompatible species Nicotiana alata Link & Otto. Plant Molecular Biology, 14 (5), 815-824. doi: 10.1007/bf00016514

Transformation and regeneration of the self-incompatible species Nicotiana alata Link & Otto

1989

Journal Article

Style self-incompatibility gene products of Nicotlana alata are ribonucleases

McClure, Bruce A., Haring, Volker, Ebert, Paul R., Anderson, Marilyn A., Simpson, Richard J., Sakiyama, Fumio and Clarke, Adrienne E. (1989). Style self-incompatibility gene products of Nicotlana alata are ribonucleases. Nature, 342 (6252), 955-957. doi: 10.1038/342955a0

Style self-incompatibility gene products of Nicotlana alata are ribonucleases

1989

Book Chapter

Binary vectors

An, Gynheung, Ebert, Paul R., Mitra, Amitava and Ha, Sam B. (1989). Binary vectors. Plant molecular biology manual. (pp. 29-47) Dordrecht: Springer Netherlands. doi: 10.1007/978-94-009-0951-9_3

Binary vectors

1988

Book Chapter

Binary vectors

An, Gynheung, Ebert, Paul R., Mitra, Amitava and Ha, Sam B. (1988). Binary vectors. Plant molecular biology manual. (pp. 45-63) Dordrecht: Springer Netherlands.

Binary vectors

1987

Journal Article

Identification of an essential upstream element in the nopaline synthase promoter by stable and transient assays

Ebert, P.R., Ha, S.B. and An, G. (1987). Identification of an essential upstream element in the nopaline synthase promoter by stable and transient assays. Proceedings of the National Academy of Sciences, 84 (16), 5745-5749. doi: 10.1073/pnas.84.16.5745

Identification of an essential upstream element in the nopaline synthase promoter by stable and transient assays

1986

Journal Article

A gene essential for Agrobacterium virulence is homologous to a family of positive regulatory loci

Winans, S. C., Ebert, P. R., Stachel, S. E., Gordon, M. P. and Nester, E. W. (1986). A gene essential for Agrobacterium virulence is homologous to a family of positive regulatory loci. Proceedings of the National Academy of Sciences, 83 (21), 8278-8282. doi: 10.1073/pnas.83.21.8278

A gene essential for Agrobacterium virulence is homologous to a family of positive regulatory loci

1986

Journal Article

Both TATA box and upstream regions are required for the nopaline synthase promoter activity in transformed tobacco cells

An, Gynheung, Ebert, Paul R., Yi, Bu-Young and Choi, Chul-Hi (1986). Both TATA box and upstream regions are required for the nopaline synthase promoter activity in transformed tobacco cells. Molecular & General Genetics, 203 (2), 245-250. doi: 10.1007/bf00333961

Both TATA box and upstream regions are required for the nopaline synthase promoter activity in transformed tobacco cells

1986

Journal Article

Promoters of Agrobacterium tumefaciens Ti-plasmid virulence genes

Das, A., Stachel, S., Ebert, P., Allenza, P., Montoya, A. and Nester, E. (1986). Promoters of Agrobacterium tumefaciens Ti-plasmid virulence genes. Nucleic Acids Research, 14 (3), 1355-1364. doi: 10.1093/nar/14.3.1355

Promoters of Agrobacterium tumefaciens Ti-plasmid virulence genes

Past funding

  • 2024
    Toward a rapid antibody test (RAT) for phosphine resistant insect pests of stored grain
    Australia's Economic Accelerator Seed Grants
    Open grant
  • 2021 - 2023
    Research and development into innovative grain refrigeration processes to disrupt breeding of established grain pests in response to resistance to grain insecticides
    Queensland Department of Agriculture and Fisheries
    Open grant
  • 2021 - 2024
    Optimisation of phosphine fumigation under low oxygen
    Queensland Department of Agriculture and Fisheries
    Open grant
  • 2019 - 2020
    National resistance monitoring for insect pests of stored grain (GRDC grant administered by QDAF)
    Queensland Department of Agriculture and Fisheries
    Open grant
  • 2019
    A versatile accurate mass, high resolution QTOF mass spectrometer for chemistry and proteomic applications
    UQ Major Equipment and Infrastructure
    Open grant
  • 2016 - 2020
    Deploying biotechnology based decision making tools in postharvest grain pest management to enhance food security and market access [AISRF administered by DAF]
    Queensland Department of Agriculture and Fisheries
    Open grant
  • 2015
    A sensitive, high resolution QTOF mass spectrometer with nanoUPLC system for qualitative and quantitative biomolecule analysis.
    UQ Major Equipment and Infrastructure
    Open grant
  • 2015
    Beyond genomes, transcriptomes and proteomes: high throughput analysis of gene and protein expression and function
    UQ Major Equipment and Infrastructure
    Open grant
  • 2014 - 2018
    DNA Marker development and their use in monitoring and eradication of phosphine resistance in stored grain pests
    Plant Biosecurity CRC
    Open grant
  • 2014 - 2017
    Investigation of new control options for phosphine resistant pests of stored grain
    Plant Biosecurity CRC
    Open grant
  • 2014 - 2016
    Comparative toxicology of a fumigant and gasotransmitters: Testing a new model of fumigant toxicity in Caenorhabditis elegans
    ARC Discovery Projects
    Open grant
  • 2012 - 2016
    Ensuring food security: harnessing science to protect our grain harvest from insect threats
    Department of Innovation, Industry, Science and Research - Australia-India Strategic Research Fund
    Open grant
  • 2010 - 2012
    Targeting mechanisms of phosphine resistance in stored grain pests
    Queensland Department of Employment, Economic Development and Innovation
    Open grant
  • 2009
    Building Capacity in Quantitative Genomics
    UQ School/Centre Co-Funding
    Open grant
  • 2008
    Controlled Environment Facilities for the Challenges of the 21st Century
    UQ Major Equipment and Infrastructure
    Open grant
  • 2007 - 2008
    A national curriculum for entomology: Capacity building through collaborative, web-based delivery
    Carrick Competitive Grants
    Open grant
  • 2007 - 2010
    Diagnostic technologies for phosphine resistance
    QLD Department of Primary Industries & Fisheries
    Open grant
  • 2007
    Ecology of resistance to phosphine in insect pests of stored grain
    QLD Department of Primary Industries & Fisheries
    Open grant
  • 2006
    Real time PCR and nanoparticle diagnostic facilities for high-throughput quantitative analysis of genomic structure and gene expression
    ARC Linkage Infrastructure, Equipment and Facilities
    Open grant
  • 2005 - 2007
    Genetics of longevity and the delay of post-reproductive senescence
    ARC Discovery Projects
    Open grant
  • 2004 - 2005
    Devising Improved Pest Control Strategies Via Integrated Genomic, Physiological And Toxicological Profiling
    UQ FirstLink Scheme
    Open grant
  • 2004
    The Insect-Plant Chemical Ecology Network (IPCEN)
    ARC Seed Funding for Research Networks
    Open grant
  • 2003 - 2007
    Validation of resistance-gene-specific and quantitative markers of phosphine resistance in stored grain pests
    Grains Research & Development Corporation
    Open grant
  • 2002 - 2004
    Beyond the gene: Linking herbivore behaviour to plant defense gene expression.
    ARC Discovery Projects
    Open grant
  • 2000 - 2002
    Genetic and biochemical markers for strategic management of phosphine resistance in stored grain pests
    ARC Collaborative Grant (SPIRT)
    Open grant
  • 2000
    Toward isolation of phosphine resistance genes from the lesser Grain Borer: Physical characterisation of the genome.
    ARC Australian Research Council (Small grants)
    Open grant
  • 1999
    Functional analysis of a new class of dopamine receptor
    ARC Australian Research Council (Small grants)
    Open grant
  • 1998
    Neuromodulator receptors as markers of brain plasticity in a social insect
    Brain Research Fund
    Open grant
  • 1997
    An integrated behavioural genetic and physical neurogenetic map of the honey bee genome
    UQ External Support Enabling Grant
    Open grant
  • 1996
    Saturation cloning and behavioural analysis of a neuromodulator receptor gene family from the honey bee
    UQ Foundation
    Open grant

Availability

Associate Professor Paul Ebert is:
Available for supervision

Before you email them, read our advice on how to contact a supervisor.

Available projects

  • Phosphine toxicology

    This project is focused on energy metabolism and mitochondrial function as it relates to the toxicology of the agricultural fumigant, phosphine. This project employs a systems biology approach that ionvolves bioinformatics, genomics, metabolomics and functional genetics in the model organism, Caenorhabditis elegans.

  • Genetics of mental health

    A major focus of my lab is investigating the genetics of mental health in the genetic model organism, C. elegans. The fundamental insight that makes it possible to study mental health in a nematode like C. elegans is that at the foundation of every behavioural disorder is a completely normal evolved behaviour. Thus, to study anxiety, the most widespread mental health problem that affects society, one has only to recognise that it is a component of harm avoidance mechanisms. Every animal has the ability to detect and evaluate potential harms, so the genetics of harm avoidance can provide fundamental insight into a bewildering array of anxiety disorders that currently lack a unifying theoretical foundation.

    My lab is using a combination of psychoactive drugs, C. elegans strains with neural signalling mutations and the tools of systems biology to study:

    1. Eating disorders
    2. Addiction
    3. Anxiety

    And possibly:

    1. Depression
    2. Attention deficit hyperactivity disorder
    3. Learning and forgetting

Supervision history

Current supervision

  • Doctor Philosophy

    Pharmacogenetics of anorexia in the model organism C.elegans

    Principal Advisor

    Other advisors: Associate Professor Steven Zuryn

  • Doctor Philosophy

    Comparative analysis of instinctual feeding behaviour and addiction in the genetic model organism, C. elegans.

    Principal Advisor

    Other advisors: Associate Professor Steven Zuryn

  • Master Philosophy

    Mechanisms of phosphine toxicity under low oxygen

    Principal Advisor

  • Doctor Philosophy

    Transposon Activation as an Adaptive Stress Response in C. elegans

    Principal Advisor

    Other advisors: Professor Sandie Degnan

  • Doctor Philosophy

    Comparative analysis of instinctual feeding behaviour and addiction in the genetic model organism, C. elegans.

    Principal Advisor

    Other advisors: Associate Professor Steven Zuryn

  • Doctor Philosophy

    Insect P450s for degradation of polyethylene plastic

    Associate Advisor

    Other advisors: Professor Elizabeth Gillam

Completed supervision

Enquiries

Contact Associate Professor Paul Ebert directly for media enquiries about:

  • C elegans - genetics
  • Fumigant phosphine resistance in insects
  • Genetics - C elegans
  • Grain storage insects
  • Insect fumigants
  • Insect genetics

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