Overview
Background
Dr. Liu specialises in extracellular vesicles, osteosarcoma, breast cancer, tissue engineering, immunomodulation and biomaterial functionalisation.
Dr. Liu is a clinician (surgeon)-scientist with clinical and preclinical expertise in tissue repair and immunomodulation. Dr. Liu obtained Bachelor’s and Master’s degrees from Shanghai JiaoTong University (China); and a PhD degree from RWTH Aachen University (Germany).
Dr. Liu works with extracellular vesicles, including newly discovered matrix-bound nanovesicles. Dr. Liu’s current projects involve assessing the role of extracellular vesicle glycans on immunomodulation in metastatic breast cancer and metastatic pediatric cancers, such as osteosarcoma. Dr. Liu also has a background in biological scaffold functionalisation with the goal of developing innovative approaches that bring advanced benefits directly to clinical soft tissue repair.
Availability
- Dr Zhengni Liu is:
- Available for supervision
Fields of research
Qualifications
- Bachelor, Shanghai Jiao Tong University
- Masters (Research), Shanghai Jiao Tong University
- Doctoral (Research), Rheinisch Westfalische Technische Hochschule Aachen
Research interests
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Biomaterials
Biomaterials for soft tissue repair
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Extracellular Vesicles
Applications of Extracellular Vesicles in Tissue Engineering and tumor treatment
Research impacts
Advancing immunomodulation in metastatic cancers with Extracellular Vesicles
Dr. Liu's groundbreaking research focuses on extracellular vesicles (EVs), including the newly discovered matrix-bound nanovesicles, which are emerging as pivotal players in cellular communication. Their current projects delve into the crucial role of extracellular vesicle glycans in immunomodulation, particularly in metastatic breast cancer and metastatic pediatric cancers like osteosarcoma. The implications of her research are substantial and multidimensional, reflecting a significant impact on both scientific understanding and clinical applications.
Dr. Liu’s work contributes to a deeper understanding of the biochemical mechanisms that underpin cancer metastasis and immune evasion. By exploring how glycans on extracellular vesicles influence immune responses, their research uncovers novel pathways through which cancer cells manipulate the immune system to spread and thrive in other body parts. This knowledge broadens the scientific community's understanding of cancer biology and highlights the intricate networks of cell communication mediated by EVs. Understanding the role of EV glycans in immunomodulation opens up new avenues for therapeutic intervention in Targeted Therapies and Biomarkers for Cancer.
Advancing Abdominal Hernia Repair with Innovative Biomaterials
As a researcher specialising in biomaterials for abdominal hernia repair, Dr. Liu’s work focuses on developing and refining materials that enhance the effectiveness and safety of surgical interventions for hernia patients. Hernias, which involve the protrusion of internal organs through the abdominal wall, are a prevalent issue impacting millions worldwide, necessitating durable and reliable treatments.Dr. Liu is now focusing on the newly developed EVs, namely matrix-bonded nanovesicles, and their potential application for tissue engineering, especially for abdominal wall repair, including Improved Surgical Outcomes and Enhanced Patient Recover.
Dr. Liu maintains active collaborations with hospital networks and surgical teams to ensure that the benefits of our research are directly conveyed to clinical practice. Dr. Liu’s team also engages with patient advocacy groups to educate hernia sufferers about the latest treatment options, empowering them with knowledge to make informed decisions about their healthcare.
Works
Search Professor Zhengni Liu’s works on UQ eSpace
2024
Journal Article
Establishment and evaluation of rat models of parastomal hernia
Zhu, X., Liu, J., Liu, Z., Tang, R. and Fu, C. (2024). Establishment and evaluation of rat models of parastomal hernia. Hernia. doi: 10.1007/s10029-024-03010-2
2024
Journal Article
Ibuprofen-loaded bilayer electrospun mesh modulates host response toward promoting full-thickness abdominal wall defect repair
Liu, Jiajie, Tang, Rui, Zhu, Xiaoqiang, Ma, Qiaolin, Mo, Xiumei, Wu, Jinglei and Liu, Zhengni (2024). Ibuprofen-loaded bilayer electrospun mesh modulates host response toward promoting full-thickness abdominal wall defect repair. Journal of Biomedical Materials Research. Part A, 112 (6), 941-955. doi: 10.1002/jbm.a.37672
2023
Journal Article
Development of a silk fibroin-small intestinal submucosa small-diameter vascular graft with sequential VEGF and TGF-β1 inhibitor delivery for in situ tissue engineering
Liu, Zhengni, Ruetten, Stephan, Buhl, Eva Miriam, Zhang, Minjun and Liu, Jiajie (2023). Development of a silk fibroin-small intestinal submucosa small-diameter vascular graft with sequential VEGF and TGF-β1 inhibitor delivery for in situ tissue engineering. Macromolecular Bioscience, 23 (9) 2300184, e2300184. doi: 10.1002/mabi.202300184
2023
Journal Article
Comparison of open and laparoscopic inguinal-hernia repair in octogenarians
Zhu, Xiaoqiang, Liu, Zhengni, Shen, Jianfeng, Liu, Jiajie and Tang, Rui (2023). Comparison of open and laparoscopic inguinal-hernia repair in octogenarians. Asian Journal of Surgery, 46 (2), 738-741. doi: 10.1016/j.asjsur.2022.06.149
2022
Journal Article
Development of a decellularized human amniotic membrane-based electrospun vascular graft capable of rapid remodeling for small-diameter vascular applications
Liu, Jiajie, Chen, Dian, Zhu, Xiaoqiang, Liu, Nan, Zhang, Haibo, Tang, Rui and Liu, Zhengni (2022). Development of a decellularized human amniotic membrane-based electrospun vascular graft capable of rapid remodeling for small-diameter vascular applications. Acta Biomaterialia, 152, 144-156. doi: 10.1016/j.actbio.2022.09.009
2022
Journal Article
Incorporation of magnesium oxide nanoparticles into electrospun membranes improves pro-angiogenic activity and promotes diabetic wound healing
Liu, Mingyue, Wang, Ruilan, Liu, Jiajie, Zhang, Weixing, Liu, Zhengni, Lou, Xiangxin, Nie, Huali, Wang, Hongsheng, Mo, Xiumei, Abd-Elhamid, Ahmed I., Zheng, Rui and Wu, Jinglei (2022). Incorporation of magnesium oxide nanoparticles into electrospun membranes improves pro-angiogenic activity and promotes diabetic wound healing. Biomaterials Advances, 133 112609. doi: 10.1016/j.msec.2021.112609
2021
Journal Article
Nanofiber configuration affects biological performance of decellularized meniscus extracellular matrix incorporated electrospun scaffolds
Li, Haiyan, Wang, Xiaoyu, Liu, Jiajie, Liu, Zhengni, Wang, Hongsheng, Mo, Xiumei and Wu, Jinglei (2021). Nanofiber configuration affects biological performance of decellularized meniscus extracellular matrix incorporated electrospun scaffolds. Biomedical Materials, 16 (6) 065013, 065013. doi: 10.1088/1748-605x/ac28a5
2021
Journal Article
The evaluation of functional small intestinal submucosa for abdominal wall defect repair in a rat model: Potent effect of sequential release of VEGF and TGF-β1 on host integration
Liu, Zhengni, Liu, Xuezhe, Bao, Luhan, Liu, Jiajie, Zhu, Xiaoqiang, Mo, Xiumei and Tang, Rui (2021). The evaluation of functional small intestinal submucosa for abdominal wall defect repair in a rat model: Potent effect of sequential release of VEGF and TGF-β1 on host integration. Biomaterials, 276 120999, 120999. doi: 10.1016/j.biomaterials.2021.120999
2021
Journal Article
Tailoring electrospun mesh for a compliant remodeling in the repair of full-thickness abdominal wall defect-The role of decellularized human amniotic membrane and silk fibroin
Liu, Zhengni, Liu, Jiajie, Liu, Nan, Zhu, Xiaoqiang and Tang, Rui (2021). Tailoring electrospun mesh for a compliant remodeling in the repair of full-thickness abdominal wall defect-The role of decellularized human amniotic membrane and silk fibroin. Materials Science and Engineering C: Materials for Biological Applications, 127 112235. doi: 10.1016/j.msec.2021.112235
2021
Journal Article
Functionalized strategies and mechanisms of the emerging mesh for abdominal wall repair and regeneration
Liu, Zhengni, Wei, Nina and Tang, Rui (2021). Functionalized strategies and mechanisms of the emerging mesh for abdominal wall repair and regeneration. ACS Biomaterials Science & Engineering, 7 (6), 2064-2082. doi: 10.1021/acsbiomaterials.1c00118
2021
Journal Article
Magnesium oxide-incorporated electrospun membranes inhibit bacterial infections and promote the healing process of infected wounds
Liu, Mingyue, Wang, Xiaoyu, Li, Haiyan, Xia, Changlei, Liu, Zhengni, Liu, Jiajie, Yin, Anlin, Lou, Xiangxin, Wang, Hongsheng, Mo, Xiumei and Wu, Jinglei (2021). Magnesium oxide-incorporated electrospun membranes inhibit bacterial infections and promote the healing process of infected wounds. Journal of Materials Chemistry B, 9 (17), 3727-3744. doi: 10.1039/d1tb00217a
2020
Journal Article
A study of the "Swiss-roll" folding method for placement of self-gripping mesh in TAPP
Zhu, Xiaoqiang, Liu, Jiajie, Wei, Nina, Liu, Zhengni and Tang, Rui (2020). A study of the "Swiss-roll" folding method for placement of self-gripping mesh in TAPP. Minimally Invasive Therapy and Allied Technologies, 31 (2), 262-268. doi: 10.1080/13645706.2020.1780452
2020
Journal Article
Evaluation of a biocomposite mesh modified with decellularized human amniotic membrane for intraperitoneal onlay mesh repair
Liu, Zhengni, Zhu, Xiaoqiang, Zhu, Tonghe and Tang, Rui (2020). Evaluation of a biocomposite mesh modified with decellularized human amniotic membrane for intraperitoneal onlay mesh repair. ACS Omega, 5 (7), 3550-3562. doi: 10.1021/acsomega.9b03866
2020
Journal Article
Electrospun scaffold with sustained antibacterial and tissue-matched mechanical properties for potential application as functional mesh
Liu, Zhengni, Zhu, Xiaoqiang and Tang, Rui (2020). Electrospun scaffold with sustained antibacterial and tissue-matched mechanical properties for potential application as functional mesh. International Journal of Nanomedicine, 15, 4991-5004. doi: 10.2147/ijn.s248970
2019
Journal Article
Research progress on the anti-hepatic fibrosis action and mechanism of natural products
Shan, Liang, Liu, Zhenni, Ci, Leilei, Shuai, Chen, Lv, Xiongwen and Li, Jun (2019). Research progress on the anti-hepatic fibrosis action and mechanism of natural products. International Immunopharmacology, 75 105765. doi: 10.1016/j.intimp.2019.105765
2019
Journal Article
Tacrolimus exposure early after lung transplantation and exploratory associations with acute cellular rejection
Darley, D. R., Carlos, L., Hennig, S., Liu, Z., Day, R. and Glanville, A. R. (2019). Tacrolimus exposure early after lung transplantation and exploratory associations with acute cellular rejection. European Journal of Clinical Pharmacology, 75 (7), 879-888. doi: 10.1007/s00228-019-02658-5
2019
Journal Article
Triangle trocar configuration in laparoscopic totally extraperitoneal inguinal hernia repair: a prospective randomized controlled study
Zhu, Xiaoqiang, Liu, Zhengni, Shen, Jianfeng and Tang, Rui (2019). Triangle trocar configuration in laparoscopic totally extraperitoneal inguinal hernia repair: a prospective randomized controlled study. Journal of Surgical Research, 239, 149-155. doi: 10.1016/j.jss.2019.01.067
2018
Journal Article
Promoting early neovascularization of SIS-repaired abdominal wall by controlled release of bioactive VEGF
Tang, Rui, Wang, Xin, Zhang, Hanying, Liang, Xi, Feng, Xueyi, Zhu, Xiaoqiang, Lu, Xinwu, Wu, Fei and Liu, Zhengni (2018). Promoting early neovascularization of SIS-repaired abdominal wall by controlled release of bioactive VEGF. RSC Advances, 8 (9), 4548-4560. doi: 10.1039/c7ra11954b
2016
Journal Article
Hepatectomy for patients with alveolar echinococcosis: Long-term follow-up observations of 144 cases
Du, Chengsong, Liu, Zhengni, Yang, Xianwei, Yan, Lunan, Li, Bo, Wen, Tianfu, Yang, Jiangyin, Xu, Mingqing, Chen, Zheyu and Wang, Wentao (2016). Hepatectomy for patients with alveolar echinococcosis: Long-term follow-up observations of 144 cases. International Journal of Surgery, 35, 147-152. doi: 10.1016/j.ijsu.2016.09.094
2016
Journal Article
Hepatocellular carcinoma cases with high levels of c-Raf-1 expression may benefit from postoperative adjuvant sorafenib after hepatic resection even with high risk of recurrence
Lei, Jianyong, Zhong, Jinjing, Hao, Jingcheng, Liu, Zhengni, Zhang, Peng, Wu, Lixue, Yan, Lunan, Zhu, Jinqiang, Zeng, Yong, Li, Bo, Wen, Tianfu and Wang, Wentao (2016). Hepatocellular carcinoma cases with high levels of c-Raf-1 expression may benefit from postoperative adjuvant sorafenib after hepatic resection even with high risk of recurrence. OncoTarget, 7 (27), 42598-42607. doi: 10.18632/oncotarget.3799
Funding
Current funding
Supervision
Availability
- Dr Zhengni Liu is:
- Available for supervision
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Available projects
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Treating breast cancer metastasis by targeting immunosuppressive extracellular vesicles
This proposal aims to develop effective treatments for the deadliest subtype of breast cancer: triple-negative breast cancer (TNBC). To accomplish this, we will focus on targeting immunosuppressive extracellular vesicles (EVs) that promote TNBC cell survival and metastatic spread. Our approach involves identifying and implementing strategies to reactivate the immune system in patients with TNBC metastases. By enhancing the body’s ability to recognize and eliminate TNBC cells, the goal is to reduce the need for conventional therapeutics with harmful side effects.
Media
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