Mr Evan Bailey
Mr

Evan Bailey

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Background

Evan Bailey is a postdoctoral researcher in the Molecular and Systems Medicine Group at the School of Biomedical Sciences and Queensland Brain Institute. His current work focuses on the interplay between innate immune signaling and cellular metabolism in neurodegenerative diseases utilising his skills and experience in molecular genetics, cellular physiology and computational biology.

Evan started his career as a Research Assistant in the lab of Dr. Natasha Kumar at UNSW, Sydney, studying functional plasticity in chemoreceptive brainstem neurons in response to chronic hypercapnia (elevated CO2) before moving to UQ to pursue a PhD in evolutionary-developmental neuroscience. His PhD work under the supervision of Dr. Laura Fenlon and Dr. Rodrigo Suarez focused on the evolution of cellular mechanisms controlling neuronal differentiation and fate specification in the neocortex of marsupial and placental mamals, resulting in publications in Nature Communications and PNAS. Throughout his research career, Evan has had a keen interest in how cells establish and maintain their functional identity across a wide range of contexts and how homesostatic programs (e.g. energy metabolism) influence cell identity and phenotypic transitions.

Availability

Mr Evan Bailey is:
Available for supervision

Fields of research

Animal physiology - cell Biochemistry and cell biology Bioinformatics and computational biology Biological Sciences Biomedical and Clinical Sciences Cell development, proliferation and death Cell metabolism Cell physiology Developmental genetics (incl. sex determination) Epigenetics (incl. genome methylation and epigenomics) Evolution of developmental systems Evolutionary biology Genetics Genomics and transcriptomics Medical physiology Neurogenetics Neurosciences Zoology

Qualifications

  • Bachelor (Honours) of Advanced Science, University of New South Wales

Research interests

  • Innate immunity and cellular metabolism in neurodegenerative disease

    My current work focuses on the interplay between interferon signaling and the regulation of cellular metabolism within the context of Alzheimer's disease and dementia. I am using in-vitro models to characterise differences in cellular immune responses in the presence of neurodegenerative disease markers to uncover the underlying principles that govern cell-state transitions towards pathological phenotypes. This work will extend our basic understanding of the mechanisms driving neurodegeneration whilst allowing for the development of models for novel treatment and prevention strategies.

  • Cell-fate decisions in mammalian brain development and evolution

    Throughout my doctoral studies I uncovered novel molecular mechanisms and cellular processes in the differentiation and functional specification of neuronal cells in the neocortex of marsupial mammals. My work in this area spans developmental neuroscience, single-cell and bulk transcriptomics (RNA-seq), phylogenetic comparative methods, and molecular genetics. I am particularly interested in the interaction between metabolism and the mitotic cell-cycle and how differences in reproductive strategy between amniote species drive and constrain progenitor cell fate.

Availability

Mr Evan Bailey is:
Available for supervision

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Enquiries

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