Overview
Background
Evan Bailey is a postdoctoral researcher in the Molecular and Systems Medicine Group at the School of Biomedical Sciences and Queensland Brain Institute. His current work focuses on the interplay between innate immune signaling and cellular metabolism in neurodegenerative diseases utilising his skills and experience in molecular genetics, cellular physiology and computational biology.
Evan started his career as a Research Assistant in the lab of Dr. Natasha Kumar at UNSW, Sydney, studying functional plasticity in chemoreceptive brainstem neurons in response to chronic hypercapnia (elevated CO2) before moving to UQ to pursue a PhD in evolutionary-developmental neuroscience. His PhD work under the supervision of Dr. Laura Fenlon and Dr. Rodrigo Suarez focused on the evolution of cellular mechanisms controlling neuronal differentiation and fate specification in the neocortex of marsupial and placental mammals, resulting in publications in Nature Communications and PNAS. Throughout his research career, Evan has had a keen interest in how cells establish and maintain their functional identity across a wide range of contexts and how homesostatic programs (e.g. energy metabolism) influence cell identity and phenotypic transitions.
Availability
- Mr Evan Bailey is:
- Available for supervision
Fields of research
Qualifications
- Bachelor (Honours) of Advanced Science, University of New South Wales
Research interests
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Innate immunity and cellular metabolism in neurodegenerative disease
My current work focuses on the interplay between interferon signaling and the regulation of cellular metabolism within the context of Alzheimer's disease and dementia. I am using in-vitro models to characterise differences in cellular immune responses in the presence of neurodegenerative disease markers to uncover the underlying principles that govern cell-state transitions towards pathological phenotypes. This work will extend our basic understanding of the mechanisms driving neurodegeneration whilst allowing for the development of models for novel treatment and prevention strategies.
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Cell-fate decisions in mammalian brain development and evolution
Throughout my doctoral studies I uncovered novel molecular mechanisms and cellular processes in the differentiation and functional specification of neuronal cells in the neocortex of marsupial mammals. My work in this area spans developmental neuroscience, single-cell and bulk transcriptomics (RNA-seq), phylogenetic comparative methods, and molecular genetics. I am particularly interested in the interaction between metabolism and the mitotic cell-cycle and how differences in reproductive strategy between amniote species drive and constrain progenitor cell fate.
Works
Search Professor Evan Bailey’s works on UQ eSpace
2023
Journal Article
Non-uniform temporal scaling of developmental processes in the mammalian cortex
Paolino, Annalisa, Haines, Elizabeth H., Bailey, Evan J., Black, Dylan A., Moey, Ching, García-Moreno, Fernando, Richards, Linda J., Suárez, Rodrigo and Fenlon, Laura R. (2023). Non-uniform temporal scaling of developmental processes in the mammalian cortex. Nature Communications, 14 (1) 5950, 1-17. doi: 10.1038/s41467-023-41652-5
2023
Journal Article
Clade-specific forebrain cytoarchitectures of the extinct Tasmanian tiger
Haines, Elizabeth, Bailey, Evan, Nelson, John, Fenlon, Laura R. and Suárez, Rodrigo (2023). Clade-specific forebrain cytoarchitectures of the extinct Tasmanian tiger. Proceedings of the National Academy of Sciences, 120 (32) e2306516120, e2306516120. doi: 10.1073/pnas.2306516120
2021
Journal Article
Combining Multiplex Fluorescence in situ Hybridization with Fluorescent Immunohistochemistry on Fresh Frozen or Fixed Mouse Brain Sections
Dereli, Ayse S., Bailey, Evan J. and Kumar, Natasha N. (2021). Combining Multiplex Fluorescence in situ Hybridization with Fluorescent Immunohistochemistry on Fresh Frozen or Fixed Mouse Brain Sections. Journal of Visualized Experiments (172). doi: 10.3791/61709
2019
Journal Article
Analysis of mechanically activated ion channels at the cell-substrate interface: combining pillar arrays and whole-cell patch-clamp
Sianati, Setareh, Kurumlian, Anie, Bailey, Evan and Poole, Kate (2019). Analysis of mechanically activated ion channels at the cell-substrate interface: combining pillar arrays and whole-cell patch-clamp. Frontiers in Bioengineering and Biotechnology, 7 ARTN 47. doi: 10.3389/fbioe.2019.00047
Supervision
Availability
- Mr Evan Bailey is:
- Available for supervision
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Media
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