A functional interaction between domains of the flavivirus NS5 protein presents a new target for antiviral therapy (2010-2012)
Abstract
Mosquito-transmitted flaviviruses such as gengue, yellow fever, Japanese encephalitis and West Nile infect hundreds of millions of people and cause debilitating and fatal diseases. Developing anti-viral treatments against these diseases is a high priority. Our strategy is to develop small molecules that can bind to specific sites on viral proteins and prevent the virus from replicating and causing disease.
