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Force microscopy with arbitrary optically-trapped probes and application to internal mechanics of cells (2014-2017)

Abstract

The ability to perform micromanipulation on particles, macromolecules, subcellular organelles, or whole cells is fundamental in elucidating processes such as chromosome movement during cell division, and movement of cell components in and out of the cell. The recent advances in optical tweezers have allowed this type of micromanipulation to approach reality. However, determination of the true optical force is critical for this technique to reach its full potential. We will develop novel techniques to quantitatively determine the absolute optical force applied to the cell component using the process of ingestion (phagocytosis) as a proof-of-principle test, and measure forces in chromosome movement and vesicle transport within cells.

Experts

Professor Halina Rubinsztein-Dunlop

Affiliate of ARC COE for Engineered
ARC Centre of Excellence for Engineered Quantum Systems
Faculty of Science
Affiliate of ARC COE in Quantum Bio
ARC Centre of Excellence in Quantum Biotechnology
Faculty of Science
Professor
School of Mathematics and Physics
Faculty of Science
Halina Rubinsztein-Dunlop
Halina Rubinsztein-Dunlop

Dr Timo Nieminen

Senior Lecturer
School of Mathematics and Physics
Faculty of Science
Timo Nieminen
Timo Nieminen