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Probe-free biophysical force and torque measurements with optical tweezers (2018-2022)

Abstract

This project aims to develop probe-free biophysical force and torque measurement methods based on optical tweezers to determine (a) forces on chromosomes during cell division and answer long standing questions on the character of these forces; (b) the forces exerted by cells while swimming, and map out how these forces are affected by their environment; and (c) the change in the elasticity of red blood cells over storage time. Studies of these biological systems are hampered by a lack of quantitative measurements. These accurate quantitative measurements will enable in-depth understanding of forces at work during cell division, properties of blood cells and sperm motility which could generate further research leading to health benefits.

Experts

Professor Halina Rubinsztein-Dunlop

Affiliate of ARC COE for Engineered
ARC Centre of Excellence for Engineered Quantum Systems
Faculty of Science
Affiliate of ARC COE in Quantum Bio
ARC Centre of Excellence in Quantum Biotechnology
Faculty of Science
Professor
School of Mathematics and Physics
Faculty of Science
Halina Rubinsztein-Dunlop
Halina Rubinsztein-Dunlop

Dr Timo Nieminen

Senior Lecturer
School of Mathematics and Physics
Faculty of Science
Timo Nieminen
Timo Nieminen