Functional evolution and therapeutic potential of snake venom coagulotoxins (2019-2022)
Abstract
In recent years, snake venom compounds have been demonstrated as incredibly useful models from which to synthesise therapeutic drugs to improve health and well-being. This project aims to identify and understand the factors that influence the useful function of key residues (parts of larger compounds) in Australian snake venom coagulotoxins, which alter blood-clotting ability. We will test these important toxins on model systems that represent natural prey items in order to determine the molecular and functional evolution of procoagulant (blood-clot forming) enzymes. Expected outcomes include substantial contributions to the body of evolutionary biology knowledge, as well as narrowing the vast search for the ultimate drug candidates.
