Professor Bryan Fry
Professor

Bryan Fry

Email: 
Phone: 
+61 7 336 58515
Mobile: 
0400 193 182

Background

Venoms play a range of adaptive roles in the animal kingdom from predation to defense to competitor deterrence. Remarkably, despite their biological importance and uniqueness, the evolution of venom systems is poorly understood. New insights into the evolution of venom systems and the importance of the associated toxins cannot be advanced without recognition of the true biochemical, ecological, morphological and pharmacological diversity of venoms and associated venom systems. A major limitation has been the very narrow taxonomical range studied. Entire groups of venomous animals remain virtually unstudied. My research is inherently interdisciplinary, integrating ecological, evolutionary, and functional genomics approaches in order to understand the evolution of venom systems. Studies range from discovering the shock-inducing hypotensive and anticoagulant venom of the iconic Komodo Dragon through to exploring the unique temperature specific adaptations of Antarctic octopus venoms.

Availability

Professor Bryan Fry is:
Available for supervision
Media expert

Fields of research

Biological Sciences Medicinal and biomolecular chemistry Zoology

Qualifications

  • Doctor of Philosophy, The University of Queensland

Search Professor Bryan Fry’s works on UQ eSpace

246 works between 1998 and 2026
All (246) Journal Article (227) Other Outputs (1) Conference Publication (13) Book Chapter (5)

1 - 20 of 246 works

2026

Journal Article

The sting that clots: the Factor VII and Factor X activating procoagulant effects of Androctonus scorpion venoms are potentiated by Factor Va as a cofactor

Campbell, Sam I.D., Seneci, Lorenzo, Jones, Lee, Champagne, Patrick S. and Fry, Bryan G. (2026). The sting that clots: the Factor VII and Factor X activating procoagulant effects of Androctonus scorpion venoms are potentiated by Factor Va as a cofactor. Biochimie, 245, 31-39. doi: 10.1016/j.biochi.2026.02.018

The sting that clots: the Factor VII and Factor X activating procoagulant effects of Androctonus scorpion venoms are potentiated by Factor Va as a cofactor

2026

Journal Article

Pirates of the coagulase: Clinical implications of dramatic ontogenetic shifts in Yellow Beard (Bothrops atrox) lancehead pitviper Factor Va-mediated venom activation of blood clotting factors

Jordan, Katherine, Champagne, Patrick S., Seneci, Lorenzo and Fry, Bryan G. (2026). Pirates of the coagulase: Clinical implications of dramatic ontogenetic shifts in Yellow Beard (Bothrops atrox) lancehead pitviper Factor Va-mediated venom activation of blood clotting factors. Toxicon, 274 109025, 109025-274. doi: 10.1016/j.toxicon.2026.109025

Pirates of the coagulase: Clinical implications of dramatic ontogenetic shifts in Yellow Beard (Bothrops atrox) lancehead pitviper Factor Va-mediated venom activation of blood clotting factors

2026

Journal Article

Heavy metal predators: diverse elemental enrichment across the weapons of scorpions

Campbell, Sam I. D., Vicenzi, Edward P., Lam, Thomas, Fry, Bryan G. and Wood, Hannah M. (2026). Heavy metal predators: diverse elemental enrichment across the weapons of scorpions. Journal of the Royal Society Interface, 23 (237) 20250523. doi: 10.1098/rsif.2025.0523

Heavy metal predators: diverse elemental enrichment across the weapons of scorpions

2026

Journal Article

Beyond Blast Injury: Occupational Hygiene, Safety, and Toxicology Considerations for Mixed-Metal and Energetic-Chemical Exposures to Explosive Ordnance Disposal Personnel

Fry, Bryan G., Johnstone, Kelly and Pizzino, Stacey (2026). Beyond Blast Injury: Occupational Hygiene, Safety, and Toxicology Considerations for Mixed-Metal and Energetic-Chemical Exposures to Explosive Ordnance Disposal Personnel. Toxics, 14 (5), 379. doi: 10.3390/toxics14050379

Beyond Blast Injury: Occupational Hygiene, Safety, and Toxicology Considerations for Mixed-Metal and Energetic-Chemical Exposures to Explosive Ordnance Disposal Personnel

2026

Journal Article

Azemiops feae (Fea’s Viper) Envenoming: A Case Report and Review of the Literature

Qiao, Zichen, Tang, Yong, Zhou, Qianshun and Fry, Bryan G. (2026). Azemiops feae (Fea’s Viper) Envenoming: A Case Report and Review of the Literature. Toxins, 18 (5), 201. doi: 10.3390/toxins18050201

Azemiops feae (Fea’s Viper) Envenoming: A Case Report and Review of the Literature

2026

Journal Article

Hemostatic hellfire: Rhabdophis helleri (Red-necked Keelback) snake venom pathophysiologically activates Factor VII and Factor X through novel uses of the clotting cofactors calcium, phospholipid, and Factor Va

Champagne, Patrick S., Seneci, Lorenzo, Casewell, Nicholas R. and Fry, Bryan G. (2026). Hemostatic hellfire: Rhabdophis helleri (Red-necked Keelback) snake venom pathophysiologically activates Factor VII and Factor X through novel uses of the clotting cofactors calcium, phospholipid, and Factor Va. Toxicon, 271 108970, 108970. doi: 10.1016/j.toxicon.2025.108970

Hemostatic hellfire: Rhabdophis helleri (Red-necked Keelback) snake venom pathophysiologically activates Factor VII and Factor X through novel uses of the clotting cofactors calcium, phospholipid, and Factor Va

2026

Journal Article

The hills are alive with the sound of venom: Clinical implications of intraspecific variations in Factor Va mediated activations of Factor VII and Factor X in Swiss populations of Vipera aspis (Asp Viper)

Kempson, Katrina, Champagne, Patrick S., Seneci, Lorenzo, Jones, Lee, Ursenbacher, Sylvain, Dubey, Sylvain, Joudrier, Nicolas, Aldridge, Matt, Soria, Raul and Fry, Bryan G. (2026). The hills are alive with the sound of venom: Clinical implications of intraspecific variations in Factor Va mediated activations of Factor VII and Factor X in Swiss populations of Vipera aspis (Asp Viper). Biochimie, 244, 106-116. doi: 10.1016/j.biochi.2026.02.009

The hills are alive with the sound of venom: Clinical implications of intraspecific variations in Factor Va mediated activations of Factor VII and Factor X in Swiss populations of Vipera aspis (Asp Viper)

2026

Journal Article

Deadly innovations: Molecular phylogenetics and evolution of phospholipases A2 toxins in viperid snake venoms

Seneci, Lorenzo, Suranse, Vivek, Mancuso, Marco, Senoner, Tobias, Xie, Bing, Koludarov, Ivan, Sunagar, Kartik and Fry, Bryan G. (2026). Deadly innovations: Molecular phylogenetics and evolution of phospholipases A2 toxins in viperid snake venoms. Biochimie, 240, 137-152. doi: 10.1016/j.biochi.2025.10.010

Deadly innovations: Molecular phylogenetics and evolution of phospholipases A2 toxins in viperid snake venoms

2026

Journal Article

The shifting sands of venom: Divergent blood clotting factor activation pathways and differential Factor Va co-factor dependence for the venoms of Middle Eastern desert vipers (Eristicophis and Pseudocerastes species)

Champagne, Patrick S., Seneci, Lorenzo, Fathinia, Behzad, Ghezellou, Parviz, Ali, Syed A. and Fry, Bryan G. (2026). The shifting sands of venom: Divergent blood clotting factor activation pathways and differential Factor Va co-factor dependence for the venoms of Middle Eastern desert vipers (Eristicophis and Pseudocerastes species). Biochimie, 243, 112-126. doi: 10.1016/j.biochi.2026.01.011

The shifting sands of venom: Divergent blood clotting factor activation pathways and differential Factor Va co-factor dependence for the venoms of Middle Eastern desert vipers (Eristicophis and Pseudocerastes species)

2025

Journal Article

First documented cases of envenomations in mainland China by Ovophis species (mountain pitvipers): severe coagulopathy and variable antivenom response in two patients from Yunnan Province

Qiao, Zichen, Tang, Yong, Shang, Aobo, Tao, You and Fry, Bryan G. (2025). First documented cases of envenomations in mainland China by Ovophis species (mountain pitvipers): severe coagulopathy and variable antivenom response in two patients from Yunnan Province. Toxicon, 267 108583, 1-6. doi: 10.1016/j.toxicon.2025.108583

First documented cases of envenomations in mainland China by Ovophis species (mountain pitvipers): severe coagulopathy and variable antivenom response in two patients from Yunnan Province

2025

Journal Article

Context makes the clot: evolutionary and translational mismatches in snake venom thrombin-like enzyme-induced fibrin-clot formation between human and diverse animal plasmas

Fry, Bryan G., Morecroft, Holly and Chowdhury, Abhinandan (2025). Context makes the clot: evolutionary and translational mismatches in snake venom thrombin-like enzyme-induced fibrin-clot formation between human and diverse animal plasmas. Toxicon, 267 108584, 1-9. doi: 10.1016/j.toxicon.2025.108584

Context makes the clot: evolutionary and translational mismatches in snake venom thrombin-like enzyme-induced fibrin-clot formation between human and diverse animal plasmas

2025

Journal Article

The X Factor: Regional differences in the level of ontogenetic variations in procoagulant venom activity in the Northwestern Neotropical Rattlesnake (Crotalus culminatus)

Seneci, Lorenzo, Chandrasekara, Uthpala, Chowdhury, Abhinandan, Zarzosa, Vanessa, Guadarrama-Martínez, Alid, Neri-Castro, Edgar, Alagón, Alejandro, Soria, Raul and Fry, Bryan G. (2025). The X Factor: Regional differences in the level of ontogenetic variations in procoagulant venom activity in the Northwestern Neotropical Rattlesnake (Crotalus culminatus). Biochimie, 237, 138-149. doi: 10.1016/j.biochi.2025.07.015

The X Factor: Regional differences in the level of ontogenetic variations in procoagulant venom activity in the Northwestern Neotropical Rattlesnake (Crotalus culminatus)

2025

Journal Article

Sometimes size does matter: anticoagulant pathophysiological effects of Southwestern Speckled Rattlesnake (Crotalus pyrrhus) venoms are dichotomous by body size

Qiao, Zichen, Cochran, Chip, Chowdhury, Abhinandan, Bourke, Lachlan A., Seneci, Lorenzo and Fry, Bryan G. (2025). Sometimes size does matter: anticoagulant pathophysiological effects of Southwestern Speckled Rattlesnake (Crotalus pyrrhus) venoms are dichotomous by body size. Biochimie, 237, 40-53. doi: 10.1016/j.biochi.2025.07.012

Sometimes size does matter: anticoagulant pathophysiological effects of Southwestern Speckled Rattlesnake (Crotalus pyrrhus) venoms are dichotomous by body size

2025

Journal Article

Neurotoxic sleight of fang: differential antivenom efficacy against mamba (Dendroaspis spp.) venom spastic-paralysis presynaptic/synaptic vs. flaccid-paralysis postsynaptic effects

Jones, Lee, Lay, Mimi, Seneci, Lorenzo, Hodgson, Wayne C., Koludarov, Ivan, Senoner, Tobias, Soria, Raul and Fry, Bryan G. (2025). Neurotoxic sleight of fang: differential antivenom efficacy against mamba (Dendroaspis spp.) venom spastic-paralysis presynaptic/synaptic vs. flaccid-paralysis postsynaptic effects. Toxins, 17 (10) 481, 1-19. doi: 10.3390/toxins17100481

Neurotoxic sleight of fang: differential antivenom efficacy against mamba (Dendroaspis spp.) venom spastic-paralysis presynaptic/synaptic vs. flaccid-paralysis postsynaptic effects

2025

Other Outputs

80 years since the end of World War II, a dangerous legacy lingers in the Pacific

Pizzino, Stacey and Fry, Bryan G. (2025, 09 02). 80 years since the end of World War II, a dangerous legacy lingers in the Pacific The Conversation doi: 10.64628/AA.paekesk4u

80 years since the end of World War II, a dangerous legacy lingers in the Pacific

2025

Journal Article

Tailored toxins: coagulotoxic variations in Atropoides, Cerrophidion, Metlapilcoatlus, and Porthidium viperid venoms against diverse vertebrate plasmas

Jones, Lee, Neri-Castro, Edgar, Youngman, Nicholas J., Llinas, Joshua, Haworth, Mark, Gillett, Amber and Fry, Bryan G. (2025). Tailored toxins: coagulotoxic variations in Atropoides, Cerrophidion, Metlapilcoatlus, and Porthidium viperid venoms against diverse vertebrate plasmas. Toxicon, 264 108453, 108453. doi: 10.1016/j.toxicon.2025.108453

Tailored toxins: coagulotoxic variations in Atropoides, Cerrophidion, Metlapilcoatlus, and Porthidium viperid venoms against diverse vertebrate plasmas

2025

Journal Article

X marks the clot: Evolutionary and clinical implications of divergences in procoagulant Australian elapid snake venoms

Morecroft, Holly, Zdenek, Christina N., Chowdhury, Abhinandan, Dunstan, Nathan, Hay, Chris and Fry, Bryan G. (2025). X marks the clot: Evolutionary and clinical implications of divergences in procoagulant Australian elapid snake venoms. Toxins, 17 (8) 417, 1-20. doi: 10.3390/toxins17080417

X marks the clot: Evolutionary and clinical implications of divergences in procoagulant Australian elapid snake venoms

2025

Journal Article

Heating up the blunts: prothrombin activation, with factor Va as an obligate cofactor, is the dominant procoagulant mechanism of blunt-nosed viper venoms (Macrovipera species)

Champagne, Patrick S., Seneci, Lorenzo and Fry, Bryan G. (2025). Heating up the blunts: prothrombin activation, with factor Va as an obligate cofactor, is the dominant procoagulant mechanism of blunt-nosed viper venoms (Macrovipera species). Toxins, 17 (8) 398. doi: 10.3390/toxins17080398

Heating up the blunts: prothrombin activation, with factor Va as an obligate cofactor, is the dominant procoagulant mechanism of blunt-nosed viper venoms (Macrovipera species)

2025

Journal Article

Make acetylcholine great again! Australian skinks evolved multiple neurotoxin-proof nicotinic acetylcholine receptors in defiance of snake venom

Chandrasekara, Uthpala, Mancuso, Marco, Shea, Glenn, Jones, Lee, Kwiatkowski, Jacek, Trembath, Dane, Chowdhury, Abhinandan, Bertozzi, Terry, Gardner, Michael G., Hoskin, Conrad J., Zdenek, Christina N. and Fry, Bryan G. (2025). Make acetylcholine great again! Australian skinks evolved multiple neurotoxin-proof nicotinic acetylcholine receptors in defiance of snake venom. International Journal of Molecular Sciences, 26 (15) 7510, 1-20. doi: 10.3390/ijms26157510

Make acetylcholine great again! Australian skinks evolved multiple neurotoxin-proof nicotinic acetylcholine receptors in defiance of snake venom

2025

Journal Article

Ontogenetic variation in coagulotoxic activity and antivenom efficacy of Central American pit viper venoms (Cerrophidion, Metlapilcoatlus, Ophryacus and Porthidium)

Jones, Lee, Neri-Castro, Edgar, García-Vázquez, Uri O. and Fry, Bryan G. (2025). Ontogenetic variation in coagulotoxic activity and antivenom efficacy of Central American pit viper venoms (Cerrophidion, Metlapilcoatlus, Ophryacus and Porthidium). Biochimie, 235, 49-58. doi: 10.1016/j.biochi.2025.05.009

Ontogenetic variation in coagulotoxic activity and antivenom efficacy of Central American pit viper venoms (Cerrophidion, Metlapilcoatlus, Ophryacus and Porthidium)

Current funding

  • 2025 - 2027
    Adaptive Biotoxicology Lab (Venom Evolution Lab)
    The University of Queensland in America, Inc
    Open grant

Past funding

  • 2021 - 2024
    Evolutionary models and biodiscovery tools from neurotoxic snake venoms
    ARC Discovery Projects
    Open grant
  • 2020 - 2021
    Replacing the use of animals for the study of the alpha-5 subunit of nicotinic acetylcholine receptors and to probe the drug potential of novel ligands for colitis and anti-smoking
    The MAWA Trust
    Open grant
  • 2020 - 2021
    An integrated, multi-node bio-layer interferometry facility
    ARC Linkage Infrastructure, Equipment and Facilities
    Open grant
  • 2019 - 2022
    Functional evolution and therapeutic potential of snake venom coagulotoxins
    ARC Discovery Projects
    Open grant
  • 2019
    Imaging Mass Spectrometry at Higher Mass Resolution
    UQ Research Facilities Infrastructure Grants
    Open grant
  • 2018 - 2019
    Coagulotoxic effects of Brazilian snake venoms: Role in adaptive evolution and human pathophysiological implications
    UQ-FAPESP Strategic Research Fund SPRINT
    Open grant
  • 2018
    Multichannel peptide synthesiser to accelerate UQ's biodiscovery pipeline and peptide drug development programs
    UQ Major Equipment and Infrastructure
    Open grant
  • 2017
    Deep Protein Sequencing, Structure and Quantification Facility
    ARC Linkage Infrastructure, Equipment and Facilities
    Open grant
  • 2016
    Integrative blood coagulation research core facility
    UQ Major Equipment and Infrastructure
    Open grant
  • 2016
    Patch-clamp electrophysiology platform for drug and insecticide discovery
    UQ Major Equipment and Infrastructure
    Open grant
  • 2015 - 2016
    Evolution of Sea Snakes in Australia's Gulf of Carpentaria
    National Geographic Society
    Open grant
  • 2015
    A sensitive, high resolution QTOF mass spectrometer with nanoUPLC system for qualitative and quantitative biomolecule analysis.
    UQ Major Equipment and Infrastructure
    Open grant
  • 2015
    Beyond genomes, transcriptomes and proteomes: high throughput analysis of gene and protein expression and function
    UQ Major Equipment and Infrastructure
    Open grant
  • 2014 - 2017
    Imaging the world of miniature venomous arthropods
    ARC Linkage Projects
    Open grant
  • 2014 - 2016
    Fish venom as a model system for the molecular evolution of defensive toxins
    ARC Discovery Projects
    Open grant
  • 2013 - 2014
    Investigation of the venom of two endangered snakes
    Australian Geographic Pty Limited
    Open grant
  • 2013
    High throughput electrophysiology platform
    UQ Major Equipment and Infrastructure
    Open grant
  • 2013 - 2014
    ResTeach 2013 0.05 FTE School of Biological Sciences
    UQ ResTeach
    Open grant
  • 2013
    UQ Travel Awards Category 1 - Dr Nicholas Casewell
    UQ Travel Grants Scheme
    Open grant
  • 2011 - 2014
    The only poisonous primates: the ecological and behaviour context of slow loris venom.
    Oxford Brookes University
    Open grant
  • 2011 - 2012
    Molecular toxinology of Australia's lesser known venomous snakes
    ARC Discovery Projects
    Open grant
  • 2011 - 2015
    Adaptive evolution of coleoid (cuttlefish, octopus, squid) venoms
    ARC Future Fellowships
    Open grant
  • 2011
    Evolutionary venomics: Venom system diversification in the animal kingdom
    ARC Discovery Projects
    Open grant

Availability

Professor Bryan Fry is:
Available for supervision

Looking for a supervisor? Read our advice on how to choose a supervisor.

Supervision history

Current supervision

  • Master Philosophy

    Comparing Clotting Factor Activation in Bothrops species

    Principal Advisor

    Other advisors: Dr Andrew Walker

  • Doctor Philosophy

    Evolutionary and clinical implications of differential pathophysiological effects of rattlesnake venoms upon blood coagulation, cell function, and nerve transmission.

    Principal Advisor

    Other advisors: Dr Andrew Walker

  • Doctor Philosophy

    Integrated analysis of scorpion venom and morphological evolution

    Principal Advisor

    Other advisors: Professor Glenn King, Dr Sam Robinson

  • Doctor Philosophy

    Phylogenetic patterns of clotting factor activation diversity of procoagulant snakes, with perspectives on ecological implications and preclinical insights

    Principal Advisor

    Other advisors: Professor Jianxin Zhao

Completed supervision

Enquiries

Contact Professor Bryan Fry directly for media enquiries about:

  • Animal venoms
  • Antivenoms
  • Biodiscovery
  • Drug design
  • Venom

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