Professor Bryan Fry
Professor

Bryan Fry

Email: 
Phone: 
+61 7 336 58515
Mobile: 
0400 193 182

Background

Venoms play a range of adaptive roles in the animal kingdom from predation to defense to competitor deterrence. Remarkably, despite their biological importance and uniqueness, the evolution of venom systems is poorly understood. New insights into the evolution of venom systems and the importance of the associated toxins cannot be advanced without recognition of the true biochemical, ecological, morphological and pharmacological diversity of venoms and associated venom systems. A major limitation has been the very narrow taxonomical range studied. Entire groups of venomous animals remain virtually unstudied. My research is inherently interdisciplinary, integrating ecological, evolutionary, and functional genomics approaches in order to understand the evolution of venom systems. Studies range from discovering the shock-inducing hypotensive and anticoagulant venom of the iconic Komodo Dragon through to exploring the unique temperature specific adaptations of Antarctic octopus venoms.

Availability

Professor Bryan Fry is:
Available for supervision
Media expert

Fields of research

Biological Sciences Medicinal and biomolecular chemistry Zoology

Qualifications

  • Doctor of Philosophy, The University of Queensland

Search Professor Bryan Fry’s works on UQ eSpace

219 works between 1998 and 2024
All (219) Journal Article (201) Book Chapter (5) Conference Publication (13)

1 - 20 of 219 works

2024

Journal Article

In vitro anticoagulant effects of Bungarus venoms on human plasma which are effectively neutralized by the PLA2-inhibitor varespladib

Chowdhury, Abhinandan, Fry, Bryan G., Samuel, Stephen P., Bhalla, Ashish, Vaiyapuri, Sakthi, Bhargava, Parul, Carter, Rebecca W. and Lewin, Matthew R. (2024). In vitro anticoagulant effects of Bungarus venoms on human plasma which are effectively neutralized by the PLA2-inhibitor varespladib. Toxicon, 252 108178, 108178. doi: 10.1016/j.toxicon.2024.108178

In vitro anticoagulant effects of Bungarus venoms on human plasma which are effectively neutralized by the PLA2-inhibitor varespladib

2024

Journal Article

Breaking muscle: neurotoxic and myotoxic effects of Central American snake venoms and the relative efficacies of antivenom and varespladib

Jones, Lee, Lay, Mimi, Neri-Castro, Edgar, Zarzosa, Vanessa, Hodgson, Wayne C., Lewin, Matthew and Fry, Bryan G. (2024). Breaking muscle: neurotoxic and myotoxic effects of Central American snake venoms and the relative efficacies of antivenom and varespladib. BMC Biology, 22 (1) 243, 1-12. doi: 10.1186/s12915-024-02044-3

Breaking muscle: neurotoxic and myotoxic effects of Central American snake venoms and the relative efficacies of antivenom and varespladib

2024

Journal Article

From venom to vein: factor VII activation as a major pathophysiological target for procoagulant Australian elapid snake venoms

Chandrasekara, Uthpala, Chowdhury, Abhinandan, Seneci, Lorenzo, Zdenek, Christina N., Dunstan, Nathan and Fry, Bryan G. (2024). From venom to vein: factor VII activation as a major pathophysiological target for procoagulant Australian elapid snake venoms. Toxins, 16 (10) 430. doi: 10.3390/toxins16100430

From venom to vein: factor VII activation as a major pathophysiological target for procoagulant Australian elapid snake venoms

2024

Journal Article

Tiny but mighty: Vipera ammodytes meridionalis (eastern long-nosed viper) ontogenetic venom variations in procoagulant potency and the impact on antivenom efficacies

Qiao, Zichen, Jones, Lee, Bourke, Lachlan A., Seneci, Lorenzo, Chowdhury, Abhinandan, Violette, Aude, Fourmy, Rudy, Soria, Raul, Aldridge, Matt and Fry, Bryan G. (2024). Tiny but mighty: Vipera ammodytes meridionalis (eastern long-nosed viper) ontogenetic venom variations in procoagulant potency and the impact on antivenom efficacies. Toxins, 16 (9) 396. doi: 10.3390/toxins16090396

Tiny but mighty: Vipera ammodytes meridionalis (eastern long-nosed viper) ontogenetic venom variations in procoagulant potency and the impact on antivenom efficacies

2024

Journal Article

Taking the sting out of scorpions: electrophysiological investigation of the relative efficacy of three antivenoms against medically significant Centruroides species

Campbell, Sam I. D., Chow, Chun Yuen, Neri-Castro, Edgar, Alagón, Alejandro, Gómez, Aarón, Soria, Raúl, King, Glenn F. and Fry, Bryan G. (2024). Taking the sting out of scorpions: electrophysiological investigation of the relative efficacy of three antivenoms against medically significant Centruroides species. Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology, 283 109977. doi: 10.1016/j.cbpc.2024.109977

Taking the sting out of scorpions: electrophysiological investigation of the relative efficacy of three antivenoms against medically significant Centruroides species

2024

Conference Publication

Venom versus varanid: A chemical arms race in Australia's reptilian realm

Chandrasekara, Uthpala, Mancuso, Marco, Seneci, Lorenzo, Bourke, Lachlan, Trembath, Dane, Sumner, Joanna, Zdenek, Christina N. and Fry, Bryan G. (2024). Venom versus varanid: A chemical arms race in Australia's reptilian realm. IST World Congress 2024, Singapore, 20 - 25 May 2024. Oxford, United Kingdom: Elsevier. doi: 10.1016/j.toxicon.2024.107946

Venom versus varanid: A chemical arms race in Australia's reptilian realm

2024

Journal Article

Venom exaptation and adaptation during the trophic switch to blood-feeding by kissing bugs

Zdenek, Christina N., Cardoso, Fernanda C., Robinson, Samuel D., Mercedes, Raine S., Raidjõe, Enriko R., Hernandez-Vargas, María José, Jin, Jiayi, Corzo, Gerardo, Vetter, Irina, King, Glenn F., Fry, Bryan G. and Walker, Andrew A. (2024). Venom exaptation and adaptation during the trophic switch to blood-feeding by kissing bugs. iScience, 27 (9) 110723, 110723. doi: 10.1016/j.isci.2024.110723

Venom exaptation and adaptation during the trophic switch to blood-feeding by kissing bugs

2024

Journal Article

Sugar-coated survival: N-glycosylation as a unique bearded dragon venom resistance trait within Australian agamid lizards

Chandrasekara, Uthpala, Mancuso, Marco, Sumner, Joanna, Edwards, Dan, Zdenek, Christina N. and Fry, Bryan G. (2024). Sugar-coated survival: N-glycosylation as a unique bearded dragon venom resistance trait within Australian agamid lizards. Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology, 282 109929. doi: 10.1016/j.cbpc.2024.109929

Sugar-coated survival: N-glycosylation as a unique bearded dragon venom resistance trait within Australian agamid lizards

2024

Journal Article

Description of the Northern Green Anaconda (Eunectes akayima sp. nov. Serpentes; Boidae): what Is in a name?

Rivas, Jesús A., Terra, Juliana S., Roosen, Marijn, Champagne, Patrick S., Leite-Pitman, Renata, De La Quintana, Paola, Mancuso, Marco, Pacheco, Luis F., Burghardt, Gordon M., Vonk, Freek J., García-Pérez, Juán Elías, Fry, Bryan G. and Corey-Rivas, Sarah (2024). Description of the Northern Green Anaconda (Eunectes akayima sp. nov. Serpentes; Boidae): what Is in a name?. Diversity, 16 (7) 418. doi: 10.3390/d16070418

Description of the Northern Green Anaconda (Eunectes akayima sp. nov. Serpentes; Boidae): what Is in a name?

2024

Journal Article

Blood lines: intraspecific and interspecific variations in anticoagulant actions of Agkistrodon viperid venoms

Coimbra, Francisco C. P., Sanchez, Elda E., Lomonte, Bruno, Gutiérrez, José María, Calvete, Juan J. and Fry, Bryan G. (2024). Blood lines: intraspecific and interspecific variations in anticoagulant actions of Agkistrodon viperid venoms. Toxins, 16 (7) 291. doi: 10.3390/toxins16070291

Blood lines: intraspecific and interspecific variations in anticoagulant actions of Agkistrodon viperid venoms

2024

Journal Article

The clot thickens: differential coagulotoxic and cardiotoxic activities of Anguimorpha lizard venoms

Dobson, James, Chowdhury, Abhinandan, Tai-A-Pin, Jeremie, van der Ploeg, Harold, Gillett, Amber and Fry, Bryan G. (2024). The clot thickens: differential coagulotoxic and cardiotoxic activities of Anguimorpha lizard venoms. Toxins, 16 (6) 283, 283. doi: 10.3390/toxins16060283

The clot thickens: differential coagulotoxic and cardiotoxic activities of Anguimorpha lizard venoms

2024

Journal Article

Red-on-Yellow Queen: bio-layer interferometry reveals functional diversity within Micrurus venoms and toxin resistance in prey species

Dashevsky, Daniel, Harris, Richard J., Zdenek, Christina N., Benard-Valle, Melisa, Alagón, Alejandro, Portes-Junior, José A., Tanaka-Azevedo, Anita M., Grego, Kathleen F., Sant’Anna, Sávio S., Frank, Nathaniel and Fry, Bryan G. (2024). Red-on-Yellow Queen: bio-layer interferometry reveals functional diversity within Micrurus venoms and toxin resistance in prey species. Journal of Molecular Evolution, 92 (3), 317-328. doi: 10.1007/s00239-024-10176-x

Red-on-Yellow Queen: bio-layer interferometry reveals functional diversity within Micrurus venoms and toxin resistance in prey species

2024

Journal Article

Fangs and foliage: unearthing the haemotoxic secrets of cannabis-dwelling rattlesnakes

Bourke, Lachlan A., Zdenek, Christina N., Huynh, Tam M., Hodgson, Wayne C., Alagón, Alejandro, Castro, Edgar N., Jones, Jason and Fry, Bryan G. (2024). Fangs and foliage: unearthing the haemotoxic secrets of cannabis-dwelling rattlesnakes. Toxicon, 244 107756, 1-11. doi: 10.1016/j.toxicon.2024.107756

Fangs and foliage: unearthing the haemotoxic secrets of cannabis-dwelling rattlesnakes

2024

Journal Article

High-voltage toxin’roll: electrostatic charge repulsion as a dynamic venom resistance trait in pythonid snakes

Chandrasekara, Uthpala, Broussard, Emilie M., Rokyta, Darin R. and Fry, Bryan G. (2024). High-voltage toxin’roll: electrostatic charge repulsion as a dynamic venom resistance trait in pythonid snakes. Toxins, 16 (4) 176, 176. doi: 10.3390/toxins16040176

High-voltage toxin’roll: electrostatic charge repulsion as a dynamic venom resistance trait in pythonid snakes

2024

Journal Article

High-content fluorescence bioassay investigates pore formation, ion channel modulation and cell membrane lysis induced by venoms

Kramer, Simon, Kotapati, Charan, Cao, Yuanzhao, Fry, Bryan G., Palpant, Nathan J., King, Glenn F. and Cardoso, Fernanda C. (2024). High-content fluorescence bioassay investigates pore formation, ion channel modulation and cell membrane lysis induced by venoms. Toxicon: X, 21 100184. doi: 10.1016/j.toxcx.2024.100184

High-content fluorescence bioassay investigates pore formation, ion channel modulation and cell membrane lysis induced by venoms

2024

Journal Article

A Russian doll of resistance: Nested gains and losses of venom immunity in varanid lizards

Chandrasekara, Uthpala, Mancuso, Marco, Seneci, Lorenzo, Bourke, Lachlan, Trembath, Dane F., Sumner, Joanna, Zdenek, Christina N. and Fry, Bryan G. (2024). A Russian doll of resistance: Nested gains and losses of venom immunity in varanid lizards. International Journal of Molecular Sciences, 25 (5) 2628, 1-28. doi: 10.3390/ijms25052628

A Russian doll of resistance: Nested gains and losses of venom immunity in varanid lizards

2024

Journal Article

Disentangling the anacondas: revealing a new Green species and rethinking Yellows

Rivas, Jesús A., De La Quintana, Paola, Mancuso, Marco, Pacheco, Luis F., Rivas, Gilson A., Mariotto, Sandra, Salazar-Valenzuela, David, Baihua, Marcelo Tepeña, Baihua, Penti, Burghardt, Gordon M., Vonk, Freek J., Hernandez, Emil, García-Pérez, Juán Elías, Fry, Bryan G. and Corey-Rivas, Sarah (2024). Disentangling the anacondas: revealing a new Green species and rethinking Yellows. Diversity, 16 (2) 127. doi: 10.3390/d16020127

Disentangling the anacondas: revealing a new Green species and rethinking Yellows

2023

Journal Article

Malaysian and Chinese King Cobra venom cytotoxicity in melanoma and neonatal foreskin fibroblasts is mediated by age and geography

Op den Brouw, Bianca, Fernandez-Rojo, Manuel A., Charlton, Tom, Fry, Bryan G. and Ikonomopoulou, Maria P. (2023). Malaysian and Chinese King Cobra venom cytotoxicity in melanoma and neonatal foreskin fibroblasts is mediated by age and geography. Toxins, 15 (9) 549, 549. doi: 10.3390/toxins15090549

Malaysian and Chinese King Cobra venom cytotoxicity in melanoma and neonatal foreskin fibroblasts is mediated by age and geography

2023

Journal Article

Comparative analysis of alpha-1 orthosteric-site binding by a clade of central American pit vipers (genera Atropoides, Cerrophidion, Metlapilcoatlus, and Porthidium)

Jones, Lee, Waite, Callum, Neri-Castro, Edgar and Fry, Bryan G. (2023). Comparative analysis of alpha-1 orthosteric-site binding by a clade of central American pit vipers (genera Atropoides, Cerrophidion, Metlapilcoatlus, and Porthidium). Toxins, 15 (8) 487. doi: 10.3390/toxins15080487

Comparative analysis of alpha-1 orthosteric-site binding by a clade of central American pit vipers (genera Atropoides, Cerrophidion, Metlapilcoatlus, and Porthidium)

2023

Book Chapter

Evolutionary and clinical implications of the snake venom system: dynamic diversification

Fry, Bryan G., Seneci, Lorenzo, Harris, Richard J., Cleuren, Silke G. C. and Jackson, Timothy N. W. (2023). Evolutionary and clinical implications of the snake venom system: dynamic diversification. Snakes: morphology, function, and ecology. (pp. 343-414) Hauppage, NY USA: Nova Science Publishers.

Evolutionary and clinical implications of the snake venom system: dynamic diversification

Past funding

  • 2021 - 2024
    Evolutionary models and biodiscovery tools from neurotoxic snake venoms
    ARC Discovery Projects
    Open grant
  • 2020 - 2021
    Replacing the use of animals for the study of the alpha-5 subunit of nicotinic acetylcholine receptors and to probe the drug potential of novel ligands for colitis and anti-smoking
    The MAWA Trust
    Open grant
  • 2020 - 2021
    An integrated, multi-node bio-layer interferometry facility
    ARC Linkage Infrastructure, Equipment and Facilities
    Open grant
  • 2019 - 2022
    Functional evolution and therapeutic potential of snake venom coagulotoxins
    ARC Discovery Projects
    Open grant
  • 2019
    Imaging Mass Spectrometry at Higher Mass Resolution
    UQ Research Facilities Infrastructure Grants
    Open grant
  • 2018 - 2019
    Coagulotoxic effects of Brazilian snake venoms: Role in adaptive evolution and human pathophysiological implications
    UQ-FAPESP Strategic Research Fund SPRINT
    Open grant
  • 2018
    Multichannel peptide synthesiser to accelerate UQ's biodiscovery pipeline and peptide drug development programs
    UQ Major Equipment and Infrastructure
    Open grant
  • 2017
    Deep Protein Sequencing, Structure and Quantification Facility
    ARC Linkage Infrastructure, Equipment and Facilities
    Open grant
  • 2016
    Integrative blood coagulation research core facility
    UQ Major Equipment and Infrastructure
    Open grant
  • 2016
    Patch-clamp electrophysiology platform for drug and insecticide discovery
    UQ Major Equipment and Infrastructure
    Open grant
  • 2015 - 2016
    Evolution of Sea Snakes in Australia's Gulf of Carpentaria
    National Geographic Society
    Open grant
  • 2015
    A sensitive, high resolution QTOF mass spectrometer with nanoUPLC system for qualitative and quantitative biomolecule analysis.
    UQ Major Equipment and Infrastructure
    Open grant
  • 2015
    Beyond genomes, transcriptomes and proteomes: high throughput analysis of gene and protein expression and function
    UQ Major Equipment and Infrastructure
    Open grant
  • 2014 - 2017
    Imaging the world of miniature venomous arthropods
    ARC Linkage Projects
    Open grant
  • 2014 - 2016
    Fish venom as a model system for the molecular evolution of defensive toxins
    ARC Discovery Projects
    Open grant
  • 2013 - 2014
    Investigation of the venom of two endangered snakes
    Australian Geographic Pty Limited
    Open grant
  • 2013 - 2014
    ResTeach 2013 0.05 FTE School of Biological Sciences
    UQ ResTeach
    Open grant
  • 2013
    UQ Travel Awards Category 1 - Dr Nicholas Casewell
    UQ Travel Grants Scheme
    Open grant
  • 2011 - 2014
    The only poisonous primates: the ecological and behaviour context of slow loris venom.
    Oxford Brookes University
    Open grant
  • 2011 - 2012
    Molecular toxinology of Australia's lesser known venomous snakes
    ARC Discovery Projects
    Open grant
  • 2011 - 2015
    Adaptive evolution of coleoid (cuttlefish, octopus, squid) venoms
    ARC Future Fellowships
    Open grant
  • 2011
    Evolutionary venomics: Venom system diversification in the animal kingdom
    ARC Discovery Projects
    Open grant

Availability

Professor Bryan Fry is:
Available for supervision

Before you email them, read our advice on how to contact a supervisor.

Supervision history

Current supervision

  • Doctor Philosophy

    Evaluation of Phylogenetic Patterns of Scorpion Pathophysiological Effects and Effectiveness of Next-Generation Antivenoms

    Principal Advisor

    Other advisors: Professor Glenn King, Dr Sam Robinson

  • Doctor Philosophy

    Venom variation in American pit vipers

    Principal Advisor

    Other advisors: Dr Andrew Walker

  • Doctor Philosophy

    Anacondas as sentinel species for accumulation of oil spill heavy metals into the food web

    Principal Advisor

    Other advisors: Professor Jianxin Zhao

  • Doctor Philosophy

    Evolutionary and clinical implications of differential pathophysiological effects of rattlesnake venoms upon blood coagulation, cell function, and nerve transmission.

    Principal Advisor

    Other advisors: Dr Andrew Walker

  • Doctor Philosophy

    Pathophysiological actions of elapid venom on prey and human targets

    Principal Advisor

  • Doctor Philosophy

    Evaluation of Phylogenetic Patterns of Scorpion Pathophysiological Effects and Effectiveness of Next-Generation Antivenoms

    Principal Advisor

    Other advisors: Professor Glenn King, Dr Sam Robinson

  • Doctor Philosophy

    The evolution of prey-selectivity for snake venom neurotoxins, and the parallel evolution of neurotoxin resistance in prey

    Principal Advisor

  • Doctor Philosophy

    Pathophysiological actions of elapid venom on prey and human targets

    Principal Advisor

  • Doctor Philosophy

    Venom variation in New World pit vipers

    Principal Advisor

    Other advisors: Dr Fernanda Cardoso, Dr Andrew Walker

  • Doctor Philosophy

    Utilising invertebrates to identify novel coagulotoxins

    Associate Advisor

    Other advisors: Professor Glenn King, Dr Andrew Walker

Completed supervision

Enquiries

Contact Professor Bryan Fry directly for media enquiries about:

  • Animal venoms
  • Antivenoms
  • Biodiscovery
  • Drug design
  • Venom

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