![Professor Bryan Fry](/sites/default/files/profiles/540.jpeg)
Overview
Background
Venoms play a range of adaptive roles in the animal kingdom from predation to defense to competitor deterrence. Remarkably, despite their biological importance and uniqueness, the evolution of venom systems is poorly understood. New insights into the evolution of venom systems and the importance of the associated toxins cannot be advanced without recognition of the true biochemical, ecological, morphological and pharmacological diversity of venoms and associated venom systems. A major limitation has been the very narrow taxonomical range studied. Entire groups of venomous animals remain virtually unstudied. My research is inherently interdisciplinary, integrating ecological, evolutionary, and functional genomics approaches in order to understand the evolution of venom systems. Studies range from discovering the shock-inducing hypotensive and anticoagulant venom of the iconic Komodo Dragon through to exploring the unique temperature specific adaptations of Antarctic octopus venoms.
Availability
- Professor Bryan Fry is:
- Available for supervision
- Media expert
Fields of research
Qualifications
- Doctor of Philosophy, The University of Queensland
Works
Search Professor Bryan Fry’s works on UQ eSpace
2021
Journal Article
A single-step, high throughput, and highly reproducible method for measuring IgM quantity and avidity directly from fish serum via biolayer interferometry (BLI)
Li, Angus, Harris, Richard J., Fry, Bryan G. and Barnes, Andrew C. (2021). A single-step, high throughput, and highly reproducible method for measuring IgM quantity and avidity directly from fish serum via biolayer interferometry (BLI). Fish and Shellfish Immunology, 119, 231-237. doi: 10.1016/j.fsi.2021.10.003
2021
Journal Article
Monkeying around with venom: an increased resistance to α-neurotoxins supports an evolutionary arms race between Afro-Asian primates and sympatric cobras
Harris, Richard J., Nekaris, K. Anne-Isola and Fry, Bryan G. (2021). Monkeying around with venom: an increased resistance to α-neurotoxins supports an evolutionary arms race between Afro-Asian primates and sympatric cobras. BMC Biology, 19 (1) 253, 253. doi: 10.1186/s12915-021-01195-x
2021
Journal Article
Novel neurotoxic activity in Calliophis intestinalis venom
Dashevsky, Daniel, Deuis, Jennifer R., Vetter, Irina, Huynh, Tam, Hodgson, Wayne C., Tan, Choo Hock, Nouwens, Amanda and Fry, Bryan G. (2021). Novel neurotoxic activity in Calliophis intestinalis venom. Neurotoxicity Research, 40 (1), 173-178. doi: 10.1007/s12640-021-00413-2
2021
Journal Article
An ultrapotent and selective cyclic peptide inhibitor of human β-factor XIIa in a cyclotide scaffold
Liu, Wenyu, de Veer, Simon J., Huang, Yen-Hua, Sengoku, Toru, Okada, Chikako, Ogata, Kazuhiro, Zdenek, Christina N., Fry, Bryan G., Swedberg, Joakim E., Passioura, Toby, Craik, David J. and Suga, Hiroaki (2021). An ultrapotent and selective cyclic peptide inhibitor of human β-factor XIIa in a cyclotide scaffold. Journal of the American Chemical Society, 143 (44) jacs.1c07574, 18481-18489. doi: 10.1021/jacs.1c07574
2021
Journal Article
The Relative Efficacy of Chemically Diverse Small-Molecule Enzyme-Inhibitors Against Anticoagulant Activities of African Spitting Cobra (Naja Species) Venoms
Chowdhury, Abhinandan, Lewin, Matthew R., Zdenek, Christina N., Carter, Rebecca and Fry, Bryan G. (2021). The Relative Efficacy of Chemically Diverse Small-Molecule Enzyme-Inhibitors Against Anticoagulant Activities of African Spitting Cobra (Naja Species) Venoms. Frontiers in Immunology, 12 752442, 1-9. doi: 10.3389/fimmu.2021.752442
2021
Journal Article
Clinical implications of ontogenetic differences in the coagulotoxic activity of Bothrops jararacussu venoms
Bittencourt Rodrigues, Caroline Fabri, Zdenek, Christina N., Bourke, Lachlan A., Seneci, Lorenzo, Chowdhury, Abhinandan, Freitas-de-Sousa, Luciana Aparecida, de Alcantara Menezes, Frederico, Moura-da-Silva, Ana Maria, Tanaka-Azevedo, Anita Mitico and Fry, Bryan G. (2021). Clinical implications of ontogenetic differences in the coagulotoxic activity of Bothrops jararacussu venoms. Toxicology Letters, 348, 59-72. doi: 10.1016/j.toxlet.2021.05.005
2021
Journal Article
Evidence for resistance to coagulotoxic effects of Australian elapid snake venoms by sympatric prey (blue tongue skinks) but not by predators (monitor lizards)
Youngman, Nicholas J., Llinas, Joshua and Fry, Bryan G. (2021). Evidence for resistance to coagulotoxic effects of Australian elapid snake venoms by sympatric prey (blue tongue skinks) but not by predators (monitor lizards). Toxins, 13 (9) 590, 590. doi: 10.3390/toxins13090590
2021
Journal Article
The dragon’s paralysing spell: evidence of sodium and calcium ion channel binding neurotoxins in helodermatid and varanid lizard venoms
Dobson, James S., Harris, Richard J., Zdenek, Christina N., Huynh, Tam, Hodgson, Wayne C., Bosmans, Frank, Fourmy, Rudy, Violette, Aude and Fry, Bryan G. (2021). The dragon’s paralysing spell: evidence of sodium and calcium ion channel binding neurotoxins in helodermatid and varanid lizard venoms. Toxins, 13 (8) 549, 1-14. doi: 10.3390/toxins13080549
2021
Journal Article
A symphony of destruction: dynamic differential fibrinogenolytic toxicity by rattlesnake (Crotalus and Sistrurus) venoms
Seneci, Lorenzo, Zdenek, Christina N., Bourke, Lachlan A., Cochran, Chip, Sánchez, Elda E., Neri-Castro, Edgar, Bénard-Valle, Melisa, Alagón, Alejandro, Frank, Nathaniel and Fry, Bryan G. (2021). A symphony of destruction: dynamic differential fibrinogenolytic toxicity by rattlesnake (Crotalus and Sistrurus) venoms. Comparative Biochemistry and Physiology Part - C: Toxicology and Pharmacology, 245 109034, 109034. doi: 10.1016/j.cbpc.2021.109034
2021
Journal Article
Pharmacological characterisation of Pseudocerastes and Eristicophis viper venoms reveal anticancer (melanoma) properties and a potentially novel mode of fibrinogenolysis
op den Brouw, Bianca, Ghezellou, Parviz, Casewell, Nicholas R., Ali, Syed Abid, Fathinia, Behzad, Fry, Bryan G., Bos, Mettine H.A. and Ikonomopoulou, Maria P. (2021). Pharmacological characterisation of Pseudocerastes and Eristicophis viper venoms reveal anticancer (melanoma) properties and a potentially novel mode of fibrinogenolysis. International Journal of Molecular Sciences, 22 (13) 6896, 1-17. doi: 10.3390/ijms22136896
2021
Journal Article
Editorial: venoms and toxins: at the crossroads of basic, applied and clinical immunology
Pucca, Manuela B., Fry, Bryan G., Sartim, Marco A., Peigneur, Steve and Monteiro, Wuelton M. (2021). Editorial: venoms and toxins: at the crossroads of basic, applied and clinical immunology. Frontiers in Immunology, 12 716508, 716508. doi: 10.3389/fimmu.2021.716508
2021
Journal Article
Venom-induced blood disturbances by palearctic viperid snakes, and their relative neutralization by antivenoms and enzyme-inhibitors
Chowdhury, Abhinandan, Zdenek, Christina N., Lewin, Matthew R., Carter, Rebecca, Jagar, Tomaž, Ostanek, Erika, Harjen, Hannah, Aldridge, Matt, Soria, Raul, Haw, Grace and Fry, Bryan G. (2021). Venom-induced blood disturbances by palearctic viperid snakes, and their relative neutralization by antivenoms and enzyme-inhibitors. Frontiers in Immunology, 12 688802, 688802. doi: 10.3389/fimmu.2021.688802
2021
Journal Article
Production, composition, and mode of action of the painful defensive venom produced by a limacodid caterpillar, Doratifera vulnerans
Walker, Andrew A., Robinson, Samuel D., Paluzzi, Jean-Paul V., Merritt, David J., Nixon, Samantha A., Schroeder, Christina I., Jin, Jiayi, Goudarzi, Mohaddeseh Hedayati, Kotze, Andrew C., Dekan, Zoltan, Sombke, Andy, Alewood, Paul F., Fry, Bryan G., Epstein, Marc E., Vetter, Irina and King, Glenn F. (2021). Production, composition, and mode of action of the painful defensive venom produced by a limacodid caterpillar, Doratifera vulnerans. Proceedings of the National Academy of Sciences of the United States of America, 118 (18) 2023815118, e2023815118. doi: 10.1073/pnas.2023815118
2021
Journal Article
Getting stoned: Characterisation of the coagulotoxic and neurotoxic effects of reef stonefish (Synanceia verrucosa) venom
Harris, Richard J., Youngman, Nicholas J., Chan, Weili, Bosmans, Frank, Cheney, Karen L. and Fry, Bryan G. (2021). Getting stoned: Characterisation of the coagulotoxic and neurotoxic effects of reef stonefish (Synanceia verrucosa) venom. Toxicology Letters, 346, 16-22. doi: 10.1016/j.toxlet.2021.04.007
2021
Journal Article
Clinical implications of differential procoagulant toxicity of the palearctic viperid genus Macrovipera, and the relative neutralization efficacy of antivenoms and enzyme inhibitors
Chowdhury, Abhinandan, Zdenek, Christina N., Dobson, James S., Bourke, Lachlan A., Soria, Raul and Fry, Bryan G. (2021). Clinical implications of differential procoagulant toxicity of the palearctic viperid genus Macrovipera, and the relative neutralization efficacy of antivenoms and enzyme inhibitors. Toxicology Letters, 340, 77-88. doi: 10.1016/j.toxlet.2020.12.019
2021
Journal Article
Not Goanna Get Me: Mutations in the Savannah Monitor Lizard (Varanus exanthematicus) nicotinic acetylcholine receptor confer reduced susceptibility to sympatric cobra venoms
Jones, Lee, Harris, Richard J. and Fry, Bryan G. (2021). Not Goanna Get Me: Mutations in the Savannah Monitor Lizard (Varanus exanthematicus) nicotinic acetylcholine receptor confer reduced susceptibility to sympatric cobra venoms. Neurotoxicity Research, 39 (4), 1116-1122. doi: 10.1007/s12640-021-00351-z
2021
Journal Article
A clot twist: extreme variation in coagulotoxicity mechanisms in Mexican neotropical rattlesnake venoms
Seneci, Lorenzo, Zdenek, Christina N., Chowdhury, Abhinandan, Rodrigues, Caroline F. B., Neri-Castro, Edgar, Benard-Valle, Melisa, Alagon, Alejandro and Fry, Bryan G. (2021). A clot twist: extreme variation in coagulotoxicity mechanisms in Mexican neotropical rattlesnake venoms. Frontiers in Immunology, 12 612846, 612846. doi: 10.3389/fimmu.2021.612846
2021
Journal Article
ERK and mTORC1 inhibitors enhance the anti-cancer capacity of the octpep-1 venom-derived peptide in melanoma BRAF(V600E) mutations
Moral-Sanz, Javier, Fernandez-Rojo, Manuel A., Potriquet, Jeremy, Mukhopadhyay, Pamela, Brust, Andreas, Wilhelm, Patrick, Smallwood, Taylor B., Clark, Richard J., Fry, Bryan G., Alewood, Paul F., Waddell, Nicola, Miles, John J., Mulvenna, Jason P. and Ikonomopoulou, Maria P. (2021). ERK and mTORC1 inhibitors enhance the anti-cancer capacity of the octpep-1 venom-derived peptide in melanoma BRAF(V600E) mutations. Toxins, 13 (2) 146, 1-19. doi: 10.3390/toxins13020146
2021
Journal Article
Electric blue: molecular evolution of three-finger toxins in the long-glanded coral snake species Calliophis bivirgatus
Dashevsky, Daniel, Rokyta, Darin, Frank, Nathaniel, Nouwens, Amanda and Fry, Bryan G. (2021). Electric blue: molecular evolution of three-finger toxins in the long-glanded coral snake species Calliophis bivirgatus. Toxins, 13 (2) 124, 1-16. doi: 10.3390/toxins13020124
2021
Journal Article
Extensive variation in the activities of Pseudocerastes and Eristicophis viper venoms suggests divergent envenoming strategies are used for prey capture
op den Brouw, Bianca, Coimbra, Francisco C. P., Bourke, Lachlan A., Huynh, Tam Minh, Vlecken, Danielle H. W., Ghezellou, Parviz, Visser, Jeroen C., Dobson, James S., Fernandez-Rojo, Manuel A., Ikonomopoulou, Maria P., Casewell, Nicholas R., Ali, Syed A., Fathinia, Behzad, Hodgson, Wayne C. and Fry, Bryan G. (2021). Extensive variation in the activities of Pseudocerastes and Eristicophis viper venoms suggests divergent envenoming strategies are used for prey capture. Toxins, 13 (2) 112, 1-21. doi: 10.3390/toxins13020112
Funding
Supervision
Availability
- Professor Bryan Fry is:
- Available for supervision
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Supervision history
Current supervision
-
Doctor Philosophy
Venom variation in American pit vipers
Principal Advisor
Other advisors: Dr Andrew Walker
-
Doctor Philosophy
Evolutionary and clinical implications of differential pathophysiological effects of rattlesnake venoms upon blood coagulation, cell function, and nerve transmission.
Principal Advisor
Other advisors: Dr Andrew Walker
-
Doctor Philosophy
Evaluation of Phylogenetic Patterns of Scorpion Pathophysiological Effects and Effectiveness of Next-Generation Antivenoms
Principal Advisor
Other advisors: Professor Glenn King, Dr Sam Robinson
-
Doctor Philosophy
The evolution of prey-selectivity for snake venom neurotoxins, and the parallel evolution of neurotoxin resistance in prey
Principal Advisor
-
Doctor Philosophy
Venom variation in New World pit vipers
Principal Advisor
Other advisors: Dr Fernanda Cardoso, Dr Andrew Walker
-
Doctor Philosophy
Utilising invertebrates to identify novel coagulotoxins
Associate Advisor
Other advisors: Professor Glenn King, Dr Andrew Walker
Completed supervision
-
2023
Doctor Philosophy
Therapeutic options for divergent snake venom.
Principal Advisor
Other advisors: Dr Mary-Louise Roy Manchadi
-
2023
Doctor Philosophy
Coagulotoxicity and neurotoxicity variation in Bitis venoms: Evolutionary, pathophysiological and biodiscovery implications
Principal Advisor
Other advisors: Dr Andrew Walker
-
2022
Doctor Philosophy
The Co-Evolutionary Dynamics of alpha-Neurotoxic Snake Venoms and their Nicotinic Acetylcholine Receptor Targets
Principal Advisor
Other advisors: Dr Andrew Walker
-
2022
Doctor Philosophy
Evolution and Diversification of the Anguimorphan Lizard Venom System
Principal Advisor
Other advisors: Professor Irina Vetter
-
2020
Doctor Philosophy
Characterising venom variation and antivenom effectiveness within the "True" vipers (Viperinae: Viperidae)
Principal Advisor
Other advisors: Professor Irina Vetter
-
2020
Doctor Philosophy
Effects of Australian snake venoms on coagulation: Differential potency, biochemistry, and antivenom efficacy
Principal Advisor
Other advisors: Professor Irina Vetter
-
2020
Doctor Philosophy
Novelty in three-finger toxin evolution
Principal Advisor
Other advisors: Professor Irina Vetter
-
2019
Doctor Philosophy
A Blood Bond: Evolutionary, Pathophysiological and Biodiscovery implications of coagulotoxic snake venoms
Principal Advisor
Other advisors: Professor Irina Vetter
-
2019
Doctor Philosophy
Tarantulas of Australia: phylogenetics and venomics
Principal Advisor
Other advisors: Professor Glenn King, Associate Professor Lyn Cook
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2018
Doctor Philosophy
Evolution of the venom system in aculeate hymenoptera
Principal Advisor
Other advisors: Professor Irina Vetter
-
2017
Doctor Philosophy
An investigation of the evolution of the Anguimorph lizard venom system
Principal Advisor
-
2016
Doctor Philosophy
Evolution and diversification of the cnidarian venom system
Principal Advisor
-
2016
Doctor Philosophy
A philosophical and empirical investigation of the evolution of the toxicoferan reptile venom system
Principal Advisor
Other advisors: Professor Irina Vetter, Professor Glenn King
-
2014
Doctor Philosophy
Centipede Venom Evolution: Casting light on a neglected group of venomous animals
Associate Advisor
Other advisors: Professor Glenn King
Media
Enquiries
Contact Professor Bryan Fry directly for media enquiries about:
- Animal venoms
- Antivenoms
- Biodiscovery
- Drug design
- Venom
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