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2014 Journal Article Weight loss independent association of TCF7 L2 gene polymorphism with fasting blood glucose after Roux-en-Y gastric bypass in type 2 diabetic patientsRouskas, Konstantinos, Cauchi, Stephane, Raverdy, Violeta, Yengo, Loic, Froguel, Philippe and Pattou, Francois (2014). Weight loss independent association of TCF7 L2 gene polymorphism with fasting blood glucose after Roux-en-Y gastric bypass in type 2 diabetic patients. Surgery for Obesity and Related Diseases, 10 (4), 679-683. doi: 10.1016/j.soard.2013.12.016 |
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2014 Journal Article Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibilityDIAbetes Genetics Replication And Meta-analysis (DIAGRAM) Consortium, Asian Genetic Epidemiology Network Type 2 Diabetes (AGEN-T2D) Consortium, South Asian Type 2 Diabetes (SAT2D) Consortium, Mexican American Type 2 Diabetes (MAT2D) Consortium, Type 2 Diabetes Genetic Exploration by Next-generation sequencing in multi-Ethnic Samples (T2D-GENES) Consortium, Shah, Sonia and Yengo, Loic (2014). Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility. Nature Genetics, 46 (3), 234-246. doi: 10.1038/ng.2897 |
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2013 Journal Article Parental history of type 2 diabetes, TCF7L2 variant and lower insulin secretion are associated with incident hypertension. Data from the DESIR and RISC cohortsBonnet, Fabrice, Roussel, Ronan, Natali, Andrea, Cauchi, Stephane, Petrie, John, Laville, Martine, Yengo, Loic, Froguel, Philippe, Lange, Celine, Lantieri, Olivier, Marre, Michel, Balkau, Beverley and Ferrannini, Ele (2013). Parental history of type 2 diabetes, TCF7L2 variant and lower insulin secretion are associated with incident hypertension. Data from the DESIR and RISC cohorts. Diabetologia, 56 (11), 2414-2423. doi: 10.1007/s00125-013-3021-y |
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2013 Journal Article Common variants near BDNF and SH2B1 show nominal evidence of association with snacking behavior in European populationsRobiou-du-Pont, Sebastien, Yengo, Loic, Vaillant, Emmanuel, Lobbens, Stephane, Durand, Emmanuelle, Horber, Fritz, Lantieri, Olivier, Marre, Michel, Balkau, Beverley, Froguel, Philippe and Meyre, David (2013). Common variants near BDNF and SH2B1 show nominal evidence of association with snacking behavior in European populations. Journal of Molecular Medicine, 91 (9), 1109-1115. doi: 10.1007/s00109-013-1027-z |
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2013 Journal Article Association between large detectable clonal mosaicism and type 2 diabetes with vascular complicationsBonnefond, Amelie, Skrobek, Boris, Lobbens, Stephane, Eury, Elodie, Thuillier, Dorothee, Cauchi, Stephane, Lantieri, Olivier, Balkau, Beverley, Riboli, Elio, Marre, Michel, Charpentier, Guillaume, Yengo, Loic and Froguel, Philippe (2013). Association between large detectable clonal mosaicism and type 2 diabetes with vascular complications. Nature Genetics, 45 (9), 1040-1043. doi: 10.1038/ng.2700 |
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2013 Journal Article Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disordersden Hoed, Marcel, Eijgelsheim, Mark, Esko, Tonu, Brundel, Bianca J. J. M., Peal, David S., Evans, David M., Nolte, Ilja M., Segre, Ayellet V., Holm, Hilma, Handsaker, Robert E., Westra, Harm-Jan, Johnson, Toby, Isaacs, Aaron, Yang, Jian, Lundby, Alicia, Zhao, Jing Hua, Kim, Young Jin, Go, Min Jin, Almgren, Peter, Bochud, Murielle, Boucher, Gabrielle, Cornelis, Marilyn C., Gudbjartsson, Daniel, Hadley, David, van der Harst, Pim, Hayward, Caroline, den Heijer, Martin, Igl, Wilmar, Jackson, Anne U. ... Loos, Ruth J. F. (2013). Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders. Nature Genetics, 45 (6), 621-634. doi: 10.1038/ng.2610 |
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2013 Journal Article Transcription factor gene MNX1 is a novel cause of permanent neonatal diabetes in a consanguineous familyBonnefond, A., Vaillant, E., Philippe, J., Skrobek, B., Lobbens, S., Yengo, L., Huyvaert, M., Cave, H., Busiah, K., Scharfmann, R., Polak, M., Abdul-Rasoul, M., Froguel, P. and Vaxillaire, M. (2013). Transcription factor gene MNX1 is a novel cause of permanent neonatal diabetes in a consanguineous family. Diabetes and Metabolism, 39 (3), 276-280. doi: 10.1016/j.diabet.2013.02.007 |
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2013 Journal Article Reassessment of the putative role of BLK-p.A71T loss-of-function mutation in MODY and type 2 diabetesBonnefond, A., Yengo, L., Philippe, J., Dechaume, A., Ezzidi, I., Vaillant, E., Gjesing, A. P., Andersson, E. A., Czernichow, S., Hercberg, S., Hadjadj, S., Charpentier, G., Lantieri, O., Balkau, B., Marre, M., Pedersen, O., Hansen, T., Froguel, P. and Vaxillaire, M. (2013). Reassessment of the putative role of BLK-p.A71T loss-of-function mutation in MODY and type 2 diabetes. Diabetologia, 56 (3), 492-496. doi: 10.1007/s00125-012-2794-8 |
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2013 Journal Article Analysis of the contribution of FTO, NPC1, ENPP1, NEGR1, GNPDA2 and MC4R genes to obesity in Mexican childrenMejia-Benitez, Aurora, Kluender-Kluender, Miguel, Yengo, Loic, Meyre, David, Aradillas, Celia, Cruz, Esperanza, Perez-Luque, Elva, Manuel Malacara, Juan, Eugenia Garay, Maria, Peralta-Romero, Jesus, Flores-Huerta, Samuel, Garcia-Mena, Jaime, Froguel, Philippe, Cruz, Miguel and Bonnefond, Amelie (2013). Analysis of the contribution of FTO, NPC1, ENPP1, NEGR1, GNPDA2 and MC4R genes to obesity in Mexican children. Bmc Medical Genetics, 14 (1) 21. doi: 10.1186/1471-2350-14-21 |
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2013 Journal Article Genome-wide association analyses identify 18 new loci associated with serum urate concentrationsKoettgen, Anna, Albrecht, Eva, Teumer, Alexander, Vitart, Veronique, Krumsiek, Jan, Hundertmark, Claudia, Pistis, Giorgio, Ruggiero, Daniela, O'Seaghdha, Conall M., Haller, Toomas, Yang, Qiong, Tanaka, Toshiko, Johnson, Andrew D., Kutalik, Zoltan, Smith, Albert V., Shi, Julia, Struchalin, Maksim, Middelberg, Rita P. S., Brown, Morris J., Gaffo, Angelo L., Pirastu, Nicola, Li, Guo, Hayward, Caroline, Zemunik, Tatijana, Huffman, Jennifer, Yengo, Loic, Zhao, Jing Hua, Demirkan, Ayse, Feitosa, Mary F. ... Gieger, Christian (2013). Genome-wide association analyses identify 18 new loci associated with serum urate concentrations. Nature Genetics, 45 (2), 145-154. doi: 10.1038/ng.2500 |
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2013 Journal Article Exome sequencing-driven discovery of coding polymorphisms associated with common metabolic phenotypesAlbrechtsen, A., Grarup, N., Li, Y., Sparso, T., Tian, G., Cao, H., Jiang, T., Kim, S. Y., Korneliussen, T., Li, Q., Nie, C., Wu, R., Skotte, L., Morris, A. P., Ladenvall, C., Cauchi, S., Stancakova, A., Andersen, G., Astrup, A., Banasik, K., Bennett, A. J., Bolund, L., Charpentier, G., Chen, Y., Dekker, J. M., Doney, A. S. F., Dorkhan, M., Forsen, T., Frayling, T. M. ... Pedersen, O. (2013). Exome sequencing-driven discovery of coding polymorphisms associated with common metabolic phenotypes. Diabetologia, 56 (2), 298-310. doi: 10.1007/s00125-012-2756-1 |
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2013 Journal Article Contribution of 24 obesity-associated genetic variants to insulin resistance, pancreatic beta-cell function and type 2 diabetes risk in the French populationRobiou-du-Pont, S., Bonnefond, A., Yengo, L., Vaillant, E., Lobbens, S., Durand, E., Weill, J., Lantieri, O., Balkau, B., Charpentier, G., Marre, M., Froguel, P. and Meyre, D. (2013). Contribution of 24 obesity-associated genetic variants to insulin resistance, pancreatic beta-cell function and type 2 diabetes risk in the French population. International Journal of Obesity, 37 (7), 980-985. doi: 10.1038/ijo.2012.175 |
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2013 Journal Article GUESS-ing Polygenic Associations with Multiple Phenotypes Using a GPU-Based Evolutionary Stochastic Search AlgorithmBottolo, Leonardo, Chadeau-Hyam, Marc, Hastie, David I., Zeller, Tanja, Liquet, Benoit, Newcombe, Paul, Yengo, Loic, Wild, Philipp S., Schillert, Arne, Ziegler, Andreas, Nielsen, Sune F., Butterworth, Adam S., Ho, Weang Kee, Castagne, Raphaele, Munzel, Thomas, Tregouet, David, Falchi, Mario, Cambien, Francois, Nordestgaard, Borge G., Fumeron, Frederic, Tybjaerg-Hansen, Anne, Froguel, Philippe, Danesh, John, Petretto, Enrico, Blankenberg, Stefan, Tiret, Laurence and Richardson, Sylvia (2013). GUESS-ing Polygenic Associations with Multiple Phenotypes Using a GPU-Based Evolutionary Stochastic Search Algorithm. PLoS Genetics, 9 (8) e1003657, e1003657. doi: 10.1371/journal.pgen.1003657 |
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2012 Journal Article European genetic variants associated with type 2 diabetes in North African ArabsCauchi, S., Ezzidi, I., El Achhab, Y., Mtiraoui, N., Chaieb, L., Salah, D., Nejjari, C., Labrune, Y., Yengo, L., Beury, D., Vaxillaire, M., Mahjoub, T., Chikri, M. and Froguel, P. (2012). European genetic variants associated with type 2 diabetes in North African Arabs. Diabetes and Metabolism, 38 (4), 316-323. doi: 10.1016/j.diabet.2012.02.003 |
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2012 Journal Article Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetesMorris, Andrew P., Voight, Benjamin F., Teslovich, Tanya M., Ferreira, Teresa, Segre, Ayellet V., Steinthorsdottir, Valgerdur, Strawbridge, Rona J., Khan, Hassan, Grallert, Harald, Mahajan, Anubha, Prokopenko, Inga, Kang, Hyun Min, Dina, Christian, Esko, Tonu, Fraser, Ross M., Kanoni, Stavroula, Kumar, Ashish, Lagou, Vasiliki, Langenberg, Claudia, Luan, Jian'an, Lindgren, Cecilia M., Mueller-Nurasyid, Martina, Pechlivanis, Sonali, Rayner, N. William, Scott, Laura J., Wiltshire, Steven, Yengo, Loic, Kinnunen, Leena, Rossin, Elizabeth J. ... Shah, Sonia (2012). Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes. Nature Genetics, 44 (9), 981-990. doi: 10.1038/ng.2383 |
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2012 Journal Article Meta-analysis identifies multiple loci associated with kidney function-related traits in east Asian populationsOkada, Y., Sim, X., Go, M. J., Wu, J. Y., Gu, D., Takeuchi, F., Takahashi, A., Maeda, S., Tsunoda, T., Chen, P., Lim, S. C., Wong, T. Y., Liu, J., Young, T. L., Aung, T., Seielstad, M., Teo, Y. Y., Kim, Y. J., Lee, J. Y., Han, B. g., Kang, D., Chen, C. h., Tsai, F. j., Chang, L. c., Fann, S. j., Mei, H., Rao, D. c., Hixson, J. e., Chen, S. ... Gieger, C. (2012). Meta-analysis identifies multiple loci associated with kidney function-related traits in east Asian populations. Nature Genetics, 44 (8), 904-909. doi: 10.1038/ng.2352 |
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2012 Journal Article Stratifying type 2 diabetes cases by BMI identifies genetic risk variants in LAMA1 and enrichment for risk variants in lean compared to obese casesPerry, John R. B., Voight, Benjamin F., Yengo, Loic, Amin, Najaf, Dupuis, Josee, Ganser, Martha, Grallert, Harald, Navarro, Pau, Li, Man, Qi, Lu, Steinthorsdottir, Valgerdur, Scott, Robert A., Almgren, Peter, Arking, Dan E., Aulchenko, Yurii, Balkau, Beverley, Benediktsson, Rafn, Bergman, Richard N., Boerwinkle, Eric, Bonnycastle, Lori, Burtt, Noel P., Campbell, Harry, Charpentier, Guillaume, Collins, Francis S., Gieger, Christian, Green, Todd, Hadjadj, Samy, Hattersley, Andrew T., Herder, Christian ... Cauchi, Stephane (2012). Stratifying type 2 diabetes cases by BMI identifies genetic risk variants in LAMA1 and enrichment for risk variants in lean compared to obese cases. Plos Genetics, 8 (5) e1002741, e1002741. doi: 10.1371/journal.pgen.1002741 |
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2012 Journal Article O53 - Alteration of the omega-3 unsaturated fatty acid receptor GPR120 leads to obesity in humans and mice O53 L'altération du récepteur des acides gras insaturés de type omega-3 GPR120 entraîne une obésité chez l'Homme et la SourisBonnefond, A., Poulain-Godefroy, O., Ichimura, A., Hirasawa, A., Yengo, L., Leloire, A., Choquet, H., Meyre, D., Pattou, F., Wolowczuk, I., Tsujimoto, G. and Froguel, P. (2012). O53 - Alteration of the omega-3 unsaturated fatty acid receptor GPR120 leads to obesity in humans and mice O53 L'altération du récepteur des acides gras insaturés de type omega-3 GPR120 entraîne une obésité chez l'Homme et la Souris. Diabetes and Metabolism, 38. doi: 10.1016/S1262-3636(12)71031-5 |
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2012 Journal Article Dysfunction of lipid sensor GPR120 leads to obesity in both mouse and humanIchimura, Atsuhiko, Hirasawa, Akira, Poulain-Godefroy, Odile, Bonnefond, Amelie, Hara, Takafumi, Yengo, Loic, Kimura, Ikuo, Leloire, Audrey, Liu, Ning, Iida, Keiko, Choquet, Helene, Besnard, Philippe, Lecoeur, Cecile, Vivequin, Sidonie, Ayukawa, Kumiko, Takeuchi, Masato, Ozawa, Kentaro, Tauber, Maithe, Maffeis, Claudio, Morandi, Anita, Buzzetti, Raffaella, Elliott, Paul, Pouta, Anneli, Jarvelin, Marjo-Riitta, Koerner, Antje, Kiess, Wieland, Pigeyre, Marie, Caiazzo, Roberto, Van Hul, Wim ... Froguel, Philippe (2012). Dysfunction of lipid sensor GPR120 leads to obesity in both mouse and human. Nature, 483 (7389), 350-354. doi: 10.1038/nature10798 |
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2012 Journal Article Low-frequency variants in HMGA1 are not associated with type 2 diabetes riskMarquez, Marcel, Huyvaert, Marlene, Perry, John R. B., Pearson, Richard D., Falchi, Mario, Morris, Andrew P., Vivequin, Sidonie, Lobbens, Stephane, Yengo, Loic, Gaget, Stefan, Pattou, Francois, Poulain-Godefroy, Odile, Charpentier, Guillaume, Carlsson, Lena M. S., Jacobson, Peter, Sjostrom, Lars, Lantieri, Olivier, Heude, Barbara, Walley, Andrew, Balkau, Beverley, Marre, Michel, Froguel, Philippe and Cauchi, Stephane (2012). Low-frequency variants in HMGA1 are not associated with type 2 diabetes risk. Diabetes, 61 (2), 524-530. doi: 10.2337/db11-0728 |
