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2020 Journal Article Genome-wide association and Mendelian randomisation analysis provide insights into the pathogenesis of heart failureShah, Sonia, Henry, Albert, Roselli, Carolina, Lin, Honghuang, Sveinbjörnsson, Garðar, Fatemifar, Ghazaleh, Hedman, Åsa K., Wilk, Jemma B., Morley, Michael P., Chaffin, Mark D., Helgadottir, Anna, Verweij, Niek, Dehghan, Abbas, Almgren, Peter, Andersson, Charlotte, Aragam, Krishna G., Ärnlöv, Johan, Backman, Joshua D., Biggs, Mary L., Bloom, Heather L., Brandimarto, Jeffrey, Brown, Michael R., Buckbinder, Leonard, Carey, David J., Chasman, Daniel I., Chen, Xing, Chen, Xu, Chung, Jonathan, Chutkow, William ... Lumbers, R. Thomas (2020). Genome-wide association and Mendelian randomisation analysis provide insights into the pathogenesis of heart failure. Nature Communications, 11 (1) 163, 163. doi: 10.1038/s41467-019-13690-5 |
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2020 Journal Article ATXN1 repeat expansions confer risk for amyotrophic lateral sclerosis and contribute to TDP-43 mislocalizationTazelaar, Gijs H.P., Boeynaems, Steven, De Decker, Mathias, van Vugt, Joke J.F.A., Kool, Lindy, Goedee, H. Stephan, McLaughlin, Russell L., Sproviero, William, Iacoangeli, Alfredo, Moisse, Matthieu, Jacquemyn, Maarten, Daelemans, Dirk, Dekker, Annelot M., van der Spek, Rick A., Westeneng, Henk-Jan, Kenna, Kevin P., Assialioui, Abdelilah, Silva, Nica Da, Povedano, Mónica, Mora Pardina, Jesus S., Hardiman, Orla, Salachas, François, Millecamps, Stéphanie, Vourc’h, Patrick, Corcia, Philippe, Couratier, Philippe, Morrison, Karen E., Shaw, Pamela J., Shaw, Christopher E. ... Project MinE ALS Sequencing Consortium (2020). ATXN1 repeat expansions confer risk for amyotrophic lateral sclerosis and contribute to TDP-43 mislocalization. Brain Communications, 2 (2) fcaa064. doi: 10.1093/braincomms/fcaa064 |
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2019 Journal Article An epigenome-wide association study of sex-specific chronological ageingMcCartney, Daniel L., Zhang, Futao, Hillary, Robert F., Zhang, Qian, Stevenson, Anna J., Walker, Rosie M., Bermingham, Mairead L., Boutin, Thibaud, Morris, Stewart W., Campbell, Archie, Murray, Alison D., Whalley, Heather C., Porteous, David J., Hayward, Caroline, Evans, Kathryn L., Chandra, Tamir, Deary, Ian J., McIntosh, Andrew M., Yang, Jian, Visscher, Peter M., McRae, Allan F. and Marioni, Riccardo E. (2019). An epigenome-wide association study of sex-specific chronological ageing. Genome Medicine, 12 (1) 1, 1. doi: 10.1186/s13073-019-0693-z |
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2019 Journal Article Integrated analysis of environmental and genetic influences on cord blood DNA methylation in new-bornsCzamara, Darina, Eraslan, Gökçen, Page, Christian M., Lahti, Jari, Lahti-Pulkkinen, Marius, Hämäläinen, Esa, Kajantie, Eero, Laivuori, Hannele, Villa, Pia M., Reynolds, Rebecca M., Nystad, Wenche, Håberg, Siri E., London, Stephanie J., O’Donnell, Kieran J., Garg, Elika, Meaney, Michael J., Entringer, Sonja, Wadhwa, Pathik D., Buss, Claudia, Jones, Meaghan J., Lin, David T. S., MacIsaac, Julie L., Kobor, Michael S., Koen, Nastassja, Zar, Heather J., Koenen, Karestan C., Dalvie, Shareefa, Stein, Dan J., Kondofersky, Ivan ... Binder, Elisabeth B. (2019). Integrated analysis of environmental and genetic influences on cord blood DNA methylation in new-borns. Nature Communications, 10 (1) 2548. doi: 10.1038/s41467-019-10461-0 |
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2019 Journal Article Identification of novel risk loci, causal insights, and heritable risk for Parkinson's disease: a meta-analysis of genome-wide association studiesNalls, Mike A, Blauwendraat, Cornelis, Vallerga, Costanza L, Heilbron, Karl, Bandres-Ciga, Sara, Chang, Diana, Tan, Manuela, Kia, Demis A, Noyce, Alastair J, Xue, Angli, Bras, Jose, Young, Emily, von Coelln, Rainer, Simón-Sánchez, Javier, Schulte, Claudia, Sharma, Manu, Krohn, Lynne, Pihlstrøm, Lasse, Siitonen, Ari, Iwaki, Hirotaka, Leonard, Hampton, Faghri, Faraz, Gibbs, J Raphael, Hernandez, Dena G, Scholz, Sonja W, Botia, Juan A, Martinez, Maria, Corvol, Jean-Christophe, Lesage, Suzanne ... Zhang, Futao (2019). Identification of novel risk loci, causal insights, and heritable risk for Parkinson's disease: a meta-analysis of genome-wide association studies. The Lancet Neurology, 18 (12), 1091-1102. doi: 10.1016/S1474-4422(19)30320-5 |
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2019 Journal Article A resource-efficient tool for mixed model association analysis of large-scale dataJiang, Longda, Zheng, Zhili, Qi, Ting, Kemper, Kathryn E., Wray, Naomi R., Visscher, Peter M. and Yang, Jian (2019). A resource-efficient tool for mixed model association analysis of large-scale data. Nature Genetics, 51 (12), 1749-1755. doi: 10.1038/s41588-019-0530-8 |
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2019 Journal Article No evidence for social genetic effects or genetic similarity among friends beyond that due to population stratification: A reappraisal of Domingue et al (2018)Yengo, Loic, Sidari, Morgan, Verweij, Karin J. H., Visscher, Peter M., Keller, Matthew C. and Zietsch, Brendan P. (2019). No evidence for social genetic effects or genetic similarity among friends beyond that due to population stratification: A reappraisal of Domingue et al (2018). Behavior Genetics, 50 (1), 67-71. doi: 10.1007/s10519-019-09979-2 |
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2019 Journal Article Improved polygenic prediction by Bayesian multiple regression on summary statisticsLloyd-Jones, Luke R., Zeng, Jian, Sidorenko, Julia, Yengo, Loïc, Moser, Gerhard, Kemper, Kathryn E., Wang, Huanwei, Zheng, Zhili, Magi, Reedik, Esko, Tõnu, Metspalu, Andres, Wray, Naomi R., Goddard, Michael E., Yang, Jian and Visscher, Peter M. (2019). Improved polygenic prediction by Bayesian multiple regression on summary statistics. Nature Communications, 10 (1) 5086, 1-10. doi: 10.1038/s41467-019-12653-0 |
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2019 Journal Article Bipolar multiplex families have an increased burden of common risk variants for psychiatric disordersAndlauer, Till F. M., Guzman-Parra, Jose, Streit, Fabian, Strohmaier, Jana, González, Maria José, Gil Flores, Susana, Cabaleiro Fabeiro, Francisco J., del Río Noriega, Francisco, Perez, Fermin Perez, Haro González, Jesus, Orozco Diaz, Guillermo, de Diego-Otero, Yolanda, Moreno-Küstner, Berta, Auburger, Georg, Degenhardt, Franziska, Heilmann-Heimbach, Stefanie, Herms, Stefan, Hoffmann, Per, Frank, Josef, Foo, Jerome C., Treutlein, Jens, Witt, Stephanie H., Cichon, Sven, Kogevinas, Manolis, Stahl, Eli A, Breen, Gerome, Forstner, Andreas J, McQuillin, Andrew, Ripke, Stephan ... Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium (2019). Bipolar multiplex families have an increased burden of common risk variants for psychiatric disorders. Molecular Psychiatry, 26 (4), 1286-1298. doi: 10.1038/s41380-019-0558-2 |
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2019 Journal Article The genetics of the mood disorder spectrum: Genome-wide association analyses of more than 185,000 cases and 439,000 controlsColeman, Jonathan R.I., Gaspar, Héléna A., Bryois, Julien, Byrne, Enda M., Forstner, Andreas J., Holmans, Peter A., de Leeuw, Christiaan A., Mattheisen, Manuel, McQuillin, Andrew, Whitehead Pavlides, Jennifer M., Pers, Tune H., Ripke, Stephan, Stahl, Eli A., Steinberg, Stacy, Trubetskoy, Vassily, Trzaskowski, Maciej, Wang, Yunpeng, Abbott, Liam, Abdellaoui, Abdel, Adams, Mark J., Adolfsson, Annelie Nordin, Agerbo, Esben, Akil, Huda, Albani, Diego, Alliey-Rodriguez, Ney, Als, Thomas D., Andlauer, Till F.M., Anjorin, Adebayo, Antilla, Verneri ... Breen, Gerome (2019). The genetics of the mood disorder spectrum: Genome-wide association analyses of more than 185,000 cases and 439,000 controls. Biological Psychiatry, 88 (2), 169-184. doi: 10.1016/j.biopsych.2019.10.015 |
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2019 Journal Article The Parkinson's disease Mendelian randomization research portalNoyce, Alastair J., Bandres-Ciga, Sara, Kim, Jonggeol, Heilbron, Karl, Kia, Demis, Hemani, Gibran, Xue, Angli, Lawlor, Debbie A., Smith, George Davey, Duran, Raquel, Gan-Or, Ziv, Blauwendraat, Cornelis, Gibbs, J. Raphael, Hinds, David A., Yang, Jian, Visscher, Peter, Cuzick, Jack, Morris, Huw, Hardy, John, Wood, Nicholas W., Nalls, Mike A., Singleton, Andrew B., Agee, Michelle, Alipanahi, Babak, Auton, Adam, Bell, Robert K., Bryc, Katarzyna, Elson, Sarah L., Fontanillas, Pierre ... Wilson, Catherine H. (2019). The Parkinson's disease Mendelian randomization research portal. Movement Disorders, 34 (12) mds.27873, 1864-1872. doi: 10.1002/mds.27873 |
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2019 Journal Article Genetic correlates of social stratification in Great BritainAbdellaoui, Abdel, Hugh-Jones, David, Yengo, Loic, Kemper, Kathryn E., Nivard, Michel G., Veul, Laura, Holtz, Yan, Zietsch, Brendan P., Frayling, Timothy M., Wray, Naomi R., Yang, Jian, Verweij, Karin J. H. and Visscher, Peter M. (2019). Genetic correlates of social stratification in Great Britain. Nature Human Behaviour, 3 (12), 1332-1342. doi: 10.1038/s41562-019-0757-5 |
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2019 Journal Article Prediction of the calcium carbonate budget in a sedimentary basin: A "source-to-sink" approach applied to Great Salt Lake, Utah, USABouton, Anthony, Vennin, Emmanuelle, Amiotte-Suchet, Philippe, Thomazo, Christophe, Sizun, Jean-Pierre, Virgone, Aurelien, Gaucher, Eric C. and Visscher, Pieter T. (2019). Prediction of the calcium carbonate budget in a sedimentary basin: A "source-to-sink" approach applied to Great Salt Lake, Utah, USA. Basin Research, 32 (5), 1015-1044. doi: 10.1111/bre.12412 |
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2019 Journal Article Editorial: Characterizing Modern Microbialites and the Geobiological Processes Underlying Their FormationFoster, Jamie S., Reid, R. Pamela, Visscher, Pieter T. and Dupraz, Christophe (2019). Editorial: Characterizing Modern Microbialites and the Geobiological Processes Underlying Their Formation. Frontiers in Microbiology, 10 2299. doi: 10.3389/fmicb.2019.02299 |
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2019 Journal Article Extreme inbreeding in a European ancestry sample from the contemporary UK populationYengo, Loic, Wray, Naomi R. and Visscher, Peter M. (2019). Extreme inbreeding in a European ancestry sample from the contemporary UK population. Nature Communications, 10 (1) 3719, 3719. doi: 10.1038/s41467-019-11724-6 |
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2019 Journal Article Improved precision of epigenetic clock estimates across tissues and its implication for biological ageingZhang, Qian, Vallerga, Costanza L., Walker, Rosie M., Lin, Tian, Henders, Anjali K., Montgomery, Grant W., He, Ji, Fan, Dongsheng, Fowdar, Javed, Kennedy, Martin, Pitcher, Toni, Pearson, John, Halliday, Glenda, Kwok, John B., Hickie, Ian, Lewis, Simon, Anderson, Tim, Silburn, Peter A., Mellick, George D., Harris, Sarah E., Redmond, Paul, Murray, Alison D., Porteous, David J., Haley, Christopher S., Evans, Kathryn L., McIntosh, Andrew M., Yang, Jian, Gratten, Jacob, Marioni, Riccardo E. ... Visscher, Peter M. (2019). Improved precision of epigenetic clock estimates across tissues and its implication for biological ageing. Genome Medicine, 11 (1) 54, 54. doi: 10.1186/s13073-019-0667-1 |
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2019 Journal Article Genotype-by-environment interactions inferred from genetic effects on phenotypic variability in the UK BiobankWang, Huanwei, Zhang, Futao, Zeng, Jian, Wu, Yang, Kemper, Kathryn E., Xue, Angli, Zhang, Min, Powell, Joseph E., Goddard, Michael E., Wray, Naomi R., Visscher, Peter M., McRae, Allan F. and Yang, Jian (2019). Genotype-by-environment interactions inferred from genetic effects on phenotypic variability in the UK Biobank. Science Advances, 5 (8) eaaw3538, 1-12. doi: 10.1126/sciadv.aaw3538 |
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2019 Journal Article Classical human leukocyte antigen alleles and C4 haplotypes are not significantly associated With depressionGlanville, Kylie P., Coleman, Jonathan R. I., Hanscombe, Ken B., Euesden, Jack, Choi, Shing Wan, Purves, Kirstin L., Breen, Gerome, Air, Tracy M., Andlauer, Till F. M., Baune, Bernhard T., Binder, Elisabeth B., Blackwood, Douglas H. R., Boomsma, Dorret I., Buttenschøn, Henriette N., Colodro-Conde, Lucía, Dannlowski, Udo, Direk, Nese, Dunn, Erin C., Forstner, Andreas J., de Geus, Eco J. C., Grabe, Hans J., Hamilton, Steven P., Jones, Ian, Jones, Lisa A., Knowles, James A., Kutalik, Zoltán, Levinson, Douglas F., Lewis, Glyn, Lind, Penelope A. ... Børglum, Anders D. (2019). Classical human leukocyte antigen alleles and C4 haplotypes are not significantly associated With depression. Biological Psychiatry, 87 (5), 419-430. doi: 10.1016/j.biopsych.2019.06.031 |
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2019 Journal Article Mendelian randomization integrating GWAS and eQTL data reveals genetic determinants of complex and clinical traitsPorcu, Eleonora, Rüeger, Sina, Lepik, Kaido, Agbessi, Mawussé, Ahsan, Habibul, Alves, Isabel, Andiappan, Anand, Arindrarto, Wibowo, Awadalla, Philip, Battle, Alexis, Beutner, Frank, Jan Bonder, Marc, Boomsma, Dorret, Christiansen, Mark, Claringbould, Annique, Deelen, Patrick, Esko, Tõnu, Favé, Marie-Julie, Franke, Lude, Frayling, Timothy, Gharib, Sina A., Gibson, Gregory, Heijmans, Bastiaan T., Hemani, Gibran, Jansen, Rick, Kähönen, Mika, Kalnapenkis, Anette, Kasela, Silva, Kettunen, Johannes ... Kutalik, Zoltán (2019). Mendelian randomization integrating GWAS and eQTL data reveals genetic determinants of complex and clinical traits. Nature Communications, 10 (1) 3300. doi: 10.1038/s41467-019-10936-0 |
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2019 Journal Article Genome and epigenome wide studies of neurological protein biomarkers in the Lothian Birth Cohort 1936Hillary, Robert F., McCartney, Daniel L., Harris, Sarah E., Stevenson, Anna J., Seeboth, Anne, Zhang, Qian, Liewald, David C., Evans, Kathryn L., Ritchie, Craig W., Tucker-Drob, Elliot M., Wray, Naomi R., McRae, Allan F., Visscher, Peter M., Deary, Ian J. and Marioni, Riccardo E. (2019). Genome and epigenome wide studies of neurological protein biomarkers in the Lothian Birth Cohort 1936. Nature Communications, 10 (1) 3160, 3160. doi: 10.1038/s41467-019-11177-x |
