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2025 Journal Article Heritable polygenic editing: the next frontier in genomic medicine?Visscher, Peter M., Gyngell, Christopher, Yengo, Loic and Savulescu, Julian (2025). Heritable polygenic editing: the next frontier in genomic medicine?. Nature, 637 (8046) 86, 637-645. doi: 10.1038/s41586-024-08300-4 |
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2024 Journal Article Distinct genetic liability profiles define clinically relevant patient strata across common diseasesTrastulla, Lucia, Dolgalev, Georgii, Moser, Sylvain, Jiménez-Barrón, Laura T., Andlauer, Till F. M., von Scheidt, Moritz, Ruderfer, Douglas M., Ripke, Stephan, McQuillin, Andrew, Stahl, Eli A., Domenici, Enrico, Adolfsson, Rolf, Agartz, Ingrid, Agerbo, Esben, Albus, Margot, Alexander, Madeline, Amin, Farooq, Bacanu, Silviu A., Begemann, Martin, Belliveau, Richard A., Bene, Judit, Bergen, Sarah E., Bevilacqua, Elizabeth, Bigdeli, Tim B., Black, Donald W., Blackwood, Douglas H. R., Borglum, Anders D., Bramon, Elvira, Bruggeman, Richard ... Ziller, Michael J. (2024). Distinct genetic liability profiles define clinically relevant patient strata across common diseases. Nature Communications , 15 (1) 5534. doi: 10.1038/s41467-024-49338-2 |
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2024 Journal Article The importance of family-based sampling for biobanksDavies, Neil M., Hemani, Gibran, Neiderhiser, Jenae M., Martin, Hilary C., Mills, Melinda C., Visscher, Peter M., Yengo, Loïc, Young, Alexander Strudwick and Keller, Matthew C. (2024). The importance of family-based sampling for biobanks. Nature, 634 (8035), 795-803. doi: 10.1038/s41586-024-07721-5 |
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2024 Journal Article Genetic architecture reconciles linkage and association studies of complex traitsSidorenko, Julia, Couvy-Duchesne, Baptiste, Kemper, Kathryn E., Moen, Gunn-Helen, Bhatta, Laxmi, Åsvold, Bjørn Olav, Mägi, Reedik, Estonian Biobank Research Team, Ani, Alireza, Wang, Rujia, Nolte, Ilja M., Lifelines Cohort Study, Nolte, Ilja M., Gordon, Scott, Hayward, Caroline, Campbell, Archie, Benjamin, Daniel J., Cesarini, David, Evans, David M., Goddard, Michael E., Haley, Chris S., Porteous, David, Medland, Sarah E., Martin, Nicholas G., Snieder, Harold, Metspalu, Andres, Hveem, Kristian, Brumpton, Ben, Visscher, Peter M. and Yengo, Loic (2024). Genetic architecture reconciles linkage and association studies of complex traits. Nature Genetics, 56 (11), 2352-2360. doi: 10.1038/s41588-024-01940-2 |
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2024 Conference Publication Genome-wide Fine-mapping Improves Identification Of Causal VariantsZeng, Jian, Wu, Yang, Zheng, Zhili, Thibaut, Loic, Goddard, Michael, Wray, Naomi and Visscher, Peter (2024). Genome-wide Fine-mapping Improves Identification Of Causal Variants. World Congress of Psychiatric Genetics WCPG 2024, Singapore, 15-19 October 2024. Amsterdam, Netherlands: Elsevier. doi: 10.1016/j.euroneuro.2024.08.037 |
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2024 Journal Article Carbonate mud production in lakes is driven by degradation of microbial substancesBoussagol, P., Vennin, E., Monna, F., Millet, L., Bonnotte, A., Motreuil, S., Bundeleva, I., Rius, D. and Visscher, P. T. (2024). Carbonate mud production in lakes is driven by degradation of microbial substances. Communications Earth & Environment, 5 (1) 533. doi: 10.1038/s43247-024-01709-9 |
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2024 Journal Article The eukaryome of modern microbialites reveals distinct colonization across aquatic ecosystemsBonacolta, Anthony M., Visscher, Pieter T., del Campo, Javier and White III, Richard Allen (2024). The eukaryome of modern microbialites reveals distinct colonization across aquatic ecosystems. Npj Biofilms and Microbiomes, 10 (1) 78. doi: 10.1038/s41522-024-00547-z |
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2024 Journal Article Pyritic stromatolites from the Paleoarchean Dresser Formation, Pilbara Craton: Resolving biogenicity and hydrothermally influenced ecosystem dynamicsBaumgartner, Raphael J., Van Kranendonk, Martin J., Caruso, Stefano, Campbell, Kathleen A., Dobson, Michaela J., Teece, Bronwyn L., Verrall, Michael, Homann, Martin, Lalonde, Stefan and Visscher, Pieter T. (2024). Pyritic stromatolites from the Paleoarchean Dresser Formation, Pilbara Craton: Resolving biogenicity and hydrothermally influenced ecosystem dynamics. Geobiology, 22 (4) e12610. doi: 10.1111/gbi.12610 |
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2024 Journal Article Genetic influence on within-person longitudinal change in anthropometric traits in the UK BiobankKemper, Kathryn E., Sidorenko, Julia, Wang, Huanwei, Hayes, Ben J., Wray, Naomi R., Yengo, Loic, Keller, Matthew C., Goddard, Michael and Visscher, Peter M. (2024). Genetic influence on within-person longitudinal change in anthropometric traits in the UK Biobank. Nature Communications, 15 (1) 3776, 3776. doi: 10.1038/s41467-024-47802-7 |
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2024 Journal Article Genome-wide analysis in over 1 million individuals of European ancestry yields improved polygenic risk scores for blood pressure traitsKeaton, Jacob M., Kamali, Zoha, Xie, Tian, Vaez, Ahmad, Williams, Ariel, Goleva, Slavina B., Ani, Alireza, Evangelou, Evangelos, Hellwege, Jacklyn N., Yengo, Loic, Young, William J., Traylor, Matthew, Giri, Ayush, Zheng, Zhili, Zeng, Jian, Chasman, Daniel I., Morris, Andrew P., Caulfield, Mark J., Hwang, Shih-Jen, Kooner, Jaspal S., Conen, David, Attia, John R., Morrison, Alanna C., Loos, Ruth J. F., Kristiansson, Kati, Schmidt, Reinhold, Hicks, Andrew A., Pramstaller, Peter P., Nelson, Christopher P. ... ICBP Consortium (2024). Genome-wide analysis in over 1 million individuals of European ancestry yields improved polygenic risk scores for blood pressure traits. Nature Genetics, 56 (5), 1-14. doi: 10.1038/s41588-024-01714-w |
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2024 Journal Article Leveraging functional genomic annotations and genome coverage to improve polygenic prediction of complex traits within and between ancestriesZheng, Zhili, Liu, Shouye, Sidorenko, Julia, Wang, Ying, Lin, Tian, Yengo, Loic, Turley, Patrick, Ani, Alireza, Wang, Rujia, Nolte, Ilja M., Snieder, Harold, Aguirre-Gamboa, Raul, Deelen, Patrick, Franke, Lude, Kuivenhoven, Jan A., Lopera Maya, Esteban A., Sanna, Serena, Swertz, Morris A., Vonk, Judith M., Wijmenga, Cisca, Yang, Jian, Wray, Naomi R., Goddard, Michael E., Visscher, Peter M., Zeng, Jian and LifeLines Cohort Study (2024). Leveraging functional genomic annotations and genome coverage to improve polygenic prediction of complex traits within and between ancestries. Nature Genetics, 56 (5), 1-11. doi: 10.1038/s41588-024-01704-y |
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2024 Journal Article Genome-wide Studies Reveal Genetic Risk Factors for Hepatic Fat ContentLi, Yanni, Van Den Berg, Eline H., Kurilshikov, Alexander, Zhernakova, Dasha V., Gacesa, Ranko, Hu, Shixian, Lopera-Maya, Esteban A., Zhernakova, Alexandra, Aguirre-Gamboa, Raul, Deelen, Patrick, Franke, Lude, Kuivenhoven, Jan A., Lopera-Maya, Esteban A., Nolte, Ilja M., Sanna, Serena, Snieder, Harold, Swertz, Morris A., Visscher, Peter M., Vonk, Judith M., Wijmenga, Cisca, De Meijer, Vincent E., Sanna, Serena, Dullaart, Robin P. F., Blokzijl, Hans, Festen, Eleonora A. M., Fu, Jingyuan and Weersma, Rinse K. (2024). Genome-wide Studies Reveal Genetic Risk Factors for Hepatic Fat Content. Genomics, Proteomics and Bioinformatics, 22 (2) qzae031. doi: 10.1093/gpbjnl/qzae031 |
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2024 Journal Article Genetic control of DNA methylation is largely shared across European and East Asian populationsHatton, Alesha A., Cheng, Fei-Fei, Lin, Tian, Shen, Ren-Juan, Chen, Jie, Zheng, Zhili, Qu, Jia, Lyu, Fan, Harris, Sarah E., Cox, Simon R., Jin, Zi-Bing, Martin, Nicholas G., Fan, Dongsheng, Montgomery, Grant W., Yang, Jian, Wray, Naomi R., Marioni, Riccardo E., Visscher, Peter M. and McRae, Allan F. (2024). Genetic control of DNA methylation is largely shared across European and East Asian populations. Nature Communications, 15 (1) 2713, 1-12. doi: 10.1038/s41467-024-47005-0 |
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2024 Journal Article Unravelling the complex causal effects of substance use behaviours on common diseasesXue, Angli, Zhu, Zhihong, Wang, Huanwei, Jiang, Longda, Visscher, Peter M., Zeng, Jian and Yang, Jian (2024). Unravelling the complex causal effects of substance use behaviours on common diseases. Communications Medicine, 4 (1) 43, 1-13. doi: 10.1038/s43856-024-00473-3 |
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2024 Journal Article Host genetic regulation of human gut microbial structural variationZhernakova, Daria V., Wang, Daoming, Liu, Lei, Andreu-Sánchez, Sergio, Zhang, Yue, Ruiz-Moreno, Angel J., Peng, Haoran, Plomp, Niels, Del Castillo-Izquierdo, Ángela, Gacesa, Ranko, Lopera-Maya, Esteban A., Temba, Godfrey S., Kullaya, Vesla I., van Leeuwen, Sander S., Aguirre-Gamboa, Raul, Deelen, Patrick, Franke, Lude, Kuivenhoven, Jan A., Nolte, Ilja M., Sanna, Serena, Snieder, Harold, Swertz, Morris A., Visscher, Peter M., Vonk, Judith M., Xavier, Ramnik J., de Mast, Quirijn, Joosten, Leo A. B., Riksen, Niels P., Rutten, Joost H. W. ... Fu, Jingyuan (2024). Host genetic regulation of human gut microbial structural variation. Nature, 625 (7996), 813-821. doi: 10.1038/s41586-023-06893-w |
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2024 Journal Article Erratum: Autism-related dietary preferences mediate autism-gut microbiome associations (Cell (2021) 184(24) (5916–5931.e17), (S0092867421012319), (10.1016/j.cell.2021.10.015))Yap, Chloe X., Henders, Anjali K., Alvares, Gail A., Wood, David L.A., Krause, Lutz, Tyson, Gene W., Restuadi, Restuadi, Wallace, Leanne, McLaren, Tiana, Hansell, Narelle K., Cleary, Dominique, Grove, Rachel, Hafekost, Claire, Harun, Alexis, Holdsworth, Helen, Jellett, Rachel, Khan, Feroza, Lawson, Lauren P., Leslie, Jodie, Frenk, Mira Levis, Masi, Anne, Mathew, Nisha E., Muniandy, Melanie, Nothard, Michaela, Miller, Jessica L., Nunn, Lorelle, Holtmann, Gerald, Strike, Lachlan T., de Zubicaray, Greig I. ... Gratten, Jacob (2024). Erratum: Autism-related dietary preferences mediate autism-gut microbiome associations (Cell (2021) 184(24) (5916–5931.e17), (S0092867421012319), (10.1016/j.cell.2021.10.015)). Cell, 187 (2), 495-510. doi: 10.1016/j.cell.2023.12.001 |
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2023 Journal Article OTTERS: a powerful TWAS framework leveraging summary-level reference dataDai, Qile, Zhou, Geyu, Zhao, Hongyu, Võsa, Urmo, Franke, Lude, Battle, Alexis, Teumer, Alexander, Lehtimäki, Terho, Raitakari, Olli T., Esko, Tõnu, Agbessi, Mawussé, Ahsan, Habibul, Alves, Isabel, Andiappan, Anand Kumar, Arindrarto, Wibowo, Awadalla, Philip, Battle, Alexis, Beutner, Frank, Jan Bonder, Marc, Boomsma, Dorret I., Christiansen, Mark W., Claringbould, Annique, Deelen, Patrick, Favé, Marie-Julie, Frayling, Timothy, Gharib, Sina A., Gibson, Greg, Heijmans, Bastiaan T., Hemani, Gibran ... Yang, Jingjing (2023). OTTERS: a powerful TWAS framework leveraging summary-level reference data. Nature Communications, 14 (1) 1271, 1-13. doi: 10.1038/s41467-023-36862-w |
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2023 Journal Article Cross-ancestry analyses identify new genetic loci associated with 25-hydroxyvitamin DWang, Xiaotong, Hivert, Valentin, Groot, Shiane, Wang, Ying, Yengo, Loic, McGrath, John J., Kemper, Kathryn E., Visscher, Peter M., Wray, Naomi R. and Revez, Joana A. (2023). Cross-ancestry analyses identify new genetic loci associated with 25-hydroxyvitamin D. PLoS Genetics, 19 (11) e1011033, e1011033. doi: 10.1371/journal.pgen.1011033 |
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2023 Conference Publication Leveraging functional genomic annotations and genome coverage to improve polygenic prediction of complex traits within and between ancestriesZeng, Jian, Zheng, Zhili, Liu, Shouye, Sidorenko, Julia, Yengo, Loic, Turley, Patrick, Ani, Alireza, Wang, Rujia, Nolte, Ilja, Snieder, Harold, Yang, Jian, Wray, Naomi, Goddard, Michael and Visscher, Peter (2023). Leveraging functional genomic annotations and genome coverage to improve polygenic prediction of complex traits within and between ancestries. World Congress of Psychiatric Genetics (WCPG), Montreal, ON, Canada, 10 - 14 October 2023. Amsterdam, Netherlands: Elsevier BV. doi: 10.1016/j.euroneuro.2023.08.063 |
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2023 Journal Article Community-wide genome sequencing reveals 30 years of Darwin’s finch evolutionEnbody, Erik D., Sendell-Price, Ashley T., Sprehn, C. Grace, Rubin, Carl-Johan, Visscher, Peter M., Grant, B. Rosemary, Grant, Peter R. and Andersson, Leif (2023). Community-wide genome sequencing reveals 30 years of Darwin’s finch evolution. Science, 381 (6665) eadf6218, 1-10. doi: 10.1126/science.adf6218 |
