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2025

Journal Article

Socio-economic status is a social construct with heritable components and genetic consequences

Abdellaoui, Abdel, Martin, Hilary C., Kolk, Martin, Rutherford, Adam, Muthukrishna, Michael, Tropf, Felix C., Mills, Melinda C., Zietsch, Brendan P., Verweij, Karin J. H. and Visscher, Peter M. (2025). Socio-economic status is a social construct with heritable components and genetic consequences. Nature Human Behaviour e12925, 1-13. doi: 10.1038/s41562-025-02150-4

Socio-economic status is a social construct with heritable components and genetic consequences

2025

Journal Article

Author Correction: Heritable polygenic editing: the next frontier in genomic medicine?

Visscher, Peter M., Gyngell, Christopher, Yengo, Loic and Savulescu, Julian (2025). Author Correction: Heritable polygenic editing: the next frontier in genomic medicine?. Nature, 640 (8058), E5-E5. doi: 10.1038/s41586-025-08904-4

Author Correction: Heritable polygenic editing: the next frontier in genomic medicine?

2025

Journal Article

Heritable polygenic editing: the next frontier in genomic medicine?

Visscher, Peter M., Gyngell, Christopher, Yengo, Loic and Savulescu, Julian (2025). Heritable polygenic editing: the next frontier in genomic medicine?. Nature, 637 (8046) 86, 637-645. doi: 10.1038/s41586-024-08300-4

Heritable polygenic editing: the next frontier in genomic medicine?

2024

Journal Article

Distinct genetic liability profiles define clinically relevant patient strata across common diseases

Trastulla, Lucia, Dolgalev, Georgii, Moser, Sylvain, Jiménez-Barrón, Laura T., Andlauer, Till F. M., von Scheidt, Moritz, Ruderfer, Douglas M., Ripke, Stephan, McQuillin, Andrew, Stahl, Eli A., Domenici, Enrico, Adolfsson, Rolf, Agartz, Ingrid, Agerbo, Esben, Albus, Margot, Alexander, Madeline, Amin, Farooq, Bacanu, Silviu A., Begemann, Martin, Belliveau, Richard A., Bene, Judit, Bergen, Sarah E., Bevilacqua, Elizabeth, Bigdeli, Tim B., Black, Donald W., Blackwood, Douglas H. R., Borglum, Anders D., Bramon, Elvira, Bruggeman, Richard ... Ziller, Michael J. (2024). Distinct genetic liability profiles define clinically relevant patient strata across common diseases. Nature Communications , 15 (1) 5534. doi: 10.1038/s41467-024-49338-2

Distinct genetic liability profiles define clinically relevant patient strata across common diseases

2024

Journal Article

Genome-wide association analysis provides insights into the molecular etiology of dilated cardiomyopathy

Zheng, Sean L., Henry, Albert, Cannie, Douglas, Lee, Michael, Miller, David, McGurk, Kathryn A., Bond, Isabelle, Xu, Xiao, Issa, Hanane, Francis, Catherine, De Marvao, Antonio, Theotokis, Pantazis I., Buchan, Rachel J., Speed, Doug, Abner, Erik, Adams, Lance, Aragam, Krishna G., Arnlov, Johan, Raja, Anna Axelsson, Backman, Joshua D., Baksi, John, Barton, Paul J. R., Biddinger, Kiran J., Boersma, Eric, Brandimarto, Jeffrey, Brunak, Soren, Bundgaard, Henning, Carey, David J., Charron, Philippe ... Lumbers, R. Thomas (2024). Genome-wide association analysis provides insights into the molecular etiology of dilated cardiomyopathy. Nature Genetics, 56 (12), 2646-+. doi: 10.1038/s41588-024-01952-y

Genome-wide association analysis provides insights into the molecular etiology of dilated cardiomyopathy

2024

Journal Article

Development and external validation of multivariable risk models to predict incident and resolved neuropathic pain: a DOLORisk Dundee study (vol 270, pg 1076, 2022)

Hebert, Harry L., Veluchamy, Abirami, Baskozos, Georgios, Fardo, Francesca, Van Ryckeghem, Dimitri, Pearson, Ewan R., Colvin, Lesley A., Crombez, Geert, Bennett, David L. H., Meng, Weihua, Palmer, Colin N. A. and Smith, Blair H. (2024). Development and external validation of multivariable risk models to predict incident and resolved neuropathic pain: a DOLORisk Dundee study (vol 270, pg 1076, 2022). Journal of Neurology, 271 (12), 7652-7653. doi: 10.1007/s00415-024-12721-6

Development and external validation of multivariable risk models to predict incident and resolved neuropathic pain: a DOLORisk Dundee study (vol 270, pg 1076, 2022)

2024

Conference Publication

Using Polygenic Risk Scores to Characterise Antidepressant Treatment Response in the Australian Genetics of Depression Study

Mitchell, Brittany L., Martin, Nicholas G., Medland, Sarah E. and Wray, Naomi R. (2024). Using Polygenic Risk Scores to Characterise Antidepressant Treatment Response in the Australian Genetics of Depression Study. 54th Annual Meeting of the Behavior-Genetics-Association (BGA), London England, Jun 26-29, 2024. NEW YORK: SPRINGER.

Using Polygenic Risk Scores to Characterise Antidepressant Treatment Response in the Australian Genetics of Depression Study

2024

Journal Article

The importance of family-based sampling for biobanks

Davies, Neil M., Hemani, Gibran, Neiderhiser, Jenae M., Martin, Hilary C., Mills, Melinda C., Visscher, Peter M., Yengo, Loïc, Young, Alexander Strudwick and Keller, Matthew C. (2024). The importance of family-based sampling for biobanks. Nature, 634 (8035), 795-803. doi: 10.1038/s41586-024-07721-5

The importance of family-based sampling for biobanks

2024

Journal Article

Genetic architecture reconciles linkage and association studies of complex traits

Sidorenko, Julia, Couvy-Duchesne, Baptiste, Kemper, Kathryn E., Moen, Gunn-Helen, Bhatta, Laxmi, Åsvold, Bjørn Olav, Mägi, Reedik, Estonian Biobank Research Team, Ani, Alireza, Wang, Rujia, Nolte, Ilja M., Lifelines Cohort Study, Nolte, Ilja M., Gordon, Scott, Hayward, Caroline, Campbell, Archie, Benjamin, Daniel J., Cesarini, David, Evans, David M., Goddard, Michael E., Haley, Chris S., Porteous, David, Medland, Sarah E., Martin, Nicholas G., Snieder, Harold, Metspalu, Andres, Hveem, Kristian, Brumpton, Ben, Visscher, Peter M. and Yengo, Loic (2024). Genetic architecture reconciles linkage and association studies of complex traits. Nature Genetics, 56 (11), 2352-2360. doi: 10.1038/s41588-024-01940-2

Genetic architecture reconciles linkage and association studies of complex traits

2024

Conference Publication

Genome-wide Fine-mapping Improves Identification Of Causal Variants

Zeng, Jian, Wu, Yang, Zheng, Zhili, Thibaut, Loic, Goddard, Michael, Wray, Naomi and Visscher, Peter (2024). Genome-wide Fine-mapping Improves Identification Of Causal Variants. World Congress of Psychiatric Genetics WCPG 2024, Singapore, 15-19 October 2024. Amsterdam, Netherlands: Elsevier. doi: 10.1016/j.euroneuro.2024.08.037

Genome-wide Fine-mapping Improves Identification Of Causal Variants

2024

Journal Article

Carbonate mud production in lakes is driven by degradation of microbial substances

Boussagol, P., Vennin, E., Monna, F., Millet, L., Bonnotte, A., Motreuil, S., Bundeleva, I., Rius, D. and Visscher, P. T. (2024). Carbonate mud production in lakes is driven by degradation of microbial substances. Communications Earth & Environment, 5 (1) 533. doi: 10.1038/s43247-024-01709-9

Carbonate mud production in lakes is driven by degradation of microbial substances

2024

Journal Article

The eukaryome of modern microbialites reveals distinct colonization across aquatic ecosystems

Bonacolta, Anthony M., Visscher, Pieter T., del Campo, Javier and White III, Richard Allen (2024). The eukaryome of modern microbialites reveals distinct colonization across aquatic ecosystems. Npj Biofilms and Microbiomes, 10 (1) 78. doi: 10.1038/s41522-024-00547-z

The eukaryome of modern microbialites reveals distinct colonization across aquatic ecosystems

2024

Journal Article

Pyritic stromatolites from the Paleoarchean Dresser Formation, Pilbara Craton: Resolving biogenicity and hydrothermally influenced ecosystem dynamics

Baumgartner, Raphael J., Van Kranendonk, Martin J., Caruso, Stefano, Campbell, Kathleen A., Dobson, Michaela J., Teece, Bronwyn L., Verrall, Michael, Homann, Martin, Lalonde, Stefan and Visscher, Pieter T. (2024). Pyritic stromatolites from the Paleoarchean Dresser Formation, Pilbara Craton: Resolving biogenicity and hydrothermally influenced ecosystem dynamics. Geobiology, 22 (4) e12610. doi: 10.1111/gbi.12610

Pyritic stromatolites from the Paleoarchean Dresser Formation, Pilbara Craton: Resolving biogenicity and hydrothermally influenced ecosystem dynamics

2024

Journal Article

Genetic influence on within-person longitudinal change in anthropometric traits in the UK Biobank

Kemper, Kathryn E., Sidorenko, Julia, Wang, Huanwei, Hayes, Ben J., Wray, Naomi R., Yengo, Loic, Keller, Matthew C., Goddard, Michael and Visscher, Peter M. (2024). Genetic influence on within-person longitudinal change in anthropometric traits in the UK Biobank. Nature Communications, 15 (1) 3776, 3776. doi: 10.1038/s41467-024-47802-7

Genetic influence on within-person longitudinal change in anthropometric traits in the UK Biobank

2024

Journal Article

Genome-wide analysis in over 1 million individuals of European ancestry yields improved polygenic risk scores for blood pressure traits

Keaton, Jacob M., Kamali, Zoha, Xie, Tian, Vaez, Ahmad, Williams, Ariel, Goleva, Slavina B., Ani, Alireza, Evangelou, Evangelos, Hellwege, Jacklyn N., Yengo, Loic, Young, William J., Traylor, Matthew, Giri, Ayush, Zheng, Zhili, Zeng, Jian, Chasman, Daniel I., Morris, Andrew P., Caulfield, Mark J., Hwang, Shih-Jen, Kooner, Jaspal S., Conen, David, Attia, John R., Morrison, Alanna C., Loos, Ruth J. F., Kristiansson, Kati, Schmidt, Reinhold, Hicks, Andrew A., Pramstaller, Peter P., Nelson, Christopher P. ... ICBP Consortium (2024). Genome-wide analysis in over 1 million individuals of European ancestry yields improved polygenic risk scores for blood pressure traits. Nature Genetics, 56 (5), 1-14. doi: 10.1038/s41588-024-01714-w

Genome-wide analysis in over 1 million individuals of European ancestry yields improved polygenic risk scores for blood pressure traits

2024

Journal Article

Leveraging functional genomic annotations and genome coverage to improve polygenic prediction of complex traits within and between ancestries

Zheng, Zhili, Liu, Shouye, Sidorenko, Julia, Wang, Ying, Lin, Tian, Yengo, Loic, Turley, Patrick, Ani, Alireza, Wang, Rujia, Nolte, Ilja M., Snieder, Harold, Aguirre-Gamboa, Raul, Deelen, Patrick, Franke, Lude, Kuivenhoven, Jan A., Lopera Maya, Esteban A., Sanna, Serena, Swertz, Morris A., Vonk, Judith M., Wijmenga, Cisca, Yang, Jian, Wray, Naomi R., Goddard, Michael E., Visscher, Peter M., Zeng, Jian and LifeLines Cohort Study (2024). Leveraging functional genomic annotations and genome coverage to improve polygenic prediction of complex traits within and between ancestries. Nature Genetics, 56 (5), 1-11. doi: 10.1038/s41588-024-01704-y

Leveraging functional genomic annotations and genome coverage to improve polygenic prediction of complex traits within and between ancestries

2024

Journal Article

Genome-wide Studies Reveal Genetic Risk Factors for Hepatic Fat Content

Li, Yanni, Van Den Berg, Eline H., Kurilshikov, Alexander, Zhernakova, Dasha V., Gacesa, Ranko, Hu, Shixian, Lopera-Maya, Esteban A., Zhernakova, Alexandra, Aguirre-Gamboa, Raul, Deelen, Patrick, Franke, Lude, Kuivenhoven, Jan A., Lopera-Maya, Esteban A., Nolte, Ilja M., Sanna, Serena, Snieder, Harold, Swertz, Morris A., Visscher, Peter M., Vonk, Judith M., Wijmenga, Cisca, De Meijer, Vincent E., Sanna, Serena, Dullaart, Robin P. F., Blokzijl, Hans, Festen, Eleonora A. M., Fu, Jingyuan and Weersma, Rinse K. (2024). Genome-wide Studies Reveal Genetic Risk Factors for Hepatic Fat Content. Genomics, Proteomics and Bioinformatics, 22 (2) qzae031. doi: 10.1093/gpbjnl/qzae031

Genome-wide Studies Reveal Genetic Risk Factors for Hepatic Fat Content

2024

Journal Article

Genetic control of DNA methylation is largely shared across European and East Asian populations

Hatton, Alesha A., Cheng, Fei-Fei, Lin, Tian, Shen, Ren-Juan, Chen, Jie, Zheng, Zhili, Qu, Jia, Lyu, Fan, Harris, Sarah E., Cox, Simon R., Jin, Zi-Bing, Martin, Nicholas G., Fan, Dongsheng, Montgomery, Grant W., Yang, Jian, Wray, Naomi R., Marioni, Riccardo E., Visscher, Peter M. and McRae, Allan F. (2024). Genetic control of DNA methylation is largely shared across European and East Asian populations. Nature Communications, 15 (1) 2713, 1-12. doi: 10.1038/s41467-024-47005-0

Genetic control of DNA methylation is largely shared across European and East Asian populations

2024

Journal Article

Unravelling the complex causal effects of substance use behaviours on common diseases

Xue, Angli, Zhu, Zhihong, Wang, Huanwei, Jiang, Longda, Visscher, Peter M., Zeng, Jian and Yang, Jian (2024). Unravelling the complex causal effects of substance use behaviours on common diseases. Communications Medicine, 4 (1) 43, 1-13. doi: 10.1038/s43856-024-00473-3

Unravelling the complex causal effects of substance use behaviours on common diseases

2024

Journal Article

Host genetic regulation of human gut microbial structural variation

Zhernakova, Daria V., Wang, Daoming, Liu, Lei, Andreu-Sánchez, Sergio, Zhang, Yue, Ruiz-Moreno, Angel J., Peng, Haoran, Plomp, Niels, Del Castillo-Izquierdo, Ángela, Gacesa, Ranko, Lopera-Maya, Esteban A., Temba, Godfrey S., Kullaya, Vesla I., van Leeuwen, Sander S., Aguirre-Gamboa, Raul, Deelen, Patrick, Franke, Lude, Kuivenhoven, Jan A., Nolte, Ilja M., Sanna, Serena, Snieder, Harold, Swertz, Morris A., Visscher, Peter M., Vonk, Judith M., Xavier, Ramnik J., de Mast, Quirijn, Joosten, Leo A. B., Riksen, Niels P., Rutten, Joost H. W. ... Fu, Jingyuan (2024). Host genetic regulation of human gut microbial structural variation. Nature, 625 (7996), 813-821. doi: 10.1038/s41586-023-06893-w

Host genetic regulation of human gut microbial structural variation