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2021 Journal Article Discovery and implications of polygenicity of common diseasesVisscher, Peter M., Yengo, Loic, Cox, Nancy J. and Wray, Naomi R. (2021). Discovery and implications of polygenicity of common diseases. Science, 373 (6562), 1468-1473. doi: 10.1126/science.abi8206 |
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2021 Journal Article The genomics of heart failure: design and rationale of the HERMES consortiumLumbers, R. Thomas, Shah, Sonia, Lin, Honghuang, Czuba, Tomasz, Henry, Albert, Swerdlow, Daniel I., Mälarstig, Anders, Andersson, Charlotte, Verweij, Niek, Holmes, Michael V., Ärnlöv, Johan, Svensson, Per, Hemingway, Harry, Sallah, Neneh, Almgren, Peter, Aragam, Krishna G., Asselin, Geraldine, Backman, Joshua D., Biggs, Mary L., Bloom, Heather L., Boersma, Eric, Brandimarto, Jeffrey, Brown, Michael R., Brunner‐La Rocca, Hans‐Peter, Carey, David J., Chaffin, Mark D., Chasman, Daniel I., Chazara, Olympe, Chen, Xing ... Regeneron Genetics Center (2021). The genomics of heart failure: design and rationale of the HERMES consortium. ESC Heart Failure, 8 (6) ehf2.13517, 5531-5541. doi: 10.1002/ehf2.13517 |
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2021 Journal Article Large-scale cis- and trans-eQTL analyses identify thousands of genetic loci and polygenic scores that regulate blood gene expressionVõsa, Urmo, Claringbould, Annique, Westra, Harm-Jan, Bonder, Marc Jan, Deelen, Patrick, Zeng, Biao, Kirsten, Holger, Saha, Ashis, Kreuzhuber, Roman, Yazar, Seyhan, Brugge, Harm, Oelen, Roy, de Vries, Dylan H., van der Wijst, Monique G. P., Kasela, Silva, Pervjakova, Natalia, Alves, Isabel, Favé, Marie-Julie, Agbessi, Mawussé, Christiansen, Mark W., Jansen, Rick, Seppälä, Ilkka, Tong, Lin, Teumer, Alexander, Schramm, Katharina, Hemani, Gibran, Verlouw, Joost, Yaghootkar, Hanieh, Sönmez Flitman, Reyhan ... i2QTL Consortium (2021). Large-scale cis- and trans-eQTL analyses identify thousands of genetic loci and polygenic scores that regulate blood gene expression. Nature Genetics, 53 (9), 1300-1310. doi: 10.1038/s41588-021-00913-z |
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2021 Journal Article Genomic and phenotypic insights from an atlas of genetic effects on DNA methylationMin, Josine L., Hemani, Gibran, Hannon, Eilis, Dekkers, Koen F., Castillo-Fernandez, Juan, Luijk, René, Carnero-Montoro, Elena, Lawson, Daniel J., Burrows, Kimberley, Suderman, Matthew, Bretherick, Andrew D., Richardson, Tom G., Klughammer, Johanna, Iotchkova, Valentina, Sharp, Gemma, Al Khleifat, Ahmad, Shatunov, Aleksey, Iacoangeli, Alfredo, McArdle, Wendy L., Ho, Karen M., Kumar, Ashish, Söderhäll, Cilla, Soriano-Tárraga, Carolina, Giralt-Steinhauer, Eva, Kazmi, Nabila, Mason, Dan, McRae, Allan F., Corcoran, David L., Sugden, Karen ... BIOS Consortium (2021). Genomic and phenotypic insights from an atlas of genetic effects on DNA methylation. Nature Genetics, 53 (9), 1311-1321. doi: 10.1038/s41588-021-00923-x |
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2021 Other Outputs Improving GWAS discovery and genomic prediction accuracy in Biobank dataOrliac, Etienne J., Banos, Daniel Trejo, Ojavee, Sven E., Läll, Kristi, Mägi, Reedik, Visscher, Peter M. and Robinson, Matthew R. (2021). Improving GWAS discovery and genomic prediction accuracy in Biobank data. doi: 10.1101/2021.08.12.456099 |
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2021 Journal Article Phantom epistasis between unlinked lociHemani, Gibran, Powell, Joseph E., Wang, Huanwei, Shakhbazov, Konstantin, Westra, Harm-Jan, Esko, Tonu, Henders, Anjali K., McRae, Allan F., Martin, Nicholas G., Metspalu, Andres, Franke, Lude, Montgomery, Grant W., Goddard, Michael E., Gibson, Greg, Yang, Jian and Visscher, Peter M. (2021). Phantom epistasis between unlinked loci. Nature, 596 (7871), E1-E3. doi: 10.1038/s41586-021-03765-z |
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2021 Journal Article Using symptom-based case predictions to identify host genetic factors that contribute to COVID-19 susceptibilityvan Blokland, Irene V., Lanting, Pauline, Ori, Anil P.S., Vonk, Judith M., Warmerdam, Robert C.A., Herkert, Johanna C., Boulogne, Floranne, Claringbould, Annique, Lopera-Maya, Esteban A., Bartels, Meike, Hottenga, Jouke-Jan, Ganna, Andrea, Karjalainen, Juha, Hayward, Caroline, Fawns-Ritchie, Chloe, Campbell, Archie, Porteous, David, Cirulli, Elizabeth T., Barrett, Kelly M. Schiabor, Riffle, Stephen, Bolze, Alexandre, White, Simon, Tanudjaja, Francisco, Wang, Xueqing, Ramirez, Jimmy M., Lim, Yan Wei, Lu, James T., Washington, Nicole L., de Geus, Eco J. C. ... Yengo, Loic (2021). Using symptom-based case predictions to identify host genetic factors that contribute to COVID-19 susceptibility. PLoS One, 16 (8) e0255402, 1-18. doi: 10.1371/journal.pone.0255402 |
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2021 Journal Article Genomic partitioning of inbreeding depression in humansYengo, Loic, Yang, Jian, Keller, Matthew C., Goddard, Michael E., Wray, Naomi R. and Visscher, Peter M. (2021). Genomic partitioning of inbreeding depression in humans. American Journal of Human Genetics, 108 (8), 1488-1501. doi: 10.1016/j.ajhg.2021.06.005 |
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2021 Journal Article Problems with using polygenic scores to select embryosTurley, Patrick, Meyer, Michelle N., Wang, Nancy, Cesarini, David, Hammonds, Evelynn, Martin, Alicia R., Neale, Benjamin M., Rehm, Heidi L., Wilkins-Haug, Louise, Benjamin, Daniel J., Hyman, Steven, Laibson, David and Visscher, Peter M. (2021). Problems with using polygenic scores to select embryos. New England Journal of Medicine, 385 (1), 78-86. doi: 10.1056/NEJMsr2105065 |
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2021 Journal Article Multi-omic and multi-species meta-analyses of nicotine consumptionPalmer, Rohan H. C., Benca-Bachman, Chelsie E., Huggett, Spencer B., Bubier, Jason A., McGeary, John E., Ramgiri, Nikhil, Srijeyanthan, Jenani, Yang, Jingjing, Visscher, Peter M., Yang, Jian, Knopik, Valerie S. and Chesler, Elissa J. (2021). Multi-omic and multi-species meta-analyses of nicotine consumption. Translational Psychiatry, 11 (1) 98, 98. doi: 10.1038/s41398-021-01231-y |
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2021 Journal Article Gene action, genetic variation, and GWAS: A user-friendly web toolHivert, Valentin, Wray, Naomi R. and Visscher, Peter M. (2021). Gene action, genetic variation, and GWAS: A user-friendly web tool. PLoS Genetics, 17 (5) e1009548, 1-9. doi: 10.1371/journal.pgen.1009548 |
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2021 Journal Article Estimation of non-additive genetic variance in human complex traits from a large sample of unrelated individuals (vol 108, pg 786, 2021)Hivert, Valentin, Sidorenko, Julia, Rohart, Florian, Goddard, Michael E., Yang, Jian, Wray, Naomi R., Yengo, Loic and Visscher, Peter M. (2021). Estimation of non-additive genetic variance in human complex traits from a large sample of unrelated individuals (vol 108, pg 786, 2021). American Journal of Human Genetics, 108 (5), 962-962. doi: 10.1016/j.ajhg.2021.04.012 |
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2021 Journal Article Erratum: Alzheimer's disease genetic risk and sleep phenotypes in healthy young men: Association with more slow waves and daytime sleepiness (SLEEP DOI: 10.1093/sleep/zsaa137)Muto, Vincenzo, Koshmanova, Ekaterina, Ghaemmaghami, Pouya, Jaspar, Mathieu, Meyer, Christelle, Elansary, Mahmoud, Van Egroo, Maxime, Chylinski, Daphne, Berthomier, Christian, Brandewinder, Marie, Mouraux, Charlotte, Schmidt, Christina, Hammad, Gregory, Coppieters, Wouter, Ahariz, Naima, Degueldre, Christian, Luxen, Andre, Salmon, Eric, Phillips, Christophe, Archer, Simon N, Yengo, Loic, Byrne, Enda, Collette, Fabienne, Georges, Michel, Dijk, Derk-Jan, Maquet, Pierre, Visscher, Peter M and Vandewalle, Gilles (2021). Erratum: Alzheimer's disease genetic risk and sleep phenotypes in healthy young men: Association with more slow waves and daytime sleepiness (SLEEP DOI: 10.1093/sleep/zsaa137). Sleep, 44 (5) zsaa137. doi: 10.1093/sleep/zsab079 |
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2021 Journal Article Polygenic risk score analysis for amyotrophic lateral sclerosis leveraging cognitive performance, educational attainment and schizophreniaRestuadi, Restuadi, Garton, Fleur C., Benyamin, Beben, Lin, Tian, Williams, Kelly L., Vinkhuyzen, Anna, van Rheenen, Wouter, Zhu, Zhihong, Laing, Nigel G., Mather, Karen A., Sachdev, Perminder S., Ngo, Shyuan T., Steyn, Frederik J., Wallace, Leanne, Henders, Anjali K., Visscher, Peter M., Needham, Merrilee, Mathers, Susan, Nicholson, Garth, Rowe, Dominic B., Henderson, Robert D., McCombe, Pamela A., Pamphlett, Roger, Blair, Ian P., Wray, Naomi R. and McRae, Allan F. (2021). Polygenic risk score analysis for amyotrophic lateral sclerosis leveraging cognitive performance, educational attainment and schizophrenia. European Journal of Human Genetics, 30 (5), 1-8. doi: 10.1038/s41431-021-00885-y |
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2021 Journal Article Variation in VKORC1 is associated with vascular dementiaMur, Jure, McCartney, Daniel L., Chasman, Daniel I., Visscher, Peter M., Muniz-Terrera, Graciela, Cox, Simon R., Russ, Tom C. and Marioni, Riccardo E. (2021). Variation in VKORC1 is associated with vascular dementia. Journal of Alzheimer's Disease, 80 (3), 1329-1337. doi: 10.3233/JAD-201256 |
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2021 Journal Article Estimation of non-additive genetic variance in human complex traits from a large sample of unrelated individualsHivert, Valentin, Sidorenko, Julia, Rohart, Florian, Goddard, Michael E., Yang, Jian, Wray, Naomi R., Yengo, Loic and Visscher, Peter M. (2021). Estimation of non-additive genetic variance in human complex traits from a large sample of unrelated individuals. The American Journal of Human Genetics, 108 (5), 786-798. doi: 10.1016/j.ajhg.2021.02.014 |
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2021 Journal Article Meta-analysis of genome-wide DNA methylation identifies shared associations across neurodegenerative disordersNabais, Marta F., Laws, Simon M., Lin, Tian, Vallerga, Costanza L., Armstrong, Nicola J., Blair, Ian P., Kwok, John B., Mather, Karen A., Mellick, George D., Sachdev, Perminder S., Wallace, Leanne, Henders, Anjali K., Zwamborn, Ramona A. J., Hop, Paul J., Lunnon, Katie, Pishva, Ehsan, Roubroeks, Janou A. Y., Soininen, Hilkka, Tsolaki, Magda, Mecocci, Patrizia, Lovestone, Simon, Kloszewska, Iwona, Vellas, Bruno, Furlong, Sarah, Garton, Fleur C., Henderson, Robert D., Mathers, Susan, McCombe, Pamela A., Needham, Merrilee ... McRae, Allan F. (2021). Meta-analysis of genome-wide DNA methylation identifies shared associations across neurodegenerative disorders. Genome Biology, 22 (1) 90, 1-30. doi: 10.1186/s13059-021-02275-5 |
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2021 Journal Article Quantifying genetic heterogeneity between continental populations for human height and body mass indexGuo, Jing, Bakshi, Andrew, Wang, Ying, Jiang, Longda, Yengo, Loic, Goddard, Michael E., Visscher, Peter M. and Yang, Jian (2021). Quantifying genetic heterogeneity between continental populations for human height and body mass index. Scientific Reports, 11 (1) 5240, 1-9. doi: 10.1038/s41598-021-84739-z |
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2021 Journal Article GWAS of peptic ulcer disease implicates Helicobacter pylori infection, other gastrointestinal disorders and depressionWu, Yeda, Murray, Graham K., Byrne, Enda M., Sidorenko, Julia, Visscher, Peter M. and Wray, Naomi R. (2021). GWAS of peptic ulcer disease implicates Helicobacter pylori infection, other gastrointestinal disorders and depression. Nature Communications, 12 (1) 1146, 1-17. doi: 10.1038/s41467-021-21280-7 |
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2021 Journal Article Widespread signatures of natural selection across human complex traits and functional genomic categoriesZeng, Jian, Xue, Angli, Jiang, Longda, Lloyd-Jones, Luke R., Wu, Yang, Wang, Huanwei, Zheng, Zhili, Yengo, Loic, Kemper, Kathryn E., Goddard, Michael E., Wray, Naomi R., Visscher, Peter M. and Yang, Jian (2021). Widespread signatures of natural selection across human complex traits and functional genomic categories. Nature Communications, 12 (1) 1164, 1-12. doi: 10.1038/s41467-021-21446-3 |
