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2021

Journal Article

Epidemiology of extended-spectrum β-lactamase and metallo-β-lactamase-producing in South Asia

Islam, Kamrul, Heffernan, Aaron J., Naicker, Saiyuri, Henderson, Andrew, Chowdhury, Mohammed Abdul Hassan, Roberts, Jason A. and Sime, Fekade B. (2021). Epidemiology of extended-spectrum β-lactamase and metallo-β-lactamase-producing in South Asia. Future Microbiology, 16 (7) fmb-2020-0193, 521-535. doi: 10.2217/fmb-2020-0193

Epidemiology of extended-spectrum β-lactamase and metallo-β-lactamase-producing in South Asia

2021

Journal Article

Ceftriaxone exposure in patients undergoing extracorporeal membrane oxygenation

Gijsen, Matthias, Annaert, Pieter, Shekar, Kiran, Roberts, Jason A., Wauters, Joost and Spriet, Isabel (2021). Ceftriaxone exposure in patients undergoing extracorporeal membrane oxygenation. International Journal of Antimicrobial Agents, 57 (5) 106326, 106326. doi: 10.1016/j.ijantimicag.2021.106326

Ceftriaxone exposure in patients undergoing extracorporeal membrane oxygenation

2021

Journal Article

Microfluidic assembly of pomegranate-like hierarchical microspheres for efflux regulation in oral drug delivery

Raza, Aun, Alavi, Seyed Ebrahim, Sime, Fekade Bruck, Han, Felicity Y., Roberts, Jason A., Popat, Amirali, Falconer, James R. and Kumeria, Tushar (2021). Microfluidic assembly of pomegranate-like hierarchical microspheres for efflux regulation in oral drug delivery. Acta Biomaterialia, 126, 277-290. doi: 10.1016/j.actbio.2021.03.042

Microfluidic assembly of pomegranate-like hierarchical microspheres for efflux regulation in oral drug delivery

2021

Journal Article

Antibiotic Pharmacokinetics/Pharmacodynamics: Where are we heading?

Li, Jian and Roberts, Jason (2021). Antibiotic Pharmacokinetics/Pharmacodynamics: Where are we heading?. International Journal of Antimicrobial Agents, 58 (2) 106369, 106369. doi: 10.1016/j.ijantimicag.2021.106369

Antibiotic Pharmacokinetics/Pharmacodynamics: Where are we heading?

2021

Journal Article

Semi-mechanistic PK/PD modelling of meropenem and sulbactam combination against carbapenem-resistant strains of Acinetobacter baumannii

Mohd Sazlly Lim, Sazlyna, Heffernan, Aaron J., Zowawi, Hosam M., Roberts, Jason A. and Sime, Fekade B. (2021). Semi-mechanistic PK/PD modelling of meropenem and sulbactam combination against carbapenem-resistant strains of Acinetobacter baumannii. European Journal of Clinical Microbiology and Infectious Diseases, 40 (9), 1943-1952. doi: 10.1007/s10096-021-04252-z

Semi-mechanistic PK/PD modelling of meropenem and sulbactam combination against carbapenem-resistant strains of Acinetobacter baumannii

2021

Journal Article

Semi-mechanistic PK/PD modelling of fosfomycin and sulbactam combination against carbapenem-resistant Acinetobacter baumannii

Mohd Sazlly Lim, S., Heffernan, A.J., Roberts, J.A. and Sime, F.B. (2021). Semi-mechanistic PK/PD modelling of fosfomycin and sulbactam combination against carbapenem-resistant Acinetobacter baumannii. Antimicrobial Agents and Chemotherapy, 65 (5) e02472-20. doi: 10.1128/aac.02472-20

Semi-mechanistic PK/PD modelling of fosfomycin and sulbactam combination against carbapenem-resistant Acinetobacter baumannii

2021

Journal Article

Impact of the epithelial lining fluid milieu on amikacin pharmacodynamics against Pseudomonas aeruginosa

Heffernan, Aaron J., Sime, Fekade B., Lim, Sazlyna Mohd Sazlly, Naicker, Saiyuri, Andrews, Katherine T., Ellwood, David, Lipman, Jeffrey, Grimwood, Keith and Roberts, Jason A. (2021). Impact of the epithelial lining fluid milieu on amikacin pharmacodynamics against Pseudomonas aeruginosa. Drugs in R&D, 21 (2), 203-215. doi: 10.1007/s40268-021-00344-5

Impact of the epithelial lining fluid milieu on amikacin pharmacodynamics against Pseudomonas aeruginosa

2021

Journal Article

Standard of ​practice in intensive care for pharmacy services

Johnston, Karlee, Ankravs, Melissa J., Badman, Belinda, Choo, Chui Lynn, Cree, Michele, Fyfe, Rachel, Roberts, Jason A., Xu, Jessica and Munro, Courtney (2021). Standard of ​practice in intensive care for pharmacy services. Journal of Pharmacy Practice and Research, 51 (2), 165-183. doi: 10.1002/jppr.1718

Standard of ​practice in intensive care for pharmacy services

2021

Journal Article

Antimicrobial dosing in prolonged intermittent renal replacement therapy: a systematic review

Rawlins, Matthew D. M., Misko, Jeanie and Roberts, Jason A. (2021). Antimicrobial dosing in prolonged intermittent renal replacement therapy: a systematic review. Journal of Pharmacy Practice and Research, 51 (2), 106-120. doi: 10.1002/jppr.1723

Antimicrobial dosing in prolonged intermittent renal replacement therapy: a systematic review

2021

Journal Article

Model-informed drug development for anti-infectives: state of the art and future

Rayner, Craig R., Smith, Patrick F., Andes, David, Andrews, Kayla, Derendorf, Hartmut, Friberg, Lena E., Hanna, Debra, Lepak, Alex, Mills, Edward, Polasek, Thomas M., Roberts, Jason A., Schuck, Virna, Shelton, Mark J., Wesche, David and Rowland-Yeo, Karen (2021). Model-informed drug development for anti-infectives: state of the art and future. Clinical Pharmacology and Therapeutics, 109 (4), 867-891. doi: 10.1002/cpt.2198

Model-informed drug development for anti-infectives: state of the art and future

2021

Journal Article

Evaluation of meropenem-ciprofloxacin combination dosage regimens for the pharmacokinetics of critically ill patients with augmented renal clearance

Agyeman, Akosua A., Rogers, Kate E., Tait, Jessica R., Bergen, Phillip J., Kirkpatrick, Carl M., Wallis, Steven C., Bulitta, Jürgen B., Paterson, David L., Lipman, Jeffrey, Nation, Roger L., Roberts, Jason A. and Landersdorfer, Cornelia B. (2021). Evaluation of meropenem-ciprofloxacin combination dosage regimens for the pharmacokinetics of critically ill patients with augmented renal clearance. Clinical Pharmacology and Therapeutics, 109 (4), 1104-1115. doi: 10.1002/cpt.2191

Evaluation of meropenem-ciprofloxacin combination dosage regimens for the pharmacokinetics of critically ill patients with augmented renal clearance

2021

Journal Article

Provider perspectives on beta-lactam therapeutic drug monitoring programs in the critically ill: a protocol for a multicenter mixed-methods study

Barreto, Erin F., Rule, Andrew D., Alshaer, Mohammad H., Roberts, Jason A., Abdul Aziz, Mohd Hafiz, Scheetz, Marc H., Mara, Kristin C., Jannetto, Paul J., Gajic, Ognjen, O'Horo, John C and Boehmer, Kasey R (2021). Provider perspectives on beta-lactam therapeutic drug monitoring programs in the critically ill: a protocol for a multicenter mixed-methods study. Implementation science communications, 2 (1) 34, 34-1. doi: 10.1186/s43058-021-00134-9

Provider perspectives on beta-lactam therapeutic drug monitoring programs in the critically ill: a protocol for a multicenter mixed-methods study

2021

Journal Article

PLGA encapsulated γ-cyclodextrin-meropenem inclusion complex formulation for oral delivery

Raza, Aun, Miles, Jared A., Bruck Sime, Fekade, Ross, Benjamin P., Roberts, Jason A., Popat, Amirali, Kumeria, Tushar and Falconer, James R. (2021). PLGA encapsulated γ-cyclodextrin-meropenem inclusion complex formulation for oral delivery. International Journal of Pharmaceutics, 597 120280, 120280. doi: 10.1016/j.ijpharm.2021.120280

PLGA encapsulated γ-cyclodextrin-meropenem inclusion complex formulation for oral delivery

2021

Journal Article

Protocol for an international, multicentre, prospective, observational study of nosocomial pneumonia in intensive care units: The PneumoINSPIRE study

Koulenti, Despoina, Armaganidis, Apostolos, Arvaniti, Kostoula, Blot, Stijn, Brun-Buisson, Christian, Deja, Maria, De Waele, Jan, Du, Bin, Dulhunty, Joel M., Garcia-Diaz, Julia, Judd, Matthew, Paterson, David L., Putensen, Christian, Reina, Rosa, Rello, Jordi, Restrepo, Marcos I., Roberts, Jason A., Sjovall, Fredrik, Timsit, Jean-Francois, Tsiodras, Sotirios, Zahar, Jean-Ralph, Zhang, Yuchi, Lipman, Jeffrey and On behalf of the Working Group on Pneumonia of the European Society of Intensive Care Medicine (2021). Protocol for an international, multicentre, prospective, observational study of nosocomial pneumonia in intensive care units: The PneumoINSPIRE study. Critical Care and Resuscitation, 23 (1), 59-66. doi: 10.51893/2021.1.oa5

Protocol for an international, multicentre, prospective, observational study of nosocomial pneumonia in intensive care units: The PneumoINSPIRE study

2021

Journal Article

Pharmacodynamics of once- versus twice-daily dosing of nebulized amikacin in an in vitro Hollow-Fiber Infection Model against 3 clinical isolates of Pseudomonas aeruginosa

Heffernan, Aaron James, Sime, Fekade Bruck, Naicker, Saiyuri, Andrews, Katherine, Ellwood, David, Guerra-Valero, Yarmarly, Wallis, Steven, Lipman, Jeffrey, Grimwood, Keith and Roberts, Jason Alexander (2021). Pharmacodynamics of once- versus twice-daily dosing of nebulized amikacin in an in vitro Hollow-Fiber Infection Model against 3 clinical isolates of Pseudomonas aeruginosa. Diagnostic microbiology and infectious disease, 100 (2) 115329, 115329. doi: 10.1016/j.diagmicrobio.2021.115329

Pharmacodynamics of once- versus twice-daily dosing of nebulized amikacin in an in vitro Hollow-Fiber Infection Model against 3 clinical isolates of Pseudomonas aeruginosa

2021

Journal Article

Comparative lung distribution of radiolabeled tobramycin between nebulized and intravenous administration in a mechanically-ventilated ovine model, an observational study

Dhanani, Jayesh A., Goodman, Steven, Ahern, Benjamin, Cohen, Jeremy, Fraser, John F., Barnett, Adrian, Diab, Sara, Bhatt, Manoj and Roberts, Jason A. (2021). Comparative lung distribution of radiolabeled tobramycin between nebulized and intravenous administration in a mechanically-ventilated ovine model, an observational study. International Journal of Antimicrobial Agents, 57 (2) 106232, 106232. doi: 10.1016/j.ijantimicag.2020.106232

Comparative lung distribution of radiolabeled tobramycin between nebulized and intravenous administration in a mechanically-ventilated ovine model, an observational study

2021

Journal Article

Population pharmacokinetics analysis of amikacin initial dosing regimen in elderly patients

Kato, Hideo, Parker, Suzanne L., Roberts, Jason A., Hagihara, Mao, Asai, Nobuhiro, Yamagishi, Yuka, Paterson, David L. and Mikamo, Hiroshige (2021). Population pharmacokinetics analysis of amikacin initial dosing regimen in elderly patients. Antibiotics, 10 (2) 100, 1-13. doi: 10.3390/antibiotics10020100

Population pharmacokinetics analysis of amikacin initial dosing regimen in elderly patients

2021

Journal Article

Population pharmacokinetics of levetiracetam in patients with traumatic brain injury and subarachnoid hemorrhage exhibiting augmented renal clearance

Sime, Fekade Bruck, Roberts, Jason A., Jeffree, Rosalind L., Pandey, Saurabh, Adiraju, Santosh, Livermore, Amelia, Butler, Jenie, Parker, Suzanne L., Wallis, Steven C., Lipman, Jeffrey and Cotta, Menino Osbert (2021). Population pharmacokinetics of levetiracetam in patients with traumatic brain injury and subarachnoid hemorrhage exhibiting augmented renal clearance. Clinical Pharmacokinetics, 60 (5), 655-664. doi: 10.1007/s40262-020-00979-8

Population pharmacokinetics of levetiracetam in patients with traumatic brain injury and subarachnoid hemorrhage exhibiting augmented renal clearance

2021

Journal Article

Liquid CO2 formulated mesoporous silica nanoparticles for pH-responsive oral delivery of meropenem

Raza, Aun, Sime, Fekade Bruck, Cabot, Peter J., Roberts, Jason A., Falconer, James R., Kumeria, Tushar and Popat, Amirali (2021). Liquid CO2 formulated mesoporous silica nanoparticles for pH-responsive oral delivery of meropenem. ACS Biomaterials Science and Engineering, 7 (5) acsbiomaterials.0c01284, 1836-1853. doi: 10.1021/acsbiomaterials.0c01284

Liquid CO2 formulated mesoporous silica nanoparticles for pH-responsive oral delivery of meropenem

2021

Journal Article

Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021

Evans, Laura, Rhodes, Andrew, Alhazzani, Waleed, Antonelli, Massimo, Coopersmith, Craig M., French, Craig, Machado, Flávia R., Mcintyre, Lauralyn, Ostermann, Marlies, Prescott, Hallie C., Schorr, Christa, Simpson, Steven, Wiersinga, W. Joost, Alshamsi, Fayez, Angus, Derek C., Arabi, Yaseen, Azevedo, Luciano, Beale, Richard, Beilman, Gregory, Belley-Cote, Emilie, Burry, Lisa, Cecconi, Maurizio, Centofanti, John, Coz Yataco, Angel, De Waele, Jan, Dellinger, R. Phillip, Doi, Kent, Du, Bin, Estenssoro, Elisa ... Levy, Mitchell (2021). Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021. Intensive Care Medicine, 47 (11), 1181-1247. doi: 10.1007/s00134-021-06506-y

Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021