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2025

Journal Article

Implementation of outpatient parenteral antimicrobial therapy program in the contemporary health care system: A narrative review of the evidence

Mohammed, Solomon Ahmed, Roberts, Natasha, Nicolás, David, Unwin, Sean, Cotta, Menino, Roberts, Jason A. and Sime, Fekade B. (2025). Implementation of outpatient parenteral antimicrobial therapy program in the contemporary health care system: A narrative review of the evidence. Journal of Infection and Public Health, 18 (10) 102938, 102938. doi: 10.1016/j.jiph.2025.102938

Implementation of outpatient parenteral antimicrobial therapy program in the contemporary health care system: A narrative review of the evidence

2025

Journal Article

Phase 1, randomized, double-blind, placebo-controlled, ascending single- and multiple-dose study of the safety, tolerability, and pharmacokinetics of intravenous xeruborbactam (QPX7728) in healthy adult subjects

Hernandez-Mitre, Maria Patricia, Wallis, Steven C., Loutit, Jeffery S., Griffith, David C. and Roberts, Jason A. (2025). Phase 1, randomized, double-blind, placebo-controlled, ascending single- and multiple-dose study of the safety, tolerability, and pharmacokinetics of intravenous xeruborbactam (QPX7728) in healthy adult subjects. Antimicrobial Agents and Chemotherapy, 69 (10) e00784-25. doi: 10.1128/aac.00784-25

Phase 1, randomized, double-blind, placebo-controlled, ascending single- and multiple-dose study of the safety, tolerability, and pharmacokinetics of intravenous xeruborbactam (QPX7728) in healthy adult subjects

2025

Journal Article

Antibiotic therapy for severe bacterial infections

Timsit, Jean-Francois, Ling, Lowell, de Montmollin, Etienne, Bracht, Hendrik, Conway-Morris, Andrew, De Bus, Liesbet, Falcone, Marco, Harris, Patrick N. A., Machado, Flavia R., Paiva, Jose-Artur, Paterson, David L., Poulakou, Garyphallia, Roberts, Jason A., Roger, Claire, Shorr, Andrew F., Tabah, Alexis and Lipman, Jeffrey (2025). Antibiotic therapy for severe bacterial infections. Intensive Care Medicine, 51 (10), 1867-1885. doi: 10.1007/s00134-025-08063-0

Antibiotic therapy for severe bacterial infections

2025

Journal Article

Optimization of antimicrobial therapy in critically ill patients, What Clinicians and Searchers Must Know

Roger, Claire, Koulenti, Despoina, Novy, Emmanuel, Roberts, Jason and Dahyot-Fizelier, Claire (2025). Optimization of antimicrobial therapy in critically ill patients, What Clinicians and Searchers Must Know. Anaesthesia Critical Care and Pain Medicine, 44 (5) 101561, 1-6. doi: 10.1016/j.accpm.2025.101561

Optimization of antimicrobial therapy in critically ill patients, What Clinicians and Searchers Must Know

2025

Journal Article

Finding the optimal regimen for <i>Mycobacteroides abscessus</i> treatment (FOR<i>Ma</i>T) in people with <i>Mycobacteroides abscessus</i> pulmonary disease: a multicentre, randomised, multi-arm, adaptive platform trial

Jong, Tiffany, Baird, Timothy, Barr, Helen Louise, Bell, Scott, Bigirumurame, Theophile, Brady, Kara, Burke, Andrew, Byrnes, Joshua, Caudri, Daan, Clark, Julia E, Coin, Lachlan J M, Goh, Felicia, Grimwood, Keith, Hicks, Daniel, Jayawardana, Kaushala, Joshi, Sri, Lee, Katherine, Qvist, Tavs, Reid, David, Rice, Megan, Roberts, Jason A, Rogers, Geraint, Shackleton, Claire, Sly, Peter D, Smyth, Alan R, Stevens, Luke, Stockwell, Rebecca, Tarique, Abdullah, Taylor, Steven ... Wainwright, Claire (2025). Finding the optimal regimen for Mycobacteroides abscessus treatment (FORMaT) in people with Mycobacteroides abscessus pulmonary disease: a multicentre, randomised, multi-arm, adaptive platform trial. BMJ Open, 15 (9) e096188, e096188. doi: 10.1136/bmjopen-2024-096188

Finding the optimal regimen for <i>Mycobacteroides abscessus</i> treatment (FOR<i>Ma</i>T) in people with <i>Mycobacteroides abscessus</i> pulmonary disease: a multicentre, randomised, multi-arm, adaptive platform trial

2025

Journal Article

International Network of Antibiotic Allergy Nations (iNAAN): Protocol for a type 2 hybrid effectiveness-implementation multicentre prospective cohort and target trial emulation study evaluating penicillin allergy delabeling via direct oral challenge

Mitri, Elise A., Fletcher, Luke R., Paynter, Camille, Vogrin, Sara, James, Fiona, Ng, Irvin, Holmes, Natasha E., Ierano, Courtney, Roberts, Jason A., Fernando, Suran L., Klaic, Marlena and Trubiano, Jason A. (2025). International Network of Antibiotic Allergy Nations (iNAAN): Protocol for a type 2 hybrid effectiveness-implementation multicentre prospective cohort and target trial emulation study evaluating penicillin allergy delabeling via direct oral challenge. PLOS ONE, 20 (9 September) e0330724, e0330724. doi: 10.1371/journal.pone.0330724

International Network of Antibiotic Allergy Nations (iNAAN): Protocol for a type 2 hybrid effectiveness-implementation multicentre prospective cohort and target trial emulation study evaluating penicillin allergy delabeling via direct oral challenge

2025

Journal Article

Continuous or extended vs intermittent infusions of beta-lactam antibiotics in ICU patients with pneumonia: a systematic review and meta-analysis of randomized controlled trials

Li, Yixuan, Roberts, Jason A., Abdul-Aziz, Mohd H. and Sime, Fekade B. (2025). Continuous or extended vs intermittent infusions of beta-lactam antibiotics in ICU patients with pneumonia: a systematic review and meta-analysis of randomized controlled trials. Antimicrobial Agents and Chemotherapy, 69 (10) e0073225, 1-13. doi: 10.1128/aac.00732-25

Continuous or extended vs intermittent infusions of beta-lactam antibiotics in ICU patients with pneumonia: a systematic review and meta-analysis of randomized controlled trials

2025

Journal Article

Development of blood culture time-to-positivity as a pharmacodynamic indicator for monitoring antibiotic therapy against MDR Gram-negative bacteria

Zaghi, Irene, Cricca, Monica, Roberts, Jason A., Brandolini, Martina, Colosimo, Claudia, Montanari, Sofia, Sambri, Vittorio and Lewis, Russell E. (2025). Development of blood culture time-to-positivity as a pharmacodynamic indicator for monitoring antibiotic therapy against MDR Gram-negative bacteria. Journal of Antimicrobial Chemotherapy, 80 (10), 2705-2713. doi: 10.1093/jac/dkaf276

Development of blood culture time-to-positivity as a pharmacodynamic indicator for monitoring antibiotic therapy against MDR Gram-negative bacteria

2025

Journal Article

Meropenem and piperacillin/tazobactam optimised dosing regimens for critically ill patients receiving renal replacement therapy

Roberts, Jason A., Ulldemolins, Marta, Liu, Xin, Baptista, João P., Bilgrami, Irma, Boidin, Clement, Brinkmann, Alexander, Castro, Pedro, Choi, Gordon, Cole, Louise, De Waele, Jan J., Deans, Renae, Donnellan, Sine, Eastwood, Glenn M., Frey, Otto R., Goutelle, Sylvain, Gresham, Rebecca, Jamal, Janattul Ain, Joynt, Gavin M., Kanji, Salmaan, Kluge, Stefan, König, Christina, Koulouras, Vasilios P., Lassig-Smith, Melissa, Laterre, Pierre-Francois, Lee, Anna, Lefrant, Jean-Yves, Lei, Katie, Leung, Patricia ... Young, Helen (2025). Meropenem and piperacillin/tazobactam optimised dosing regimens for critically ill patients receiving renal replacement therapy. Intensive Care Medicine, 51 (9), 1628-1640. doi: 10.1007/s00134-025-08067-w

Meropenem and piperacillin/tazobactam optimised dosing regimens for critically ill patients receiving renal replacement therapy

2025

Journal Article

Pharmacological research agenda on adult extracorporeal membrane oxygenation using the Delphi method: a position article of the extracorporeal membrane oxygenation pharmacology network

Morales Castro, Diana, Al-Fares, Abdulrahman Abdullah, Paternoster, Gianluca, Lyster, Haifa, Hohlfelder, Benjamin, Arias Ortiz, Julian, Abdul-Aziz, Mohd Hafiz, Herr, Daniel, Alraish, Rawan, Ferre Contreras, Andrés, Palavecino, Marcela, Milella, Luigi, Watt, Kevin, Alkazemi, Afrah, Carini, Federico Carlos, Roberts, Jason A., Riera Del Brio, Jordi, Parra, Alba Pau, Kakar, Vivek, Dureau, Pauline, Duceppe, Marc-Alexandre, Alm, Mark, Cha, Stephanie, Shekar, Kiran, Dzierba, Amy L. and Extracorporeal Membrane Oxygenation Pharmacology Network (ECMOPharm Net) (2025). Pharmacological research agenda on adult extracorporeal membrane oxygenation using the Delphi method: a position article of the extracorporeal membrane oxygenation pharmacology network. Critical Care Medicine. doi: 10.1097/CCM.0000000000006806

Pharmacological research agenda on adult extracorporeal membrane oxygenation using the Delphi method: a position article of the extracorporeal membrane oxygenation pharmacology network

2025

Journal Article

Cause and effect? A review of the impact of antibiotics on the gut microbiome in patients undergoing hematopoietic stem cell transplantation

Nakagaki, Midori, Hajkowicz, Krispin, Roberts, Jason A and Henden, Andrea S (2025). Cause and effect? A review of the impact of antibiotics on the gut microbiome in patients undergoing hematopoietic stem cell transplantation. Expert Review of Anti-infective Therapy, ahead-of-print (ahead-of-print), 1-14. doi: 10.1080/14787210.2025.2527970

Cause and effect? A review of the impact of antibiotics on the gut microbiome in patients undergoing hematopoietic stem cell transplantation

2025

Journal Article

Marginal cytokine modulation by Schistosoma mansoni soluble egg antigen in SARS-CoV-2-infected K18-hACE2 mice

Mu, Yi, Yan, Kexin, McManus, Donald P., Nguyen, Wilson, Rawle, Daniel J., Roberts, Jason A., Jones, Malcolm K. and Cai, Pengfei (2025). Marginal cytokine modulation by Schistosoma mansoni soluble egg antigen in SARS-CoV-2-infected K18-hACE2 mice. Folia Parasitologica, 72 019, 72. doi: 10.14411/fp.2025.019

Marginal cytokine modulation by Schistosoma mansoni soluble egg antigen in SARS-CoV-2-infected K18-hACE2 mice

2025

Journal Article

Beta-lactam antibiotic administration in critically ill children with sepsis: an international survey of current practice

Raman, Sainath, Reddy, Rayna, de Souza, Daniela Carla, Cox, Renee, Le Marsney, Renate, Nallasamy, Karthi, Ramnarayan, Padmanabhan, Roberts, Jason A., Schlapbach, Luregn J., Gibbons, Kristen S., the Australian and New Zealand Intensive Care Society Paediatric Study Group, Kerig, Tatjana, Darvas, Jennifer, Festa, Marino, George, Shane, Balit, Corrine, Oberender, Felix, Erickson, Simon, Flores, Jenipher Chumbes, Charles, Karina, Waak, Michaela, Long, Debbie, Butt, Warwick, Delzoppo, Carmel, Gelbart, Ben, Masterson, Kate, Millar, Johnny, Ganeshalingam, Anusha, Sherring, Claire ... Smith, Vicky (2025). Beta-lactam antibiotic administration in critically ill children with sepsis: an international survey of current practice. Intensive Care Medicine – Paediatric and Neonatal, 3 (1) 18. doi: 10.1007/s44253-025-00075-4

Beta-lactam antibiotic administration in critically ill children with sepsis: an international survey of current practice

2025

Journal Article

Current practices in outpatient parenteral antimicrobial therapy programmes: an international multi-centre survey

Wolie, Zenaw T., Roberts, Jason A., López-Cortés, Luis Eduardo, Mirón-Rubio, Manuel, Pollard, James, Marizan Nor, Afra Nahdia, Abdul-Aziz, Mohd H., Jamieson, Conor, Seaton, R Andrew, Gilchrist, Mark and Sime, Fekade B. (2025). Current practices in outpatient parenteral antimicrobial therapy programmes: an international multi-centre survey. JAC - Antimicrobial Resistance, 7 (3) dlaf075, 1-11. doi: 10.1093/jacamr/dlaf075

Current practices in outpatient parenteral antimicrobial therapy programmes: an international multi-centre survey

2025

Journal Article

Evaluation of the stability of tigecycline in elastomeric infusion devices used for outpatient parenteral antimicrobial therapy

Wolie, Zenaw T., Unwin, Sean, Burke, Andrew, Won, Hayoung, Wallis, Steven C., Seaton, R Andrew, Gilchrist, Mark, Roberts, Jason A. and Sime, Fekade B. (2025). Evaluation of the stability of tigecycline in elastomeric infusion devices used for outpatient parenteral antimicrobial therapy. JAC - Antimicrobial Resistance, 7 (3) dlaf074. doi: 10.1093/jacamr/dlaf074

Evaluation of the stability of tigecycline in elastomeric infusion devices used for outpatient parenteral antimicrobial therapy

2025

Journal Article

Population pharmacokinetics of intravenous fosfomycin: dose optimization for critically ill patients with and without kidney replacement therapy

Goetz, Katharina M., Kreuer, Sascha, Volz, Anke-Katrin, Parker, Suzanne L., Roberts, Jason A., Dimopoulos, George, Dimski, Thomas, Kindgen-Milles, Detlef, Beuche, Lisa K. V., Kielstein, Jan T. and Lehr, Thorsten (2025). Population pharmacokinetics of intravenous fosfomycin: dose optimization for critically ill patients with and without kidney replacement therapy. Antimicrobial Agents and Chemotherapy, 69 (6), e0177924. doi: 10.1128/aac.01779-24

Population pharmacokinetics of intravenous fosfomycin: dose optimization for critically ill patients with and without kidney replacement therapy

2025

Journal Article

A Global Survey of Diagnostic Practices in Prosthetic Joint Infections

Subedi, Shradha, Harris, Patrick NA, Chapman, Paul, Chen, Antonia F, Davis, Joshua S, Liu, Po-Yu, Marais, Leonard C, Salles, Mauro J, Roberts, Jason A, Rodriguez-Bano, Jesus, Wouthuyzen-Bakker, Marjan, Paterson, David L and Benito, Natividad (2025). A Global Survey of Diagnostic Practices in Prosthetic Joint Infections. Diagnostic Microbiology and Infectious Disease, 113 (2) 116919, 116919-2. doi: 10.1016/j.diagmicrobio.2025.116919

A Global Survey of Diagnostic Practices in Prosthetic Joint Infections

2025

Journal Article

Dosing optimisation of intravenous lidocaine in patients with class 1–3 obesity by population pharmacokinetic analysis

Tognolini, Angela R., Liu, Xin, Pandey, Saurabh, Roberts, Jason A., Wallis, Steven C., Jackson, Dwane and Eley, Victoria A. (2025). Dosing optimisation of intravenous lidocaine in patients with class 1–3 obesity by population pharmacokinetic analysis. Anaesthesia, 80 (5), 511-521. doi: 10.1111/anae.16531

Dosing optimisation of intravenous lidocaine in patients with class 1–3 obesity by population pharmacokinetic analysis

2025

Journal Article

Ceftriaxone population pharmacokinetics in plasma and cerebrospinal fluid of neurocritical care patients

Kumta, Nilesh, Heffernan, Aaron J., Liu, Xin, Parker, Suzanne L., Cotta, Menino Osbert, Wallis, Steven C., Livermore, Amelia, Starr, Therese, Wai, Wong Tat, Joynt, Gavin M., Lipman, Jeffrey and Roberts, Jason A. (2025). Ceftriaxone population pharmacokinetics in plasma and cerebrospinal fluid of neurocritical care patients. International Journal of Antimicrobial Agents, 65 (5) 107461. doi: 10.1016/j.ijantimicag.2025.107461

Ceftriaxone population pharmacokinetics in plasma and cerebrospinal fluid of neurocritical care patients

2025

Journal Article

Population Pharmacokinetic Modelling of Remdesivir and Its Metabolite GS-441524 in Hospitalised Patients with COVID-19

Roberts, Darren M., Liu, Xin, Parker, Suzanne L., Burke, Andrew, Peek, Jenny, Carland, Jane E., Murnion, Bridin, Seah, Vincent, Wallis, Steven C., Sumi, Chandra D., Pandey, Saurabh, Buscher, Hergen, Byrne, Anthony, Sandaradura, Indy, Bowen, David, Holz, Simon, Stewart, Adam G., Hajkowicz, Krispin M. and Roberts, Jason A. (2025). Population Pharmacokinetic Modelling of Remdesivir and Its Metabolite GS-441524 in Hospitalised Patients with COVID-19. Clinical Pharmacokinetics, 64 (5) e0022222, 1-14. doi: 10.1007/s40262-025-01496-2

Population Pharmacokinetic Modelling of Remdesivir and Its Metabolite GS-441524 in Hospitalised Patients with COVID-19