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2019 Journal Article D. russelii venom mediates vasodilatation of resistance like arteries via activation of Kv and KCa ChannelsKakumanu, Rahini, Kuruppu, Sanjaya, Rash, Lachlan, Isbister, Geoffrey, Hodgson, Wayne and Kemp-Harper, Barbara (2019). D. russelii venom mediates vasodilatation of resistance like arteries via activation of Kv and KCa Channels. Toxins, 11 (4) 197, 197. doi: 10.3390/toxins11040197 |
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2019 Journal Article Novel conorfamides from Conus austini venom modulate both nicotinic acetylcholine receptors and acid-sensing ion channelsJin, Ai-hua, Cristofori-Armstrong, Ben, Rash, Lachlan D., Román González, Sergio Agustín, Espinosa, Roberto Arreguín, Lewis, Richard J., Alewood, Paul F. and Vetter, Irina (2019). Novel conorfamides from Conus austini venom modulate both nicotinic acetylcholine receptors and acid-sensing ion channels. Biochemical Pharmacology, 164, 342-348. doi: 10.1016/j.bcp.2019.04.025 |
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2018 Journal Article Defining the role of post-synaptic α-neurotoxins in paralysis due to snake envenoming in humansSilva, Anjana, Cristofori-Armstrong, Ben, Rash, Lachlan D., Hodgson, Wayne C. and Isbister, Geoffrey K. (2018). Defining the role of post-synaptic α-neurotoxins in paralysis due to snake envenoming in humans. Cellular and Molecular Life Sciences, 75 (23), 4465-4478. doi: 10.1007/s00018-018-2893-x |
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2018 Journal Article Inhibition of acid-sensing ion channels by diminazene and APETx2 evoke partial and highly variable antihyperalgesia in a rat model of inflammatory painLee, Jia Yu Peppermint, Saez, Natalie J., Cristofori-Armstrong, Ben, Anangi, Raveendra, King, Glenn F., Smith, Maree T. and Rash, Lachlan D. (2018). Inhibition of acid-sensing ion channels by diminazene and APETx2 evoke partial and highly variable antihyperalgesia in a rat model of inflammatory pain. British Journal of Pharmacology, 175 (12), 2204-2218. doi: 10.1111/bph.14089 |
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2017 Journal Article The Aromatic Head Group of Spider Toxin Polyamines Influences Toxicity to Cancer CellsWilson, David, Boyle, Glen M, McIntyre, Lachlan, Nolan, Matthew J, Parsons, Peter G, Smith, Jennifer J, Tribolet, Leon, Loukas, Alex, Liddell, Michael J, Rash, Lachlan D and Daly, Norelle L (2017). The Aromatic Head Group of Spider Toxin Polyamines Influences Toxicity to Cancer Cells. Toxins, 9 (11) 346, 1-13. doi: 10.3390/toxins9110346 |
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2017 Journal Article Acid-sensing ion channel (ASIC) structure and function: insights from spider, snake and sea anemone venomsCristofori-Armstrong, Ben and Rash, Lachlan D. (2017). Acid-sensing ion channel (ASIC) structure and function: insights from spider, snake and sea anemone venoms. Neuropharmacology, 127, 173-184. doi: 10.1016/j.neuropharm.2017.04.042 |
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2017 Journal Article The tarantula toxin β/δ-TRTX-Pre1a highlights the importance of the S1-S2 voltage-sensor region for sodium channel subtype selectivity.Wingerd, Joshua S., Mozar, Christine A., Ussing, Christine A., Murali, Swetha S., Chin, Yanni K. -Y., Cristofori-Armstrong, Ben, Durek, Thomas, Gilchrist, John, Vaughan, Christopher W., Bosmans, Frank, Adams, David J., Lewis, Richard J., Alewood, Paul F., Mobli, Mehdi, Christie, Macdonald J. and Rash, Lachlan D. (2017). The tarantula toxin β/δ-TRTX-Pre1a highlights the importance of the S1-S2 voltage-sensor region for sodium channel subtype selectivity.. Scientific Reports, 7 (1) 974, 974. doi: 10.1038/s41598-017-01129-0 |
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2017 Journal Article Modulation of ion channels by cysteine-rich peptides: from sequence to structureMobli, Mehdi, Undheim, Eivind A.B. and Rash, Lachlan D. (2017). Modulation of ion channels by cysteine-rich peptides: from sequence to structure. Advances in Pharmacology, 79, 199-223. doi: 10.1016/bs.apha.2017.03.001 |
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2017 Journal Article Discovery and molecular interaction studies of a highly stable, tarantula peptide modulator of acid-sensing ion channel 1Er, Sing Yan, Cristofori-Armstrong, Ben, Escoubas, Pierre and Rash, Lachlan D. (2017). Discovery and molecular interaction studies of a highly stable, tarantula peptide modulator of acid-sensing ion channel 1. Neuropharmacology, 127, 185-195. doi: 10.1016/j.neuropharm.2017.03.020 |
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2017 Journal Article The structure, dynamics and selectivity profile of a NaV 1.7 potency-optimised huwentoxin-IV variantRahnama, Sassan, Deuis, Jennifer R., Cardoso, Fernanda C., Ramanujam, Venkatraman, Lewis, Richard J., Rash, Lachlan D., King, Glenn F., Vetter, Irina and Mobli, Mehdi (2017). The structure, dynamics and selectivity profile of a NaV 1.7 potency-optimised huwentoxin-IV variant. PLoS One, 12 (3) e0173551, e0173551. doi: 10.1371/journal.pone.0173551 |
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2017 Journal Article Potent neuroprotection after stroke afforded by a double-knot spider-venom peptide that inhibits acid-sensing ion channel 1aChassagnon, Irene R., McCarthy, Claudia A., Chin, Yanni K.-Y., Pineda, Sandy S., Keramidas, Angelo, Mobli, Mehdi, Pham, Vi, De Silva, T. Michael, Lynch, Joseph W., Widdop, Robert E., Rash, Lachlan D. and King, Glenn F. (2017). Potent neuroprotection after stroke afforded by a double-knot spider-venom peptide that inhibits acid-sensing ion channel 1a. Proceedings from the National Academy of Sciences of the United States of America, 114 (14), 3750-3755. doi: 10.1073/pnas.1614728114 |
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2016 Journal Article NaV1.7 as a pain target – from gene to pharmacologyVetter, Irina, Deuis, Jennifer, Mueller, Alexander, Israel, Mathilde R., Hana Starobova, Zhang, Alan, Rash, Lachlan D. and Mobli, Mehdi (2016). NaV1.7 as a pain target – from gene to pharmacology. Pharmacology and Therapeutics, 172, 73-100. doi: 10.1016/j.pharmthera.2016.11.015 |
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2016 Journal Article Selective inhibition of ASIC1a confers functional and morphological neuroprotection following traumatic spinal cord injuryKoehn, Liam M, Noor, Natassya M, Dong, Qing, Er, Sing-Yan, Rash, Lachlan D, King, Glenn F, Dziegielewska, Katarzyna M, Saunders, Norman R and Habgood, Mark D (2016). Selective inhibition of ASIC1a confers functional and morphological neuroprotection following traumatic spinal cord injury. F1000Research, 5 1822, 1822. doi: 10.12688/f1000research.9094.2 |
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2016 Journal Article Selective inhibition of ASIC1a confers functional and morphological neuroprotection following traumatic spinal cord injury [version 1; referees: 1 approved, 1 approved with reservations]Koehn, Liam M., Dong, Qing, Er, Sing-Yan, Rash, Lachlan D., King, Glenn F., Dziegielewska, Katarzyna M., Saunders, Norman R. and Habgood, Mark D. (2016). Selective inhibition of ASIC1a confers functional and morphological neuroprotection following traumatic spinal cord injury [version 1; referees: 1 approved, 1 approved with reservations]. F1000Research, 5 1822, 1822. doi: 10.12688/F1000RESEARCH.9094.1 |
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2015 Journal Article PcTx1 affords neuroprotection in a conscious model of stroke in hypertensive rats via selective inhibition of ASIC1aMcCarthy, Claudia A., Rash, Lachlan D., Chassagnon, Irene R., King, Glenn F. and Widdop, Robert E. (2015). PcTx1 affords neuroprotection in a conscious model of stroke in hypertensive rats via selective inhibition of ASIC1a. Neuropharmacology, 99 5986, 650-657. doi: 10.1016/j.neuropharm.2015.08.040 |
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2015 Journal Article Xenopus borealis as an alternative source of oocytes for biophysical and pharmacological studies of neuronal ion channelsCristofori-Armstrong, Ben, Soh, Ming S., Talwar, Sahil, Brown, Darren L., Griffin, John D. O., Dekan, Zoltan, Stow, Jennifer L., King, Glenn F., Lynch, Joseph W. and Rash, Lachlan D. (2015). Xenopus borealis as an alternative source of oocytes for biophysical and pharmacological studies of neuronal ion channels. Scientific Reports, 5 (1) 14763, 14763.1-14763.12. doi: 10.1038/srep14763 |
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2015 Journal Article Molecular dynamics and functional studies define a hot spot of crystal contacts essential for PcTx1 inhibition of acid-sensing ion channel 1aSaez, Natalie J., Deplazes, Evelyne, Cristofori-Armstrong, Ben, Chassagnon, Irene R., Lin, Xiaozhen, Mobli, Mehdi, Mark, Alan E., Rash, Lachlan D. and King, Glenn F. (2015). Molecular dynamics and functional studies define a hot spot of crystal contacts essential for PcTx1 inhibition of acid-sensing ion channel 1a. British Journal of Pharmacology, 172 (20), 4985-4995. doi: 10.1111/bph.13267 |
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2015 Journal Article Three peptide modulators of the human voltage-gated sodium channel 1.7, an important analgesic target, from venom of an Australian tarantulaChow, Chun Yuen, Cristofori-Armstrong, Ben, Undheim, Eivind A. B., King, Glenn F. and Rash, Lachlan D. (2015). Three peptide modulators of the human voltage-gated sodium channel 1.7, an important analgesic target, from venom of an Australian tarantula. Toxins, 7 (7), 2494-2513. doi: 10.3390/toxins7072494 |
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2015 Journal Article Mutations in the voltage-gated potassium channel gene KCNH1 cause Temple-Baraitser syndrome and epilepsy (vol 47, pg 73, 2015)Simons, Cas, Rash, Lachlan D., Crawford, Joanna, Ma, Linlin, Cristofori-Armstrong, Ben, Miller, David, Ru, Kelin, Baillie, Gregory J., Alanay, Yasemin, Jacquinet, Adeline, Debray, Franois-Guillaume, Verloes, Alain, Shen, Joseph, Yesil, Goezde, Guler, Serhat, Yuksel, Adnan, Cleary, John G., Grimmond, Sean M., McGaughran, Julie, King, Glenn F., Gabbett, Michael T. and Taft, Ryan J. (2015). Mutations in the voltage-gated potassium channel gene KCNH1 cause Temple-Baraitser syndrome and epilepsy (vol 47, pg 73, 2015). Nature Genetics, 47 (3), 304-304. doi: 10.1038/ng0315-304b |
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2015 Journal Article Mutations in the voltage-gated potassium channel gene KCNH1 cause Temple-Baraitser syndrome and epilepsySimons Cas, Rash, Lachlan D., Crawford, Joanna, Ma, Linlin, Cristofori-Armstrong, Ben, Miller, David, Ru, Kelin, Baillie, Gregory J., Alanay, Yasemin, Jacquinet, Adeline, Debray, François-Guillaume, Verloes, Alain, Shen, Joseph, Yesil, Gözde, Guler, Serhat, Yuksel, Adnan, Cleary, John G., Grimmond, Sean M., McGaughran, Julie, King, Glenn F., Gabbett, Michael T. and Taft, Ryan J. (2015). Mutations in the voltage-gated potassium channel gene KCNH1 cause Temple-Baraitser syndrome and epilepsy. Nature Genetics, 47 (1), 73-77. doi: 10.1038/ng.3153 |
