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2011 Journal Article Discovery of (2E)-3-{2-Butyl-1-[2-(diethylamino)ethyl]-1H-benzimidazol-5-yl}-N-hydroxyacrylamide (SB939), an orally active histone deacetylase inhibitor with a superior preclinical profileWang, Haishan, Yu, Niefang, Chen, Dizhong, Lee, Ken Chi Lik, Lye, Pek Ling, Chang, Joyce Wei Wei, Deng, Weiping, Ng, Melvin Chi Yeh, Lu, Ting, Khoo, Mui Ling, Poulsen, Anders, Sangthongpitag, Kanda, Wu, Xiaofeng, Hu, Changyong, Goh, Kee Chuan, Wang, Xukun, Fang, Lijuan, Goh, Kay Lin, Khng, Hwee Hoon, Goh, Siok Kun, Yeo, Pauline, Liu, Xin, Bonday, Zahid, Wood, Jeanette M., Dymock, Brian W., Kantharaj, Kanthara and Sun, Eric T. (2011). Discovery of (2E)-3-{2-Butyl-1-[2-(diethylamino)ethyl]-1H-benzimidazol-5-yl}-N-hydroxyacrylamide (SB939), an orally active histone deacetylase inhibitor with a superior preclinical profile. Journal of Medicinal Chemistry, 54 (13), 4694-4720. doi: 10.1021/jm2003552 |
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2011 Journal Article How to measure pharmacokinetics in critically ill patients?Liu, Xin, Kruger, Peter S. and Roberts, Michael S. (2011). How to measure pharmacokinetics in critically ill patients?. Current Pharmaceutical Biotechnology, 12 (12), 2037-2043. doi: 10.2174/138920111798808239 |
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2011 Journal Article Effect of adjuvant-induced systemic inflammation in rats on hepatic disposition kinetics of taurocholateRoberts, Michael S., Liu, Xin, Zou, Yuhong, Siebert, Gerhard A., Chang, Ping, Whitehouse, Michael W., Fletcher, Linda and Crawford, Darrell H. G. (2011). Effect of adjuvant-induced systemic inflammation in rats on hepatic disposition kinetics of taurocholate. American Journal of Physiology-gastrointestinal And Liver Physiology, 300 (1), G130-G136. doi: 10.1152/ajpgi.00162.2010 |
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2010 Journal Article Nitric oxide induced sinusoidal relaxation after a propranolol priming dose in the perfused rat liver reduces propranolol availability on subsequent dosingLiu, Xin, Zou, Yuhong, Khlentzos, Alexander M., Yang, Yan, Nikolovski, Julijana, Weiss, Michael and Roberts, Michael S. (2010). Nitric oxide induced sinusoidal relaxation after a propranolol priming dose in the perfused rat liver reduces propranolol availability on subsequent dosing. Clinical and Experimental Pharmacology and Physiology, 37 (10), 1028-1033. doi: 10.1111/j.1440-1681.2010.05434.x |
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2010 Journal Article Mechanisms of transforming growth factor beta(1)/Smad signalling mediated by mitogen-activated protein kinase pathways in keloid fibroblastsHe, S., Liu, X., Yang, Y., Huang, W., Xu, S., Yang, S., Zhang, X. and Roberts, M. S. (2010). Mechanisms of transforming growth factor beta(1)/Smad signalling mediated by mitogen-activated protein kinase pathways in keloid fibroblasts. British Journal of Dermatology, 162 (3), 538-546. doi: 10.1111/j.1365-2133.2009.09511.x |
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2010 Journal Article Compound Astragalus and Salvia miltiorrhiza extract inhibits cell invasion by modulating transforming growth factor-beta/Smad in HepG2Liu, Xin, Yang, Yan, Zhang, Xiaoxiang, Xu, Shengxin, He, Shufang, Huang, Weijuan and Roberts, Michael S. (2010). Compound Astragalus and Salvia miltiorrhiza extract inhibits cell invasion by modulating transforming growth factor-beta/Smad in HepG2. Journal of Gastroenterology and Hepatology, 25 (2), 420-426. doi: 10.1111/j.1440-1746.2009.05981.x |
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2010 Journal Article Liver fibrosis impairs hepatic pharmacokinetics of liver transplant drugs in the rat modelZou, Yu-Hong, Liu, Xin, Khlentzos, Alexander M., Asadian, Peyman, Li, Peng, Thorling, Camilla A., Robertson, Thomas A., Fletcher, Linda M., Crawford, Darrell H. G. and Roberts, Michael S. (2010). Liver fibrosis impairs hepatic pharmacokinetics of liver transplant drugs in the rat model. Drug Metabolism and Pharmacokinetics, 25 (5), 442-449. doi: 10.2133/dmpk.DMPK-10-RG-031 |
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2009 Journal Article Influence of perfusate composition on drug disposition in the in-situ perfused rat lungLiu, X., Wang, J. Y., Khlentzos, A. M., Fontaine, F., Nikolovski, J., Goh, L.- A. and Roberts, M. S. (2009). Influence of perfusate composition on drug disposition in the in-situ perfused rat lung. International Journal of Pharmaceutics, 382 (1-2), 192-197. doi: 10.1016/j.ijpharm.2009.08.028 |
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2008 Journal Article Comparison of the in vitro and in vivo effects of retinoids either alone or in combination with cisplatin and 5-fluorouracil on tumor development and metastasis of melanoma.Liu, Xin, Chan, S. Y. and Ho, P. C. (2008). Comparison of the in vitro and in vivo effects of retinoids either alone or in combination with cisplatin and 5-fluorouracil on tumor development and metastasis of melanoma.. Cancer Chemotherapy and Pharmacology, 63 (1), 167-174. doi: 10.1007/s00280-008-0763-1 |
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2008 Journal Article The prediction of the hepatic clearance of Tanshinone IIA in a rat liver subcellular fractions: accuracy improvementLi, P., Wang, G-J., Li, J., Liu, X., Khlentzos, A. and Roberts, M. S. (2008). The prediction of the hepatic clearance of Tanshinone IIA in a rat liver subcellular fractions: accuracy improvement. Current Drug Metabolism, 9 (1), 39-45. doi: 10.2174/138920008783331103 |
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2007 Journal Article In vitro phase I cytochrome P450 metabolism, permeability and pharmacokinetics of SB639, a novel histone deacetylase inhibitor in preclinical speciesVenkadesh, Pilla Reddy, Goh, Evelyn, Zeng, Peizi, New, Lee Sun, Liu, Xin, Pasha, Mohammed Khalid, Sangthongpitag, Kanda, Yeo, Pauline and Kantharaj, Ethirajulu (2007). In vitro phase I cytochrome P450 metabolism, permeability and pharmacokinetics of SB639, a novel histone deacetylase inhibitor in preclinical species. Biological and Pharmaceutical Bulletin, 30 (5), 1021-1024. doi: 10.1248/bpb.30.1021 |
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2007 Journal Article Development and validation of high-performance liquid chromatography-tandem mass spectrometry assay for 6-(3-benzoyl-ureido)-hexanoic acid hydroxyamide, a novel HDAC inhibitor, in mouse plasma for pharmacokinetic studiesYeo, Pauline, Xin, Liu, Goh, Evelyn, New, Lee Sun, Zeng, Peizi, Wu, Xiaofeng, Venkatesh, P. and Kantharaj, Ethirajulu (2007). Development and validation of high-performance liquid chromatography-tandem mass spectrometry assay for 6-(3-benzoyl-ureido)-hexanoic acid hydroxyamide, a novel HDAC inhibitor, in mouse plasma for pharmacokinetic studies. Biomedical Chromatography, 21 (2), 184-189. doi: 10.1002/bmc.734 |
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2005 Journal Article Characterization of the 13-cis-retinoic acid/cyclodextrin inclusion complexes by phase solubility, photostability, physicochemical and computational analysisYap, K. L., Liu, X., Thenmozhiyal, J. C. and Ho, P. C. (2005). Characterization of the 13-cis-retinoic acid/cyclodextrin inclusion complexes by phase solubility, photostability, physicochemical and computational analysis. European Journal of Pharmaceutical Sciences, 25 (1), 49-56. doi: 10.1016/j.ejps.2005.01.021 |
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2004 Journal Article Biopharmaceutics of beta-cyclodextrin derivative-based formulations of acitretin in Sprague-Dawley ratsLiu, X., Lin, H. S., Chan, S. Y. and Ho, P. C. (2004). Biopharmaceutics of beta-cyclodextrin derivative-based formulations of acitretin in Sprague-Dawley rats. Journal of Pharmaceutical Sciences, 93 (4), 805-815. doi: 10.1002/jps.10578 |
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2003 Journal Article Inclusion of acitretin into cyclodextrins: Phase solubility, photostability, and physicochemical characterizationLiu, X., Lin, H. S., Thenmozhiyal, J. C., Chan, S. Y. and Ho, P. C. (2003). Inclusion of acitretin into cyclodextrins: Phase solubility, photostability, and physicochemical characterization. Journal of Pharmaceutical Sciences, 92 (12), 2449-2457. doi: 10.1002/jps.10495 |
