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2016 Journal Article Modulation of human Nav1.7 channel gating by synthetic alpha-scorpion toxin OD1 and its analogsMotin, Leonid, Durek, Thomas and Adams, David J. (2016). Modulation of human Nav1.7 channel gating by synthetic alpha-scorpion toxin OD1 and its analogs. Channels, 10 (2), 139-147. doi: 10.1080/19336950.2015.1120392 |
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2016 Journal Article Approaches to the stabilization of bioactive epitopes by grafting and peptide cyclizationConibear, Anne C., Chaousis, Stephanie, Durek, Thomas, Rosengren, K. Johan, Craik, David J. and Schroeder, Christina I. (2016). Approaches to the stabilization of bioactive epitopes by grafting and peptide cyclization. Biopolymers, 106 (1), 89-100. doi: 10.1002/bip.22767 |
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2015 Journal Article Efficient backbone cyclization of linear peptides by a recombinant asparaginyl endopeptidaseHarris, Karen S., Durek, Thomas, Kaas, Quentin, Poth, Aaron G., Gilding, Edward K., Conlan, Brendon F., Saska, Ivana, Daly, Norelle L., Van Der Weerden, Nicole L., Craik, David J. and Anderson, Marilyn A. (2015). Efficient backbone cyclization of linear peptides by a recombinant asparaginyl endopeptidase. Nature Communications, 6 (10199) 10199, 10199. doi: 10.1038/ncomms10199 |
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2015 Journal Article Potent complement C3a receptor agonists derived from oxazole amino acids: structure-activity relationshipsSingh, Ranee, Reed, Anthony N., Chu, Peifei, Scully, Conor C. G., Yau, Mei-Kwan, Suen, Jacky Y., Durek, Thomas, Reid, Robert C. and Fairlie, David P. (2015). Potent complement C3a receptor agonists derived from oxazole amino acids: structure-activity relationships. Bioorganic and Medicinal Chemistry Letters, 25 (23), 5604-5608. doi: 10.1016/j.bmcl.2015.10.038 |
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2015 Journal Article Cyclic alpha-conotoxin peptidomimetic chimeras as potent GLP-1R agonistsSwedberg, Joakim E., Schroeder, Christina I., Mitchell, Justin M., Durek, Thomas, Fairlie, David P., Edmonds, David J., Griffith, David A., Ruggeri, Roger B., Derksen, David R., Loria, Paula M., Liras, Spiros, Price, David A. and Craik, David J. (2015). Cyclic alpha-conotoxin peptidomimetic chimeras as potent GLP-1R agonists. European Journal of Medicinal Chemistry, 103, 175-184. doi: 10.1016/j.ejmech.2015.08.046 |
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2015 Journal Article Therapeutic conotoxins: a US patent literature surveyDurek, Thomas and Craik, David J. (2015). Therapeutic conotoxins: a US patent literature survey. Expert Opinion in Therapeutic Patents, 25 (10), 1159-1173. doi: 10.1517/13543776.2015.1054095 |
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2014 Journal Article Fmoc-based synthesis of disulfide-rich cyclic peptidesCheneval, Olivier, Schroeder, Christina I., Durek, Thomas, Walsh, Phillip, Huang, Yen-Hua, Liras, Spiros, Price, David A. and Craik, David J. (2014). Fmoc-based synthesis of disulfide-rich cyclic peptides. Journal of Organic Chemistry, 79 (12), 5538-5544. doi: 10.1021/jo500699m |
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2014 Journal Article Isolation and structural and pharmacological characterization of α-elapitoxin-Dpp2d, an amidated three finger toxin from black mamba venomWang, Ching-I Anderson, Reeks, Timothy, Vetter, Irina, Vergara, Irene, Kovtun, Oleksiy, Lewis, Richard J., Alewood, Paul F. and Durek, Thomas (2014). Isolation and structural and pharmacological characterization of α-elapitoxin-Dpp2d, an amidated three finger toxin from black mamba venom. Biochemistry, 53 (23), 3758-3766. doi: 10.1021/bi5004475 |
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2014 Journal Article Isolation, synthesis and characterization of omega-TRTX-Cc1a, a novel tarantula venom peptide that selectively targets L-type CaV channelsKlint, Julie K., Berecki, Géza, Durek, Thomas, Mobli, Mehdi, Knapp, Oliver, King, Glenn F., Adams, David J., Alewood, Paul F. and Rash, Lachlan D. (2014). Isolation, synthesis and characterization of omega-TRTX-Cc1a, a novel tarantula venom peptide that selectively targets L-type CaV channels. Biochemical Pharmacology, 89 (2), 276-286. doi: 10.1016/j.bcp.2014.02.008 |
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2014 Journal Article Disulfide-rich macrocyclic peptides as templates in drug designNorthfield, Susan E., Wang, Conan K., Schroeder, Christina I., Durek, Thomas, Kan, Meng-Wei, Swedberg, Joakim E. and Craik, David J. (2014). Disulfide-rich macrocyclic peptides as templates in drug design. European Journal of Medicinal Chemistry, 77 (2), 248-257. doi: 10.1016/j.ejmech.2014.03.011 |
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2014 Journal Article Chemical synthesis, 3D structure and ASIC binding site of mambalgin-2Schroeder, Christina I., Rash, Lachlan D., Vila-Farrés, Xavier, Rosengren, K. Johan, Mobli, Mehdi, King, Glenn F., Alewood, Paul F., Craik, David J. and Durek, Thomas (2014). Chemical synthesis, 3D structure and ASIC binding site of mambalgin-2. Angewandte Chemie International Edition, 53 (4), 1017-1020. doi: 10.1002/anie.201308898 |
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2014 Journal Article Chemical synthesis, 3D structure, and ASIC binding site of the toxin mambalgin-2Schroeder, Christina I., Rash, Lachlan D., Vila-Farrés, Xavier, Rosengren, K. Johan, Mobli, Mehdi, King, Glenn F., Alewood, Paul F., Craik, David J. and Durek, Thomas (2014). Chemical synthesis, 3D structure, and ASIC binding site of the toxin mambalgin-2. Angewandte Chemie, 126 (4), 1035-1038. doi: 10.1002/ange.201308898 |
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2013 Journal Article Chemical engineering and structural and pharmacological characterization of the alpha-scorpion toxin OD1Durek, Thomas, Vetter, Irina, Wang, Ching-I Anderson, Motin, Leonid, Knapp, Oliver, Adams, David J., Lewis, Richard J. and Alewood, Paul F. (2013). Chemical engineering and structural and pharmacological characterization of the alpha-scorpion toxin OD1. ACS Chemical Biology, 8 (6), 1215-1222. doi: 10.1021/cb400012k |
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2013 Journal Article Solid phase synthesis of peptide-selenoestersGhassemian, Artin, Vila-Farres, Xavier, Alewood, Paul F. and Durek, Thomas (2013). Solid phase synthesis of peptide-selenoesters. Bioorganic and Medicinal Chemistry, 21 (12), 3473-3478. doi: 10.1016/j.bmc.2013.03.076 |
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2013 Journal Article Efficient chemical synthesis of human complement protein C3aGhassemian, Artin, Wang, Ching-I Anderson, Yau, Mei-Kwan, Reid, Robert C., Lewis, Richard J., Fairlie, David P., Alewood, Paul F. and Durek, Thomas (2013). Efficient chemical synthesis of human complement protein C3a. Chemical Communications, 49 (23), 2356-2358. doi: 10.1039/c3cc40537k |
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2012 Journal Article Characterisation of Na-v types endogenously expressed in human SH-SY5Y neuroblastoma cellsVetter, Irina, Mozar, Christine A., Durek, Thomas, Wingerd, Joshua S., Alewood, Paul F., Christie, Macdonald J. and Lewis, Richard J. (2012). Characterisation of Na-v types endogenously expressed in human SH-SY5Y neuroblastoma cells. Biochemical Pharmacology, 83 (11), 1562-1571. doi: 10.1016/j.bcp.2012.02.022 |
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2011 Journal Article Preformed selenoesters enable rapid native chemical ligation at intractable sitesDurek, Thomas and Alewood, Paul F. (2011). Preformed selenoesters enable rapid native chemical ligation at intractable sites. Angewandte Chemie International Edition, 50 (50), 12042-12045. doi: 10.1002/anie.201105512 |
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2010 Journal Article Chemical synthesis and structure of the prokineticin Bv8Morales, Rodrigo A. V., Daly, Norelle L., Vetter, Irina, Mobli, Mehdi, Napier, Ian A., Craik, David J., Lewis, Richard J., Christie, MacDonald J., King, Glenn F., Alewood, Paul F. and Durek, Thomas (2010). Chemical synthesis and structure of the prokineticin Bv8. ChemBioChem, 11 (13), 1882-1888. doi: 10.1002/cbic.201000330 |
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2009 Journal Article Chemical synthesis and folding of APETx2, a potent and selective inhibitor of acid sensing ion channel 3Jensen, J. E., Durek, T, Alewood, P. F., Adams, D. J., King, G. F. and Rash, L. D. (2009). Chemical synthesis and folding of APETx2, a potent and selective inhibitor of acid sensing ion channel 3. TOXICON, 54 (1), 56-61. doi: 10.1016/j.toxicon.2009.03.014 |
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2007 Journal Article Synthesis of photoactive analogues of a cystine knot trypsin inhibitor proteinDurek, Thomas, Zhang, Junliang, He, Chuan and Kent, Stephen B.H. (2007). Synthesis of photoactive analogues of a cystine knot trypsin inhibitor protein. Organic Letters, 9 (26), 5497-5500. doi: 10.1021/ol702461z |
