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2019 Journal Article Determinants of Zika virus host tropism uncovered by deep mutational scanningSetoh, Yin Xiang, Amarilla, Alberto A., Peng, Nias Y. G., Griffiths, Rebecca E., Carrera, Julio, Freney, Morgan E., Nakayama, Eri, Ogawa, Shinya, Watterson, Daniel, Modhiran, Naphak, Nanyonga, Faith Elizabeth, Torres, Francisco J., Slonchak, Andrii, Periasamy, Parthiban, Prow, Natalie A., Tang, Bing, Harrison, Jessica, Hobson-Peters, Jody, Cuddihy, Thom, Cooper-White, Justin, Hall, Roy A., Young, Paul R., Mackenzie, Jason M., Wolvetang, Ernst, Bloom, Jesse D., Suhrbier, Andreas and Khromykh, Alexander A. (2019). Determinants of Zika virus host tropism uncovered by deep mutational scanning. Nature Microbiology, 4 (5), 876-887. doi: 10.1038/s41564-019-0399-4 |
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2019 Journal Article Dynamic methylation of an L1 transduction family during reprogramming and neurodifferentiationSalvador-Palomeque, Carmen, Sanchez-Luque, Francisco J., Fortuna, Patrick R. J., Ewing, Adam D., Wolvetang, Ernst J., Richardson, Sandra R. and Faulkner, Geoffrey J. (2019). Dynamic methylation of an L1 transduction family during reprogramming and neurodifferentiation. Molecular and Cellular Biology, 39 (7) e00499-18, 1-19. doi: 10.1128/mcb.00499-18 |
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2019 Journal Article GRGD-decorated three-dimensional nanoworm hydrogels for culturing human embryonic stem cellsKessel, Stefanie, Thakar, Nilay, Jia, Zhongfan, Wolvetang, Ernst J. and Monteiro, Michael J. (2019). GRGD-decorated three-dimensional nanoworm hydrogels for culturing human embryonic stem cells. Journal of Polymer Science Part A: Polymer Chemistry, 57 (18), 1956-1963. doi: 10.1002/pola.29342 |
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2019 Journal Article Platypus induced pluripotent stem cells: the unique pluripotency signature of a monotremeWhitworth, Deanne J., Limnios, Ioannis J., Gauthier, Marie-Emilie, Weeratunga, Prasanna, Ovchinnikov, Dmitry A., Baillie, Gregory, Grimmond, Sean M., Graves, Jennifer A. Marshall and Wolvetang, Ernst J. (2019). Platypus induced pluripotent stem cells: the unique pluripotency signature of a monotreme. Stem Cells and Development, 28 (3), 151-164. doi: 10.1089/scd.2018.0179 |
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2019 Journal Article Global proteomic and methylome analysis in human induced pluripotent stem cells reveals overexpression of a human TLR3 affecting proper innate immune response signalingRequena, J., Alvarez-Palomo, A. B., Codina-Pascual, M., Delgado-Morales, R., Moran, S., Esteller, M., Sal, M., Juan, M., Boronat Barado, A., Consiglio, A., Bogle, O. A., Wolvetang, E., Ovchinnikov, D., Alvarez, I., Jaraquemada, D., Mezquita-Pla, J., Oliva, R. and Edel, M. J. (2019). Global proteomic and methylome analysis in human induced pluripotent stem cells reveals overexpression of a human TLR3 affecting proper innate immune response signaling. Stem Cells, 37 (4), 476-488. doi: 10.1002/stem.2966 |
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2018 Journal Article Evaluation of variability in human kidney organoidsPhipson, Belinda, Er, Pei X., Combes, Alexander N., Forbes, Thomas A., Howden, Sara E., Zappia, Luke, Yen, Hsan-Jan, Lawlor, Kynan T., Hale, Lorna J., Sun, Jane, Wolvetang, Ernst, Takasato, Minoru, Oshlack, Alicia and Little, Melissa H. (2018). Evaluation of variability in human kidney organoids. Nature Methods, 16 (1), 79-87. doi: 10.1038/s41592-018-0253-2 |
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2018 Journal Article Identification of on-target mutagenesis during correction of a beta-thalassemia splice mutation in iPS cells with optimised CRISPR/Cas9-double nickase reveals potential safety concernsAlateeq, Suad, Ovchinnikov, Dmitry, Tracey, Timothy, Whitworth, Deanne, Al-Rubaish, Abdullah, Al-Ali, Amein and Wolvetang, Ernst (2018). Identification of on-target mutagenesis during correction of a beta-thalassemia splice mutation in iPS cells with optimised CRISPR/Cas9-double nickase reveals potential safety concerns. APL Bioengineering, 2 (4) 046103, 046103. doi: 10.1063/1.5048625 |
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2018 Journal Article Erratum to: Reprogramming triggers endogenous L1 and Alu retrotransposition in human induced pluripotent stem cells (Nature Communications, (2016), 7, 1, (10286), 10.1038/ncomms10286)Klawitter, Sabine, Fuchs, Nina V., Upton, Kyle R., Muñoz-Lopez, Martin, Shukla, Ruchi, Wang, Jichang, Garcia-Cañadas, Marta, Lopez-Ruiz, Cesar, Gerhardt, Daniel J., Sebe, Attila, Grabundzija, Ivana, Merkert, Sylvia, Gerdes, Patricia, Pulgarin, J. Andres, Bock, Anja, Held, Ulrike, Witthuhn, Anett, Haase, Alexandra, Sarkadi, Balázs, Löwer, Johannes, Wolvetang, Ernst J., Martin, Ulrich, Ivics, Zoltán, Izsvák, Zsuzsanna, Garcia-Perez, Jose L., Faulkner, Geoffrey J. and Schumann, Gerald G. (2018). Erratum to: Reprogramming triggers endogenous L1 and Alu retrotransposition in human induced pluripotent stem cells (Nature Communications, (2016), 7, 1, (10286), 10.1038/ncomms10286). Nature Communications, 9 (1) 5398, 5398. doi: 10.1038/s41467-018-07917-0 |
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2018 Journal Article PCDH19 regulation of neural progenitor cell differentiation suggests asynchrony of neurogenesis as a mechanism contributing to PCDH19 Girls Clustering EpilepsyHoman, Claire C., Pederson, Stephen, To, Thu-Hien, Tan, Chuan, Piltz, Sandra, Corbett, Mark, Wolvetang, Ernst, Thomas, Paul, Jolly, Lachlan A. and Gecz, Jozef (2018). PCDH19 regulation of neural progenitor cell differentiation suggests asynchrony of neurogenesis as a mechanism contributing to PCDH19 Girls Clustering Epilepsy. Neurobiology of Disease, 116, 106-119. doi: 10.1016/j.nbd.2018.05.004 |
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2018 Journal Article A simple bioreactor-based method to generate kidney organoids from pluripotent stem cellsPrzepiorski, Aneta, Sander, Veronika, Tran, Tracy, Hollywood, Jennifer A., Sorrenson, Brie, Shih, Jen-Hsing, Wolvetang, Ernst J., McMahon, Andrew P., Holm, Teresa M. and Davidson, Alan J. (2018). A simple bioreactor-based method to generate kidney organoids from pluripotent stem cells. Stem Cell Reports, 11 (2), 470-484. doi: 10.1016/j.stemcr.2018.06.018 |
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2018 Journal Article The impact of APP on Alzheimer-like pathogenesis and gene expression in Down syndrome iPSC-derived neuronsOvchinnikov, Dmitry A., Korn, Othmar, Virshup, Isaac, Wells, Christine A. and Wolvetang, Ernst J. (2018). The impact of APP on Alzheimer-like pathogenesis and gene expression in Down syndrome iPSC-derived neurons. Stem Cell Reports, 11 (1), 32-42. doi: 10.1016/j.stemcr.2018.05.004 |
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2018 Journal Article Modelling ischemia-reperfusion injury (IRI) in vitro using metabolically matured induced pluripotent stem cell-derived cardiomyocytesHidalgo, Alejandro, Glass, Nick, Ovchinnikov, Dmitry, Yang, Seung-Kwon, Zhang, Xinli, Mazzone, Stuart, Chen, Chen, Wolvetang, Ernst and Cooper-White, Justin (2018). Modelling ischemia-reperfusion injury (IRI) in vitro using metabolically matured induced pluripotent stem cell-derived cardiomyocytes. APL Bioengineering, 2 (2) 026102, 026102. doi: 10.1063/1.5000746 |
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2018 Journal Article Cortical neurons derived from equine induced pluripotent stem cells are susceptible to neurotropic flavivirus infection and replication: an in vitro model for equine neuropathic diseasesFortuna, Patrick R. J., Bielefeldt-Ohmann, Helle, Ovchinnikov, Dmitry A., Wolvetang, Ernst Jurgen and Whitworth, Deanne Jeanette (2018). Cortical neurons derived from equine induced pluripotent stem cells are susceptible to neurotropic flavivirus infection and replication: an in vitro model for equine neuropathic diseases. Stem Cells and Development, 27 (10), 704-715. doi: 10.1089/scd.2017.0106 |
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2018 Journal Article Expression pattern of the aspartyl-tRNA synthetase DARS in the human brainFrohlich, Dominik, Suchowerska, Alexandra K., Voss, Carola, He, Ruojie, Wolvetang, Ernst, von Jonquieres, Georg, Simon, Cas, Fath, Thomas, Housley, Gary D. and Klugmann, Matthias (2018). Expression pattern of the aspartyl-tRNA synthetase DARS in the human brain. Frontiers in Molecular Neuroscience, 11 81, 81. doi: 10.3389/fnmol.2018.00081 |
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2018 Journal Article Neuronal Lipid Metabolism: Multiple Pathways Driving Functional Outcomes in Health and DiseaseTracey, Timothy J., Steyn, Frederik J., Wolvetang, Ernst J. and Ngo, Shyuan T. (2018). Neuronal Lipid Metabolism: Multiple Pathways Driving Functional Outcomes in Health and Disease. Frontiers in Molecular Neuroscience, 11 10, 10. doi: 10.3389/fnmol.2018.00010 |
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2018 Journal Article Induced pluripotent stem cells from a marsupial, the Tasmanian devil (Sarcophilus harrisii): insight into the evolution of mammalian pluripotencyWeeratunga, Prasanna, Shahsavari, Arash, Ovchinnikov, Dmitry A., Wolvetang, Ernst J. and Whitworth, Deanne J. (2018). Induced pluripotent stem cells from a marsupial, the Tasmanian devil (Sarcophilus harrisii): insight into the evolution of mammalian pluripotency. Stem Cells and Development, 27 (2), 112-122. doi: 10.1089/scd.2017.0224 |
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2018 Journal Article Pushing the Limits of High Throughput PET-RAFT PolymerizationNg, Gervase, Yeow, Jonathan, Chapman, Robert, Isahak, Naatasha, Wolvetang, Ernst, Cooper-White, Justin J. and Boyer, Cyrille (2018). Pushing the Limits of High Throughput PET-RAFT Polymerization. Macromolecules, 51 (19), 7600-7607. doi: 10.1021/acs.macromol.8b01600 |
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2017 Journal Article Targeted, stimuli-responsive delivery of plasmid DNA and miRNAs using a facile self-assembled supramolecular nanoparticle systemWong, Li-Yen, Xia, Bingzhao, Wolvetang, Ernst and Cooper-White, Justin J. (2017). Targeted, stimuli-responsive delivery of plasmid DNA and miRNAs using a facile self-assembled supramolecular nanoparticle system. Biomacromolecules, 19 (2), 353-363. doi: 10.1021/acs.biomac.7b01462 |
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2017 Journal Article Human iPSC-Derived Cerebellar Neurons from a Patient with Ataxia-Telangiectasia Reveal Disrupted Gene Regulatory NetworksNayler, Sam P., Powell, Joseph E., Vanichkina, Darya P., Korn, Othmar, Wells, Christine A., Kanjhan, Refik, Sun, Jian, Taft, Ryan J., Lavin, Martin F. and Wolvetang, Ernst J. (2017). Human iPSC-Derived Cerebellar Neurons from a Patient with Ataxia-Telangiectasia Reveal Disrupted Gene Regulatory Networks. Frontiers in Cellular Neuroscience, 11 321, 321. doi: 10.3389/fncel.2017.00321 |
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2017 Journal Article Inhibition of DYRK1A disrupts neural lineage specificationin human pluripotent stem cellsBellmaine, Stephanie F., Ovchinnikov, Dmitry A., Manallack, David T., Cuddy, Claire E., Elefanty, Andrew G., Stanley, Edouard G., Wolvetang, Ernst J., Williams, Spencer J. and Pera, Martin (2017). Inhibition of DYRK1A disrupts neural lineage specificationin human pluripotent stem cells. Elife, 6 e24502. doi: 10.7554/eLife.24502 |
