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Featured 2024 Journal Article A novel inhibitor of class IIa histone deacetylases attenuates collagen‐induced arthritisPoon, Eunice K., Liu, Ligong, Wu, Kai‐Chen, Lim, Junxian, Sweet, Matthew J., Lohman, Rink‐Jan, Iyer, Abishek and Fairlie, David P. (2024). A novel inhibitor of class IIa histone deacetylases attenuates collagen‐induced arthritis. British Journal of Pharmacology, 181 (23), 4804-4821. doi: 10.1111/bph.17306 |
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2023 Journal Article Exploring the therapeutic potential of an antinociceptive and anti-inflammatory peptide from wasp venomGalante, Priscilla, Campos, Gabriel A. A., Moser, Jacqueline C. G., Martins, Danubia B., Dos Santos Cabrera, Marcia P., Rangel, Marisa, Coelho, Luiza C., Simon, Karina S., Amado, Veronica M., de A. I. Muller, Jessica, Koehbach, Johannes, Lohman, Rink-Jan, Cabot, Peter J., Vetter, Irina, Craik, David J., Toffoli-Kadri, Monica C., Monge-Fuentes, Victoria, Goulart, Jair T., Schwartz, Elisabeth F., Silva, Luciano P., Bocca, Anamelia L. and Mortari, Márcia R (2023). Exploring the therapeutic potential of an antinociceptive and anti-inflammatory peptide from wasp venom. Scientific Reports, 13 (1) 12491, 1-15. doi: 10.1038/s41598-023-38828-w |
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2023 Journal Article Design and development of novel, short, stable dynorphin-based opioid agonists for safer analgesic therapyLohman, Rink-Jan, Tupally, Karnaker Reddy, Kandale, Ajit, Cabot, Peter J and Parekh, Harendra S (2023). Design and development of novel, short, stable dynorphin-based opioid agonists for safer analgesic therapy. Frontiers in Pharmacology, 14 1150313, 1150313-14. doi: 10.3389/fphar.2023.1150313 |
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2022 Journal Article Design and development of novel, short, stable dynorphin-based opioid agonists for safer analgesic therapyLohman, Rink-Jan, Tupally, Karnaker Reddy, Kandale, Ajit, Cabot, Peter J. and Parekh, Harendra S. (2022). Design and development of novel, short, stable dynorphin-based opioid agonists for safer analgesic therapy. British Journal of Pharmacology, 180 (1), 129-129. doi: 10.1111/bph.15862 |
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2022 Journal Article Fabrication and Characterization of Clozapine Nanoemulsion Sol–Gel for Intranasal AdministrationTan, Madeleine S. A., Pandey, Preeti, Lohman, Rink-Jan, Falconer, James R., Siskind, Dan J. and Parekh, Harendra S. (2022). Fabrication and Characterization of Clozapine Nanoemulsion Sol–Gel for Intranasal Administration. Molecular Pharmaceutics, 19 (11), 4055-4066. doi: 10.1021/acs.molpharmaceut.2c00513 |
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2020 Journal Article Protease-activated receptor-2 ligands reveal orthosteric and allosteric mechanisms of receptor inhibitionKennedy, Amanda J., Sundström, Linda, Geschwindner, Stefan, Poon, Eunice K. Y., Jiang, Yuhong, Chen, Rongfeng, Cooke, Rob, Johnstone, Shawn, Madin, Andrew, Lim, Junxian, Liu, Qingqi, Lohman, Rink-Jan, Nordqvist, Anneli, Fridén-Saxin, Maria, Yang, Wenzhen, Brown, Dean G., Fairlie, David P. and Dekker, Niek (2020). Protease-activated receptor-2 ligands reveal orthosteric and allosteric mechanisms of receptor inhibition. Communications Biology, 3 (1) 782, 782. doi: 10.1038/s42003-020-01504-0 |
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2020 Journal Article Potent thiophene antagonists of human complement C3a receptor with anti-inflammatory activityRowley, Jessica A., Reid, Robert C., Poon, Eunice K. Y., Wu, Kai-Chen, Lim, Junxian, Lohman, Rink-Jan, Hamidon, Johan K., Yau, Mei-Kwan, Halili, Maria A., Durek, Thomas, Iyer, Abishek and Fairlie, David P. (2020). Potent thiophene antagonists of human complement C3a receptor with anti-inflammatory activity. Journal of Medicinal Chemistry, 63 (2) acs.jmedchem.9b00927, 529-541. doi: 10.1021/acs.jmedchem.9b00927 |
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2020 Journal Article High cell permeability does not predict oral bioavailability for analogues of cyclic heptapeptide sanguinamide ANielsen, Daniel S., Lohman, Rink-Jan, Hoang, Huy N., Fairlie, David P. and Hill, Timothy A. (2020). High cell permeability does not predict oral bioavailability for analogues of cyclic heptapeptide sanguinamide A. Australian Journal of Chemistry, 73 (4), 344-351. doi: 10.1071/ch19479 |
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2019 Journal Article Mirror image pairs of cyclic hexapeptides have different oral bioavailabilities and metabolic stabilitiesLohman, Rink-Jan, Nielsen, Daniel S., Kok, W. Mei, Hoang, Huy N., Hill, Timothy A. and Fairlie, David P. (2019). Mirror image pairs of cyclic hexapeptides have different oral bioavailabilities and metabolic stabilities. Chemical Communications, 55 (89), 13362-13365. doi: 10.1039/c9cc06234c |
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2019 Journal Article Protease-activated receptor 2 does not contribute to renal inflammation or fibrosis in the obstructed kidneyMa, Frank Y., Han, Yingjie, Ozols, Elyce, Chew, Phyllis, Vesey, David A., Gobe, Glenda C., Morais, Christudas, Lohman, Rink-Jan, Suen, Jacky Y., Johnson, David W., Fairlie, David P. and Nikolic-Paterson, David J. (2019). Protease-activated receptor 2 does not contribute to renal inflammation or fibrosis in the obstructed kidney. Nephrology, 24 (9) nep.13635, 983-991. doi: 10.1111/nep.13635 |
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2019 Journal Article Minocycline prevents the development of mechanical allodynia in mouse models of vincristine-induced peripheral neuropathyStarobova, H., Mueller, A., Allavena, R., Lohman, R. J., Sweet, M. J. and Vetter, I. (2019). Minocycline prevents the development of mechanical allodynia in mouse models of vincristine-induced peripheral neuropathy. Frontiers in Neuroscience, 13 (JUN) 653, 653. doi: 10.3389/fnins.2019.00653 |
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2019 Journal Article Pharmacological inhibition of protease-activated receptor-2 reduces crescent formation in rat nephrotoxic serum nephritisHan, Yingjie, Tian, Lifang, Ma, Frank, Tesch, Greg, Vesey, David A., Gobe, Glenda C., Lohman, Rink-Jan, Morais, Christudas, Suen, Jacky Y., Fairlie, David P. and Nikolic-Paterson, David J. (2019). Pharmacological inhibition of protease-activated receptor-2 reduces crescent formation in rat nephrotoxic serum nephritis. Clinical and Experimental Pharmacology and Physiology, 46 (5) 1440-1681.13077, 456-464. doi: 10.1111/1440-1681.13077 |
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2019 Journal Article Structure-activity relationships of wollamide cyclic hexapeptides with activity against drug-resistant and intracellularKhalil, Zeinab G., Hill, Timothy A., De Leon Rodriguez, Luis M., Lohman, Rink-Jan, Hoang, Huy N., Reiling, Norbert, Hillemann, Doris, Brimble, Margaret A., Fairlie, David, Blumenthal, Antje and Capon, Robert J. (2019). Structure-activity relationships of wollamide cyclic hexapeptides with activity against drug-resistant and intracellular. Antimicrobial Agents and Chemotherapy, 63 (3) e01773-18. doi: 10.1128/AAC.01773-18 |
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Featured 2017 Journal Article Exploiting a novel conformational switch to control innate immunity mediated by complement protein C3aLohman, Rink-Jan, Hamidon, Johan K., Reid, Robert C., Rowley, Jessica A., Yau, Mei-Kwan, Halili, Maria A., Nielsen, Daniel S., Lim, Junxian, Wu, Kai-Chen, Loh, Zhixuan, Do, Anh, Suen, Jacky Y., Iyer, Abishek and Fairlie, David P. (2017). Exploiting a novel conformational switch to control innate immunity mediated by complement protein C3a. Nature Communications, 8 (1) 351, 351. doi: 10.1038/s41467-017-00414-w |
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2017 Journal Article An HDAC6 inhibitor confers protection and selectively inhibits B-cell infiltration in DSS-induced colitis in miceDo, Anh, Reid, Robert C., Lohman, Rink-Jan, Sweet, Matthew J., Fairlie, David P. and Iyer, Abishek (2017). An HDAC6 inhibitor confers protection and selectively inhibits B-cell infiltration in DSS-induced colitis in mice. The Journal of Pharmacology and Experimental Therapeutics, 360 (1), 140-151. doi: 10.1124/jpet.116.236711 |
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2016 Journal Article Antagonism of the proinflammatory and pronociceptive actions of canonical and biased agonists of protease-activated receptor-2Lieu, T., Savage, E., Zhao, P., Edgington-Mitchell, L., Barlow, N., Bron, R., Poole, D. P., Mclean, P., Lohman, R. -J., Fairlie, D. P. and Bunnett, N. W. (2016). Antagonism of the proinflammatory and pronociceptive actions of canonical and biased agonists of protease-activated receptor-2. British Journal of Pharmacology, 173 (18), 2752-2765. doi: 10.1111/bph.13554 |
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2016 Journal Article Receptor residence time trumps drug-likeness and oral bioavailability in determining efficacy of complement C5a antagonistsSeow, Vernon, Lim, Junxian, Cotterell, Adam J., Yau, Mei-Kwan, Xu, Weijun, Lohman, Rink-Jan, Kok, W. Mei, Stoermer, Martin J., Sweet, Matthew J., Reid, Robert C., Suen, Jacky Y. and Farilie, David P. (2016). Receptor residence time trumps drug-likeness and oral bioavailability in determining efficacy of complement C5a antagonists. Scientific Reports, 6 (1) 24575, 24575.1-24575.12. doi: 10.1038/srep24575 |
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2016 Journal Article Benzylamide antagonists of protease activated receptor 2 with anti-inflammatory activityYau, Mei-Kwan, Liu, Ligong, Lim, Junxian, Lohman, Rink-Jan, Cotterell, Adam J., Suen, Jacky Y., Vesey, David A., Reid, Robert C. and Fairlie, David P. (2016). Benzylamide antagonists of protease activated receptor 2 with anti-inflammatory activity. Bioorganic and Medicinal Chemistry Letters, 26 (3), 986-991. doi: 10.1016/j.bmcl.2015.12.048 |
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2016 Journal Article Differential anti-inflammatory activity of HDAC inhibitors in human macrophages and rat arthritisLohman, Rink-Jan, Iyer, Abishek, Fairlie, Thomas J., Cotterell, Adam, Gupta, Praveer, Reid, Robert C., Vesey, David A., Sweet, Matthew J. and Fairlie, David P. (2016). Differential anti-inflammatory activity of HDAC inhibitors in human macrophages and rat arthritis. Journal of Pharmacology and Experimental Therapeutics, 356 (2), 387-396. doi: 10.1124/jpet.115.229328 |
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2016 Journal Article PAR2 modulators derived from GB88Yau, Mei-Kwan, Liu, Ligong, Suen, Jacky Y., Lim, Junxian, Lohman, Rink-Jan, Jiang, Yuhong, Cotterell, Adam J., Barry, Grant D., Mak, Jeffrey Y. W., Vesey, David A., Reid, Robert C. and Fairlie, David P. (2016). PAR2 modulators derived from GB88. ACS Medicinal Chemistry Letters, 7 (12), 1179-1184. doi: 10.1021/acsmedchemlett.6b00306 |
