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2024 Journal Article Endothelial c-Src Mediates Neovascular Tuft Formation in Oxygen-Induced RetinopathyFrampton, Emmanuelle, Som, Priyanka, Hill, Brittany, Yu, Alexander, Naval-Sanchez, Marina, Nefzger, Chistian M., Noordstra, Ivar, Gordon, Emma and Schimmel, Lilian (2024). Endothelial c-Src Mediates Neovascular Tuft Formation in Oxygen-Induced Retinopathy. The American Journal of Pathology, 194 (12), 2239-2251. doi: 10.1016/j.ajpath.2024.09.003 |
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2024 Journal Article c-Src induced vascular malformations require localised matrix degradation at focal adhesionsEssebier, Patricia, Keyser, Mikaela, Yordanov, Teodor, Hill, Brittany, Yu, Alexander, Noordstra, Ivar, Yap, Alpha S., Stehbens, Samantha J., Lagendijk, Anne K., Schimmel, Lilian and Gordon, Emma J. (2024). c-Src induced vascular malformations require localised matrix degradation at focal adhesions. Journal of Cell Science, 137 (13) jcs262101, 1-15. doi: 10.1242/jcs.262101 |
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2023 Journal Article Epithelial cell spreading assay on E-cadherin-coated glass or PDMS substrates for microscopy-based analysis of cadherin adhesionsSchimmel, Lilian and Noordstra, Ivar (2023). Epithelial cell spreading assay on E-cadherin-coated glass or PDMS substrates for microscopy-based analysis of cadherin adhesions. STAR Protocols, 4 (4) 102626, 102626. doi: 10.1016/j.xpro.2023.102626 |
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2023 Journal Article An E-cadherin-actin clutch translates the mechanical force of cortical flow for cell-cell contact to inhibit epithelial cell locomotionNoordstra, Ivar, Hermoso, Mario Díez, Schimmel, Lilian, Bonfim-Melo, Alexis, Currin-Ross, Denni, Duong, Cao Nguyen, Kalappurakkal, Joseph Mathew, Morris, Richard G., Vestweber, Dietmar, Mayor, Satyajit, Gordon, Emma, Roca-Cusachs, Pere and Yap, Alpha S. (2023). An E-cadherin-actin clutch translates the mechanical force of cortical flow for cell-cell contact to inhibit epithelial cell locomotion. Developmental Cell, 58 (18), 1748-1763.e6. doi: 10.1016/j.devcel.2023.06.011 |
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2022 Journal Article Tyrosine-protein kinase Yes controls endothelial junctional plasticity and barrier integrity by regulating VE-cadherin phosphorylation and endocytosisJin, Yi, Ding, Yindi, Richards, Mark, Kaakinen, Mika, Giese, Wolfgang, Baumann, Elisabeth, Szymborska, Anna, Rosa, André, Nordling, Sofia, Schimmel, Lilian, Akmeriç, Emir Bora, Pena, Andreia, Nwadozi, Emmanuel, Jamalpour, Maria, Holstein, Katrin, Sáinz-Jaspeado, Miguel, Bernabeu, Miguel O., Welsh, Michael, Gordon, Emma, Franco, Claudio A., Vestweber, Dietmar, Eklund, Lauri, Gerhardt, Holger and Claesson-Welsh, Lena (2022). Tyrosine-protein kinase Yes controls endothelial junctional plasticity and barrier integrity by regulating VE-cadherin phosphorylation and endocytosis. Nature Cardiovascular Research, 1 (12), 1156-1173+. doi: 10.1038/s44161-022-00172-z |
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2021 Journal Article Endothelial cells are not productively infected by SARS‐CoV‐2Schimmel, Lilian, Chew, Keng Yih, Stocks, Claudia J., Yordanov, Teodor E., Essebier, Patricia, Kulasinghe, Arutha, Monkman, James, Santos Miggiolaro, Anna Flavia Ribeiro, Cooper, Caroline, Noronha, Lucia, Schroder, Kate, Lagendijk, Anne Karine, Labzin, Larisa I., Short, Kirsty R. and Gordon, Emma J. (2021). Endothelial cells are not productively infected by SARS‐CoV‐2. Clinical and Translational Immunology, 10 (10) e1350, e1350. doi: 10.1002/cti2.1350 |
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2021 Journal Article Endothelial junctional membrane protrusions serve as hotspots for neutrophil transmigrationArts, Janine J. G., Mahlandt, Eike K., Grönloh, Max, Schimmel, Lilian, Noordstra, Ivar, Gordon, Emma, van Steen, Abraham C.I., Tol, Simon, Walzog, Barbara, van Rijssel, Jos, Nolte, Martijn A., Postma, Marten, Khuon, Satya, Heddleston, John M., Wait, Eric, Chew, Teng Leong, Winter, Mark, Montanez, Eloi, Goedhart, Joachim and van Buul, Jaap D. (2021). Endothelial junctional membrane protrusions serve as hotspots for neutrophil transmigration. eLife, 10 e66074. doi: 10.7554/elife.66074 |
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2021 Journal Article Endothelial focal adhesions are functional obstacles for leukocytes during basolateral crawlingArts, Janine J. G., Mahlandt, Eike K., Schimmel, Lilian, Grönloh, Max L. B., van der Niet, Sanne, Klein, Bart J. A. M., Fernandez-Borja, Mar, van Geemen, Daphne, Huveneers, Stephan, van Rijssel, Jos, Goedhart, Joachim and van Buul, Jaap D. (2021). Endothelial focal adhesions are functional obstacles for leukocytes during basolateral crawling. Frontiers in Immunology, 12 667213, 1-14. doi: 10.3389/fimmu.2021.667213 |
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2020 Journal Article The importance of mechanical forces for in vitro endothelial cell biologyGordon, Emma, Schimmel, Lilian and Frye, Maike (2020). The importance of mechanical forces for in vitro endothelial cell biology. Frontiers in Physiology, 11 684, 684. doi: 10.3389/fphys.2020.00684 |
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2020 Journal Article c-Src controls stability of sprouting blood vessels in the developing retina independently of cell-cell adhesion through focal adhesion assemblySchimmel, Lilian, Fukuhara, Daisuke, Richards, Mark, Jin, Yi, Essebier, Patricia, Frampton, Emmanuelle, Hedlund, Marie, Dejana, Elisabetta, Claesson-Welsh, Lena and Gordon, Emma (2020). c-Src controls stability of sprouting blood vessels in the developing retina independently of cell-cell adhesion through focal adhesion assembly. Development, 147 (7) 185405, dev.185405. doi: 10.1242/dev.185405 |
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2020 Journal Article DLC1 is a direct target of activated YAP/TAZ that drives collective migration and sprouting angiogenesisvan der Stoel, Miesje, Schimmel, Lilian, Nawaz, Kalim, van Stalborch, Anne-Marieke, de Haan, Annett, Klaus-Bergmann, Alexandra, Valent, Erik T., Koenis, Duco S., van Nieuw Amerongen, Geerten P., de Vries, Carlie J., de Waard, Vivian, Gloerich, Martijn, van Buul, Jaap D. and Huveneers, Stephan (2020). DLC1 is a direct target of activated YAP/TAZ that drives collective migration and sprouting angiogenesis. Journal of Cell Science, 133 (3) jcs239947, jcs239947. doi: 10.1242/jcs.239947 |
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2018 Journal Article The precise molecular signals that control endothelial cell–cell adhesion within the vessel wallSchimmel, Lilian and Gordon, Emma (2018). The precise molecular signals that control endothelial cell–cell adhesion within the vessel wall. Biochemical Society Transactions, 46 (6), 1673-1680. doi: 10.1042/bst20180377 |
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2018 Journal Article Stiffness-induced endothelial DLC-1 expression forces leukocyte spreading through stabilization of the ICAM-1 adhesomeSchimmel, Lilian, van der Stoel, Miesje, Rianna, Carmela, van Stalborch, Anne-Marieke, de Ligt, Aafke, Hoogenboezem, Mark, Tol, Simon, van Rijssel, Jos, Szulcek, Robert, Bogaard, Harm Jan, Hofmann, Patrick, Boon, Reinier, Radmacher, Manfred, de Waard, Vivian, Huveneers, Stephan and van Buul, Jaap D. (2018). Stiffness-induced endothelial DLC-1 expression forces leukocyte spreading through stabilization of the ICAM-1 adhesome. Cell Reports, 24 (12), 3115-3124. doi: 10.1016/j.celrep.2018.08.045 |
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2017 Journal Article Endothelial RhoB and RhoC are dispensable for leukocyte diapedesis and for maintaining vascular integrity during diapedesisSchimmel, Lilian, de Ligt, Aafke, Tol, Simon, de Waard, Vivian and van Buul, Jaap D (2017). Endothelial RhoB and RhoC are dispensable for leukocyte diapedesis and for maintaining vascular integrity during diapedesis. Small GTPases, 11 (3), 1-8. doi: 10.1080/21541248.2017.1377815 |
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2016 Journal Article Leukocyte transendothelial migration: a local affairSchimmel, Lilian, Heemskerk, Niels and van Buul, Jaap D. (2016). Leukocyte transendothelial migration: a local affair. Small GTPases, 8 (1), 1-15. doi: 10.1080/21541248.2016.1197872 |
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2016 Journal Article F-actin-rich contractile endothelial pores prevent vascular leakage during leukocyte diapedesis through local RhoA signallingHeemskerk, Niels, Schimmel, Lilian, Oort, Chantal, van Rijssel, Jos, Yin, Taofei, Ma, Bin, van Unen, Jakobus, Pitter, Bettina, Huveneers, Stephan, Goedhart, Joachim, Wu, Yi, Montanez, Eloi, Woodfin, Abigail and van Buul, Jaap D. (2016). F-actin-rich contractile endothelial pores prevent vascular leakage during leukocyte diapedesis through local RhoA signalling. Nature Communications, 7 (1) 10493. doi: 10.1038/ncomms10493 |
