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2023 Journal Article Senolytic therapy alleviates physiological human brain aging and COVID-19 neuropathologyAguado, Julio, Amarilla, Alberto A., Taherian Fard, Atefeh, Albornoz, Eduardo A., Tyshkovskiy, Alexander, Schwabenland, Marius, Chaggar, Harman K., Modhiran, Naphak, Gómez-Inclán, Cecilia, Javed, Ibrahim, Baradar, Alireza A., Liang, Benjamin, Peng, Lianli, Dharmaratne, Malindrie, Pietrogrande, Giovanni, Padmanabhan, Pranesh, Freney, Morgan E., Parry, Rhys, Sng, Julian D. J., Isaacs, Ariel, Khromykh, Alexander A., Valenzuela Nieto, Guillermo, Rojas-Fernandez, Alejandro, Davis, Thomas P., Prinz, Marco, Bengsch, Bertram, Gladyshev, Vadim N., Woodruff, Trent M., Mar, Jessica C. ... Wolvetang, Ernst J. (2023). Senolytic therapy alleviates physiological human brain aging and COVID-19 neuropathology. Nature Aging, 3 (12), 1561-1575. doi: 10.1038/s43587-023-00519-6 |
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2023 Journal Article 200 Complement drives Parkinson’s disease neuropathology through activation of microglial C5a receptorsAlbornoz, Eduardo and Woodruff, Trent (2023). 200 Complement drives Parkinson’s disease neuropathology through activation of microglial C5a receptors. Immunobiology, 228 (5) 152650, 1-1. doi: 10.1016/j.imbio.2023.152650 |
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2023 Journal Article Response to comment on “Inflammasome inhibition prevents α-synuclein pathology and dopaminergic neurodegeneration in mice”Albornoz, Eduardo A., Gordon, Richard, Kumar, Vinod, Robertson, Avril A. B., Schroder, Kate and Woodruff, Trent M. (2023). Response to comment on “Inflammasome inhibition prevents α-synuclein pathology and dopaminergic neurodegeneration in mice”. Science Translational Medicine, 15 (696) adh0604, 1-4. doi: 10.1126/scitranslmed.adh0604 |
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2023 Journal Article SARS-CoV-2 drives NLRP3 inflammasome activation in human microglia through spike proteinAlbornoz, Eduardo A., Amarilla, Alberto A., Modhiran, Naphak, Parker, Sandra, Li, Xaria X., Wijesundara, Danushka K., Aguado, Julio, Zamora, Adriana Pliego, McMillan, Christopher L. D., Liang, Benjamin, Peng, Nias Y. G., Sng, Julian D. J., Saima, Fatema Tuj, Fung, Jenny N., Lee, John D., Paramitha, Devina, Parry, Rhys, Avumegah, Michael S., Isaacs, Ariel, Lo, Martin W., Miranda-Chacon, Zaray, Bradshaw, Daniella, Salinas-Rebolledo, Constanza, Rajapakse, Niwanthi W., Wolvetang, Ernst J., Munro, Trent P., Rojas-Fernandez, Alejandro, Young, Paul R., Stacey, Katryn J. ... Woodruff, Trent M. (2023). SARS-CoV-2 drives NLRP3 inflammasome activation in human microglia through spike protein. Molecular Psychiatry, 28 (7), 2878-2893. doi: 10.1038/s41380-022-01831-0 |
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2022 Journal Article SARS-CoV-2 triggers complement activation through interactions with heparan sulfateLo, Martin W., Amarilla, Alberto A., Lee, John D., Albornoz, Eduardo A., Modhiran, Naphak, Clark, Richard J., Ferro, Vito, Chhabra, Mohit, Khromykh, Alexander A., Watterson, Daniel and Woodruff, Trent M. (2022). SARS-CoV-2 triggers complement activation through interactions with heparan sulfate. Clinical and Translational Immunology, 11 (8) e1413, e1413. doi: 10.1002/cti2.1413 |
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2022 Journal Article Nucleocapsid specific diagnostics for the detection of divergent SARS-CoV-2 variantsIsaacs, Ariel, Amarilla, Alberto A., Aguado, Julio, Modhiran, Naphak, Albornoz, Eduardo A., Baradar, Alireza A., McMillan, Christopher L. D., Choo, Jovin J. Y., Idris, Adi, Supramaniam, Aroon, McMillan, Nigel A. J., Muller, David A., Young, Paul R., Woodruff, Trent M., Wolvetang, Ernst J., Chappell, Keith J. and Watterson, Daniel (2022). Nucleocapsid specific diagnostics for the detection of divergent SARS-CoV-2 variants. Frontiers in Immunology, 13 926262, 926262. doi: 10.3389/fimmu.2022.926262 |
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2020 Journal Article The microglial NLRP3 inflammasome is activated by amyotrophic lateral sclerosis proteinsDeora, Vandana, Lee, John D., Albornoz, Eduardo A., McAlary, Luke, Jagaraj, Cyril J., Robertson, Avril A. B., Atkin, Julie D, Cooper, Matthew A., Schroder, Kate, Yerbury, Justin J., Gordon, Richard and Woodruff, Trent M. (2020). The microglial NLRP3 inflammasome is activated by amyotrophic lateral sclerosis proteins. Glia, 68 (2) glia.23728, 407-421. doi: 10.1002/glia.23728 |
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2018 Journal Article Inflammasome inhibition prevents α-synuclein pathology and dopaminergic neurodegeneration in miceGordon, Richard, Albornoz, Eduardo A., Christie, Daniel C., Langley, Monica R., Kumar, Vinod, Mantovani, Susanna, Robertson, Avril A. B., Butler, Mark S., Rowe, Dominic B., O'Neill, Luke A., Kanthasamy, Anumantha G., Schroder, Kate, Cooper, Matthew A. and Woodruff, Trent M. (2018). Inflammasome inhibition prevents α-synuclein pathology and dopaminergic neurodegeneration in mice. Science Translational Medicine, 10 (465) aah4066, eaah4066. doi: 10.1126/scitranslmed.aah4066 |
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2018 Journal Article Gestational hypothyroxinemia affects its offspring with a reduced suppressive capacity impairing the outcome of the experimental autoimmune encephalomyelitisHaensgen, Henny, Albornoz, Eduardo, Opazo, María C., Bugueño, Katherinne, Jara Fernández, Evelyn Liliana, Binzberger, Rebecca, Rivero-Castillo, Tomás, Venegas Salas, Luis F., Simon, Felipe, Cabello-Verrugio, Claudio, Elorza, Alvaro A., Kalergis, Alexis M., Bueno, Susan M. and Riedel, Claudia A. (2018). Gestational hypothyroxinemia affects its offspring with a reduced suppressive capacity impairing the outcome of the experimental autoimmune encephalomyelitis. Frontiers in Immunology, 9 (JUN) 1257. doi: 10.3389/fimmu.2018.01257 |
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2018 Journal Article Gestational hypothyroxinemia imprints a switch in the capacity of astrocytes and microglial cells of the offspring to react in inflammationOpazo, María C., González, Pablo A., Flores, Betsi D., Venegas, Luis F., Albornoz, Eduardo A., Cisternas, Pablo, Bohmwald, Karen, Nieto, Pamela A., Bueno, Susan M., Kalergis, Alexis M. and Riedel, Claudia A. (2018). Gestational hypothyroxinemia imprints a switch in the capacity of astrocytes and microglial cells of the offspring to react in inflammation. Molecular Neurobiology, 55 (5), 4373-4387. doi: 10.1007/s12035-017-0627-y |
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2018 Journal Article Chronic helminth infection perturbs the gut-brain axis, promotes neuropathology and alters behaviourGiacomin, Paul R., Kraeuter, Ann Katrin, Albornoz, Eduardo A., Jin, Shuting, Bengtsson, Mia, Gordon, Richard, Woodruff, Trent M., Urich, Tim, Sarnyai, Zoltán and Soares Magalhães, Ricardo J. (2018). Chronic helminth infection perturbs the gut-brain axis, promotes neuropathology and alters behaviour. The Journal of Infectious Diseases, 218 (9), 1511-1516. doi: 10.1093/infdis/jiy092 |
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2017 Journal Article The ketone body β-hydroxybutyrate does not inhibit synuclein mediated inflammasome activation in microgliaDeora, Vandana, Albornoz, Eduardo A., Zhu, Kevin, Woodruff, Trent M. and Gordon, Richard (2017). The ketone body β-hydroxybutyrate does not inhibit synuclein mediated inflammasome activation in microglia. Journal of Neuroimmune Pharmacology, 12 (4), 1-7. doi: 10.1007/s11481-017-9754-5 |
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2015 Journal Article Gestational hypothyroidism increases the severity of experimental autoimmune encephalomyelitis in adult offspring (vol 23, pg 1627, 2013)Albornoz, E. A., Carreno, L. J., Cortes, C. M., Gonzalez, P. A., Cisternas, P. A., Cautivo, K. M., Catalan, T. P., Opazo, M. C., Eugenin, E. A., Berman, J. W., Bueno, S. M., Kalergis, A. M. and Riedel, C. A. (2015). Gestational hypothyroidism increases the severity of experimental autoimmune encephalomyelitis in adult offspring (vol 23, pg 1627, 2013). Thyroid, 25 (9), 1068-1068. doi: 10.1089/thy.2012.0401.cxn |
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2015 Journal Article Excess iodide induces an acute inhibition of the sodium/iodide symporter in thyroid male rat cells by increasing reactive oxygen speciesArriagada, Alejandro A., Albornoz, Eduardo, Cecilia Opazo, Ma., Becerra, Alvaro, Vidal, Gonzalo, Fardella, Carlos, Michea, Luis, Carrasco, Nancy, Simon, Felipe, Elorza, Alvaro A., Bueno, Susan M., Kalergis, Alexis M. and Riedel, Claudia A. (2015). Excess iodide induces an acute inhibition of the sodium/iodide symporter in thyroid male rat cells by increasing reactive oxygen species. Endocrinology, 156 (4), 1540-1551. doi: 10.1210/en.2014-1371 |
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2013 Journal Article Gestational hypothyroidism increases the severity of experimental autoimmune encephalomyelitis in adult offspringAlbornoz, Eduardo A., Carreno, Leandro J., Cortes, Claudia M., Gonzalez, Pablo A., Cisternas, Pablo A., Cautivo, Kelly M., Catalan, Tamara P., Cecilia Opazo, M., Eugenin, Eliseo A., Berman, Joan W., Bueno, Susan M., Kalergis, Alexis M. and Riedel, Claudia A. (2013). Gestational hypothyroidism increases the severity of experimental autoimmune encephalomyelitis in adult offspring. Thyroid, 23 (12), 1627-1637. doi: 10.1089/thy.2012.0401 |
